Increases in Tryptophan-kynurenine pathway metabolism following interferon-induced depression
Project/Area Number |
23390149
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Laboratory medicine
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Research Institution | Kyoto University |
Principal Investigator |
SAITO KUNIAKI 京都大学, 医学(系)研究科(研究院), 教授 (80262765)
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Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Yasuko 京都大学, 大学院・医学研究科, 助教 (00331869)
MURAKAMI Yuki 京都大学, 大学院・医学研究科, 研究員 (50580106)
竹田 真由 東北福祉大学, 健康科学部, 助手 (00423054)
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Project Period (FY) |
2011-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2011: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
|
Keywords | サイトカイン / インターフェロン / トリプトファン / IDO / 抑うつ / ウイルス性肝炎 / コンパニオン診断 / 病態検査学 / 酵素誘導 / うつ病 |
Research Abstract |
Increases in L-tryptophhn (TRP) to L-kynurenine (KYN) pathway metabolism were found in interferon (IFN) treated-HCV patients with depressive symptoms. Further, mice with Interferon (IFN) gene transfection induced indoleamine 2,3-dioxygenase (IDO1) , resulting marked increase in TRP to KYN pathway metabolites, which well correlated with depression. The blockade of IDO1 activation prevented the development of depressive-like behavior.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Kynurenine production mediated by indoleamine 2, 3-dioxygenase aggravates liver injury in HBV-specific CTL-induced fulminant hepatitis2014
Author(s)
Ohtaki H, Ito H, Ando K, Ishikawa T, Hoshi M, Ando T, Takamatsu M, Hara A, Moriwaki H, Saito K, Seishima M
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Journal Title
Biochim Biophys Acta
Volume: 1842(9)
Issue: 9
Pages: 1464-71
DOI
Related Report
Peer Reviewed
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[Journal Article] Effects of indoleamine 2, 3-dioxygenase deficiency on high-fat diet-induced hepatic inflammation2013
Author(s)
Nagano J, Shimizu M, Hara T, Shirakami Y, Kochi T, Nakamura N, Ohtaki H, Ito H, Tanaka T, Tsurumi H, Saito K, Seishima M, Moriwaki H
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Journal Title
PLoS One
Volume: 9;8(9)
Issue: 9
Pages: e73404-e73404
DOI
Related Report
Peer Reviewed
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[Journal Article] IDO1 plays an immunosuppressive role in 2, 4, 6-trinitrobenzene sulfate-induced colitis in mice2013
Author(s)
Takamatsu M, Hirata A, Ohtaki H, Hoshi M, Hatano Y, Tomita H, Kuno T, Saito K, Hara A
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Journal Title
J Immunol
Volume: 15;191(6)
Issue: 6
Pages: 3057-64
DOI
Related Report
Peer Reviewed
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[Journal Article] Acquired resistance of leukemic cells to AraC is associated with the upregulation of aldehyde dehydrogenase 1 family member A2.2013
Author(s)
Kawasoe M, Yamamoto Y, Okawa K, Funato T, Takeda M, Hara T, Tsurumi H, Moriwaki H, Arioka Y, Takemura M, Matsunami H, Markey SP, Saito K.
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Journal Title
Exp Hematol.
Volume: 41(7)
Issue: 7
Pages: 597-603
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Epigallocatechin gallate inhibits the expression of indoleamine 2, 3-dioxygenase in human colorectal cancer cells2012
Author(s)
Ogawa K, Hara T, Shimizu M, Nagano J, Ohno T, Hoshi M, Ito H, Tsurumi H, Saito K, Seishima M, Moriwaki H
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Journal Title
Oncol Lett
Volume: 4(3)
Pages: 546-550
Related Report
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[Journal Article] Inhibition of increased indoleamine 2, 3-dioxygenase activity attenuates Toxoplasma gondii replication in the lung during acute infection2012
Author(s)
Murakami Y, Hoshi M, Hara A, Takemura M, Arioka Y, Yamamoto Y, Matsunami H, Funato T, Seishima M, Saito K
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Journal Title
Cytokine
Volume: 59(2)
Issue: 2
Pages: 245-51
DOI
Related Report
Peer Reviewed
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[Presentation] Labdane-type diterpene, constituent from myoga which are traditional Japanese food inhibit enzyme activity and gene expression of in doleamine 2, 3-dioxygenase 12013
Author(s)
Imai, R Yamamoto, Y Yamamoto, Y Katayan agi, R Fukutomi, M Abe, Y Ozawa, K Saito
Place of Presentation
Milan, Italy
Related Report
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[Presentation] Labdane-type diterpene, constituent from myoga which are traditional Japanese food inhibit enzyme activity and gene expression of indoleamine 2,3-dioxygenase 12013
Author(s)
S Imai, R Yamamoto, Y Yamamoto, Y Katayanagi, R Fukutomi, M Abe, Y Ozawa, K Saito
Organizer
15thInternational Congress of Immunology
Place of Presentation
Milan, Italy
Related Report
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[Book] :Tumor Necrosis factor2014
Author(s)
Murakami Y, Imamura Y, Mitani S, Hoshi M, Arioka Y, Yamamoto Y, Seiyama A, Saito K.
Publisher
Nova Science Publishers, Inc.
Related Report
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[Book] Tumor Necrosis factor
Author(s)
Murakami Y, Imamura Y, Mitani S, Hoshi M, Arioka Y, Yamamoto Y, Seiyama A, Saito K
Publisher
Nova Science Publishers, Inc
Related Report
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