| Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2014: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
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| Outline of Final Research Achievements |
We investigated the role of toxic shock syndrome toxin-1 (TSST-1), a superantigenic toxin produced by Staphylococcus aureus during infection.
(1) As the suppressive mechanism of autophagy by TSST-1, accumulation of LC3-II and the expression of LC3B were inhibited by TSST-1 in starvation-induced epithelial cells. (2) Suppression of autophagy by TSST-1 was independent of superantigenic activity. (3) The results of S. aureus infection in epithelial cells suggested that autophagy might be involved in intracellular survival and proliferation of S. aureus. (4) Vaccination of a superantigenic activity-deficient TSST-1 (mTSST-1) induced IL-17A-dependent protection against S. aureus infection in mice. On the other hand, long-term memory by vaccination was masked by IL-10.
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