Physiological and pathological roles of PYND, an anti-inflammatory NLR protein
| Project/Area Number |
23390092
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Kanazawa University |
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Principal Investigator |
SUDA Takashi 金沢大学, がん進展制御研究所, 教授 (70250090)
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| Co-Investigator(Renkei-kenkyūsha) |
OSHIMA Masanobu 金沢大学, がん進展制御研究所, 教授 (40324610)
IMAMURA Ryu 金沢大学, がん進展制御研究所, 助教 (10311680)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2013: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Keywords | PYNOD / 自然免疫応答 / 獲得免疫応答 / 樹状細胞 / エフェクターT細胞 / 炎症性発がんモデル / NLRファミリー / 炎症 / 自然免疫 / 獲得免疫 / マクロファージ / 感染免疫 |
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| Research Abstract |
In this study, we have investigated the physiological role of PYNOD (a cytoplasmic protein belonging to the NLR family), especially its role in the immune system using PYNOD-deficient mice. PYNOD-deficient mice exhibited a clear defect in the delayed type hypersensitivity that is a type of acquired immune responses, whereas we could find no apparent defect in innate immune responses in these mice. However, draining lymph node cells isolated from PYNOD-deficient mice that had been immunized through skin routes exhibited normal antigen-specific IFN-gamma production, suggesting that peripheral antigen was successfully delivered to draining lymph nodes and effecter T cells were normally generated in these mice. Thus, it is likely that the cause of the defect in the acquired immune system of PYNOD-deficient mice exist in a process of or after the migration of effecter T cells from draining lymph nodes to peripheral tissues.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] Pyroptotic cells externalize eat-me and release find-me signals and are efficiently engulfed by macrophages.2013
Author(s)
Wang, Q., Imamura, R., Motani, K., Kushiyama, H., Nagata, S. and Suda, T.
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Journal Title
Int Immunol.
Volume: 25
Issue: 6
Pages: 363-372
DOI
Related Report
Peer Reviewed
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[Journal Article] Fas Ligand Has a Greater Impact than TNF-α on Apoptosis and Inflammation in Ischemic Acute Kidney Injury2012
Author(s)
Furuichi K, Kokubo S, Hara A, Imamura R, Wang Q, Kitajima S, Toyama T, Okumura T, Matsushima K, Suda T, Mukaida N, Kaneko S, Wada T
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Journal Title
Nephron Extra
Volume: 2
Issue: 1
Pages: 27-38
DOI
Related Report
Peer Reviewed
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