| Project/Area Number |
23390144
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | National Institute of Health Sciences |
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Principal Investigator |
SAITO Yoshiro 国立医薬品食品衛生研究所, 医薬安全科学部, 部長 (50215571)
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| Co-Investigator(Kenkyū-buntansha) |
ISHII Akiko 国立医薬品食品衛生研究所, 生物薬品部, 第二室長 (50291117)
KATO Ken 国立がん研究センター, 中央病院, 医長 (50501855)
KUROSE Koichi 国立医薬品食品衛生研究所, 医薬安全科学部, 第三室長 (30280754)
NAKAMURA Ryosuke 国立医薬品食品衛生研究所, 医薬安全科学部, 第三室長 (50333357)
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| Co-Investigator(Renkei-kenkyūsha) |
TADA Minoru 国立医薬品食品衛生研究所, 生物薬品部, 第三室長 (50506954)
SUGIYAMA Emiko 国立医薬品食品衛生研究所, 医薬安全科学部, 第三室非常勤職員 (40574695)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2012: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2011: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
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| Keywords | 抗体医薬品 / 副作用 / 抗がん剤 / 医薬品副作用 / ファーマコゲノミクス |
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| Research Abstract |
Infusion reaction (IF) is a severe adverse reaction often caused by therapeutic antibodies and occurs at the first time of infusing the antibodies. The mechanistic analysis and prediction of IF in the pre-clinical stage is important for preventing patients from IF in the clinical stage. The results of this study was follows: 1) List of suspected drugs for IF by Japanese Adverse Drug Event Report database. 2) Analysis of FCGR1A, FCGR2A, FCGR3A genes to screen genetic polymorphisms using genomic DNAs from cetuximab-administered patients. 3) Functional analysis of a novel genetic polymorphism 818T>C (L273P) found in FCGR2A gene encoding FcgammaRIIa. 4) Development of in vitro assay system for assessing causability of IF using human peripheral blood mononuclear cells.
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