| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2013: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2012: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2011: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Research Abstract |
To elucidate the physiological and pharmacokinetic significance of the renal drug transporters, we carried out the pharmacokinetic and toxicokinetic analyses of various drugs using transporter-deficient mice. It was demonstrated that the contribution of renal drug transporters to urinary excretion vary among substrate drugs. In addition, it was found that loss of transporter function lead to the changes in blood and tissue concentration of drugs, which in turn causes the adverse reaction of drugs.
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