The role of CD169 macrophages in anti-tumor immunity induced by dead tumor cells
| Project/Area Number |
23390095
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
TANAKA Masato 東京薬科大学, 生命科学部, 教授 (00294059)
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| Co-Investigator(Renkei-kenkyūsha) |
ASANO Kenichi 東京薬科大学, 生命科学部, 准教授 (10513400)
NISHITAI Gen 東京薬科大学, 生命科学部, 助教 (60509941)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2013: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2012: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2011: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Keywords | がん / マクロファージ / 細胞死 |
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| Research Abstract |
In this study, we tried to reveal the molecular and cellular mechanisms of activation of anti-tumor immunity by CD169-positive macrophages located in lymph node sinus. We generated CD169-Cre-YFP mice, in which CD169-positive macrophages were specifically labeled with YFP, and examined the character of these cells using the mice. We also identified CD169 macrophages-producing molecules that may be able to activate anti-tumor immunity. We established an experimental model to induce cell death of tumor cells in tumor-bearing mice, found the drastic changes in tumor-associated macrophages after tumor cell death. We also reveal the roles of CD169 macrophages in the immune regulation in non-immune tissues.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Colony-StimulatingFactor-1 Signaling Suppresses Renal Crystal Formation.2015
Author(s)
Taguchi Kazumi, Okada Atsushi, Kitamura Hiroshi, Yasui Takahiro, Naiki Taku, Hamamoto Shuzo, Ando Ryosuke, Mizuno Kentaro, Kawai Noriyasu, Tozawa Keiichi, Asano Kenichi, Tanaka Masato, Miyoshi Ichiro, Kohri Kenjiro
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Journal Title
Journal of the American Society of Nephrology
Volume: 25
Issue: 8
Pages: 1680-1697
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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