Application of novel clinicopathological biomarkers to cancer treatment
| Project/Area Number |
23390148
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
CHANO Tokuhiro 滋賀医科大学, 医学部, 准教授 (40346028)
ISONO Takahiro 滋賀医科大学, 医学部, 准教授 (20176259)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2013: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2012: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2011: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Keywords | 臨床病理 / 分子標的治療 / バイオマーカー / siRNA / 癌 |
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| Research Abstract |
In salivary gland cancers, RB1CC1 was demonstrated to be a useful prognostic predictor. In head and neck carcinomas, QL1 & WRN DNA helicase were therapeutic targetting molecules, and the siRNA silencing could result specifically cell death in the cancers. p62/SQSTM1 was highly expressed in head and neck carcinomas. p62/SQSTM1 could induce GSH, cause a resistance to oxidative stress, be associated with a resisitance to radiation therapy, and finally predict the worse prognosis. In testicular embryonal carcinomas, SOX2-siRNA caused significant inhibition for the tumor growth in vivo, suggesting that it will be a promising therapeutic target in the future.
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] Hyperbranched Polyglycerol-Grafted Superparamagnetic Iron Oxide Nanoparticles : Synthesis, Characterization, Functionalization, Size Separation, Magnetic Properties, and Biological Applications2012
Author(s)
Zhao L, Chano T, Morikawa S, Saito Y, Shiino A, Shimizu S, Maeda T, Irie T, Aonuma S, Okabe H, Kimura T, Inubushi T, Komatsu N
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Journal Title
Adv Funct Mater
Volume: 22(24)
Pages: 5107-5117
Related Report
Peer Reviewed
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[Journal Article] RECQL1 and WRN proteins are potential therapeutic targets in head and neck squamous cell carcinoma2011
Author(s)
Arai A, Chano T, Futami K, Furuichi Y, Ikebuchi K, Inui T, Tameno H, Ochi Y, Shimada T, Hisa Y, Okabe H
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Journal Title
Cancer Res
Volume: 71 (13)
Pages: 4598-4607
Related Report
Peer Reviewed
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[Journal Article] p53 inhibits autophagy by interacting with the human ortholog of yeast Atg17, RB1CC1/FIP2002011
Author(s)
Morselli E, Shen S, Ruckenstuhl C, Bauer MA, Mariño G, Galluzzi L, Criollo A, Michaud M, Maiuri MC, Chano T, Madeo F, Kroemer G
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Journal Title
Cell Cycle
Volume: 10(16)
Pages: 2763-2769
Related Report
Peer Reviewed
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[Journal Article] RB1CC1 protein positively regulates transforming growth factor-beta signaling through the modulation of Arkadia E3 ubiquitin ligase activity2011
Author(s)
Koinuma D, Shinozaki M, Nagano Y, Ikushima H, Horiguchi K, Goto K, Chano T, Saitoh M, Imamura T, Miyazono K, Miyazawa K
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Journal Title
J Biol Chem
Volume: 286(37)
Pages: 32502-32512
Related Report
Peer Reviewed
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[Journal Article] RECQL1 and WRN proteins are potential therapeutic targets in head and neck squamous cell carcinoma.2011
Author(s)
Arai A, Chano T, Futami K, Furuichi Y, Ikebuchi K, Inui T, Tameno H, Ochi Y, Shimada T, Hisa Y, Okabe H.
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Journal Title
Cancer Res.
Volume: 71(13)
Issue: 13
Pages: 4598-4607
DOI
Related Report
Peer Reviewed
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[Journal Article] p53 inhibits autophagy by interacting with the human ortholog of yeast Atg17, RB1CC1/FIP200.2011
Author(s)
Morselli E, Shen S, Ruckenstuhl C, Bauer MA, Mariño G, Galluzzi L, Criollo A, Michaud M, Maiuri MC, Chano T, Madeo F, Kroemer G.
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Journal Title
Cell Cycle.
Volume: 10(16)
Pages: 2763-2769
Related Report
Peer Reviewed
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