Development of new method detecting redox regulation against oxidative stress
| Project/Area Number |
23390152
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | The Tazuke Kofukai |
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Principal Investigator |
NAKAMURA Hajime 公益財団法人田附興風会, 医学研究所 第8研究部, 部長 (70303914)
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| Co-Investigator(Kenkyū-buntansha) |
KASUNO Kenji 福井大学, 医学部, 准教授 (60455243)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2011: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
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| Keywords | チオレドキシン / 急性腎障害 / 慢性腎臓病 / 酸化ストレス / 血液透析 / 末梢血リンパ球 / 過酸化水素 / バイオマーカー / レドックス / ヒト末梢血リンパ球 / mRNA / RT-PCR |
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| Research Abstract |
Thioredoxin is a redox-regulating protein which is induced by oxidative stress. We previously reported that plasma/serum levels of thioredoxin are elevated in diseases associated with oxidative stress. In this study, we found that urinary levels of thioredoxin are correlated with urinary levels of N-acetyl-beta-D-glucosamidase which is a marker for damage of renal tubules in chronic renal diseases. We have developed a new rapid method detecting the elevation of thioredoxin mRNA. It is possible to diagnose rapidly the pathological condition suffering from oxidative stress.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] Treatment of nonalcoholic steatohepatitis with vitamins E and C : a pilot study2013
Author(s)
Kawanaka M, Nishino K, Nakamura J, Suehiro M, Goto D, Urata N, Kawamoto T, Nakamura H, Yodoi J, Hino K, Yamada G
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Journal Title
Hepat Med
Volume: 5
Pages: 11-16
Related Report
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[Journal Article] The protective role of the transmembrane thioredoxin-related protein TMX in inflammatory liver injury2013
Author(s)
Matsuo Y, Irie K, Kiyonari H, Okuyama H, Nakamura H, Son A, Lopez-Ramos DA, Tian H, Oka S, Okawa K, Kizaki-Kondoh S, Masutani H, Yodoi J
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Journal Title
Antiox. Redox Signal
Volume: 18
Pages: 1263-1272
Related Report
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[Journal Article] Treatment of nonalcoholic steatohepatitis with vitamins Eand C : a pilot study2013
Author(s)
Kawanaka M, Nishino K, Nakamura J, Suehiro M, Goto D, Urata N, Oka T, Kawamoto H, Nakamura H, Yodoi J, Yamada G
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Journal Title
Hepat. Med
Volume: 5
Pages: 11-16
Related Report
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[Journal Article] The protective role of transmembrane thioredoxin-related protein TMX in inflammatory liver injury2013
Author(s)
Matsuo Y, Irie K, Kiyonari H, Okuyama H, Nakamura H, Son A, Lopez-Ramos DA, Tian H, Oka S, Okawa K, Kizaki-Kondoh S, Masutani H, Yodoi J
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Journal Title
Antiox. Redox Signal
Volume: 18
Pages: 1263-1272
Related Report
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[Presentation] 胃癌術後の誤嚥性肺炎に対して口腔ケア介入が著効した一症例2013
Author(s)
岩崎聡美, 内田洋一朗, 野田祥子, 井下春美, 山田信子, 久保麻友子, 阿賀千賀子, 池上由利子, 山崎みどり, 藤本寛太, 佐藤正人, 中村肇
Organizer
第50回日本外科代謝栄養学会学術集会
Place of Presentation
東京
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