Host factors involved in natural HIV resistance

• Project/Area Number: 23390111
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Virology
• Research Institution: Osaka University
• Principal Investigator: SHIODA Tatsuo 大阪大学, 微生物病研究所, 教授 (00187329)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000); Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2012: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2011: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
• Keywords: HIV感染症 / 宿主因子 / 感染抵抗性 / 生理的リガンド / TRIM5α / TAB2 / TAK1 / 生理リガンド

Research Abstract

In order to identify novel therapeutic target(s) for AIDS/HIV-infection, we have analyzed detailed molecular mechanisms of anti-viral activity of HIV restriction factor TRIM5alpha. We were able to obtain following results: 1.In situ uncoating assay revealed that an HIV-1 mutant strain, which could replicate in the presence of monkey TRIM5alpha, showed delayed uncoating process. 2. A naturally occurring single amino acid substitution in human TRIM5alpha linker region between coiled-coil and SPRY regions affects its anti-HIV-1 activity. 3. TRIM5alpha could bind to TAB2, which is in the TLR4-mediated signal transduction pathway, probably through its SPRY region.

Research Products

• [Journal Article] Moderate Restriction of Macrophage-Tropic Human Immunodeficiency Virus Type 1 by SAMHD1 in Monocyte-Derived Macrophages (2014)
  • Author(s): Taya K, Nakayama EE, Shioda T
  • Journal Title: PLoS One Volume: 9(3) Issue: 3 Pages: e90969-e90969
  • DOI: 10.1371/journal.pone.0090969
  • Peer Reviewed
• [Journal Article] Generation of rhesus macaque-tropic HIV-1 clones that are resistant to major anti-HIV-1 restriction factors (2013)
  • Author(s): Nomaguchi M, Yokoyama M, Kono K, Nakayama EE, Shioda T, Doi N, Fujiwara S, Saito A, Akari H, Miyakawa K, Ryo A, Ode H, Iwatani Y, Miura T, Igarashi T, Sato H, Adachi A
  • Journal Title: J Virol Volume: 87(21) Issue: 21 Pages: 11447-11461
  • DOI: 10.1128/jvi.01549-13
  • Peer Reviewed
• [Journal Article] Slower Uncoating Is Associated with Impaired Replicative Capability of Simian-Tropic HIV-1 (2013)
  • Author(s): Kono K, Takeda E, Tsutsui H, Kuroishi A, Hulme AE, Hope TJ, Nakayama EE, Shioda T
  • Journal Title: PLoS One Volume: 8(8) Issue: 8 Pages: e72531-e72531
  • DOI: 10.1371/journal.pone.0072531
  • Peer Reviewed
• [Journal Article] TRIM5 genotypes in cynomolgus monkeys primarily influence inter-individual diversity in susceptibility to monkey-tropic human immunodeficiency virus type 1 (2013)
  • Author(s): Saito A, Nomaguchi M, Kono K, Iwatani Y, Yokoyama M, Yasutomi Y, Sato H, Shioda T, Sugiura W, Matano T, Adachi A, Nakayama E, Akari H
  • Journal Title: J Gen Virol Volume: 94(Pt 6) Issue: 6 Pages: 1318-24
  • DOI: 10.1099/vir.0.050252-0
  • Peer Reviewed
• [Journal Article] Systemic biological analysis of the mutations in two distinct HIV-1mt genomes occurred during replication in macaque cells (2013)
  • Author(s): Nomaguchi M, DOI N, Fujiwara S, Saito A, Akari H, Nakayama EE, Shioda T, Yokoyama M, Sato H, Adachi A
  • Journal Title: Microbes Infect Volume: 15(4) Issue: 4 Pages: 319-28
  • DOI: 10.1016/j.micinf.2013.01.005
  • Peer Reviewed
• [Journal Article] A naturally occurring single amino acid substitution in human TRIM5α linker region affects its anti-HIV-1 activity and susceptibility to HIV-1 infection (2013)
  • Author(s): Nakayama EE, Nakajima T, Kaur G, Mimaya JI, Terunuma H, Mehra N, Kimura A, Shioda T
  • Journal Title: AIDS Res Hum Retroviruses Volume: 29(6) Issue: 6 Pages: 919-24
  • DOI: 10.1089/aid.2012.0369
  • Peer Reviewed
• [Journal Article] Gag-CA Q110D mutation elicits TRIM5-independent enhancement of HIV-1mt replication in macaque cells (2013)
  • Author(s): Nomaguchi M, Yokoyama M, Kono K, Nakayama EE, Shioda T, Saito A, Akari H, Yasutomi Y, Matano T, Sato H, Adachi A
  • Journal Title: Microbes and Infection Volume: 15(1) Issue: 1 Pages: 56-65
  • DOI: 10.1016/j.micinf.2012.10.013
  • Peer Reviewed
• [Journal Article] Polymorphisms in Fas gene is associated with HIV-related lipoatrophy in Thai patients (2013)
  • Author(s): Likanonsakul S, Rattanatham T, Feangvad S, Uttayamakul S, Prasithsirikul W, Srisopha S, Nitiyanontakij R, Tengtrakulcharoen P, Tarkowski M, Riva A, Nakayama EE, Shioda T
  • Journal Title: AIDS Res Hum Retroviruses Volume: 29(1) Issue: 1 Pages: 142-50
  • DOI: 10.1089/aid.2012.0114
  • Peer Reviewed
• [Journal Article] TRIM5 genotypes in cynomolgus monkeys primarily influence inter-individual diversity in susceptibility to monkey-tropic human immunodeficiency virus type 1. (2013)
  • Author(s): Saito A
  • Journal Title: J Gen Virol. Volume: -
  • Peer Reviewed
• [Journal Article] A naturally occurring single amino acid substitution in human TRIM5α linker region affects its anti-HIV-1 activity and susceptibility to HIV-1 infection. (2013)
  • Author(s): Nakayama EE
  • Journal Title: AIDS Res Hum Retroviruses. Volume: -
  • Peer Reviewed
• [Journal Article] Elicitation of Both Anti HIV-1 Env Humoral and Cellular Immunities by Replicating Vaccinia Prime Sendai Virus Boost Regimen and Boosting by CD40Lm (2012)
  • Author(s): Zhang X, Sobue T, Isshiki M, Makino S, Inoue M, Kato K, Shioda T, Ohashi T, Sato H, Komano J, Hanabusa H, Shida H
  • Journal Title: PLoS One Volume: 7(12) Pages: 206-206
  • DOI: 10.3389/fmicb.2012.00206
  • Peer Reviewed
• [Journal Article] The carboxyl-terminus of human immunodeficiency virus type 2 circulating recombinant form 01_AB capsid protein affects sensitivity to human TRIM5 α (2012)
  • Author(s): Miyamoto T, Nakayama EE, Yokoyama M, Ibe S, Takehara S, Kono K, Yokomaku Y, Pizzato M, Luban J, Sugiura W, Sato H, Shioda T
  • Journal Title: PLoS One Volume: 7(10) Issue: 10 Pages: 347757-347757
  • DOI: 10.1371/journal.pone.0047757
  • Peer Reviewed
• [Journal Article] Allele frequency of antiretroviral host factor TRIMCyp in wild-caught cynomolgus macaques (Macaca fascicularis) (2012)
  • Author(s): Saito A、Kawamoto Y、Higashino A、Yoshida T、Ikoma T、Suzaki Y、Ami Y、Shioda T、Nakayama EE、Akari H
  • Journal Title: Frontier in Microbiology Volume: Vol 3 Pages: 314-314
  • DOI: 10.3389/fmicb.2012.00314
  • Peer Reviewed
• [Journal Article] Role of human TRIM5αin intrinsic inmunity (2012)
  • Author(s): Nakayama EE
  • Journal Title: Front Microbiol Volume: 3 Pages: 97-97
  • DOI: 10.3389/fmicb.2012.00097
  • Peer Reviewed
• [Journal Article] A proposal for a new HIV-1 DLS structural model (2012)
  • Author(s): Sakuragi JI, Ode H, Sakuragi S, Shioda T, Sato H
  • Journal Title: Nucleic Acids Res Volume: 40(11) Issue: 11 Pages: 5012-22
  • DOI: 10.1093/nar/gks156
  • Peer Reviewed
• [Journal Article] TRIM5 α and Species Tropism of HIV/SIV (2012)
  • Author(s): Nakayama EE
  • Journal Title: Front Microbiol Volume: 3 Pages: 13-13
  • DOI: 10.3389/fmicb.2012.00013
  • Peer Reviewed
• [Journal Article] Geographical, genetic and functional diversity of antiretroviral host factor TRIMCyp in cynomolgus macaque (Macaca fascicularis) (2012)
  • Author(s): Akatsuki Saito
  • Journal Title: Journal of General Virology Volume: 93 Issue: 3 Pages: 594-602
  • DOI: 10.1099/vir.0.038075-0
  • Peer Reviewed
• [Journal Article] Influence of ABCB-1 C3435T polymorphisms on Plasma nevirapine and efavirenz levels and their effects on virologic and immunological outcomes in HIV/TB co-infected THAI adults under antiミ retroviral therapy (2012)
  • Author(s): Uttayamakul S, Likanonsakul S, Manosuthi W, Wichukchinda N, Shioda T and Khusmith1 S
  • Journal Title: Southeast Asian J Trop Med Public Health Volume: 43(1) Pages: 78-88
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/23082557
  • Peer Reviewed
• [Journal Article] Geographic, Genetic and functional diversity of antiretroviral host factor TRIMCyp in cynomolgus macaque (Macaca fascicularis) (2012)
  • Author(s): Saito A
  • Journal Title: J Gen Virol Volume: 93 Pages: 594-602
  • Peer Reviewed
• [Journal Article] A proposal for a new HIV-1 DLS structural model (2012)
  • Author(s): Sakuragi JI
  • Journal Title: Nucleic Acids Res Volume: (In press)
  • Peer Reviewed
• [Journal Article] A Single Amino Acid of Human Immunodeficiency Virus Type 2 Capsid Protein Affects Conformation of Two External Loops and Viral Sensitivity to TRIM5alpha (2011)
  • Author(s): Miyamoto T, Yokoyama M, Kono K, Shioda T, Sato H, Nakayama EE
  • Journal Title: PLoS ONE Volume: 6(7) Issue: 7 Pages: e22779-e22779
  • DOI: 10.1371/journal.pone.0022779
  • Peer Reviewed
• [Journal Article] The relationship between HIV-1 genome RNA dimerization, virion maturation and infectivity (2011)
  • Author(s): Ohishi M, Nakano T, Sakuragi S, Shioda T, Sano K, Sakuragi JI
  • Journal Title: Nucleic Acids Res Volume: 39(8) Issue: 8 Pages: 3404-17
  • DOI: 10.1093/nar/gkq1314
  • Peer Reviewed
• [Journal Article] The relationship between HIV-1 genome RNA dimerization, virion maturation and infectivity (2011)
  • Author(s): Ohishi M
  • Journal Title: Nucleic Acids Res Volume: 39 Pages: 3404-17
  • Peer Reviewed
• [Journal Article] A Single Amino Acid of Human Immunodeficiency Virus Type 2 Capsid Protein Affects Conformation of Two External Loops and Viral Sensitivity to TRIM5alpha (2011)
  • Author(s): Miyamoto T
  • Journal Title: PLoS ONE Volume: 6
  • Peer Reviewed
• [Presentation] HIV サブタイプ比較によるゲノムパッケージングに関する解析 (2013)
  • Author(s): 櫻木淳一, 櫻木小百合, 塩田達雄
  • Organizer: 第27回日本エイズ学会学術集会・総会
  • Place of Presentation: 熊本
• [Presentation] マクロファージ指向性 HIV-1 も, マクロファージおよび単球において SAMHD1 による増殖抑制を受けている (2013)
  • Author(s): 田谷かほる, 中山英美, 塩田達雄
  • Organizer: 第27回日本エイズ学会学術集会・総会
  • Place of Presentation: 熊本
• [Presentation] レンチウイルスの Gag 開始コドンおよび翻訳とゲノムパッケージングに関する解析 (2013)
  • Author(s): 櫻木淳一, 夏井洋和, 櫻木小百合, 塩田達雄
  • Organizer: 第61回日本ウイルス学会学術集会
  • Place of Presentation: 神戸
• [Presentation] 可視化ウイルスをつかった HIV-2 カプシドコアの脱核速度測定法の確立 (2013)
  • Author(s): 武田英里, 河野健, Hulme Amy E., Hope Thomas J., 中山英美, 塩田達雄
  • Organizer: 第61回日本ウイルス学会学術集会
  • Place of Presentation: 神戸
• [Presentation] Slower uncoating is associated with impaired replicative capability of simian-tropic HIV-1 (2013)
  • Author(s): Eri Takeda, Ken Kono, Hiromi Tsutsui, Ayumu Kuroishi, Amy E. Hulme, Thomas J. Hope, Emi. E Nakayama, Tatsuo Shioda
  • Organizer: 第12回あわじしま感染症・免疫フォーラム
  • Place of Presentation: 淡路島
• [Presentation] Moderate restriction of macrophage tropic human immunodeficiency virus type 1 by SAMHD1 in monocyte-derived macrophages (2013)
  • Author(s): Kahoru Taya, Emi E Nakayama, Tatsuo Shioda
  • Organizer: 第12回あわじしま感染症・免疫フォーラム
  • Place of Presentation: 淡路島
• [Presentation] レトロウイルスのGagAUG および翻訳とゲノムパッケージングに関する解析 (2013)
  • Author(s): 櫻木淳一、夏井洋和、櫻木小百合、塩田達雄
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸国際会議場（兵庫県）
• [Presentation] マクロファージ指向性 HIV-1も、マクロファージおよび単球において SAMHD1 による増殖抑制を受けている (2013)
  • Author(s): 田谷かほる、中山英美、塩田達雄
  • Organizer: 第27回日本エイズ学会学術集会・総会
  • Place of Presentation: 市民会館崇城大学ホール（熊本県）
• [Presentation] HIVサブタイプ比較によるゲノムパッケージングに関する解析 (2013)
  • Author(s): 櫻木淳一、櫻木小百合、塩田達雄
  • Organizer: 第27回日本エイズ学会学術集会・総会
  • Place of Presentation: 市民会館崇城大学ホール（熊本県）
• [Presentation] 可視化ウイルスをつかったHIV-2カプシドコアの脱核速度測定法の確立 (2013)
  • Author(s): 武田英里、河野健、Hulme Amy E.、Hope Thomas J.、中山英美、塩田達雄
  • Organizer: 第61回日本ウイルス学会学術集会
  • Place of Presentation: 神戸国際会議場（兵庫県）
• [Presentation] レンチウイルスのGag開始コドンおよび翻訳とゲノムパッケージングに関する解析 (2013)
  • Author(s): 櫻木淳一、夏井洋和、櫻木小百合、塩田達雄
  • Organizer: 第61回日本ウイルス学会学術集会
  • Place of Presentation: 神戸国際会議場（兵庫県）
• [Presentation] Moderate restriction of macrophage tropic human immunodeficiency virus type 1 by SAMHD1 in monocyte-derived macrophages. (2013)
  • Author(s): Kahoru Taya, Emi E Nakayama, Shioda Tatsuo
  • Organizer: 第12回あわじしま感染症・免疫フォーラム
  • Place of Presentation: 淡路夢舞台国際会議場（兵庫県）
• [Presentation] Slower uncoating is associated with impaired replicative capability of simian-tropic HIV-1. (2013)
  • Author(s): Eri Takeda, Ken Kono, Hiromi Tsutsui, Ayumu Kuroishi, Amy E. Hulme, Thomas J. Hope, Emi. E Nakayama, Tatsuo Shioda
  • Organizer: 第12回あわじしま感染症・免疫フォーラム
  • Place of Presentation: 淡路夢舞台国際会議場（兵庫県）
• [Presentation] Relationship between genome packaging and Gag translation of various mammal retroviruses. (2013)
  • Author(s): Sayuri Sakuragi, Hirokazu Natsui, Tatsuo Shioda, Jun-ichi Sakuragi
  • Organizer: The 25th Workshop on Retroviral Pathogenesis
  • Place of Presentation: アイスランド大学（アイスランド）
• [Presentation] A Naturally Occurring Single Amino Acid Substitution in Human TRIM5? Linker Region Affects Its Anti-HIV-1 Activity and Susceptibility to HIV-1 Infection (2012)
  • Author(s): E Nakayama
  • Organizer: 19th Conference on Retroviruses and Opportunistic Infections
  • Place of Presentation: Washington State Convention Center (USA)
  • Year and Date: 2012-03-07
• [Presentation] ヒト TRIM5α リンカー領域の多型の抗HIV-1活性に及ぼす影響 (2012)
  • Author(s): 中山英美, 中島敏晶, Gurvinder Kaur, 三間屋純一, 照沼 裕, Narinder Mehra, 木村彰方, 塩田達雄
  • Organizer: 第26回エイズ学会学術集会・総会
  • Place of Presentation: 横浜
• [Presentation] SL1 Revisited : Functional analysis of the structure and conformation of HIV-1 Genome RNA (2012)
  • Author(s): 櫻木淳一, 櫻木小百合, 塩田達雄
  • Organizer: 第26回エイズ学会学術集会・総会
  • Place of Presentation: 横浜
• [Presentation] HIV ゲノム RNA 二量体化シグナルの新規構造モデル (2012)
  • Author(s): 櫻木淳一, 大出裕高, 櫻木小百合, 塩田達雄, 佐藤裕徳
  • Organizer: 第60回日本ウイルス学会学術集会
  • Place of Presentation: 大阪
• [Presentation] A naturally occurring single amino acid substitution in human TRIM5 α linker region affects its anti-HIV-1 activity and susceptibility to HIV-1 infection (2012)
  • Author(s): Emi Nakayama, Toshiaki Nakajima, Gurvinder Kaur, Jun-ich Mimaya, Hiroshi Terunuma, Narinder Mehra, Akinori Kimura, Tatsuo Shioda
  • Organizer: 第11回あわじしま感染症・免疫フォーラム
  • Place of Presentation: 淡路島
• [Presentation] HIV 感染症に関わる宿主因子 (2012)
  • Author(s): 塩田達雄
  • Organizer: 第14回白馬シンポジウム in 京都
  • Place of Presentation: 京都
• [Presentation] A naturally occurring single amino acid substitution in human TRIM5α linker region affects its anti-HIV-1 activity and susceptibility to HIV-1 infection (2012)
  • Author(s): E Nakayama, T Nakajima, G Kaur, H Terunuma, J-I Mimaya, H Ohtani, N Mehra, A Kimura, Tatsuo Shioda
  • Organizer: Cold Spring Harbor Laboratory (Retroviruses)2012
  • Place of Presentation: Seattle(USA)
• [Presentation] A Naturally Occurring Single Amino Acid Substitution in Human TRIM5α Linker Region Affects Its Anti-HIV-1 Activity and Susceptibility to HIV-1 Infection. (2012)
  • Author(s): E Nakayama
  • Organizer: Cold Spring Harbor Laboratory (Retroviruses)
  • Place of Presentation: Cold Spring Harbor Laboratory,Seattle,USA
• [Presentation] HIV感染症に関わる宿主因子 (2012)
  • Author(s): 塩田達雄
  • Organizer: 第14回白馬シンポジウムin京都
  • Place of Presentation: 京都市国際交流会館（京都府）
• [Presentation] A naturally occurring single amino acid substitution in human TRIM5α linker region affects its anti-HIV-1 activity and susceptibility to HIV-1 infection. (2012)
  • Author(s): Emi Nakayama
  • Organizer: 第11回あわじしま感染症・免疫フォーラム
  • Place of Presentation: 淡路夢舞台国際会議場（兵庫県）
• [Presentation] HIVゲノムRNA二量体化シグナルの新規構造モデル (2012)
  • Author(s): 櫻木淳一
  • Organizer: 第60回日本ウイルス学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府）
• [Presentation] ヒトTRIM5α リンカー領域の多型の抗HIV-1活性に及ぼす影響 (2012)
  • Author(s): 中山英美
  • Organizer: 第26回エイズ学会学術集会・総会
  • Place of Presentation: 慶応義塾大学（神奈川県）
• [Presentation] SL1 REVISITED: FUNCTIONAL ANALYSIS OF THE STRUCTURE AND CONFORMATION OF HIV-1 GENOME RNA (2012)
  • Author(s): 櫻木淳一
  • Organizer: 第26回エイズ学会学術集会・総会
  • Place of Presentation: 慶応義塾大学（神奈川県）
• [Presentation] 抗レトロウイルス療法副作用の発症に関わる宿主因子 (2011)
  • Author(s): 中山英美
  • Organizer: 第25回エイズ学会学術集会・総会
  • Place of Presentation: ハイアットリージェンシー東京(東京都)
  • Year and Date: 2011-11-30
• [Presentation] サル指向性HIV-1への感受性に影響を与えるマカクサルTRIM5遺伝子の多様性 (2011)
  • Author(s): 齋藤暁
  • Organizer: 第25回エイズ学会学術集会・総会
  • Place of Presentation: ハイアットリージェンシー東京(東京都)
  • Year and Date: 2011-11-30
• [Presentation] HIV-1ゲノム二量体化シグナルの新規構造モデル (2011)
  • Author(s): 櫻木淳一
  • Organizer: 第25回エイズ学会学術集会・総会
  • Place of Presentation: ハイアットリージェンシー東京(東京都)
  • Year and Date: 2011-11-30
• [Presentation] Genetic polymorphisms of TRIM5 gene in human and macaques (2011)
  • Author(s): 塩田達雄
  • Organizer: 第12回熊本エイズセミナー・グローバル COE 合同国際シンポジウム
  • Place of Presentation: 熊本
  • Year and Date: 2011-10-19
• [Presentation] Genetic polymorphisms of TRIM5 gene in human and macaques (2011)
  • Author(s): 塩田達雄
  • Organizer: 第12回熊本エイズセミナー・グローバルCOE合同国際シンポジウム
  • Place of Presentation: ホテル日航熊本(熊本県)(招待講演)
  • Year and Date: 2011-10-19
• [Presentation] GENOTYPIC VARIATION OF CYNOMOLGUS MONKEY TRIM5ALPHA DETERMINES THE SUS CEPTIBILITY TO MONKEY-TROPIC HIV-1 INFECTION (2011)
  • Author(s): Saito, A
  • Organizer: 第59回日本ウイルス学会学術集会
  • Place of Presentation: 札幌コンベンションセンター(北海道)
  • Year and Date: 2011-09-13
• [Presentation] A single amino acid of human immunodeficiency virus type 2 capsid protein affects conformation of two external loops and viral sensitivity to TRIM5 alpha (2011)
  • Author(s): Miyamoto, T
  • Organizer: 第59回日本ウイルス学会学術集会
  • Place of Presentation: 札幌コンベンションセンター(北海道)
  • Year and Date: 2011-09-13
• [Presentation] Simian-tropic HIV-1 NL-4/5S6/7SVIFS shows slower capsid脱殻in human cells (2011)
  • Author(s): Kono, K
  • Organizer: 第59回日本ウイルス学会学術集会
  • Place of Presentation: 札幌コンベンションセンター(北海道)
  • Year and Date: 2011-09-13
• [Presentation] SL1 revisited : functional analysis of the structure and conformation of HIV-1 genome RNA (2011)
  • Author(s): Sakuragi, JI
  • Organizer: 第59回日本ウイルス学会学術集会
  • Place of Presentation: 札幌コンベンションセンター(北海道)
  • Year and Date: 2011-09-13
• [Presentation] 抗レトロウイルス療法副作用の発症に関わる宿主因子 (2011)
  • Author(s): 中山英美 , Likanonsakul, S., Rattanatham, T., Feangvad, S., Uttayamakul, S., Prasithsirikul, W., Tarkowski, M., Riva, A., 塩田達雄
  • Organizer: 第25回エイズ学会学術集会・総会
  • Place of Presentation: 東京
• [Presentation] サル指向性 HIV-1 への感受性に影響を与えるマカクサル TRIM5 遺伝子の多様性 (2011)
  • Author(s): 齋藤暁, 河野健, 中山英美, 足立昭夫, 野間口雅子, 保富康宏, 俣野哲朗, 塩田達雄, 明里宏文
  • Organizer: 第25回エイズ学会学術集会・総会
  • Place of Presentation: 東京
• [Presentation] HIV-1 ゲノム二量体化シグナルの新規構造モデル (2011)
  • Author(s): 櫻木淳一, 大出裕高, 櫻木小百合, 塩田達雄, 佐藤裕徳
  • Organizer: 第25回エイズ学会学術集会・総会
  • Place of Presentation: 東京
• [Presentation] Genotypic variation of cynomolgus monkey TRIM5Alpha determines the susceptibility to monkey-tropic HIV-1 infection (2011)
  • Author(s): Saito, A., Nomaguchi, M., Kono, K., Nakayama, EE., Shioda T., Yoshida1, T., Yasutomi, Y., Matano, T., Adachi, A., Akari, H
  • Organizer: 第59回日本ウイルス学会学術集会 (International Congress of Virology)
  • Place of Presentation: 札幌
• [Presentation] A single amino acid of human immunodeficiency virus type 2 capsid protein affects conformation of two external loops and viral sensitivity to TRIM5α (2011)
  • Author(s): Miyamoto, T., Yokoyama, M., Kono, K., Shioda T., Sato, H., Nakayama, EE
  • Organizer: 第59回日本ウイルス学会学術集会(International Congress of Virology)
  • Place of Presentation: 札幌
• [Presentation] Simian-Tropic HIV-1 NL-4/5S6/7SVIFS shows slower capsid uncoating in human Cells (2011)
  • Author(s): Kono, K., Kuroishi, A., Nakayama, EE., Hulme, AE., Hope, TJ., Shioda T
  • Organizer: 第59回日本ウイルス学会学術集会(International Congress of Virology)
  • Place of Presentation: 札幌
• [Presentation] Functional analysis of the structure and conformation of HIV-1 genome RNA (2011)
  • Author(s): Sakuragi, JI., Sakuragi, S., Shioda T. SL1 Revisited
  • Organizer: 第59回日本ウイルス学会学術集会(International Congress of Virology)
  • Place of Presentation: 札幌