| Project/Area Number |
23390105
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Osaka University |
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Principal Investigator |
NAGAI Hiroki 大阪大学, 微生物病研究所, 准教授 (80222173)
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| Co-Investigator(Renkei-kenkyūsha) |
AIZAWA Shin-ichi 県立広島大学, 生命環境学部, 教授 (50222451)
IMADA Katsumi 大阪大学, 理学系研究科, 教授 (40346143)
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| Project Period (FY) |
2011-11-18 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Keywords | 細菌 / タンパク質分泌 / IV型分泌 / レジオネラ / 接合伝達 |
|---|
| Research Abstract |
Bacterial pathogens manipulate host cellular processes using their own proteins. These proteins, so-called effectors, are injected into host cells using specialized nanomachines assembled on the bacterial cell surface. One such nanomachine is the type IV secretion system (T4SS). Here we have successfully unveiled the electron microscopic structure of the core complex of the Dot/Icm T4SS, which is essential for Legionella pathogenesis. This is the first report unveiling the structure of a T4SS core complex essential for bacterial pathogenesis.
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