| Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2013: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2012: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
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| Outline of Final Research Achievements |
The C-type lectin is a large group of transmembrane and extracellular proteins and is characterized by the extracellular domain called CRD (carbohydrate binding domain). Although C-type lectins expressed in dendritic cells (DCs) and macrophages had been suggested to be members of pattern recognition receptors (PRRs), their functions have long been remained unclear. Therefore, we aimed to clarify the molecular mechanisms of C-type lectins in the host defense against microbial infections. In this study, we found that Dectin-1 is a receptor for fungal cell wall beta-glucans and Dectin-2 is a receptor for another fungal cell wall carbohydrate alpha-mannans as well as bacterial cell wall component. More importantly, these C-type lectins are crucial for the host defense against fungal and bacterial infections. Thus, the studies clearly showed that both Dectin-1 and Dectin-2 are PRRs that control microbial infections.
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