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Clarification of molecular mechanisms for regulating dendritic cell subset functions

Research Project

Project/Area Number 23390124
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Immunology
Research InstitutionOsaka University

Principal Investigator

KAISHO Tsuneyasu  大阪大学, 免疫学フロンティア研究センター, 寄附研究部門教授 (60224325)

Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2013: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2011: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Keywords樹状細胞 / インターフェロン / クロスプライミング / シグナル伝達 / サブセット / クロスプレゼンテーション / XCR1 / ジフテリアトキシン / I型インターフェロン / 転写因子 / インターフェロン制御因子(IRF) / Etsファミリー / インターフェロン制御因子(IRF)
Research Abstract

Dendritic cells (DCs) consist of various subsets and functions in a subset-specific manner. Plasmacytoid DC (PDC) produce type I interferons (IFNs) in response to the signaling through nucleic acid sensors, TLR7/9, thereby being involved in antiviral defense and pathogenesis of certain autoimmune diseases. An Ets family transcription factor, Spi-B, highly expressed in PDC, is critical for this PDC activity. Furthremore, CD8alpha+ DC is featured by its high crosspresenting ability. The mutant mice, in which CD8alpha+ DC can be traced by fluorescence protein expression and ablated conditionally, were generated. By using the mice, CD8alpha+ DC was found to be critical for in vivio crosspresentation. Thus, molecular and cellular mechansims on the DC subset-specific functions were clarified.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (98 results)

All 2014 2013 2012 2011 Other

All Journal Article (26 results) (of which Peer Reviewed: 18 results,  Open Access: 1 results) Presentation (61 results) (of which Invited: 4 results) Book (9 results) Remarks (2 results)

  • [Journal Article] Olfactory plays a key role in spatiotemporal pathogenesis of cerebral malaria.2014

    • Author(s)
      H. Zhao, T. Aoshi, S. Kawai, Y. Mori, A. Konishi, M. Ozkan, Y. Fujita, Y. Haseda, M. Shimizu, M. Kohyama, K. Kobiyama, K. Eto, J. Nabekura, T. Horii, T. Ishino, M. Yuda, H. Hemmi, T. Kaisho, S. Akira, M. Kinoshita, K. Tohyama, Y. Yoshioka, K. J. Ishii, C. Coban
    • Journal Title

      Cell Host Microbe

      Volume: 15 Issue: 5 Pages: 551-563

    • DOI

      10.1016/j.chom.2014.04.008

    • Related Report
      2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enhanced Apoptosis by Disruption of the STAT3-I κ B-ζ Signaling Pathway in Epithelial Cells Induces Sjogren' S Syndrome-like Autoimmune Disease.2013

    • Author(s)
      大熊敦史
    • Journal Title

      Immunity

      Volume: 38 Issue: 3 Pages: 450-460

    • DOI

      10.1016/j.immuni.2012.11.016

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Double-stranded RNA of small intestinal commensal but not pathogenic bacteria triggers TLR3-mediated IFN-β production by dendritic cells2013

    • Author(s)
      T. Kawashima, A. Kosaka, H. Yan, G. Zijin, R. Uchiyama, R. Fukui, D. Kaneko; Y. Kumagai; D.-J. You, J. Carreras, S. Uematsu, M. H. Jang, O. Takeuchi, T. Kaisho, S. Akira, K. Miyake, H. Tsutsui, T. Saito, I. Nishimura, N. M. Tsuji
    • Journal Title

      Immunity

      Volume: 38 Issue: 6 Pages: 1187-1197

    • DOI

      10.1016/j.immuni.2013.02.024

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Invariant NKT cells induce plasmacytoid DC cross-talk with conventional DCs for efficient memory CD8+ T cell induction2013

    • Author(s)
      Shimizu K, Asakura M, Shinga J, Sato Y, Kitaha Hoshino K, Kaisho T, Schoenberger SP, Ezaki T, Fujii S
    • Journal Title

      J Immunol

      Volume: 190 Issue: 11 Pages: 5609-5619

    • DOI

      10.4049/jimmunol.1300033

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Critical roles of a dendritic cell subset expressing a chemokine receptor, XCR12013

    • Author(s)
      C. Yamazaki, M. Sugiyama, T. Ohta, H. Hemmi, E. Hamada, I. Sasaki, Y. Fukuda, T. Yano, M. Nobuoka, T. Hirashima, A. Iizuka, K. Sato, T. Tanaka, K. Hoshino, T. Kaisho
    • Journal Title

      J. Immunol

      Volume: 190 Issue: 12 Pages: 6071-6082

    • DOI

      10.4049/jimmunol.1202798

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 自然免疫とアレルギー2013

    • Author(s)
      改正恒康
    • Journal Title

      アレルギー

      Volume: 62(7) Pages: 789-796

    • Related Report
      2013 Final Research Report
  • [Journal Article] Double-stranded RNA of small intestinal commensal but not pathogenic bacteria triggers TLR3-mediated IFN-β production by dendritic cells2013

    • Author(s)
      T. Kawashima
    • Journal Title

      Immunity

      Volume: in press

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical roles of a dendritic cell subset expressing a chemokine receptor, XCR1.2013

    • Author(s)
      C. Yamazaki
    • Journal Title

      J Immunol

      Volume: in press

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] nvariant NKT cells induce plasmacytoid DC cross-talk with conventional DCs for efficient memory CD8+ T cell induction2013

    • Author(s)
      K. Shimizu
    • Journal Title

      J Immunol

      Volume: in press

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pathogen sensors and chemokine receptors in dendritic cell subsets2012

    • Author(s)
      T. Kaisho
    • Journal Title

      Vaccine

      Volume: 30 Issue: 52 Pages: 7652-7657

    • DOI

      10.1016/j.vaccine.2012.10.043

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Treml4, an Ig Superfamily Member, Mediates Presentation of Several Antigens to T Cells In Vivo, Including Protective Immunity to HER2 Protein2012

    • Author(s)
      Hiroaki Hemmi, Neeha Zaidi, Bei Wang, Ines Matos, Christopher Fiorese, Ashira Lubkin, Lori Zbytnuik, Koji Suda, Kenneth Zhang, Masaki Noda, Tsuneyasu Kaisho, Ralph M. Steinman, and Juliana Idoyaga
    • Journal Title

      J Immunol

      Volume: 188 Issue: 3 Pages: 1147-1155

    • DOI

      10.4049/jimmunol.1102541

    • Related Report
      2013 Final Research Report 2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential MyD88/IRAK4 requirements for cross-priming and tumor rejection induced by hsp70-model Ag fusion protein.2012

    • Author(s)
      MizukamiS, KajiwaraC, TanakaM, KaishoT, Udono H.
    • Journal Title

      Cancer Science

      Volume: 103 Issue: 5 Pages: 851-859

    • DOI

      10.1111/j.1349-7006.2012.02233.x

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells2012

    • Author(s)
      Kanaya, T., Hase, K., Takahashi, D., Fukuda, S., Hoshino, K., Sasaki, I., Hemmi, H., Knoop, K. A., Kumar, N., Sato, M., Katsuno, T., Yokosuka, O., Toyooka, K., Nakai, K., Sakamoto, A., Kitahara, Y., Jinnohara, T., McSorley, S. J., Kaisho, T., Williams, I. R., and Ohno, H.
    • Journal Title

      Nat Immunol

      Volume: 13 Issue: 8 Pages: 729-736

    • DOI

      10.1038/ni.2352

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spi-B is critical for plasmacytoid dendritic cell function and development2012

    • Author(s)
      Sasaki, K. Hoshino, T. Sugiyama, C. Yamazaki, T. Yano, A. Iizuka, H. Hemmi, T. Tanaka, M. Saito, M. Sugiyama, Y. Fukuda, T. Ohta, K. Sato, A. Ainai, T. Suzuki, H. Hasegawa, N. Toyama-Sorimachi, H. Kohara, T. Nagasawa, T. Kaisho
    • Journal Title

      Blood

      Volume: 120 Issue: 24 Pages: 4733-4743

    • DOI

      10.1182/blood-2012-06-436527

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lactococcus lactis subsp. cremoris FC triggers IFN-γ production from NK and T cells via IL-12 and IL-182012

    • Author(s)
      A. Kosaka, H. Yan, S. Ohashi, Y. Gotoh, A. Sato, H. Tsutsui, T. Kaisho, T. Toda, Tsuji NM
    • Journal Title

      Int Immunopharmacol

      Volume: 14(4) Issue: 4 Pages: 729-33

    • DOI

      10.1016/j.intimp.2012.10.007

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD8 陽性樹状細胞サブセットの動的制御機構の解析2012

    • Author(s)
      邊見弘明, 山崎千尋, 星野克明, 改正恒康
    • Journal Title

      Cytometry Research

      Volume: 22(1) Pages: 31-35

    • NAID

      10030199789

    • Related Report
      2013 Final Research Report
  • [Journal Article] 樹状細胞サブセットの機能と生理的意義2012

    • Author(s)
      佐々木泉, 改正恒康
    • Journal Title

      炎症と免疫

      Volume: 20(1) Pages: 21-26

    • Related Report
      2013 Final Research Report
  • [Journal Article] 樹状細胞に関する私の初仕事2012

    • Author(s)
      改正恒康
    • Journal Title

      アレルギ - の臨床

      Volume: 32(12) Pages: 13-13

    • Related Report
      2013 Final Research Report
  • [Journal Article] Differential MyD88/IRAK4 requirements for cross-priming and tumor rejection induced by heat shock protein 70-model antigen fusion protein.2012

    • Author(s)
      S. Mizukami
    • Journal Title

      Cancer Sci

      Volume: 103 Pages: 851-859

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A chemokine system in CD8 positive dendritic cells2012

    • Author(s)
      H.Hemmi
    • Journal Title

      Cytometry Research

      Volume: 22 Pages: 31-35

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 樹状細胞サブセットの機能と生理的意義2012

    • Author(s)
      佐々木泉
    • Journal Title

      炎症と免疫

      Volume: 20 Pages: 21-26

    • Related Report
      2011 Annual Research Report
  • [Journal Article] PDLIM2 inhibits T helper cell development and granulomatous inflammation through degradation of STAT32011

    • Author(s)
      T.Tanaka
    • Journal Title

      J.Immunol

      Volume: 188 Issue: 202 Pages: 141-151

    • DOI

      10.1126/scisignal.2001637

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plasmacytoid dendritic cells are crucial for the initiation of inflammation and T cell immunity in vivo2011

    • Author(s)
      H.Takagi
    • Journal Title

      Immunity

      Volume: 35 Issue: 6 Pages: 958-971

    • DOI

      10.1016/j.immuni.2011.10.014

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 免疫アジュバントの特性と Th 細胞分化誘導2011

    • Author(s)
      大田友和, 改正恒康
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 56(5) Pages: 558-563

    • NAID

      40019087195

    • Related Report
      2013 Final Research Report
  • [Journal Article] 樹状細胞サブセット機能を制御する分子機構2011

    • Author(s)
      改正恒康
    • Journal Title

      アレルギー

      Volume: 60(5) Pages: 559-565

    • NAID

      110008661490

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Journal Article] 免疫アジュバントの特性とTh細胞分化誘導2011

    • Author(s)
      大田友和
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 188 Pages: 1147-1155

    • Related Report
      2011 Annual Research Report
  • [Presentation] In vivo roles of XCR1-expressing dendric cells2013

    • Author(s)
      T. Kaisho
    • Organizer
      第42回日本免疫学会総会
    • Place of Presentation
      幕張メッセ
    • Year and Date
      2013-12-12
    • Related Report
      2013 Final Research Report
  • [Presentation] The transcription factor IRF8 is required for basophil development2013

    • Author(s)
      H. Sasaki, D. Kurotaki, N. Osato, I. Sasaki, C. Kaneda, A. Nishiyama, T.Kaisho , H. C. III. Morse, K. Ozato, T. Tamura
    • Organizer
      第42回日本免疫学会総会
    • Place of Presentation
      幕張メッセ
    • Related Report
      2013 Final Research Report
  • [Presentation] Double-stranded RNA of intestinal commensal but not pathogenic bacteria triggers production of protective IFN- β2013

    • Author(s)
      T. Kawashima, H Yan, Z. Guo, J. Carreras, R. Uchiyama, R. Fukui, T. Kaisho , S. Akira, K. Miyake, H. Tsutsui, T. Saito, N.M.Tsuji
    • Organizer
      第42回日本免疫学会総会
    • Place of Presentation
      幕張メッセ
    • Related Report
      2013 Final Research Report
  • [Presentation] A novel mechanism to generate the intestinal intraepithelial T lymphocytes by XCR-expressing dendric cells2013

    • Author(s)
      T. Ohta, H. Hemmi, C. Yamazaki, M. Sugiyama, I. Sasaki, K. Hoshino, T. Kaisho
    • Organizer
      第42回日本免疫学会総会
    • Place of Presentation
      幕張メッセ
    • Related Report
      2013 Final Research Report
  • [Presentation] Function of XCR1-expressing dendric cells in oral tolerance2013

    • Author(s)
      H. Hemmi, M. Sugiyama, T. Ohta, I. Sasaki, C. Yamazaki, T. Tanaka, K. Hoshino, T. Kaisho
    • Organizer
      第42回日本免疫学会総会
    • Place of Presentation
      幕張メッセ
    • Related Report
      2013 Final Research Report
  • [Presentation] Long-term memory T cell response induced by adjuvant role of iNKT cells2013

    • Author(s)
      K. Shimizu, Y. Sato, J. Shinga, M. Asakura, T. Kaisho
    • Organizer
      第42回日本免疫学会総会
    • Place of Presentation
      幕張メッセ
    • Related Report
      2013 Final Research Report
  • [Presentation] Lactococcus lactis subsp. cremoris FC triggers IFN-ɤproduction from NK and T cells via IL-12 and IL-182013

    • Author(s)
      Kosaka, H. Yan, H. Tsutsui, T. Kaisho , N. Tsuji
    • Organizer
      第42回日本免疫学会総会
    • Place of Presentation
      幕張メッセ
    • Related Report
      2013 Final Research Report
  • [Presentation] The role of M cells in intestinal helminthic infection2013

    • Author(s)
      C. Shimokawa, T. Kanaya, T. Kaisho
    • Organizer
      第42回日本免疫学会総会
    • Place of Presentation
      幕張メッセ
    • Related Report
      2013 Final Research Report
  • [Presentation] Critical roles of dendritic cells expressing a chemokine receptor XCR1.2013

    • Author(s)
      T. Kaisho, H. Hemmi, M. Sugiyama, T. Ohta.
    • Organizer
      The Joint international Meeting of The 78th Meeting of the Japanese Society of Interferon and Cytokine Research and The 21st International Symposium on Molecular Cell Biology of Macrophage
    • Place of Presentation
      都市センターホテル、東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] In vivo roles of dendritic cells expressing a chemokine receptor, XCR12013

    • Author(s)
      T. Kaisho
    • Organizer
      France-Japan Joint Forum “Frontiers in Innate Immunity'
    • Place of Presentation
      ストラスブルグ、フランス
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Molecular mechanisms for dendritic cell subset functions.2013

    • Author(s)
      T. Kaisho
    • Organizer
      Agricultural Biotechnology Symposium ‘Immune Modulation and Bioconvergence
    • Place of Presentation
      ソウル、韓国
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Critical in vivo roles of dendritic cells expressing a chemokine receptor, XCR12013

    • Author(s)
      T. Kaisho
    • Organizer
      The 2013 Fall Conference of the Korean Association of Immunologists
    • Place of Presentation
      ソウル、韓国
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] In vivo roles of XCR1-expressing dendric cells.2013

    • Author(s)
      T. Kaisho
    • Organizer
      第42回日本免疫学会総会
    • Place of Presentation
      幕張メッセ 千葉
    • Related Report
      2013 Annual Research Report
  • [Presentation] In vivo roles of XC chemokine receptor 1-expressing dendritic cells.2013

    • Author(s)
      T. Ohta, H. Hemmi, C. Yamazaki, M. Sugiyama, I. Sasaki, K. Hoshino, T. Kaisho.
    • Organizer
      The 15th International Congress of Immunology
    • Place of Presentation
      ミラノ、イタリア
    • Related Report
      2013 Annual Research Report
  • [Presentation] Visualization of Inflammasome activation : monitoring caspase-1 activity in living cells by a genetically-encoded probe SCAT12012

    • Author(s)
      劉霆, 山口良文, 星野克明, 改正恒康, 竹本研, 倉永英里奈, 三浦正幸
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      マリンメッセ福岡
    • Related Report
      2013 Final Research Report
  • [Presentation] The Ets transcription factor Spi-B is essential for M-cell differentiation2012

    • Author(s)
      T. Kanaya, K. Hase, T. Kaisho , R. W. Ifor, H Ohno
    • Organizer
      第41回日本免疫学会総会
    • Place of Presentation
      神戸ポートピアホテル
    • Related Report
      2013 Final Research Report
  • [Presentation] Spi-B is critical for plasmacytoid dendric cell development in bone marrow2012

    • Author(s)
      I. Sasaki, K. Hoshino, H. Hemmi, M. Sugiyama, T. Yamaguchi, T. Kaisho
    • Organizer
      第41回日本免疫学会総会
    • Place of Presentation
      神戸ポートピアホテル
    • Related Report
      2013 Final Research Report
  • [Presentation] Analysis of in vivo function of XC chemokine receptor-expressing dendric cells2012

    • Author(s)
      M. Sugiyama, H. Hemmi, C. Yamazaki, T. Ohta, I. Sasaki, K. Hoshino, T. Kaisho
    • Organizer
      第41回日本免疫学会総会
    • Place of Presentation
      神戸ポートピアホテル
    • Related Report
      2013 Final Research Report
  • [Presentation] Long-term memory T cell response induced by adjuvant role of iNKT cells2012

    • Author(s)
      K. Shimizu, M. Asakura, J. Shinga, Y. Sato, K. Hoshino, T.Kaisho , T. Ezaki, S. Fujii
    • Organizer
      第41回日本免疫学会総会
    • Place of Presentation
      神戸ポートピアホテル
    • Related Report
      2013 Final Research Report
  • [Presentation] IL-27 affects immune responses via regulation of prostaglandin E2 production by macrophages2012

    • Author(s)
      Y. Sato, S. Suzuki, H. Hara, T. Kaisho , H. Yoshida
    • Organizer
      第41回日本免疫学会総会
    • Place of Presentation
      神戸ポートピアホテル
    • Related Report
      2013 Final Research Report
  • [Presentation] A non-synonymous SNP (single nucleotide polymorphism) of PDLIM4 is associated with susceptibility of rheumatoid arthritis and Graves diseases2012

    • Author(s)
      T. Tanaka, Y. Kochi, K. Yamamoto, T. Kaisho
    • Organizer
      第41回日本免疫学会総会
    • Place of Presentation
      神戸ポートピアホテル
    • Related Report
      2013 Final Research Report
  • [Presentation] IκB-ζ-deficiency in Epithelial Cells Elicits Sjogren's Syndrome-like Autoimmune Disease2012

    • Author(s)
      A. Okuma, K. Hoshino, T.Kaisho , T. Muta
    • Organizer
      第41回日本免疫学会総会
    • Place of Presentation
      神戸ポートピアホテル
    • Related Report
      2013 Final Research Report
  • [Presentation] In vivo ablation of XC chemokine receptor 1-expressing dendritic cell subset.2012

    • Author(s)
      M. Sugiyama
    • Organizer
      20th International Symposium on Molecular Cell Biology of Macrophages 2012
    • Place of Presentation
      東京大学山上会館(東京大学)
    • Related Report
      2012 Annual Research Report
  • [Presentation] M cells, a unique subset of intestinal epithelial cells specialized for mucosal antigen2012

    • Author(s)
      T. Kanaya
    • Organizer
      The Awaji International Forum on Infection and Immunity
    • Place of Presentation
      ウエスティンホテル(兵庫県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Function and differentiation of M cells, a unique subset of intestinal epithelial cells specialized for mucosal antigen2012

    • Author(s)
      T. Kanaya
    • Organizer
      12th International Symposium On Dendritic Cells
    • Place of Presentation
      Daege, Korea
    • Related Report
      2012 Annual Research Report
  • [Presentation] Critical role of Siglec-H in the function of plasmacytoid dendritic cells for the regulation of inflammation and T cell immunity in vivo.2012

    • Author(s)
      R. Murakami
    • Organizer
      12th International Symposium On Dendritic Cells
    • Place of Presentation
      Daege, Korea
    • Related Report
      2012 Annual Research Report
  • [Presentation] Ablation of a dendritic cell subset expressing XC chemokine receptor 1 in vivo.2012

    • Author(s)
      H. Hemmi
    • Organizer
      12th International Symposium On Dendritic Cells
    • Place of Presentation
      Daege, Korea
    • Related Report
      2012 Annual Research Report
  • [Presentation] Plasmacytoid dendritic cells are crucial for the initiation of inflammation and T cell immunity in vivo.2012

    • Author(s)
      H. Takagi
    • Organizer
      12th International Symposium On Dendritic Cells
    • Place of Presentation
      Daege, Korea
    • Related Report
      2012 Annual Research Report
  • [Presentation] Dendritic cell subsets in inflammation.2012

    • Author(s)
      T. Kaisho
    • Organizer
      The 12th Biennial International Endotoxin & Innate Immunity Society (IEIIS) Meeting
    • Place of Presentation
      学術総合センター(東京都)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] The role of M cells in intestinal immunity2012

    • Author(s)
      T. Kanaya
    • Organizer
      The 12th Biennial International Endotoxin & Innate Immunity Society (IEIIS) Meeting
    • Place of Presentation
      学術総合センター(東京都)
    • Related Report
      2012 Annual Research Report
  • [Presentation] In vivo roles of XC chemokine receptor 1-expressing dendritic cells.2012

    • Author(s)
      M. Sugiyama
    • Organizer
      The 12th Biennial International Endotoxin & Innate Immunity Society (IEIIS) Meeting
    • Place of Presentation
      学術総合センター(東京都)
    • Related Report
      2012 Annual Research Report
  • [Presentation] oles of an Ets family transcription factor, Spi-B, in plasmacytoid dendritic cell development in the bone marrow.2012

    • Author(s)
      I. Sasaki
    • Organizer
      The 12th Biennial International Endotoxin & Innate Immunity Society (IEIIS) Meeting
    • Place of Presentation
      学術総合センター(東京都)
    • Related Report
      2012 Annual Research Report
  • [Presentation] IκB-ζ-deficient Mice Develop Sjögren’s Syndrome-like Chronic Inflammation Caused by Dysregulation of Epithelial Homeostasis2012

    • Author(s)
      A. Okuma
    • Organizer
      The 12th Biennial International Endotoxin & Innate Immunity Society (IEIIS) Meeting
    • Place of Presentation
      学術総合センター(東京都)
    • Related Report
      2012 Annual Research Report
  • [Presentation] The Ets transcription factor Spi-B is essential for M-cell differentiation2012

    • Author(s)
      T. Kanaya
    • Organizer
      第41回日本免疫学会総会•学術集会
    • Place of Presentation
      神戸ポートピアホテル(兵庫県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Spi-B is critical for plasmacytoid dendric cell development in bone marrow2012

    • Author(s)
      I. Sasaki
    • Organizer
      第41回日本免疫学会総会•学術集会
    • Place of Presentation
      神戸ポートピアホテル(兵庫県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Analysis of in vivo function of XC chemokine receptor-expressing dendric cells.2012

    • Author(s)
      M. Sugiyama
    • Organizer
      第41回日本免疫学会総会•学術集会
    • Place of Presentation
      神戸ポートピアホテル(兵庫県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Long-term memory T cell response induced by adjuvant role of iNKT cells.2012

    • Author(s)
      K. Shimizu
    • Organizer
      第41回日本免疫学会総会•学術集会
    • Place of Presentation
      神戸ポートピアホテル(兵庫県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] IL-27 affects immune responses via regulation of prostaglandin E2 production by macrophages2012

    • Author(s)
      Y. Sato
    • Organizer
      第41回日本免疫学会総会•学術集会
    • Place of Presentation
      神戸ポートピアホテル(兵庫県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] A non-synonymous SNP(single nucleotide polymorphism) of PDLIM4 is associated with susceptibility of rheumatoid arthritis and Graves diseases.2012

    • Author(s)
      T. Tanaka
    • Organizer
      第41回日本免疫学会総会•学術集会
    • Place of Presentation
      神戸ポートピアホテル(兵庫県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] I κΒ-ζ-deficiency in Epithelial Cells Elicits Sjogren’s Syndrome-like Autoimmune Disease.2012

    • Author(s)
      A. Okuma
    • Organizer
      第41回日本免疫学会総会•学術集会
    • Place of Presentation
      神戸ポートピアホテル(兵庫県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 自然免疫~感染の検知システム2011

    • Author(s)
      改正恒康
    • Organizer
      免疫ふしぎ未来
    • Place of Presentation
      日本科学未来館(東京)
    • Year and Date
      2011-08-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 樹状細胞機能制御の分子基盤2011

    • Author(s)
      改正恒康
    • Organizer
      免疫サマースクール
    • Place of Presentation
      ラフォーレ蔵王(宮城県)
    • Year and Date
      2011-08-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] Dendritic cell sensing and responses for nucleic acid adjuvants2011

    • Author(s)
      T.Kaisho
    • Organizer
      KSBMB
    • Place of Presentation
      COEX, Inter Continental Seoul(韓国)(招待講演)
    • Year and Date
      2011-05-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Dendritic cell sensing and responses for nucleic acid adjuvants2011

    • Author(s)
      T.Kaisho
    • Organizer
      IVI seminar
    • Place of Presentation
      International Vaccine Institute(韓国)
    • Year and Date
      2011-05-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] 核酸系免疫アジュバントに対する樹状細胞サブセットの応答機構2011

    • Author(s)
      改正恒康
    • Organizer
      第29回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      大分
    • Year and Date
      2011-02-10
    • Related Report
      2013 Final Research Report
  • [Presentation] Evaluation of SCAT1 : a genetically-encoded probe for detecting activation of caspase-1 in living cells2011

    • Author(s)
      K. Shikada, Y. Yamaguchi, T. Liu, K. Takemoto, K. Hoshino, T. Kaisho . E. Kuranaga, M. Miura
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] HSP70 は PDLIM による NF-κB シグナルの負の制御に必須である2011

    • Author(s)
      田中貴志, 改正恒康
    • Organizer
      第40回日本免疫学会総会
    • Place of Presentation
      幕張メッセ
    • Related Report
      2013 Final Research Report
  • [Presentation] PDLIM4による STAT シグナルの負の制御機構2011

    • Author(s)
      平島健志, 改正恒康, 田中貴志
    • Organizer
      第40回日本免疫学会総会
    • Place of Presentation
      幕張メッセ
    • Related Report
      2013 Final Research Report
  • [Presentation] 形質細胞様樹状細胞による炎症反応とT細胞免疫応答の制御2011

    • Author(s)
      H. Takagi, T. Fukaya, Y. Sato, K. Sato, A. Shibazaki, A. Hijikata, O. Ohara, T. Kasiho , B. Malissen, K. Sato
    • Organizer
      第40回日本免疫学会総会
    • Place of Presentation
      幕張メッセ
    • Related Report
      2013 Final Research Report
  • [Presentation] Siglec-H による形質細胞様樹状細胞の機能制御2011

    • Author(s)
      K. Sato, H. Takagi, T. Fukaya, Y. Sato, K. Sato, A. Shibazaki, A. Hijikata, O. Ohara, T. Kasiho , B. Malissen
    • Organizer
      第40回日本免疫学会総会
    • Place of Presentation
      幕張メッセ
    • Related Report
      2013 Final Research Report
  • [Presentation] ケモカイン受容体 Xcrl 発現樹状細胞の in vivo における機能的意義2011

    • Author(s)
      C. Yamazaki, H. Hemmi, R. Miyamoto, I. Sasaki, T. Ito, K. Hoshino, T. Kaisho
    • Organizer
      第40回日本免疫学会総会
    • Place of Presentation
      幕張メッセ
    • Related Report
      2013 Final Research Report
  • [Presentation] TLR3を介した乳酸菌2本鎖RNA の IFN-β産生誘導/Double-stranded RNA of lactic acid bacteria triggers TLR3 -mediated IFN-ɤ production by dendritic cells2011

    • Author(s)
      T. Kawashima, H. Yan, Z. Guo, R. Uchiyama, J. Carreras, T. Kaisho , O. Takeuchi, S. Akira, H. Tsutsui, T. Saito, I. Nishimura, N. Tsuji
    • Organizer
      第40回日本免疫学会総会
    • Place of Presentation
      幕張メッセ幕張メッセ
    • Related Report
      2013 Final Research Report
  • [Presentation] BDCA3+DC の発現するケモカインレセプター XCR1 と NK 細胞活性化能の解析2011

    • Author(s)
      伊藤量基, 宮本理恵, 山崎千尋, 星野克明, 改正恒康, 野村昌作
    • Organizer
      第40回日本免疫学会総会
    • Place of Presentation
      幕張メッセ
    • Related Report
      2013 Final Research Report
  • [Presentation] Evaluation of SCAT1 : a genetically-encoded probe for detecting activation of caspase-1 in living cells2011

    • Author(s)
      K.Shikada
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] HSP70はPDLIMによるNF-κBシグナルの負の制御に必須である/HSP70 is essential for PDLIM2-mediated termination of NF-κB signaling2011

    • Author(s)
      田中貴志
    • Organizer
      第40回日本免疫学会総会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] PDLIM4によるSTATシグナルの負の制御機構/PDLIM4 negatively regulates STAT signaling by recruiting protein tyrosine phosphatases2011

    • Author(s)
      平島健志
    • Organizer
      第40回日本免疫学会総会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 形質細胞様樹状細胞による炎症反応とT細胞免疫応答の制御/Crucial role of plasmacytoid dendritic cells in the regulation of inflammation and T Cell immunity in vivo2011

    • Author(s)
      H.Takagi
    • Organizer
      第40回日本免疫学会総会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Malissen. Siglec-Hによる形質細胞様樹状細胞の機能制御/Critical role of siglec-H in the function of plasmacytoid dendritic cells for the regulation of inflammation and T Cell immunity in vivo2011

    • Author(s)
      K.Sato
    • Organizer
      第40回日本免疫学会総会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] ケモカイン受容体Xcrl発現樹状細胞のin vivoにおける機能的意義/Critical roles of murine XC chemokine receptor 1-expressing DC subset in vivo2011

    • Author(s)
      C.Yamazaki
    • Organizer
      第40回日本免疫学会総会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] TLR3を介した乳酸菌2本鎖RNAのIFN-β産生誘導/Double-stranded RNA of lactic acid bacteria triggers TLR3-mediated IFN-β production by dendritic cells2011

    • Author(s)
      T.Kawashima
    • Organizer
      第40回日本免疫学会総会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] BDCA3+DCの発現するケモカインレセプターXCR1とNK細胞活性化能の解析/Importance of chemokines system between, human BDC A3+ dendritic cells and NK cells in innate cytotoxic response2011

    • Author(s)
      伊藤量基
    • Organizer
      第40回日本免疫学会総会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Related Report
      2011 Annual Research Report
  • [Book] 標準免疫学2013

    • Author(s)
      改正恒康
    • Publisher
      医学書院
    • Related Report
      2013 Final Research Report
  • [Book] サイトカインのすべて(完全改訂版)2012

    • Author(s)
      改正恒康
    • Publisher
      化学評論社
    • Related Report
      2013 Final Research Report
  • [Book] 改正恒康 免疫学 Update- 分子病態の解明と治療への展開2012

    • Author(s)
      邊見弘明, 改正恒康
    • Publisher
      南山堂
    • Related Report
      2013 Final Research Report
  • [Book] サイトカインのすべて2012

    • Author(s)
      改正恒康
    • Publisher
      化学評論社
    • Related Report
      2012 Annual Research Report
  • [Book] 免疫学Update2012

    • Author(s)
      邊見弘明
    • Publisher
      南山堂
    • Related Report
      2012 Annual Research Report
  • [Book] 免疫の事典2011

    • Author(s)
      改正恒康
    • Publisher
      朝倉書店
    • Related Report
      2013 Final Research Report
  • [Book] Rheumatology(Marc C. Hochberg 他編)2011

    • Author(s)
      T. Kaisho and S. Akira
    • Publisher
      ELSEVIER
    • Related Report
      2013 Final Research Report
  • [Book] アジュバント開発研究の新展開2011

    • Author(s)
      改正恒康
    • Publisher
      シーエムシー出版
    • Related Report
      2013 Final Research Report
  • [Book] Principles of innate immunity, in Fifth Edition Rheumatology vol.12011

    • Author(s)
      T.Kaisho
    • Publisher
      ELSEVIER
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://immreg.ifrec.osaka-u.ac.jp/www/

    • Related Report
      2013 Final Research Report
  • [Remarks] 改正研究室 研究業績 2012年

    • URL

      http://immreg.ifrec.osaka-u.ac.jp/www/publication/2012/06/2012.html

    • Related Report
      2012 Annual Research Report

URL: 

Published: 2011-04-06   Modified: 2019-07-29  

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