Molecular mechanisms of memory B cell differentiation in germinal centers
Project/Area Number |
23390121
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Immunology
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Research Institution | Chiba University |
Principal Investigator |
TOKUHISA Takeshi 千葉大学, 医学(系)研究科(研究院), 教授 (20134364)
|
Co-Investigator(Kenkyū-buntansha) |
ARIMA Masafumi 千葉大学, 大学院・医学研究院, 講師 (00202763)
SAKAMOTO Akemi 千葉大学, 大学院・医学研究院, 助教 (90359597)
|
Project Period (FY) |
2011-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2012: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2011: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
|
Keywords | 免疫記憶 / Bリンパ球 / 胚中心 / サイトカイン / 抗体産生細胞 / IgE抗体 / Bリンパ球 |
Research Abstract |
To elucidate a role of IL-21 or Bcl6 in differentiation of high affinity IgG producing memory B cells and long-lived plasma cells in germinal centers, we used IL-21-deficient or Bcl6-deficient mice. Using these mice, we demonstrated that IL-21 is essential to differentiation of high affinity IgG producing long-lived plasma cells, and that IL-21 or Bcl6 represses the Ig class switch recombination to IgE and augments the differentiation of high affinity IgG producing memory B cells and long-lived plasma cells.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Plant homeodomain finger protein 11 promotes class switch recombination to IgE in murine activated B cells.2014
Author(s)
Ikari J, Inamine A, Yamamoto T, Watanabe-Takano H, Yoshid a N, Fujimura L, Taniguchi T, Sakamoto A, Hatano M, Tatsumi K, Tokuhisa T, Arima M.
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Journal Title
Allergy.
Volume: 69
Issue: 2
Pages: 223-230
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Lack of both α2-antiplasmin and plasminogen activator inhibitor type-1 induces high IgE production2013
Author(s)
Okada K, Ueshima S, Kawao N, Yano M, Tamura Y, Tanaka M, Sakamoto A, Hatano M, Arima M, Miyata S, Nagai N, Tokuhisa T, and Matsuo O
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Journal Title
Life Sci
Volume: 93
Issue: 2-3
Pages: 89-95
DOI
Related Report
Peer Reviewed
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[Journal Article] ADAR1 induces adenosine-targeted DNA mutations in senescent Bcl6-deficient cells2013
Author(s)
Tsuruoka, N., Arima, M., Yoshida, N., Okada, S., Sakamoto, A., Hatano, M., Satake, H., Arguni, E., Wang, J.-Y., Yang, J.-H., Nishikura, K., Sekiya, S., Shozu, M. and Tokuhisa, T.
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Journal Title
J. Biol. Chem.
Volume: 288
Issue: 2
Pages: 826-836
DOI
Related Report
Peer Reviewed
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[Journal Article] Critical role of the IgM Fc receptor in IgM homeostasis, B cell survival and humoral immune responses2012
Author(s)
Ouchida, R., Mori, H., Hase, K., Takatsu, H., Kurosaki, T., Tokuhisa, T., Ohno, H., Wang. J. -Y.
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Journal Title
Proc. Natl. Acad. Sci. USA
Volume: 109
Issue: 40
Pages: 2699-2706
DOI
Related Report
Peer Reviewed
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[Journal Article] CD40 amplifies Fas-mediated apoptosis: a mechanism contributing to emphysema2012
Author(s)
Shigeta, A., Tada, Y., Wang, J.-Y., Ishizaki, S., Tuyusaki, J., Yamauchi, K., Kasahara, Y., Iesato, K., Tanabe, N., Takiguchi, Y., Sakamoto, A., Tokuhisa, T., Shibuya, K., Hiroshima, K., West, J. and Tatsumi, K.
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Journal Title
American Journal of Physiology
Volume: 303
Issue: 2
Pages: 141-151
DOI
Related Report
Peer Reviewed
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[Journal Article] BAZF, a novel component of cullin3-based E3 ligase complex, mediates VEGFR and Notch cross-signalling in angiogenesis2012
Author(s)
Ohnuki H, Inoue H, Takemori N, Nakayama H, Sakaue T, Fukuda S, Miwa D, Nishiwaki E, Hatano M, Tokuhisa T, Endo Y, Nose M, and Higashiyama S
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Journal Title
Blood
Volume: 119
Issue: 11
Pages: 2688-2698
DOI
Related Report
Peer Reviewed
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[Journal Article] Outcome prediction in sepsis combined use of genetic polymorphisms - A study in Japanese population2011
Author(s)
Shimada T, Oda S, Sadahiro T, Nakamura M, Hirayama Y, Watanabe E, Abe R, Nakada TA, Tateishi Y, Otani S, Hirasawa H, Tokuhisa T, and Uno H
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Journal Title
Cytokine
Volume: 54
Issue: 1
Pages: 79-84
DOI
Related Report
Peer Reviewed
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