| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2014: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
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| Outline of Final Research Achievements |
Cancer is known to be caused by gene mutations. However, how gene mutations occur remains unknown. A mutagenic enzyme, activation-induced cytidine deaminase (AID), mainly expressed in B lymphocytes, is required for antibody gene diversification. AID expression is induced in epithelial cells by inflammatory stimuli, can cause mutations in non-antibody genes. AID-transgenic mice develop lymphoma, liver cancer and cancers of other organs. These results suggest involvement of AID in human cancers. In this study, we demonstrated that endogenous AID is involved in chemical-induced skin cancer model in mice. By analyzing the lung of AID-transgenic mice, we observed cell death by AID overexpression, leading to tissue regeneration. Expression of AID in regenerating tissue may be responsible for cancer development in organs under inflammation.
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