Analysis of immune evasion system of Streptococcus pneumoniae
| Project/Area Number |
23390103
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAWABATA Shigetada 大阪大学, 歯学研究科, 教授 (50273694)
TERAO Yutaka 新潟大学, 医歯学系, 教授 (50397717)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2011: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Keywords | 肺炎レンサ球菌 / 免疫回避 / 菌体表層タンパク / 貪食細胞 / 肺炎球菌 / 立体構造 / プロテアーゼ |
|---|
| Research Abstract |
Streptococcus pneumoniae is a common causative agent of pneumonia with high morbidity and mortality rates. In this study, we analyzed how Streptococcus pneumoniae evades host innate immunity. We revealed that pneumococcal a-enolase induce neutrophil extracellular trap formation and NETosis. Utilizing several biochemical assays and a recombinant procedure, a pneumococcal cell wall anchoring protein, PfbA, was found to function as an anti-phagocytic factor. In addition, we elucidated that S. pneumoniae invades human erythrocytes and escapes from neutrophil- and antibiotics-mediated killing.
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Report
(4 results)
Research Products
(93 results)
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[Journal Article] Development of a two-step multiplex PCR assay for typing of capsular polysaccharide synthesis gene clusters of Streptococcus suis2014
Author(s)
Okura M, Lachance C, Osaki M, Sekizaki T, Maruyama F, Nozawa T, Nakagawa I, Hamada S, Rossignol C, Gottschalk M, Takamatsu D
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Journal Title
J Clin Microbiol
Volume: 52
Issue: 5
Pages: 1714-1719
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Population-based Study of Streptococcus suis Infection in Humans in Phayao Province in Northern Thailand2012
Author(s)
Takeuchi D, Kerdsin A, Pienpringam A, Loetthong P, Samerchea S, Pakkinee Loetthong P, Khamisra K, Wongwan N, Areeratana P, Chiranairadul P, Lertchayanti S, Petcharat S, Yowang A, Chaiwongsaen P, Nakayama T, Akeda Y, Hamada S, Sawanpanyalert P, Dejsirilert
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Journal Title
PLoS ONE
Volume: 7(2)
Issue: 2
Pages: e31265-e31265
DOI
Related Report
Peer Reviewed
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[Journal Article] Assembly mechanism of FCT region type 1 pili in serotype M6 Streptococcus pyogenes2011
Author(s)
Nakata M, Kimura KR, Sumitomo T, Wada S, Sugauchi A, Oiki E, Higashino M, Kreikemeyer B, Podbielski A, Okahashi N, Hamada S, Isoda R, Terao Y, and Kawabata S
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Journal Title
J Biol Chem
Volume: 286
Issue: 43
Pages: 37566-37577
DOI
Related Report
Peer Reviewed
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