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Physiological and pathological roles of PYND, an anti-inflammatory NLR protein

Research Project

Project/Area Number 23390092
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionKanazawa University

Principal Investigator

SUDA Takashi  金沢大学, がん進展制御研究所, 教授 (70250090)

Co-Investigator(Renkei-kenkyūsha) OSHIMA Masanobu  金沢大学, がん進展制御研究所, 教授 (40324610)
IMAMURA Ryu  金沢大学, がん進展制御研究所, 助教 (10311680)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2013: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
KeywordsPYNOD / 自然免疫応答 / 獲得免疫応答 / 樹状細胞 / エフェクターT細胞 / 炎症性発がんモデル / NLRファミリー / 炎症 / 自然免疫 / 獲得免疫 / マクロファージ / 感染免疫
Research Abstract

In this study, we have investigated the physiological role of PYNOD (a cytoplasmic protein belonging to the NLR family), especially its role in the immune system using PYNOD-deficient mice. PYNOD-deficient mice exhibited a clear defect in the delayed type hypersensitivity that is a type of acquired immune responses, whereas we could find no apparent defect in innate immune responses in these mice. However, draining lymph node cells isolated from PYNOD-deficient mice that had been immunized through skin routes exhibited normal antigen-specific IFN-gamma production, suggesting that peripheral antigen was successfully delivered to draining lymph nodes and effecter T cells were normally generated in these mice. Thus, it is likely that the cause of the defect in the acquired immune system of PYNOD-deficient mice exist in a process of or after the migration of effecter T cells from draining lymph nodes to peripheral tissues.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (27 results)

All 2013 2012 2011 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (19 results) Book (1 results) Remarks (3 results)

  • [Journal Article] Pyroptotic cells externalize eat-me and release find-me signals and are efficiently engulfed by macrophages.2013

    • Author(s)
      Wang, Q., Imamura, R., Motani, K., Kushiyama, H., Nagata, S. and Suda, T.
    • Journal Title

      Int Immunol.

      Volume: 25 Issue: 6 Pages: 363-372

    • DOI

      10.1093/intimm/dxs161

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of the PI3 K/Akt pathway and autophagy in TLR3 sig naling-induced apoptosis and growth arr est of human prostate cancer cells2012

    • Author(s)
      Harashima, N., Inao, T., Imamura, R., et. al.
    • Journal Title

      Cancer Immunol. Immunother

      Volume: (in press) Issue: 5 Pages: 667-676

    • DOI

      10.1007/s00262-011-1132-1

    • Related Report
      2013 Final Research Report 2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fas Ligand Has a Greater Impact than TNF-α on Apoptosis and Inflammation in Ischemic Acute Kidney Injury2012

    • Author(s)
      Furuichi K, Kokubo S, Hara A, Imamura R, Wang Q, Kitajima S, Toyama T, Okumura T, Matsushima K, Suda T, Mukaida N, Kaneko S, Wada T
    • Journal Title

      Nephron Extra

      Volume: 2 Issue: 1 Pages: 27-38

    • DOI

      10.1159/000335533

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Caspase-1 protein induces apoptosis-associated speck-like protein containing a caspase recruit ment domain(ASC)-mediated necrosis ind ependently of its catalytic activity2011

    • Author(s)
      Motani, K., Kushiyama, H., Imamura, R., et. al.
    • Journal Title

      J. Biol. Chem

      Volume: 286 Issue: 39 Pages: 33963-33972

    • DOI

      10.1074/jbc.m111.286823

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] パイロプトーシスとその被貪食機構2013

    • Author(s)
      須田貴司
    • Organizer
      第86回日本生化学会大会 シンポジウム
    • Place of Presentation
      横浜
    • Year and Date
      2013-09-11
    • Related Report
      2013 Final Research Report
  • [Presentation] Functional Analyses of PYNOD (NLRP10) in Mice2013

    • Author(s)
      Imamura, R
    • Organizer
      3rd International Symposium on Carcinogenic Spiral and International Symposium on Tumor Biology in Kanazawa
    • Place of Presentation
      金沢
    • Related Report
      2013 Final Research Report
  • [Presentation] The Role of NLRP3 in the Induction of Cytokine Gene Expression in Tumor Cells2012

    • Author(s)
      Kinoshita, T., Imamura, R., and Suda, T
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report
  • [Presentation] Functional analyses of PYNOD (NLRP10) in mice2012

    • Author(s)
      Imamura, R., and Suda, T
    • Organizer
      2012年日本免疫学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2013 Final Research Report
  • [Presentation] NLRs : cytoplasmic stress sensors mediating inflammation and cell death2011

    • Author(s)
      須田貴司
    • Organizer
      第34回日本分子生物学会年会(シンポジウム)
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-12-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] NLRP3 mediates NF-κВ activation and cytokine induction in microbially induced and sterile inflammation2011

    • Author(s)
      木下健
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-12-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Trichostatin A induces macrophage IL-1βproduction by activating NLRP3 inflammasome2011

    • Author(s)
      串山裕子
    • Organizer
      2011年日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Year and Date
      2011-11-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 細胞死の様態を決定する新しい分子機構2011

    • Author(s)
      須田貴司
    • Organizer
      第20回日本Cell Death学会学術集会
    • Place of Presentation
      東京大学(東京都)
    • Year and Date
      2011-07-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Caspase-1 induces ASC-mediated necrosis independently of its catalytic activity2011

    • Author(s)
      Motani, K., Kushiyama, H., Imamura, R., Kinoshita, T., and Suda, T
    • Organizer
      13th International TNF Conference
    • Place of Presentation
      Awaji
    • Year and Date
      2011-05-18
    • Related Report
      2013 Final Research Report
  • [Presentation] Caspase-1 induces ASC-mediated necrosis independently of its catalytic activity2011

    • Author(s)
      茂谷康
    • Organizer
      13^<th> International TNF Conference
    • Place of Presentation
      Awaji Yumebutai International Conference Center(兵庫県)
    • Year and Date
      2011-05-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] NLRs : cytoplasmic stress sensors mediating inflammation and cell death2011

    • Author(s)
      Suda, T.
    • Organizer
      第34回日本分子生物学会年会 シンポジウム
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] NLRP3 mediates NF- ・ B activation and cytokine induction in microbially induced and sterile inflammation2011

    • Author(s)
      Kinoshita, T., Imamura, R., and Suda, T
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] Trichostatin A induces macrophage IL-1β production by activating NLRP3 inflammasome2011

    • Author(s)
      Kushiyama, H., Imamura, R., Suda, T
    • Organizer
      2011年日本免疫学会学術集会 ワークショップ
    • Place of Presentation
      幕張
    • Related Report
      2013 Final Research Report
  • [Presentation] Anti- inflammatory activity of PYNOD and its mechanism in humans and mice2011

    • Author(s)
      Imamura, R., Kinoshita, T., Wang, Q., Kushiyama, H., and Suda, T
    • Organizer
      日本分子生物学会 第11回春季シンポジウム・金沢国際がん生物学シンポジウム
    • Place of Presentation
      金沢
    • Related Report
      2013 Final Research Report
  • [Presentation] Anti-inflammatory activity of PYNOD and its mechanism in humans and mice2011

    • Author(s)
      今村龍
    • Organizer
      日本分子生物学会第11回春季シンポジウム
    • Place of Presentation
      石川県立音楽堂(石川県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] パイロトーシス細胞の貪食とそのメカニズム

    • Author(s)
      須田貴司
    • Organizer
      第22回日本Cell Death学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] パイロプトーシスとその被貪食機構

    • Author(s)
      須田貴司
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Functional analyses of PYNOD (NLRP10) in mice

    • Author(s)
      Imamura, Ryu
    • Organizer
      日本免疫学会学術集会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] The Role of NLRP3 in the Induction of Cytokine Gene Expression in Tumor

    • Author(s)
      Kinoshita, Takeshi
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      マリンメッセ福岡
    • Related Report
      2012 Annual Research Report
  • [Book] 細菌感染による能動的細胞死とインフラマソーム 実験医学2012

    • Author(s)
      須田貴司
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://dimb.w3.kanazawa-u.ac.jp/index.html

    • Related Report
      2013 Final Research Report
  • [Remarks] Division of Immunology and Molecular Biology

    • URL

      http://dimb.w3.kanazawa-u.ac.jp/index.html

    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://dimb.w3.kanazawa-u.ac.jp/

    • Related Report
      2011 Annual Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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