Mechanism of herpesvirus infection

• Project/Area Number: 23390112
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Virology
• Research Institution: Osaka University
• Principal Investigator: ARASE Hisashi 大阪大学, 微生物病研究所, 教授 (10261900)
• Co-Investigator(Kenkyū-buntansha): SUENAGA Tadahiro 大阪大学, 微生物病研究所, 助教 (20396675) ; UEHORI Junji 大阪大学, 微生物病研究所, 助教 (20432429)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000); Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000); Fiscal Year 2012: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000); Fiscal Year 2011: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
• Keywords: 膜融合 / ヘルペスウイルス / 糖鎖 / エントリー

Outline of Final Research Achievements

We have analyzed association of herpesvirus glycoprotein B (gB) with PILR and found that PILR recognizes both glycan and peptide structure of gB (Kuroki et al. PNAS 2014). From the analyses of varicella zoster virus (VZV) gB and MAG, we found that specific glycan structures on gB is involved in membrane fusion at VZV infection. On the other hand, we have established new method to modify the genome of herpesviruses using CRISPR-Cas9 system (Suenaga et al., Microbes Immunol. 2014). We have also established membrane fusion assay of human herpesivirus 6 (HHV6) and found that gB, gH, gL and gQ are required for membrane fusion of HHV6 (Tanaka et al., J. Virol. 2013).

Research Products

• [Journal Article] β2-glycoprotein I/ HLA class II complexes are novel autoantigens in antiphospholipid syndrome. (2015)
  • Author(s): Tanimura K, Jin H, Suenaga T, Morikami S, Arase N, Kishida K, Hirayasu K, Kohyama M, Ebina Y, Yasuda S, Horita T, Takasugi K, Ohmura K, Yamamoto K, Katayama I, Sasazuki T, Lanier LL, Atsumi T, Yamada H, Arase H.
  • Journal Title: Blood Volume: 125 Issue: 18 Pages: 2835-2844
  • DOI: 10.1182/blood-2014-08-593624
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] ミスフォールド蛋白質／MHCクラスII分子複合体による新たな自己免疫疾患発症機構 (2015)
  • Author(s): 荒瀬 尚
  • Journal Title: 臨床免疫・アレルギー科 Volume: 63(2) Pages: 187-192
• [Journal Article] Negative regulation of DSS-induced experimental colitis by PILRα. (2015)
  • Author(s): Kishida, K., Kohyama, M., Kurashima, Y., Kogure, Y., Wang, J., Hirayasu, K., Suenaga, T., Kiyono, H., Kunisawa, J. and Arase, H.
  • Journal Title: Int. Immunol. Volume: - Issue: 6 Pages: 307-314
  • DOI: 10.1093/intimm/dxv004
  • Peer Reviewed / Open Access
• [Journal Article] 自己免疫疾患におけるMHC(HLA)クラスⅡ分子のあらたな機能 (2014)
  • Author(s): 荒瀬 尚
  • Journal Title: 週刊 医学のあゆみ 「HLAのブレイクスルー ー臨床応用と疾患研究の進歩」 Volume: 251(4) Pages: 283-288
• [Journal Article] Engineering large viral DNA genomes using the CRISPR-Cas9 system. (2014)
  • Author(s): Suenaga T, Kohyama M, Hirayasu K, Arase H.
  • Journal Title: Microbiol Immunol. Volume: 58（9） Issue: 9 Pages: 513-522
  • DOI: 10.1111/1348-0421.12180
  • NAID: 40020207309
  • Peer Reviewed
• [Journal Article] A motif in LILRB2 critical for Angptl2 binding and activation. (2014)
  • Author(s): Deng M, Lu Z, Zheng J, Wan X, Chen X, Hirayasu K, Sun H, Lam Y, Chen L, Wang Q, Song C, Huang N, Gao GF, Jiang Y, Arase H, Zhang CC.
  • Journal Title: Blood. Volume: 124(6) Issue: 6 Pages: 924-935
  • DOI: 10.1182/blood-2014-01-549162
  • Peer Reviewed
• [Journal Article] 自己免疫疾患の新たな発症メカニズム (2014)
  • Author(s): 荒瀬 規子、金 暉、荒瀬 尚
  • Journal Title: 感染・炎症・免疫 Volume: 44(2) Pages: 67-69
• [Journal Article] 自己免疫疾患の新たな発症メカニズム (2014)
  • Author(s): 荒瀬 規子、金 暉、荒瀬 尚
  • Journal Title: 細胞工学 Volume: 33(7) Pages: 762-763
• [Journal Article] Structural basis for simultaneous recognition of an O-glycan and its attached peptide of mucin family by immune receptor PILRα. (2014)
  • Author(s): Kuroki K, Wang J, Ose T, Yamaguchi M, Tabata S, Maita N, Nakamura S, Kajikawa M, Kogure A, Satoh T, Arase H, Maenaka K.
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 111(24) Issue: 24 Pages: 8877-8882
  • DOI: 10.1073/pnas.1324105111
  • Peer Reviewed / Open Access
• [Journal Article] Us3 kinase encoded by herpes simplex virus 1 mediates down regulation of cell surface major histocompatibility complex class Iand evasion of CD8+ T cells. (2013)
  • Author(s): Imai, T., et al.
  • Journal Title: PLos One Volume: 8 Issue: 8 Pages: e72050-e72050
  • DOI: 10.1371/journal.pone.0072050
  • Peer Reviewed
• [Journal Article] CD1a-positive familial cutaneous mastocytosis without germ-line or somatic mutations in c-kit (2013)
  • Author(s): Arase, N., Wataya-Kaneda, M., Oiso, N., Arase, H., Katayama, I.
  • Journal Title: Br. J. Dermatol. Volume: 169 Issue: 1 Pages: 201-204
  • DOI: 10.1111/bjd.12265
  • Peer Reviewed
• [Journal Article] Transport of misfolded endoplasmic reticulum proteins to the cell surface by MHC class II molecules. (2013)
  • Author(s): Jiang, Y., Arase, N., Kohyama, M., Hirayasu, K., Suenaga, T., Jin, H., Matsumoto, M., Shida, K., L. Lanier, L., Saito, T. and Arase, H.
  • Journal Title: Int. Immunol. Volume: 25 Issue: 4 Pages: 235-246
  • DOI: 10.1093/intimm/dxs155
  • Peer Reviewed
• [Journal Article] The development of colitogenic CD4+ T cells is regulated by IL-7 in collaboration with natural killer cell function in a murine model of colitis (2012)
  • Author(s): Yamaji O, Totsuka T
  • Journal Title: J Immunol Volume: 188 Issue: 6 Pages: 2524-2536
  • DOI: 10.4049/jimmunol.1100371
  • Peer Reviewed
• [Journal Article] Significant Association of KIR2DL3-HLA-C1 Combination with Cerebral Malaria and Implications for Co-evolution of KIR and HLA. (2012)
  • Author(s): Hirayasu, K., Ohashi, J., Kashiwase, K., Hananantachai, H., Naka, I., Ogawa, A., Takanashi, M., Satake, M., Nakajima, K., Parham, P., Arase, H., Tokunaga, K., Patarapotikul, J., Yabe, T.
  • Journal Title: PLoS Pathog. Volume: 8 Issue: 3 Pages: e1002565-e1002565
  • DOI: 10.1371/journal.ppat.1002565
  • Peer Reviewed
• [Journal Article] Inhibitory Roles of Signal Transducer and Activator of Transcription 3 in Antitumor Immunity during Carcinogen-Induced Lung Tumorigenesis. (2012)
  • Author(s): Ihara, S., Kida, H., Arase, H., et. al.
  • Journal Title: Cancer Res. Volume: 72 Issue: 12 Pages: 2990-2999
  • DOI: 10.1158/0008-5472.can-11-4062
  • Peer Reviewed
• [Journal Article] Neutrophil infiltration during inflammation is regulated by PILRalpha via modulation of integrin activation (2012)
  • Author(s): Wang J, et al.
  • Journal Title: Nat Immunol Volume: 14 Issue: 1 Pages: 2019-2025
  • DOI: 10.1038/ni.2456
  • Peer Reviewed
• [Presentation] Cellular misfolded proteins rescued from protein degradation by MHC class II molecules are targets for autoantibodies in autoimmune diseases (2015)
  • Author(s): Hisashi Arase
  • Organizer: Immunology at the Forefront, the 6th IFReC International Symposium
  • Place of Presentation: KNOWLEDGE THEATER, Grand Front Osaka, Japan
  • Year and Date: 2015-02-23 – 2015-02-24
  • Invited
• [Presentation] 自己免疫疾患の新たな標的分子：ミスフォールド蛋白質／MHCクラスⅡ分子複合体 (2015)
  • Author(s): 荒瀬 尚
  • Organizer: 第22回自己抗体と自己免疫シンポジウム
  • Place of Presentation: 丸ビルホール（東京）
  • Year and Date: 2015-02-07
  • Invited
• [Presentation] Cellular misfolded proteins rescued from protein degradation by MHC class II molecules are targets for autoantibodies in autoimmune diseases (2015)
  • Author(s): Hui Jin, Lewis L. Lanier and Hisashi Arase
  • Organizer: Keystone Symposia on Autoimmunity and Tolerance
  • Place of Presentation: Keystone (U.S.A)
  • Year and Date: 2015-02-02 – 2015-02-08
• [Presentation] Cellular misfolded proteins complexed with MHC class II molecules are targets for autoimmune diseases (2015)
  • Author(s): 荒瀬 尚
  • Organizer: 第4回眉山免疫シンポジウム
  • Place of Presentation: 徳島大学（徳島市）
  • Year and Date: 2015-01-29 – 2015-01-30
  • Invited
• [Presentation] ミスフォールド蛋白質/MHCクラスII分子複合体による新たな自己免疫疾患発症機構 (2015)
  • Author(s): 荒瀬 尚
  • Organizer: 千葉アレルギークリニカルカンファレンス2015
  • Place of Presentation: オークラ千葉ホテル（千葉市）
  • Year and Date: 2015-01-21
  • Invited
• [Presentation] Inhibition of melanogenesis by HLA class II molecules (2014)
  • Author(s): Noriko Arase, Atsushi Tanemura, You Reiri, Megumi Nishioka, Jin Hui, Hisashi Arase, Ichro Katayama
  • Organizer: 日本研究皮膚科学会 第39回年次学術大会・総会
  • Place of Presentation: ホテル阪急エキスポパーク（大阪）
  • Year and Date: 2014-12-12 – 2014-12-14
• [Presentation] Myeloperoxidase/HLA class II complexes are targets for autoantibodies in microscopic polyangiitis. (2014)
  • Author(s): Hiwa Ryosuke, Ohmura Koichiro, Arase Noriko, Jin Hui, Hirayasu Kouyuki, Kohayama Masako, Suenaga Tadahiro, Matsuoka Sumiko, Iwatani Hirotsugu, Atsumi Tatsuya, Terao Chikashi, Mimori Tsuneyo, Arase Hisashi
  • Organizer: 第43回日本免疫学会学術集会
  • Place of Presentation: 国立京都国際会館（京都）
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] Processing of cellular misfolded protein complexed with MHC class II molecules (2014)
  • Author(s): Kishida Kazuki, Arase Hisashi
  • Organizer: 第43回日本免疫学会学術集会
  • Place of Presentation: 国立京都国際会館（京都）
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] PILRα negatively regulates size of adipose tissue by controlling monocyte mobility (2014)
  • Author(s): Kohyama Masako, Kishida Kazuki, Arase Hisashi
  • Organizer: 第43回日本免疫学会学術集会
  • Place of Presentation: 国立京都国際会館（京都）
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] MHC class II-restricted recognition of self-antigen/MHC class II complexes by autoantibodies (2014)
  • Author(s): Jin Hui, Arase Noriko, Matsuoka Sumiko, Hirayasu Kouyuki, Kohayama Masako, Suenaga Tadahiro, Nakamaru Yuji, Imatani Yoshinori, Katayama Ichiro, Arase Hisashi
  • Organizer: 第43回日本免疫学会学術集会
  • Place of Presentation: 国立京都国際会館（京都）
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] ペア型レセプターPILRによる糖鎖認識を介した免疫制御機構 (2014)
  • Author(s): 荒瀬 尚
  • Organizer: 第12回糖鎖学コンソーシアムシンポジウム
  • Place of Presentation: 東京医科歯科大学鈴木章夫記念講堂（東京）
  • Year and Date: 2014-12-04 – 2014-12-05
  • Invited
• [Presentation] ペア型レセプターを介した宿主病原体相互作用 (2014)
  • Author(s): 荒瀬 尚
  • Organizer: 千葉大学感染症グローバルネットワークフォーラム2014
  • Place of Presentation: 千葉大学医学部記念講堂（千葉市）
  • Year and Date: 2014-11-15
  • Invited
• [Presentation] CRISPR/Cas9システムを用いた DNA ウイルスのゲノム改変 (2014)
  • Author(s): 末永忠広、荒瀬尚
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: パシフィコ横浜（横浜）
  • Year and Date: 2014-11-10 – 2014-11-12
• [Presentation] Cellular misfolded proteins complexed with MHC class II molecules are targets for autoantibodies in autoimmune diseases (2014)
  • Author(s): Hisashi Arase
  • Organizer: France-Japan Workshop
  • Place of Presentation: The conference room in Cassis is l'Oustau Calendal, Cassis (France)
  • Year and Date: 2014-10-22 – 2014-10-23
  • Invited
• [Presentation] Paired receptors in host pathogen interaction (2014)
  • Author(s): Hisashi Arase
  • Organizer: 2014 NHRI/IBMS Joint International Conference on Inflammation & Disease
  • Place of Presentation: 2014 NHRI/IBMS Joint International Conference on Inflammation & Disease
  • Year and Date: 2014-10-16 – 2014-10-18
  • Invited
• [Presentation] Cellular misfolded proteins transported to the cell surface by MHC class II molecules are targets for autoantibodies (2014)
  • Author(s): 荒瀬 尚
  • Organizer: Novo Nordisk Innovation Summit 2014
  • Place of Presentation: 東京大学（東京）
  • Year and Date: 2014-10-01 – 2014-10-02
  • Invited
• [Presentation] Engineering of large viral DNA genomes using the CRISPR-Cas9 system (2014)
  • Author(s): Tadahiro Suenaga, Hisashi Arase
  • Organizer: 第13回あわじしま感染症・免疫フォーラム
  • Place of Presentation: 奈良県新公会堂（奈良市）
  • Year and Date: 2014-09-23 – 2014-09-26
• [Presentation] Immune sensing system for bacterially degraded immunoglobulin via activating receptor DIR (2014)
  • Author(s): Kouyuki Hirayasu, Fumiji Saito, Hiroki Nagai, Kyoko Shida, Noriko Arase, Yasuhiko Horiguchi, Yuji Nakamaru, Ichiro Katayama, Hisashi Arase
  • Organizer: 第13回あわじしま感染症・免疫フォーラム
  • Place of Presentation: 奈良県新公会堂（奈良市）
  • Year and Date: 2014-09-23 – 2014-09-26
• [Presentation] ミスフォールド蛋白質／MHCクラスII分子複合体による新たな自己免疫疾患発症機構 (2014)
  • Author(s): 荒瀬 尚
  • Organizer: 第57回日本臨床検査医学会近畿支部総会
  • Place of Presentation: 神戸国際会議場（神戸市）
  • Year and Date: 2014-09-20
  • Invited
• [Presentation] ミスフォールド蛋白質／MHCクラスII分子複合体による新たな自己免疫疾患発症機構 (2014)
  • Author(s): 荒瀬 尚
  • Organizer: Meet The Expert
  • Place of Presentation: 熊本大学医学部（熊本市）
  • Year and Date: 2014-09-09
  • Invited
• [Presentation] Regulation of Immune Response by Paired Receptors (2014)
  • Author(s): Hisashi Arase
  • Organizer: Taishan Academic Forum on Cancer & Immune Singnaling Pathways And First Session Stem Cell Immunology Qilu International Forum
  • Place of Presentation: Yantai,China
  • Year and Date: 2014-08-09 – 2014-08-11
  • Invited
• [Presentation] ミスフォールド蛋白質／MHCクラスII分子複合体による新たな自己免疫疾患発症機構 (2014)
  • Author(s): 荒瀬 尚
  • Organizer: 第21回リウマチ・膠原病セミナー
  • Place of Presentation: 広島大学病院（広島市）
  • Year and Date: 2014-07-31
  • Invited
• [Presentation] HLAクラスⅡ/ミスフォールド蛋白質複合体と自己免疫疾患 (2014)
  • Author(s): 荒瀬 尚
  • Organizer: 静岡リウマチネットワーク学術講演会
  • Place of Presentation: ホテルアソシア静岡（静岡市）
  • Year and Date: 2014-07-12
  • Invited
• [Presentation] Autoantibodies in Rheumatoid Arthritis Specifically Recognize IgG Heavy Chain Complexed with HLA-DR, Which is Strongly Associated with Rheumatoid Arthritis Susceptibility. (2014)
  • Author(s): Jin H, Arase N, Hirayasu K, Kohyama M, Suenaga T, Saito F, Tanimura K, Matsuoka S, Ebina K, Shi K, Toyama-Sorimachi N, Yasuda S, Horita T, Hiwa R, Takasugi K, Ohmura K, Yoshikawa H, Saito T, Atsumi T, Sasazuki T, Katayama I, Lanier LL, Arase H.
  • Organizer: The 15th Annual European Congress of Rheumatology EULAR 2014
  • Place of Presentation: Paris(France)
  • Year and Date: 2014-06-11 – 2014-06-14
• [Presentation] 病原体とペア型レセプター (2014)
  • Author(s): 荒瀬 尚
  • Organizer: 第31回日本産婦人科感染症研究会 学術集会
  • Place of Presentation: 神戸国際会議場（神戸市）
  • Year and Date: 2014-06-07 – 2014-06-08
  • Invited
• [Presentation] MHCクラスⅡ分子によって細胞外へ輸送された細胞内ミスフォールド蛋白質が自己抗体の標的分子である (2014)
  • Author(s): 金暉、荒瀬規子、平安恒幸、香山雅子、末永忠広、松岡須美子、斉藤隆、Lewis L. Lanier、荒瀬尚
  • Organizer: 第24回Kyoto T cell Conference
  • Place of Presentation: 京都大学（京都市）
  • Year and Date: 2014-05-16 – 2014-05-17
• [Presentation] 水痘帯状疱疹ウイルス(VZV)の膜融合におけるシアル酸の役割
  • Author(s): 末永忠広、松本麻紀、有澤 史倫、森康子、荒瀬尚
  • Organizer: 第27回ヘルペスウイルス研究会
  • Place of Presentation: あいち健康プラザ健康宿泊館プラザホール（愛知県）
• [Presentation] 妊娠中の水痘初感染により子宮内胎児死亡に至った1例
  • Author(s): 谷村 憲司、小嶋 伸恵、荒瀬 尚、山田 秀人
  • Organizer: 第27回ヘルペスウイルス研究会
  • Place of Presentation: あいち健康プラザ健康宿泊館プラザホール（愛知県）
• [Presentation] ペア型レセプターPILRのリガンド認識における糖鎖修飾の機能
  • Author(s): 荒瀬 尚
  • Organizer: 第12回日本蛋白質科学会年会
  • Place of Presentation: 名古屋国際会議場（愛知県）
  • Invited
• [Presentation] Glycoprotein B (gB), gH, gL, gQ1 and gQ2 of Human Herpesvirus 6 Mediate Membrane Fusion
  • Author(s): Yuki Tanaka, Tadahiro Suenaga, Maki Matsumoto, Yasuko Mori, Hisashi Arase
  • Organizer: 第11回あわじしま感染症・免疫フォーラム
  • Place of Presentation: 淡路夢舞台国際会議場（兵庫県）
• [Presentation] Human cytomegalovirus UL10 regulates immune response via inhibitory PILRα
  • Author(s): Fuminori Arisawa, Jing Wang, Tadahiro Suenaga, Hisashi Arase
  • Organizer: 第11回あわじしま感染症・免疫フォーラム
  • Place of Presentation: 淡路夢舞台国際会議場（兵庫県）
• [Presentation] Neutrophil infiltration during inflammation is regulated by PILRα via modulation of integrin activation
  • Author(s): Jing Wang, Ikuo Shiratori, Junji Uehori, Masahito Ikawa & Hisashi Arase
  • Organizer: IEIIS2012
  • Place of Presentation: National Center of Sciences Building, Tokyo
• [Presentation] 水痘帯状疱疹ウイルス(VZV)の感染におけるシアル酸の役割
  • Author(s): 末永 忠広、松本 麻紀、有澤 史倫、森 康子、荒瀬 尚
  • Organizer: 第60回日本ウイルス学会学術集会
  • Place of Presentation: グランキューブ大阪（大阪国際会議場)(大阪府)
• [Presentation] ヘルペスウイルス6型の膜融合はgB, gH, gL, gQによって引き起こされる
  • Author(s): 田中 悠喜、末永 忠広、松本 麻紀、森 康子、荒瀬 尚
  • Organizer: 第60回日本ウイルス学会学術集会
  • Place of Presentation: グランキューブ大阪（大阪国際会議場)(大阪府)
• [Presentation] Transport of misfolded ER proteins to the cell surface by MHC class II molecules
  • Author(s): Jiang Y, Arase N, Kohyama M, Hirayasu K, Suenaga T, Jin H, Matsumoto M, Shida K, Lanier LL, Saito T, Arase H.
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸国際会議場（兵庫県）
• [Presentation] Human cytomegalovirus UL10 regulates immune response via inhibitory PILRα
  • Author(s): Fuminori Arisawa, Jing Wang, Tadahiro Suenaga, Hisashi Arase
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸国際会議場（兵庫県）
• [Presentation] Neutrophil infiltration during inflammation is regulated by PILRa via modulation of integrin activation
  • Author(s): Jing Wang, Ikuo Shiratori, Junji Uehori, Masahito Ikawa, Hisashi Arase
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸国際会議場（兵庫県）
• [Presentation] Misfolded ER proteins transported to the cell surface by MHC class II molecules are targeted by autoantibodies
  • Author(s): Hisashi Arase
  • Organizer: Immune Regulation by Immunoreceptors
  • Place of Presentation: 筑波大学（つくば市）
  • Invited
• [Presentation] 水痘帯状疱疹ウイルス（VZV）glycoprotein H (gH)受容体の解析
  • Author(s): 末永忠広、松本麻紀、有澤史倫、森康子、荒瀬尚
  • Organizer: 第28回ヘルペスウイルス研究会
  • Place of Presentation: 淡路夢舞台国際会議場（淡路市）
• [Presentation] Herpesvirus 6 Glycoprotein B (gB), gH, gL and gQ are Necessary and Sufficient for Cell-to-Cell Fusion
  • Author(s): Tadahiro Suenaga, Yuki Tanaka, Misako Matsumoto, Tsukasa Seya, Hisashi Arase
  • Organizer: 38th International Herpesvirus Workshop
  • Place of Presentation: Grand Rapids, Michigan (USA)
• [Presentation] MHCクラスII分子と自己抗体
  • Author(s): 荒瀬尚
  • Organizer: 免疫サマースクール2013
  • Place of Presentation: ザ・ルイガンズ(福岡)
  • Invited
• [Presentation] 病原体とペア型レセプター
  • Author(s): 荒瀬尚
  • Organizer: 第67回日本細菌学会東北支部総会
  • Place of Presentation: 東北大学（仙台市）
  • Invited
• [Presentation] 神経指向性ヘルペスウイルスに対する糖鎖を利用した新規感染制御法
  • Author(s): 末永 忠広
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋国際会議場（愛知県）
• [Presentation] 水痘帯状疱疹ウイルス(VZV)の膜融合機序の解析
  • Author(s): 末永忠広、松本麻紀、森康子、荒瀬尚
  • Organizer: 第26回ヘルペスウイルス研究会
  • Place of Presentation: 大阪アカデミア（大阪府）
• [Presentation] Regulation of herpesvirus infection by paired receptors
  • Author(s): Hisashi Arase
  • Organizer: 45th Joint Working Conference on Immunology and Viral Disease
  • Place of Presentation: Stanford University, CA, (U.S.A.)
  • Invited
• [Presentation] Newly Identified Varicella-Zoster Virus(VZV) gB Receptor that Mediates Membrane Fusion and VZV Entry into Hematopoetic Cells
  • Author(s): Tadahiro Suenaga, Fuminori Arisawa, Yasuko Mori, Hisashi Arase
  • Organizer: 36th International Herpesvirus Workshop
  • Place of Presentation: Gdansk（Poland）
• [Presentation] Newly Identified Varicella-Zoster Virus(VZV) Entry Receptor Expressed in Hematopoietic Cells
  • Author(s): Tadahiro Suenaga, Fuminori Arisawa, Yasuko Mori, Hisashi Aras
  • Organizer: International Union of Microbiological Societies Congresses 2011
  • Place of Presentation: 札幌コンベンションセンター(北海道)
• [Presentation] A Varicella-Zoster Virus entry receptor that expresses on hematopoietic cells
  • Author(s): T.Suenaga, M.Matsumoto, Y.Mori, H.Arase
  • Organizer: 15th International Conference on Immunobiology and Prophylaxis of Human Herpesvirus Infections
  • Place of Presentation: San Servolo,Venice (Italy)
• [Presentation] 水痘帯状疱疹ウイルス(VZV)の膜融合におけるシアル酸の役割
  • Author(s): 末永忠広、松本麻紀、有澤 史倫、森康子、荒瀬尚
  • Organizer: 第27回ヘルペスウイルス研究会
  • Place of Presentation: あいち健康プラザ健康宿泊館プラザホール(愛知県)
• [Book] 血液フロンティア (2013)
  • Author(s): 荒瀬 規子、荒瀬 尚
  • Publisher: 医薬ジャーナル社
• [Book] 週刊 医学のあゆみ「免疫グロブリン様受容体による免疫制御と疾患」 (2013)
  • Author(s): 王 静、荒瀬 尚
  • Publisher: 医歯薬出版株式会社
• [Remarks] 免疫化学分野ホームページ
  • URL: http://immchem.biken.osaka-u.ac.jp/
• [Remarks] 大阪大学微生物病研究所／免疫学フロンティア研究センター 免疫化学分野
  • URL: http://immchem.biken.osaka-u.ac.jp/
• [Remarks] 大阪大学微生物病研究所／免疫学フロンティア研究センター 免疫化学分野
  • URL: http://immchem.biken.osaka-u.ac.jp/
• [Patent(Industrial Property Rights)] 自己抗体の検出方法、自己免疫疾患の罹患の可能性を試験する方法、自己抗体の検出試薬および自己免疫疾患用の試験試薬 (2013)
  • Inventor(s): 荒瀬尚, 谷村憲司, 金暉, 荒瀬規子
  • Industrial Property Rights Holder: 荒瀬尚, 谷村憲司, 金暉, 荒瀬規子
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2013-148833
  • Filing Date: 2013-07-17