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Analysis of signal transduction pathways evoked by virus infection

Research Project

Project/Area Number 23390090
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionHokkaido University

Principal Investigator

OHBA Yusuke  北海道大学, 医学(系)研究科(研究院), 教授 (30333503)

Co-Investigator(Renkei-kenkyūsha) TSUDA Masumi  北海道大学, 大学院・医学研究科, 助教 (30431307)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2013: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2012: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2011: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Keywordsシグナル伝達 / エンドサイトーシス / バイオイメージング / インフルエンザウイルス / ウイルス感染
Research Abstract

Virus infections are one of the largest threats of humanity in modern society with scientific and technological advances, of which the H1N1 pandemic in 2009 would be a practical example. We have previously reported that PI3K bound to and activated by Ras plays a crucial role in the regulation of endocytosis by deciphering the signal transduction pathways with the best use of fluorescence bioimaging techniques.
In this study, we found that Ras-PI3K signaling is required for influenza virus infection, and identified intracellular calcium as a key molecule to regulate a series of influenza virus infection processes. It might also be expected to lead to a new concept of antivirus therapeutics through application of these results.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (74 results)

All 2014 2013 2012 2011 Other

All Journal Article (20 results) (of which Peer Reviewed: 13 results,  Open Access: 1 results) Presentation (31 results) (of which Invited: 5 results) Book (7 results) Remarks (2 results) Patent(Industrial Property Rights) (14 results) (of which Overseas: 8 results)

  • [Journal Article] Sustained elevation of Snail promotes Glial- Mesenchymal Transition (GMT) after irradiation in malignant glioma2014

    • Author(s)
      R. Mahabir, M, Tanino, E. Aiman, L. Wang, T. Kimura, T. Itoh, Y. Ohba, H. Nishihara, H. Shirato, M. Tsuda, and S. Tanaka
    • Journal Title

      Neuro-Oncology

      Volume: 6 Pages: 671-685

    • Related Report
      2013 Final Research Report
  • [Journal Article] Histone deacetylase inhibitors sensitize lung cancer cells to hyperthermia : involvement of Ku70/SirT-1 in thermo-protection2014

    • Author(s)
      M.K. Hassan, H. Watari, A.E. Salah-EldinAE, A.S. Sultan, Z. Mohamed, Y. Fujioka, Y. Ohba, N. Sakuragi
    • Journal Title

      PLoS One

      Volume: 9 Issue: 4 Pages: e94213-e94213

    • DOI

      10.1371/journal.pone.0094213

    • NAID

      120005462418

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lysosomal interaction of Akt with Phafin2 : a critical step in the induction of autophagy2014

    • Author(s)
      M. Matsuda-Lennikov, F. Suizu, N. Hirata, M. Hashimoto, K. Kimura, T. Nagamine, Y. Fujioka, Y. Ohba, T. Iwanaga, and M. Noguchi
    • Journal Title

      PLoS One

      Volume: 9 Issue: 5 Pages: 671-685

    • DOI

      10.1093/neuonc/not239

    • NAID

      120005385325

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 細胞の少数制と多様性に挑むシングルセルアナリシス-患者血液と FRET バイオセンサーを用いた薬効効果予測生体の科学2014

    • Author(s)
      大場雄介
    • Journal Title

      金原出版

      Volume: 65 Pages: 171-175

    • Related Report
      2013 Final Research Report
  • [Journal Article] [特集]細胞の少数制と多様性に挑むシングルセルアナリシス―患者血液とFRETバイオセンサーを用いた薬効効果予測2014

    • Author(s)
      大場雄介
    • Journal Title

      生体の科学

      Volume: 65 Pages: 171-175

    • Related Report
      2013 Annual Research Report
  • [Journal Article] A Ca2+-dependent signaling circuit regulates influenza A virus internalization and infection2013

    • Author(s)
      Fujioka Y, Tsuda M, Nanbo A, Hattori T, Sasaki J, Sasaki T, Miyazaki T, Ohba Y
    • Journal Title

      Nature Co㎜unnications

      Volume: 4 Issue: 1 Pages: 2-763

    • DOI

      10.1038/ncomms3763

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Beneficial innate signaling interference for anti-bacterial responses by a TLR-mediated enhancement of the MKP-IRF3 axis2013

    • Author(s)
      Negishi H, Matsuki K, Endo N, Sarashina H. Miki S, Matsuda A, Fukazawa K, Taguchi-Atarashi N, Ikushima H, Yanai H, Nishio J, Honda K, Fujioka Y, Ohba Y, Noda T, Taniguchi S, Nishida E, Zhang Y, Chi H, Flavell RA, Taniguchi T
    • Journal Title

      Proc Nat1 Acad Sci U S A

      Volume: 49 Issue: 49 Pages: 19884-19889

    • DOI

      10.1073/pnas.1320145110

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of influenza A virus infection by Galectin-92013

    • Author(s)
      T. Hattori, J. Maruyama, Y. Fujioka, Y. Nakayama, Y. Ohba, T. Niki, T. Arikawa, T. Miyazaki, M. Hirashima, and H. Kida
    • Journal Title

      Jpn. J. Vet. Res.

      Volume: 61 Pages: 5-18

    • NAID

      120005289519

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] All members of the EPI64 subfamily of TBC/RabGAPs also have GAP activities toward Ras2013

    • Author(s)
      Hiroyuki Nagai
    • Journal Title

      J. Biochem

      Volume: 153 Issue: 3 Pages: 283-288

    • DOI

      10.1093/jb/mvs147

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of influenza A virus infection by Galectin-92013

    • Author(s)
      T. Hattori, et al.
    • Journal Title

      Jpn. J. Vet. Res.

      Volume: -

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1. S.2012

    • Author(s)
      Chiba, M. Baghdadi, H. Akiba, H. Yoshiyama, I. Kinoshita, H. Dosaka-Akita, Y. Fujioka, Y. Ohba, J. V. Gorman, J. D. Colgan, M. Hirashima, T. Uede, A. Takaoka, H. Yagita and M. Jinushi.
    • Journal Title

      Nat. Immunol.

      Volume: 13 Issue: 9 Pages: 832-842

    • DOI

      10.1038/ni.2376

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simultaneous inhibition of Src and Aurora kinases by SU6656 induces therapeutic synergy in human synovial sarcoma growth, invasion and angiogenesis in vivo.2012

    • Author(s)
      Arai R
    • Journal Title

      European journal of cancer(Oxford,England:1990)

      Volume: 48 Issue: 15 Pages: 2417-2430

    • DOI

      10.1016/j.ejca.2011.12.028

    • Related Report
      2013 Final Research Report 2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DJ-1 associates with synaptic membranes2011

    • Author(s)
      Yukiko Usami, Taku Hatano, Satoshi Imai, Shin-ichiro Kubo, Shigeto Sato, Shinji Saiki, Yoichiro Fujioka, Yusuke Ohba, Fumiaki Sato, Manabu Funayama. Hiroto Eguchi, Kaori Shiba, Hiroyoshi Ariga, Jie Shen, Nobutaka Hattori
    • Journal Title

      Neurobiology of Disease

      Volume: 43 Issue: 3 Pages: 651-662

    • DOI

      10.1016/j.nbd.2011.05.014

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RANKL expression specifically observed in vivo promotes epithelial mesenchymal transition and tumor progression2011

    • Author(s)
      Yamada T, et al
    • Journal Title

      Am.J.Pathol.

      Volume: 178 Issue: 6 Pages: 2846-2857

    • DOI

      10.1016/j.ajpath.2011.02.003

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IRF3 regulates cardiac fibrosis but not hypertrophy in mice during angiotensin II-induced hypertension2011

    • Author(s)
      Tsushima K, Osawa T, Yanak H, Nakajima A, Takaoka A, Manabe I, Ohba Y, Imai Y, Taniguchi T, Nagai R
    • Journal Title

      The FASEB Journal

      Volume: 25 Issue: 5 Pages: 1531-1543

    • DOI

      10.1096/fj.10-174615

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Pas-PI3K signaling pathway is involved in clathrin-independent endocytosis and the internalization of influenza viruses2011

    • Author(s)
      Fujioka, Y., Tsuda, M., et al(7名中4番目)
    • Journal Title

      PLoS One

      Volume: 6 Issue: 1 Pages: e16324-e16324

    • DOI

      10.1371/journal.pone.0016324

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of colonic regulatory T cells by indigenous Clostridium species2011

    • Author(s)
      K. Atarashi, T. Tanoue, T. Shima, A. Imaoka, T. Kuwahara, Y. Momose, G. Cheng, S. Yamasaki, T. Saito, Y. Ohba, T. Taniguchi, K. Takeda, S. Hori, I.I. Ivanov, Y. Umesaki, K. Itoh and K. Honda
    • Journal Title

      Science

      Volume: 331 Issue: 6015 Pages: 337-341

    • DOI

      10.1126/science.1198469

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] ZAPS is a potent stimulator of RIG-I-mediated signaling for antiviral response2011

    • Author(s)
      S. Hayakawa, S. Shiratori, H. Yamato, T. Kameyama, C. Kitatsuji, F. Kashigi, S. Goto, S. Kameoka, D. Fujikura, T. Yamada, T. Mizutani, M. Kazumata, M. Sato, J. Tanaka, M. Asaka, Y. Ohba, T. Miyazaki, M. Imamura and A. Takaoka
    • Journal Title

      Nat. Immunol

      Volume: 12 Issue: 1 Pages: 37-44

    • DOI

      10.1038/ni.1963

    • Related Report
      2013 Final Research Report
  • [Journal Article] 蛍光タンパク質を用いた細胞内シグナル伝達の可視化2011

    • Author(s)
      大場雄介, 津田真寿美
    • Journal Title

      日薬理誌

      Volume: 138 Pages: 271-275

    • NAID

      10029417873

    • Related Report
      2013 Final Research Report
  • [Journal Article] 蛍光タンパク質を用いた白血病分子標的治療薬の効果判定技術2011

    • Author(s)
      大場雄介
    • Journal Title

      バイオインダストリー

      Volume: 28 Pages: 33-39

    • Related Report
      2013 Final Research Report
  • [Presentation] フェルスター共鳴エネルギー移動を用いたシグナル伝達の可視化とその応用2014

    • Author(s)
      大場雄介
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島大学郡元キャンパス(鹿児島)
    • Related Report
      2013 Final Research Report
  • [Presentation] インフルエンザウイルスのCa2+シグナルを介した宿主細胞侵入機構2014

    • Author(s)
      藤岡容一朗、津田真寿美、南保明日香、服部ともえ、佐々木純子、佐々木雄彦、宮崎忠昭、大場雄介
    • Organizer
      第66回日本細胞生物学会大会
    • Place of Presentation
      奈良県新公会堂他(奈良)
    • Related Report
      2013 Annual Research Report
  • [Presentation] フェルスター共鳴エネルギー移動を用いたシグナル伝達の可視化とその応用2014

    • Author(s)
      大場雄介
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島大学郡元キャンパス(鹿児島)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Involvement of Ras-PI3K-mediated calcium signaling in the regulation of endocytosis2014

    • Author(s)
      Y. Fujioka, M. Tsuda, A. Nanbo, T. Hattori, J. Sasaki, T. Sasaki, T. Miyazaki and Y. Ohba
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島大学郡元キャンパス(鹿児島)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 細胞機能とシグナル伝達の蛍光イメージング2013

    • Author(s)
      大場雄介
    • Organizer
      日本生化学会北海道支部例会第50回記念大会
    • Place of Presentation
      北海道大学医学部学友会館(札幌市)
    • Related Report
      2013 Final Research Report
  • [Presentation] 細胞機能の蛍光バイオイメージング2013

    • Author(s)
      大場雄介
    • Organizer
      第33回日本骨形態計測学会
    • Place of Presentation
      アクトシティ浜松コングレスセンター(浜松)
    • Related Report
      2013 Final Research Report
  • [Presentation] Influenza viruses internalize into host cells via calcium signaling2013

    • Author(s)
      Y. Fujioka, M. Tsuda, A. Nanbo, T. Hattori, J. Sasaki, T. Sasaki, T. Miyazaki and Y. Ohba
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸国際会議場他(神戸)
    • Related Report
      2013 Annual Research Report
  • [Presentation] P-gp阻害剤はメトロノミックケモセラピーの血管新生阻害効果を強める2013

    • Author(s)
      秋山廣輔,大賀則孝,樋田泰浩,間石奈湖,Alam Mohammad Towfik,川本泰輔,大村瞳,山田健司,鳥居ちさほ,進藤正信,大場雄介,樋田京子
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 血管内皮細胞によるがん転移促進2013

    • Author(s)
      間石奈湖,大場雄介,大賀則孝,秋山廣輔,山本和幸,浜田淳一,川本泰輔,Alam Mohammad Towfik, 大村瞳,進藤正信,樋田泰浩,樋田京子
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 細胞機能の蛍光バイオイメージング2013

    • Author(s)
      大場雄介
    • Organizer
      第33回日本骨形態計測学会
    • Place of Presentation
      アクトシティ浜松コングレスセンター(浜松)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Involvement of Ras-PI3K signaling in the uptake of exogenous factors into cells2013

    • Author(s)
      Y. Fujioka, M. Tsuda, A. Nanbo, T. Hattori, J. Sasaki, T. Sasaki, T. Miyazaki and Y. Ohba
    • Organizer
      第65回日本細胞生物学会大会
    • Place of Presentation
      ウインクあいち(名古屋)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 蛍光タンパク質を用いた細胞内シグナル伝達の解析と応用2012

    • Author(s)
      大場雄介
    • Organizer
      日本薬学会第132回年会
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2012-03-30
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 蛍光タンパク質を用いた細胞内シグナル伝達の解析と応用2012

    • Author(s)
      大場雄介
    • Organizer
      日本薬学会第132回年会
    • Place of Presentation
      北海道大学(札幌)(招待講演)
    • Year and Date
      2012-03-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] RANKL ENHANCES INTEGRIN α2 EXPRESSION AND CELL ADHESIONIN ORAL CANCER CELLS.2012

    • Author(s)
      T. Wagatsuma, et al.
    • Organizer
      The 31st Sapporo International Cancer Symposium, Advanced Radiation Therapy and Cancer Research.
    • Place of Presentation
      The Alumni Hall "Frate" Graduate School of Medicine, Hokkaido University (Sapporo)
    • Related Report
      2012 Annual Research Report
  • [Presentation] FRETによる慢性骨髄性白血病分子標的治療薬の効果判定法2012

    • Author(s)
      大場雄介
    • Organizer
      徳島大学大学院HBS研究部総合研究支援センターバイオイメージング研究部門キックオフシンポジウム
    • Place of Presentation
      徳島大学病院日亜メディカルホール(徳島)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Ras-PI3Kシグナルによる外来因子取込み制御機構の解析2012

    • Author(s)
      藤岡容一朗 他
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Related Report
      2012 Annual Research Report
  • [Presentation] RANKL はインテグリン α2 の発現とエンドサイトーシスを介したインテグリンの細胞内輸送を亢進する2012

    • Author(s)
      我妻孝則 他
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Involvement of RhoA-PIP5K-mediated calcium signaling in influenza virus entry and infection2011

    • Author(s)
      藤岡容一朗, 他
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2011-12-16
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] 慢性骨髄性白血病薬剤耐性細胞の分離と解析2011

    • Author(s)
      金安顕子, 他
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2011-12-14
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] SU6656 suppresses human synovial sarcoma progression through Src and Aurora kinase inhibition2011

    • Author(s)
      新井隆太, 他
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2011-12-14
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] 腫瘍血管内皮細胞とがん転移の相互作用解析2011

    • Author(s)
      間石奈湖, 他
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Year and Date
      2011-10-05
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] 慢性骨髄性白血病に対する分子標的治療薬の反応性・抵抗性判定試験2011

    • Author(s)
      大場雄介, 他
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Year and Date
      2011-10-04
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] Src および Aurora キナーゼ 2 重阻害による滑膜肉腫の相乗的 in vivo 抗腫瘍効果2011

    • Author(s)
      津田真寿美, 他
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Year and Date
      2011-10-04
    • Related Report
      2013 Final Research Report
  • [Presentation] SrcおよびAuroraキナーゼ2重阻害による滑膜肉腫の相乗的in vivo抗腫瘍効果2011

    • Author(s)
      津田真寿美, 他
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] RANKL は口腔癌細胞のインテグリン α2 の発現と細胞接着を亢進する2011

    • Author(s)
      大場雄介, 他
    • Organizer
      第63回日本細胞生物学会大会
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2011-06-29
    • Related Report
      2013 Final Research Report
  • [Presentation] SU6656 は Aurora kinaseを標的にすることにより G2/M 進行を阻害する2011

    • Author(s)
      津田真寿美, 他
    • Organizer
      第63回日本細胞生物学会大会
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2011-06-29
    • Related Report
      2013 Final Research Report
  • [Presentation] RANKLは口腔癌細胞のインテグリンα2の発現と細胞接着を亢進する2011

    • Author(s)
      大場雄介, 他
    • Organizer
      第63回日本細胞生物学会大会
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2011-06-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] SU6656はAurora kinaseを標的にすることによりG2/M進行を阻害する2011

    • Author(s)
      津田真寿美, 他
    • Organizer
      第63回日本細胞生物学会大会
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2011-06-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Influenza viruses activate Ras-PI3K-mediated endocytosis via calcium signaling2011

    • Author(s)
      藤岡容一朗, 他
    • Organizer
      第63回日本細胞生物学会大会
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2011-06-28
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] RANKL upregulates integrin α2 expression and cell adhesion in oral cancer cells2011

    • Author(s)
      我妻孝則, 他
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] 細胞機能とシグナル伝達の蛍光イメージング

    • Author(s)
      大場雄介
    • Organizer
      日本生化学会北海道支部例会第50回記念大会
    • Place of Presentation
      北海道大学医学部学友会館(札幌市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] Fluorescence- Based Biosensors-concepts and applications. Progress in Molecular Biology and Translational Science2013

    • Author(s)
      Y. Ohba, Y. Fujioka, S. Nakada and M. Tsuda
    • Total Pages
      429
    • Publisher
      Elsevier, London
    • Related Report
      2013 Final Research Report
  • [Book] Fluorescence-Based Biosensors-concepts and applications. Progress in Molecular Biology and Translational Science2013

    • Author(s)
      Y, Ohba, Y. Fujioka, S. Nakada and M. Tsuda
    • Total Pages
      429
    • Publisher
      Elsevier, London
    • Related Report
      2013 Annual Research Report
  • [Book] Progress in Molecular Biology and Translational Science2013

    • Author(s)
      Y. Ohba, et al.
    • Total Pages
      414
    • Publisher
      Elsevier
    • Related Report
      2012 Annual Research Report
  • [Book] Biosensors for BCR-ABL activity and their application to cancer. Biosensors and Cancer Hunter RJ and Preedy VR (ed.)2012

    • Author(s)
      Y. Ohba, S. Darmanin, T. Mizutani, M. Tsuda and T. Kondo
    • Total Pages
      408
    • Publisher
      SCIENCE PUBLISHERS, London
    • Related Report
      2013 Final Research Report
  • [Book] Functional Biomaekers of Oral Cancer. Oral Cancer Kalu U. E. Ogbureke (.ed)2012

    • Author(s)
      M. Tsuda and Y. Ohba
    • Total Pages
      388
    • Publisher
      InTech, Croatia
    • Related Report
      2013 Final Research Report
  • [Book] Biosensors and Cancer2012

    • Author(s)
      Y. Ohba, et al.
    • Total Pages
      408
    • Publisher
      SCIENCE PUBLISHERS
    • Related Report
      2012 Annual Research Report
  • [Book] Oral Cancer Ed. Kalu U. E. Ogbureke (Chapter 15 Functional Biomarkers of Oral Cancer)2012

    • Author(s)
      Tsuda, M., Ohba, Y
    • Total Pages
      388
    • Publisher
      InTech
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://cp.med.hokudai.ac.jp

    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.cellsignal-imaging.com/

    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] フェルスター共鳴エネルギー移動用ポリペプチド2014

    • Inventor(s)
      大場雄介
    • Industrial Property Rights Holder
      北海道大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-04-08
    • Related Report
      2013 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] フェルスター共鳴エネルギー移動用ポリペプチド2014

    • Inventor(s)
      大場雄介
    • Industrial Property Rights Holder
      北海道大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-04-08
    • Related Report
      2013 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] フェルスター共鳴エネルギー移動用ポリペプチド2013

    • Inventor(s)
      大場雄介
    • Industrial Property Rights Holder
      北海道大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-04-08
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] FRET 計測措置及び FRET 計測方法2013

    • Inventor(s)
      中田成幸, 大場雄介, 他
    • Industrial Property Rights Holder
      三井造船株式会社
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-03-22
    • Related Report
      2013 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] フェルスター共鳴エネルギー移動用ポリペプチド2013

    • Inventor(s)
      大場雄介
    • Industrial Property Rights Holder
      北海道大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-04-08
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] FRET計測措置及びFRET計測方法2013

    • Inventor(s)
      中田成幸・大場雄介 他
    • Industrial Property Rights Holder
      三井造船(株)、北海道大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-03-22
    • Related Report
      2012 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] FRET計測措置及びFRET計測方法2013

    • Inventor(s)
      中田成幸・大場雄介 他
    • Industrial Property Rights Holder
      三井造船(株)、北海道大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-03-22
    • Related Report
      2012 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] FRET 計測措置及び FRET 計測方法2012

    • Inventor(s)
      中田成幸, 大場雄介, 他
    • Industrial Property Rights Holder
      三井造船株式会社
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-03-22
    • Related Report
      2013 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] FRET 計測措置及び FRET 計測方法2012

    • Inventor(s)
      中田成幸, 大場雄介, 他
    • Industrial Property Rights Holder
      三井造船株式会社
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-03-22
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] FRET 計測措置及び FRET 計測方法2012

    • Inventor(s)
      中田成幸, 大場雄介, 他
    • Industrial Property Rights Holder
      三井造船株式会社
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-03-22
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] FRET計測措置及びFRET計測方法2012

    • Inventor(s)
      中田成幸・大場雄介, 他
    • Industrial Property Rights Holder
      二井造船(株)北海道大学
    • Filing Date
      2012-03-22
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] FRET計測措置及びFRET計測方法2012

    • Inventor(s)
      中田成幸・大場雄介, 他
    • Industrial Property Rights Holder
      三井造船(株)北海道大学
    • Filing Date
      2012-03-22
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] ウイルス感染抑制および/または感染症治療剤, ならびにウイルスの感染を抑制および/または感染症を治療する方法2011

    • Inventor(s)
      大場雄介, 宮崎忠昭
    • Industrial Property Rights Holder
      大場雄介, 宮崎忠昭
    • Industrial Property Rights Type
      特許
    • Filing Date
      2011-04-07
    • Related Report
      2013 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] ウイルス感染抑制およひ/または感染症治療剤、ならびにウイルスの感染を抑制および/または感染症を治療する方法2011

    • Inventor(s)
      大場雄介, 他
    • Industrial Property Rights Holder
      北海道大学
    • Filing Date
      2011-04-07
    • Related Report
      2011 Annual Research Report
    • Overseas

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Published: 2011-04-06   Modified: 2019-07-29  

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