| Budget Amount *help |
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2012: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2011: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Outline of Final Research Achievements |
We have analyzed association of herpesvirus glycoprotein B (gB) with PILR and found that PILR recognizes both glycan and peptide structure of gB (Kuroki et al. PNAS 2014). From the analyses of varicella zoster virus (VZV) gB and MAG, we found that specific glycan structures on gB is involved in membrane fusion at VZV infection. On the other hand, we have established new method to modify the genome of herpesviruses using CRISPR-Cas9 system (Suenaga et al., Microbes Immunol. 2014). We have also established membrane fusion assay of human herpesivirus 6 (HHV6) and found that gB, gH, gL and gQ are required for membrane fusion of HHV6 (Tanaka et al., J. Virol. 2013).
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