Cellular immune responses in AIDS virus controllers

• Project/Area Number: 23390115
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Virology
• Research Institution: National Institute of Infectious Diseases
• Principal Investigator: MATANO TETSURO 国立感染症研究所, エイズ研究センター, センター長 (00270653)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000); Fiscal Year 2013: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2012: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2011: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
• Keywords: ウイルス / 感染症 / 微生物 / 免疫学 / エイズ / 細胞傷害性Tリンパ球 / 変異 / HIV / SIV / ワクチン / 逃避変異

Research Abstract

To elucidate the mechanism for sustained control of HIV replication, this study analyzed vaccinated rhesus macaques that controlled simian immunodeficiency virus (SIV) replication for more than 2 years after challenge. Remarkably, half of these SIV controllers had multiple proviral gag and nef mutations at 2 years whereas the remaining half did not. At 1 year, the former group showed broader cytotoxic T lymphocyte (CTL) responses targeting viral non-Gag/Nef proteins as well as Gag/Nef, whereas Gag- and Nef-specific CTL responses were still dominant in the latter. The latter group represents an extremely stable SIV control by Gag/Nef-specific CTLs, providing a possible mechanism of functional HIV cure by CTLs.

Research Products

• [Journal Article] Control of SIV replication by vaccine-induced Gag- and Vif-specific CD8^+ T cells (2014)
  • Author(s): Iwamoto N, Takahashi N, Seki S, Nomura T, Yamamoto H, Inoue M, Shu T, Naruse TK, Kimura A, Matano T
  • Journal Title: J Virol Volume: 88 Pages: 425-433
  • Peer Reviewed
• [Journal Article] Tertiary mutations stabilize CD8^+ T lymphocyte escape-associated compensatory mutations following transmission of simian immunodeficiency virus (2014)
  • Author(s): Burwitz BJ, Wu HL, Reed JS, Hammond KB, Newman LP, Bimber BN, Nimiyongskul FA, Leon EJ, Maness NJ, Friedrich TC, Yokoyama M, Sato H, Matano T, O'Connor DH, Sacha JB
  • Journal Title: J Virol Volume: 88 Pages: 3598-3604
  • Peer Reviewed
• [Journal Article] Divergence and diversity of ULBP2 genes in rhesus and cynomolgus macaques (2014)
  • Author(s): Naruse TK, Akari H, Matano T, Kimura A
  • Journal Title: Immunogenetics Volume: 66 Pages: 161-170
  • Peer Reviewed
• [Journal Article] Control of SIV replication by vaccine-induced Gag- and Vif-specific CD8+ T cells (2014)
  • Author(s): Nami Iwamoto, Naofumi Takahashi, Sayuri Seki, Takushi Nomura, Hiroyuki Yamamoto, Makoto Inoue, Tsugumine Shu, Taeko K. Naruse, Akinori Kimura, and Tetsuro Matano
  • Journal Title: J. Virol. Volume: 88 Issue: 1 Pages: 425-433
  • DOI: 10.1128/jvi.02634-13
  • Peer Reviewed
• [Journal Article] Tertiary mutations stabilize CD8+ T lymphocyte escape-associated compensatory mutations following transmission of simian immunodeficiency virus (2014)
  • Author(s): Benjamin J. Burwitz, Helen L. Wu, Jason S. Reed, Katherine B. Hammond, Laura P. Newman, Benjamin N. Bimber, Francesca A. Nimiyongskul, Enrique J. Leon, Nicholas J. Maness, Thomas C. Friedrich, Masaru Yokoyama, Hironori Sato, Tetsuro Matano, David H. O’Connor, and Jonah B. Sacha
  • Journal Title: J. Virol. Volume: 88 Issue: 6 Pages: 3598-3604
  • DOI: 10.1128/jvi.03304-13
  • Peer Reviewed
• [Journal Article] A novel protective MHC-I haplotype not associated with dominant Gag-specific CD8+ T-cell responses in SIVmac239 infection of Burmese rhesus macaques (2013)
  • Author(s): Takahashi N, Nomura T, Takahara Y, Yamamoto H, Shiino T, Takeda A, Inoue M, Iida A, Hara H, Shu T, Hasegawa M, Sakawaki H, Miura T, Igarashi T, Koyanagi Y, Naruse TK, Kimura A, Matano T
  • Journal Title: PLoS ONE Volume: 8
  • Peer Reviewed
• [Journal Article] IL-21-producer CD4+ T cell kinetics during primary simian immunodeficiency virus infection (2013)
  • Author(s): Shi S, Seki S, Matano T, Yamamoto H
  • Journal Title: Microbes Infect Volume: 15 Pages: 697-707
  • Peer Reviewed
• [Journal Article] Limited impact of passive non-neutralizing antibody immunization in acute SIV infection on viremia control in rhesus macaques (2013)
  • Author(s): Nakane T, Nomura T, Shi S, Nakamura M, Naruse TK, Kimura A, Matano T, Yamamoto H
  • Journal Title: PLoS ONE Volume: 8
  • Peer Reviewed
• [Journal Article] IL-21-producer CD4+ T cell kinetics during primary simian immunodeficiency virus infection (2013)
  • Author(s): Shoi Shi, Sayuri Seki, Tetsuro Matano, and Hiroyuki Yamamoto
  • Journal Title: Microbes Infect. Volume: 15 Issue: 10-11 Pages: 697-707
  • DOI: 10.1016/j.micinf.2013.06.004
  • Peer Reviewed
• [Journal Article] Limited impact of passive non-neutralizing antibody immunization in acute SIV infection on viremia control in rhesus macaques (2013)
  • Author(s): Taku Nakane, Takushi Nomura, Shoi Shi, Midori Nakamura, Taeko K. Naruse, Akinori Kimura, Tetsuro Matano, and Hiroyuki Yamamoto
  • Journal Title: PLoS ONE Volume: 8 Issue: 9 Pages: e73453-e73453
  • DOI: 10.1371/journal.pone.0073453
  • Peer Reviewed
• [Journal Article] A novel protective MHC-I haplotype not associated with dominant Gag-specific CD8+ T-cell responses in SIVmac239 infection of Burmese rhesus macaques (2013)
  • Author(s): Naofumi Takahashi
  • Journal Title: PLoS ONE Volume: 8 Issue: 1 Pages: e54300-e54300
  • DOI: 10.1371/journal.pone.0054300
  • Peer Reviewed
• [Journal Article] Impact of vaccination on cytotoxic T lymphocyte immunodominance and cooperation against simian immunodeficiency virus replication in rhesus macaques (2012)
  • Author(s): Ishii H, Kawada M, Tsukamoto T, Yamamoto H, Matsuoka S, Shiino T, Takeda A, Inoue M, Iida A, Hara H, Shu T, Hasegawa M, Naruse TK, Kimura A, Takiguchi M, Matano T
  • Journal Title: J Virol Volume: 86 Pages: 738-745
  • Peer Reviewed
• [Journal Article] CTL escape and viral fitness in HIV/SIV infection (2012)
  • Author(s): Seki S, Matano T
  • Journal Title: Front Microbio Volume: 2 Pages: 267-267
  • Peer Reviewed
• [Journal Article] Host cell species-specific effect of cyclosporine A on simian immunodeficiency virus replication (2012)
  • Author(s): Takeuchi H, Ishii H, Kuwano T, Inagaki N, Akari H, Matano T
  • Journal Title: Retrovirology Volume: 9 Pages: 3-3
  • Peer Reviewed
• [Journal Article] Association of major histocompatibility complex class I haplotypes with disease progression after simian immunodeficiency virus challenge in Burmese rhesus macaques (2012)
  • Author(s): Nomura T, Yamamoto H, Shiino T, Takahashi N, Nakane T, Iwamoto N, Ishii H, Tsukamoto T, Kawada M, Matsuoka S, Takeda A, Terahara K, Tsunetsugu-Yokota Y, Iwata-Yoshikawa N, Hasegawa H, Sata T, Naruse TK, Kimura A, Matano T
  • Journal Title: J Virol Volume: 86 Pages: 6481-6490
  • Peer Reviewed
• [Journal Article] Lineage-specific evolution of T-cell immunoglobulin and mucin domain 1 gene in the primates (2012)
  • Author(s): Ohtani H, Naruse TK, Iwasaki Y, Akari H, Ishida T, Matano T, Kimura A
  • Journal Title: Immunogenetics Volume: 64 Pages: 669-678
  • Peer Reviewed
• [Journal Article] Association of MHC-I genotypes with disease progression in HIV/SIV infections (2012)
  • Author(s): Nomura T, Matano T
  • Journal Title: Front Microbio Volume: 3 Pages: 234-234
  • Peer Reviewed
• [Journal Article] Immunogenicity of repeated Sendai viral vector vaccination in macaques (2012)
  • Author(s): Kurihara K, Takahara Y, Nomura T, Ishii H, Iwamoto N, Takahashi N, Inoue M, Iida A, Hara H, Shu T, Hasegawa M, Moriya C, Matano T
  • Journal Title: Microbes Infect Volume: 14 Pages: 1169-1176
  • Peer Reviewed
• [Journal Article] Association of major histocompatibility complex class I haplotypes with disease progression after simian immunodeficiency virus challenge in Burmese rhesus macaques (2012)
  • Author(s): Nomura, T., Yamamoto, H., Shiino, T., Takahashi, N., Nakane, T., Iwamoto, N., Ishii, H., Tsukamoto, T., Kawada, M., Matsuoka, S., Takeda, A., Terahara, K., Tsunetsugu-Yokota, Y., Iwata-Yoshikawa, N., Hasegawa, H., Sata, T., Naruse T.K., Kimura, A., Matano, T.
  • Journal Title: Journal of Virology Volume: (in press) Issue: 12 Pages: 6481-90
  • DOI: 10.1128/jvi.07077-11
  • Peer Reviewed
• [Journal Article] Association of MHC-I genotypes with disease progression in HIV/SIV infections (2012)
  • Author(s): Takushi Nomura
  • Journal Title: Front. Microbio. Volume: 3 Pages: 234-234
  • DOI: 10.3389/fmicb.2012.00234
  • Peer Reviewed
• [Journal Article] Immunogenicity of repeated Sendai viral vector vaccination in macaques (2012)
  • Author(s): Kurihara K, Takahara Y, Nomura T, Ishii H, Iwamoto N, Takahashi N, Inoue M. Iida A, Hara H, Shu T, Hasegawa M, Moriya C, Matano T
  • Journal Title: Microbes Infection Volume: 13 Issue: 13 Pages: 1169-76
  • DOI: 10.1016/j.micinf.2012.07.016
  • Peer Reviewed
• [Journal Article] CTL escape and viral fitness in HIV/SIV infection (2012)
  • Author(s): Seki S, 他
  • Journal Title: Front Microbiol Volume: 2 Pages: 267-267
  • DOI: 10.3389/fmicb.2011.00267
  • Peer Reviewed
• [Journal Article] Host cell species-specific effect of cyclosporine A on simian 1 immunodeficiency virus replication (2012)
  • Author(s): Takeuchi H, 他
  • Journal Title: Retrovirology Volume: 9 Issue: 1 Pages: 3-3
  • DOI: 10.1186/1742-4690-9-3
  • Peer Reviewed
• [Journal Article] Dominant induction of vaccine antigen-specific cytotoxic T lymphocyte responses after simian immunodeficiency virus challenge (2011)
  • Author(s): Takahara Y, Matsuoka S, Kuwano T, Tsukamoto T, Yamamoto H, Ishii H, Nakasone T, Takeda A, Inoue M, Iida A, Hara H, Shu T, Hasegawa M, Sakawaki H, Horiike M, Miura T, Igarashi T, Naruse TK, Kimura A, Matano T
  • Journal Title: Biochem Biophys Res Commun Volume: 408 Pages: 615-619
  • Peer Reviewed
• [Journal Article] Major histocompatibility complex class I-restricted cytotoxic T lymphocyte responses during primary simian immunodeficiency virus infection in Burmese rhesus macaques (2011)
  • Author(s): Nakamura M, Takahara Y, Ishii H, Sakawaki H, Horiike M, Miura T, Igarashi T, Naruse TK, Kimura A, Matano T, Matsuoka S
  • Journal Title: Microbiol Immunol Volume: 55 Pages: 768-773
  • NAID: 10031121531
  • Peer Reviewed
• [Journal Article] Intranasal Sendai viral vector vaccination is more immunogenic than intramuscular under pre-existing anti-vector antibodies (2011)
  • Author(s): Moriya C, Horiba S, Kurihara K, Kamada T, Takahara Y, Inoue M, Iida A, Hara H, Shu T, Hasegawa M, Matano T
  • Journal Title: Vaccine Volume: 29 Pages: 8557-8563
  • Peer Reviewed
• [Presentation] HIV 持続感染成立阻止に結びつく細胞性免疫機序 : サルエイズモデルにおける解析 (2013)
  • Author(s): 俣野哲朗
  • Organizer: 第27回日本エイズ学会学術集会
  • Place of Presentation: 熊本
  • Year and Date: 2013-11-20
  • Invited
• [Presentation] SIV 感染制御群における制御維持への Vif および Nef 特異的細胞傷害性 T リンパ球反応の関与に関する研究 (2013)
  • Author(s): 野村拓志, 俣野哲朗
  • Organizer: 第61回日本ウイルス学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2013-11-12
• [Presentation] Reinforcement of CD8^+ cell capacity to control viral replication by therapeutic vaccination under antiretroviral therapy in SIV-infected rhesus macaques (2013)
  • Author(s): Nakamura M, Takahara Y, Matsuoka S, Matano T
  • Organizer: The 31st annual symposium on non-human primate models for AIDS
  • Place of Presentation: Atlanta, GA, USA
  • Year and Date: 2013-11-04
• [Presentation] Vif can be a promising CD8 T cell target for HIV/SIV control (2013)
  • Author(s): Matano T
  • Organizer: The 14th Kumamoto AIDS Seminar
  • Place of Presentation: Kumamoto
  • Year and Date: 2013-10-29
  • Invited
• [Presentation] Sendai virus vector vaccine (2013)
  • Author(s): Matano T
  • Organizer: AIDS Vaccine Congress 2013
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2013-10-09
  • Invited
• [Presentation] Viral control mechanisms in a macaque AIDS model (2013)
  • Author(s): Matano T
  • Organizer: US-Japan Cooperative Medical Science Program, Joint Meeting of the AIDS Panels
  • Place of Presentation: Singapore
  • Year and Date: 2013-03-13
  • Invited
• [Presentation] エイズワクチン開発 (2012)
  • Author(s): 俣野哲朗
  • Organizer: ポスト日本ワクチン学会シンポ・サテライトシンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2012-11-19
  • Invited
• [Presentation] SIV 複製抑制マカクサルにおける CTL 逃避変異体の選択による複製抑制破綻機構の解析 (2012)
  • Author(s): 野村拓志, 山本浩之, 明里宏文, 俣野哲朗
  • Organizer: 第60回日本ウイルス学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2012-11-14
• [Presentation] Stable viral control in the presence of silent proviruses in a macaque AIDS model (2012)
  • Author(s): Matano T
  • Organizer: The 13th Kumamoto AIDS Seminar
  • Place of Presentation: Kumamoto
  • Year and Date: 2012-10-24
  • Invited
• [Presentation] SIV control by vaccine-based Gag/Vif-specific CTL induction (2012)
  • Author(s): Matano T
  • Organizer: 14th Annual International Meeting, Institute of Human Virology
  • Place of Presentation: Baltimore, MA, USA
  • Year and Date: 2012-10-16
  • Invited
• [Presentation] HIV 感染症におけるウイルスと宿主細胞性免疫の相互作用 (2012)
  • Author(s): 俣野哲朗
  • Organizer: 平成 24年度遺伝子病制御研究所研究集会 : 感染・免疫・炎症・発癌
  • Place of Presentation: 札幌
  • Year and Date: 2012-06-19
  • Invited
• [Presentation] HIV vaccine development (2012)
  • Author(s): Matano T
  • Organizer: Symposium on Research and Quality Control of Vaccines
  • Place of Presentation: Beijing, China
  • Year and Date: 2012-02-20
  • Invited
• [Presentation] HIV vaccine development (2012)
  • Author(s): 俣野哲朗
  • Organizer: Symposium on Research and Quality Control of Vaccines
  • Place of Presentation: National Institutes for Food and Drug Control(北京市)
  • Year and Date: 2012-02-20
• [Presentation] Impact of therapeutic vaccination on CTL immunodominance and viral suppression in SIV-infected rhesus macaques under HAART (2012)
  • Author(s): Takahara Y, Nakamura M, Matsuoka S, Sakawaki H, Miura T, Igarashi T, Koyanagi Y, Naruse T, Kimura A, Matano T
  • Organizer: Towards an HIV cure, Pre-conference symposium and The XIXth International AIDS Conference
  • Place of Presentation: Washington, DC, USA
• [Presentation] Impact of therapeutic vaccination on CTL immunodominance and viral suppression in SIV-infected rhesus macaques under HAART (2012)
  • Author(s): Yusuke Takahara
  • Organizer: Pre-conference symposium and The XIXth International AIDS Conference
  • Place of Presentation: Walter E. Washington Convention Center (Washington, DC)
• [Presentation] サルモデルを用いたエイズワクチン開発研究 (2011)
  • Author(s): 俣野哲朗
  • Organizer: 第4回滋賀医科大学サルシンポジウム : サル類と感染症 - 最近の話題
  • Place of Presentation: 大津
  • Year and Date: 2011-12-19
  • Invited
• [Presentation] サルモデルを用いたエイズワクチン開発研究 (2011)
  • Author(s): 俣野哲朗
  • Organizer: 第4回滋賀医科大学サルシンポジウム「サル類と感染症、最近の話題」
  • Place of Presentation: 滋賀医大(大津市)
  • Year and Date: 2011-12-19
• [Presentation] Impact of prophylactic vaccination on post-exposure CTL cooperation against SIV replication in rhesus macaques (2011)
  • Author(s): Matano T
  • Organizer: The 12th Kumamoto AIDS Seminar
  • Place of Presentation: Kumamoto
  • Year and Date: 2011-10-20
  • Invited
• [Presentation] Impact of prophylactic vaccination on post-exposure CTL cooperation against SIV replication in rhesus macaques (2011)
  • Author(s): 俣野哲朗
  • Organizer: The 12th Kumamoto AIDS Seminar
  • Place of Presentation: 阿蘇リゾートグランヴィリオホテル(阿蘇市)
  • Year and Date: 2011-10-20
• [Presentation] Impact of prophylactic vaccination with Sendai viral vectors on post-challenge CTL responses in a macaque AIDS model (2011)
  • Author(s): Matano T
  • Organizer: The 5th Vaccine and ISV Annual Global Congress
  • Place of Presentation: Seattle, WA, USA
  • Year and Date: 2011-10-02
  • Invited
• [Presentation] Impact of prophylactic vaccination with Sendai viral vectors on post-challenge CTL responses in a macaque AIDS model (2011)
  • Author(s): 俣野哲朗
  • Organizer: The 5th Vaccine and ISV Annual Global Congress
  • Place of Presentation: Seattle Marriott Waterfront(シアトル市)
  • Year and Date: 2011-10-02
• [Presentation] ost-challenge SIV-specific CTL responses in vaccinated macaques (2011)
  • Author(s): Matano T
  • Organizer: US-Japan Cooperative Medical Science Program, Joint Meeting of the AIDS Panels
  • Place of Presentation: Atlanta, GA, USA
  • Year and Date: 2011-09-23
  • Invited
• [Presentation] Post-challenge SIV-specific CTL responses in vaccinated macaques (2011)
  • Author(s): 俣野哲朗
  • Organizer: The 25th Joint Meeting of the United States-Japan Cooperative Medical Science Program AIDS Panels
  • Place of Presentation: Emory University(アトランタ市)
  • Year and Date: 2011-09-23
• [Presentation] Efficacy of single epitope-specific cytotoxic T lymphocyte induction by vaccination against a simian immunodeficiency virus challenge (2011)
  • Author(s): Ishii H, Iwamoto N, Matsuoka S, Inoue M, Iida A, Hara H, Shu T, Hasegawa M, Naruse T, Kimura A, Matano T
  • Organizer: The XVth International Congress of Virology
  • Place of Presentation: Sapporo
  • Year and Date: 2011-09-16
• [Presentation] Analysis of viral genome sequences in SIV controllers (2011)
  • Author(s): Nomura T, Yamamoto H, Shi S, Iwamoto N, Matano T
  • Organizer: The XVth International Congress of Virology
  • Place of Presentation: Sapporo
  • Year and Date: 2011-09-15
• [Presentation] Analysis of viral genome sequences in SIV controllers (2011)
  • Author(s): 野村拓志, 他
  • Organizer: The XVth International Congress of Virology
  • Place of Presentation: 札幌コンベンションセンター(札幌市)
  • Year and Date: 2011-09-15
• [Presentation] Efficacy of single epitope-specific cytotoxic T lymphocvte induction by vaccination against a simian immunodeficiency virus challenge (2011)
  • Author(s): 石井洋, 他
  • Organizer: The XVth International Congress of Virology
  • Place of Presentation: 札幌コンベンションセンター(札幌市)
  • Year and Date: 2011-09-15
• [Presentation] Sendai virus vector vaccine
  • Author(s): Tetsuro Matano
  • Organizer: AIDS Vaccine Congress 2013
  • Place of Presentation: Barcelona International Convention Center, Barcelona, Spain
  • Invited
• [Presentation] Vif can be a promising CD8 T cell target for HIV/SIV control
  • Author(s): Tetsuro Matano
  • Organizer: The 14th Kumamoto AIDS Seminar
  • Place of Presentation: Hotel Nikko Kumamoto, Kumamoto, Japan
  • Invited
• [Presentation] Reinforcement of CD8+ cell capacity to control viral replication by therapeutic vaccination under antiretroviral therapy in SIV-infected rhesus macaques
  • Author(s): Midori Nakamura, Yusuke Takahara, Saori Matsuoka, Tetsuro Matano
  • Organizer: The 31st annual symposium on non-human primate models for AIDS
  • Place of Presentation: JW Marriott Atlanta Buckhead, Atlanta, GA, USA
• [Presentation] SIV感染制御群における制御維持へのVifおよびNef特異的細胞傷害性Tリンパ球反応の関与に関する研究
  • Author(s): 野村拓志、俣野哲朗
  • Organizer: 第61回日本ウイルス学会学術集会
  • Place of Presentation: 神戸国際会議場、神戸
• [Presentation] HIV持続感染成立阻止に結びつく細胞性免疫機序：サルエイズモデルにおける解析
  • Author(s): 俣野哲朗
  • Organizer: 第27回日本エイズ学会学術集会
  • Place of Presentation: 熊本市民会館、熊本
  • Invited
• [Presentation] HIV 感染症におけるウイルスと宿主細胞性免疫の相互作用
  • Author(s): 俣野哲朗
  • Organizer: 平成24年度遺伝子病制御研究所研究集会：感染・免疫・炎症・発癌
  • Place of Presentation: 北海道大学（札幌市）
  • Invited
• [Presentation] Efficacy of CTL induction by vaccination under antiretroviral therapy in SIV-infected rhesus macaques
  • Author(s): Midori Nakamura
  • Organizer: The 11th Awaji International Forum on Infection and Immunity
  • Place of Presentation: 淡路夢舞台国際会議場（淡路島）
• [Presentation] SIV control by vaccine-based Gag/Vif-specific CTL induction
  • Author(s): Tetsuro Matano
  • Organizer: 14th Annual International Meeting, Institute of Human Virology
  • Place of Presentation: Baltimore Marriott Waterfront (Baltimore, MD)
  • Invited
• [Presentation] Stable viral control in the presence of silent proviruses in a macaque AIDS model
  • Author(s): Tetsuro Matano
  • Organizer: The 13th Kumamoto AIDS Seminar
  • Place of Presentation: ホテル日航熊本（熊本）
  • Invited
• [Presentation] SIV複製抑制マカクサルにおけるCTL逃避変異体の選択による複製抑制破綻機構の解析
  • Author(s): 野村拓志
  • Organizer: 第60回日本ウイルス学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪）
• [Presentation] エイズワクチン開発
  • Author(s): 俣野哲朗
  • Organizer: ポスト日本ワクチン学会シンポ・サテライトシンポジウム
  • Place of Presentation: 東京コンファレンスセンター（東京）
  • Invited
• [Presentation] Viral control mechanisms in a macaque AIDS model
  • Author(s): Tetsuro Matano
  • Organizer: US-Japan Cooperative Medical Science Program, Joint Meeting of the AIDS Panels
  • Place of Presentation: Mandarin Oriental (Singapore)
  • Invited
• [Remarks]
  • URL: http://square.umin.ac.jp/arc/