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Increases in Tryptophan-kynurenine pathway metabolism following interferon-induced depression

Research Project

Project/Area Number 23390149
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionKyoto University

Principal Investigator

SAITO KUNIAKI  京都大学, 医学(系)研究科(研究院), 教授 (80262765)

Co-Investigator(Kenkyū-buntansha) YAMAMOTO Yasuko  京都大学, 大学院・医学研究科, 助教 (00331869)
MURAKAMI Yuki  京都大学, 大学院・医学研究科, 研究員 (50580106)
竹田 真由  東北福祉大学, 健康科学部, 助手 (00423054)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2011: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Keywordsサイトカイン / インターフェロン / トリプトファン / IDO / 抑うつ / ウイルス性肝炎 / コンパニオン診断 / 病態検査学 / 酵素誘導 / うつ病
Research Abstract

Increases in L-tryptophhn (TRP) to L-kynurenine (KYN) pathway metabolism were found in interferon (IFN) treated-HCV patients with depressive symptoms. Further, mice with Interferon (IFN) gene transfection induced indoleamine 2,3-dioxygenase (IDO1) , resulting marked increase in TRP to KYN pathway metabolites, which well correlated with depression. The blockade of IDO1 activation prevented the development of depressive-like behavior.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (31 results)

All 2014 2013 2012 Other

All Journal Article (16 results) (of which Peer Reviewed: 13 results) Presentation (8 results) (of which Invited: 3 results) Book (3 results) Remarks (3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Effects of various phytochemicals on indoleamine 2, 3-dioxygenase 1 activity : galanal is a novel, competitive inhibitor of the enzyme2014

    • Author(s)
      Yamamoto R, Yamamoto Y, Imai S, Fukutomi R, Ozawa Y, Abe M, Matuo Y, Saito K
    • Journal Title

      PLoS One

      Volume: 12;9(2) Issue: 2 Pages: e88789-e88789

    • DOI

      10.1371/journal.pone.0088789

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Kynurenine production mediated by indoleamine 2, 3-dioxygenase aggravates liver injury in HBV-specific CTL-induced fulminant hepatitis2014

    • Author(s)
      Ohtaki H, Ito H, Ando K, Ishikawa T, Hoshi M, Ando T, Takamatsu M, Hara A, Moriwaki H, Saito K, Seishima M
    • Journal Title

      Biochim Biophys Acta

      Volume: 1842(9) Issue: 9 Pages: 1464-71

    • DOI

      10.1016/j.bbadis.2014.04.015

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of HBsAg-specific cytotoxic T lymphocytes can be up-regulated by the inhibition of indoleamine 2, 3-dioxygenase activity2014

    • Author(s)
      Ito H, Ando T, Ando K, Ishikawa T, Saito K, Moriwaki H, Seishima M
    • Journal Title

      Immunology

      Volume: 印刷中 Issue: 4 Pages: 614-623

    • DOI

      10.1111/imm.12274

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of indoleamine 2, 3-dioxygenase deficiency on high-fat diet-induced hepatic inflammation2013

    • Author(s)
      Nagano J, Shimizu M, Hara T, Shirakami Y, Kochi T, Nakamura N, Ohtaki H, Ito H, Tanaka T, Tsurumi H, Saito K, Seishima M, Moriwaki H
    • Journal Title

      PLoS One

      Volume: 9;8(9) Issue: 9 Pages: e73404-e73404

    • DOI

      10.1371/journal.pone.0073404

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] IDO1 plays an immunosuppressive role in 2, 4, 6-trinitrobenzene sulfate-induced colitis in mice2013

    • Author(s)
      Takamatsu M, Hirata A, Ohtaki H, Hoshi M, Hatano Y, Tomita H, Kuno T, Saito K, Hara A
    • Journal Title

      J Immunol

      Volume: 15;191(6) Issue: 6 Pages: 3057-64

    • DOI

      10.4049/jimmunol.1203306

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Remarkable role of indoleamine 2, 3-dioxygenase and tryptophan metabolites in infectious diseases : potential role in macrophage-mediated inflammatory diseases2013

    • Author(s)
      Murakami Y, Hoshi M, Imamura Y, Arioka Y, Yamamoto Y, Saito K
    • Journal Title

      Mediators Inflamm

      Volume: 2013 Pages: 391984-391984

    • DOI

      10.1155/2013/391984

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Species and cell types difference in tryptophan metabolism2013

    • Author(s)
      Murakami Y, Saito K
    • Journal Title

      Int J Tryptophan Res

      Volume: 21;6 Pages: 47-54

    • DOI

      10.4137/ijtr.s11558

    • Related Report
      2013 Final Research Report
  • [Journal Article] Acquired resistance of leukemic cells to AraC is associated with the upregulation of aldehyde dehydrogenase 1 family member A2.2013

    • Author(s)
      Kawasoe M, Yamamoto Y, Okawa K, Funato T, Takeda M, Hara T, Tsurumi H, Moriwaki H, Arioka Y, Takemura M, Matsunami H, Markey SP, Saito K.
    • Journal Title

      Exp Hematol.

      Volume: 41(7) Issue: 7 Pages: 597-603

    • DOI

      10.1016/j.exphem.2013.03.004

    • NAID

      120005302084

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epigallocatechin gallate inhibits the expression of indoleamine 2, 3-dioxygenase in human colorectal cancer cells2012

    • Author(s)
      Ogawa K, Hara T, Shimizu M, Nagano J, Ohno T, Hoshi M, Ito H, Tsurumi H, Saito K, Seishima M, Moriwaki H
    • Journal Title

      Oncol Lett

      Volume: 4(3) Pages: 546-550

    • Related Report
      2013 Final Research Report
  • [Journal Article] Studies on tissue and cellular distribution of indoleamine 2, 3-dioxygenase 2 : the absence of IDO1 upregulates IDO2 expression in the epididymis2012

    • Author(s)
      Fukunaga M, Yamamoto Y, Kawasoe M, Arioka Y, Murakami Y, Hoshi M, Saito K
    • Journal Title

      J Histochem Cytochem

      Volume: 60(11) Issue: 11 Pages: 854-60

    • DOI

      10.1369/0022155412458926

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of increased indoleamine 2, 3-dioxygenase activity attenuates Toxoplasma gondii replication in the lung during acute infection2012

    • Author(s)
      Murakami Y, Hoshi M, Hara A, Takemura M, Arioka Y, Yamamoto Y, Matsunami H, Funato T, Seishima M, Saito K
    • Journal Title

      Cytokine

      Volume: 59(2) Issue: 2 Pages: 245-51

    • DOI

      10.1016/j.cyto.2012.04.022

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] L-tryptophan-kynurenine pathway metabolites regulate type 1 IFNs of acute viral myocarditis in mice2012

    • Author(s)
      Hoshi M
    • Journal Title

      J Immunol

      Volume: 188 Issue: 8 Pages: 3980-3987

    • DOI

      10.4049/jimmunol.1100997

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Posttranslational modification of indoleamine 2, 3-dioxygenase2012

    • Author(s)
      Fujigaki H, Seishima M, Saito K
    • Journal Title

      Anal Bioanal Chem

      Volume: 403(7) Issue: 7 Pages: 1777-82

    • DOI

      10.1007/s00216-012-5946-2

    • Related Report
      2013 Final Research Report
  • [Journal Article] Pre-administration of L-tryptophan improved ADR-induced early renal failure in mice2012

    • Author(s)
      Arioka Y
    • Journal Title

      Life Sci

      Volume: 59 Issue: 3-4 Pages: 100-106

    • DOI

      10.1016/j.lfs.2012.06.018

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] L-Tryptophan-kynurenine pathway metabolites regulate type I IFNs of acute viral myocarditis in mice2012

    • Author(s)
      Hoshi M, Yamamoto Y, Saito K, 他4名
    • Journal Title

      J Immunol

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Posttranslational modification of indoleamine 2,3-dioxygenase2012

    • Author(s)
      Fujigaki H, Seishima M, Saito K
    • Journal Title

      Anal Bioanal Chem

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Recent advances of biomarker discovery in biological fluids by using Mass Spec trometry2013

    • Author(s)
      Saito, K
    • Organizer
      8th International Conference of Clinica l Laboratory Automation
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Labdane-type diterpene, constituent from myoga which are traditional Japanese food inhibit enzyme activity and gene expression of in doleamine 2, 3-dioxygenase 12013

    • Author(s)
      Imai, R Yamamoto, Y Yamamoto, Y Katayan agi, R Fukutomi, M Abe, Y Ozawa, K Saito
    • Place of Presentation
      Milan, Italy
    • Related Report
      2013 Final Research Report
  • [Presentation] 疾患メタボローム・疾患プロテオミクス解析2013

    • Author(s)
      斉藤邦明
    • Place of Presentation
      仙台市
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 免疫調節因子インドールアミン 2, 3-ジオキシゲナーゼ1の新規阻害剤探索 : フィトケミカルを中心として2013

    • Author(s)
      山本梨絵, 山本康子, 今井伸二郎, 松尾雄志, 小澤好夫, 阿部雅子, 福富竜太, 斉藤邦明
    • Organizer
      第36回日本分子生物学会年会
    • Related Report
      2013 Final Research Report
  • [Presentation] Labdane-type diterpene, constituent from myoga which are traditional Japanese food inhibit enzyme activity and gene expression of indoleamine 2,3-dioxygenase 12013

    • Author(s)
      S Imai, R Yamamoto, Y Yamamoto, Y Katayanagi, R Fukutomi, M Abe, Y Ozawa, K Saito
    • Organizer
      15thInternational Congress of Immunology
    • Place of Presentation
      Milan, Italy
    • Related Report
      2013 Annual Research Report
  • [Presentation] 免疫調節因子インドールアミン 2,3-ジオキシゲナーゼ1の新規阻害剤探索:フィトケミカルを中心として2013

    • Author(s)
      山本梨絵, 山本康子, 今井伸二郎, 松尾雄志, 小澤好夫, 阿部雅子, 福富竜太, 斉藤邦明
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] Species and cell types differences in L-tryptophan metabolism2012

    • Author(s)
      Murakami Y
    • Organizer
      13th International Society for Tryptophan Research Conference Satellite Symposium
    • Place of Presentation
      Brisbane, Australia
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Recent advances of biomarker discovery in biological fluids by using Mass Spectrometry2012

    • Author(s)
      Saito K
    • Organizer
      8th International Conference of Clinical Laboratory Automation
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] :Tumor Necrosis factor2014

    • Author(s)
      Murakami Y, Imamura Y, Mitani S, Hoshi M, Arioka Y, Yamamoto Y, Seiyama A, Saito K.
    • Publisher
      Nova Science Publishers, Inc.
    • Related Report
      2013 Annual Research Report
  • [Book] Tumor Necrosis Factor-alpha Related Signal Pathways and Neuronal Diseases2013

    • Author(s)
      Murakami Y
    • Total Pages
      28
    • Publisher
      Nova Science Publishers, Inc.
    • Related Report
      2012 Annual Research Report
  • [Book] Tumor Necrosis factor

    • Author(s)
      Murakami Y, Imamura Y, Mitani S, Hoshi M, Arioka Y, Yamamoto Y, Seiyama A, Saito K
    • Publisher
      Nova Science Publishers, Inc
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.saito-lab-kyotouniv.com

    • Related Report
      2013 Final Research Report
  • [Remarks] ホームページ

    • URL

      http://www.saito-lab-kyotouniv.com

    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.hs.med.kyoto-u.ac.jp/saito-k/index.html

    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 関節リューマチ患者における生物学的製剤の有効性の予測方法2013

    • Inventor(s)
      斉藤邦明, 坪井彩, 山本康子
    • Industrial Property Rights Holder
      国立大学法人京都大学
    • Industrial Property Number
      2013-127092
    • Filing Date
      2013-06-18
    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-04-06   Modified: 2019-07-29  

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