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Central modulation of spinal nociceptive synaptic transmission in vivo

Research Project

Project/Area Number 23390156
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Pain science
Research InstitutionNational Institute for Physiological Sciences

Principal Investigator

FURUE Hidemasa  生理学研究所, 生体情報研究系, 准教授 (20304884)

Co-Investigator(Kenkyū-buntansha) JINNO Shozo  九州大学, 医学研究院, 教授 (10325524)
FUKAZAWA Yugo  名古屋大学, 医学研究科, 准教授 (60343745)
Co-Investigator(Renkei-kenkyūsha) IMOTO Keiji  生理学研究所, 所長 (00176512)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2011: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Keywords疼痛の神経機構 / 鎮痛 / 下行性痛覚抑制 / 光操作 / 神経生理 / ノルアドレナリン / 鎮静 / in vivoパッチクランプ / 脳・神経 / シナプス / 神経科学 / 神経回路 / 痛み・鎮痛 / 青斑核 / チャネルロドプシン / ノルアドレナ
Research Abstract

Descending noxious inhibitory system was studied with a combination of in vivo optogenetic and electrophysiological approaches. Locus coeruleus neurons in the brain stem in vivo elicited a slow inward current without eliciting a barrage of synaptic responses in response to noxious cutaneous stimulation, and showed an excitation-inhibition, biphasic firing response. A tonic activation of the locus coeruleus neurons expressing channel rhodopsin by light stimulation excited spinal GABAergic neurons to suppress noxious synaptic transmission. Alpha2 agonist, a chronically used sedative agent, at low doses also activated the descending pontospinal noradrenergic system. The present study represents a new target for the treatment of chronic pain.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (88 results)

All 2014 2013 2012 2011 Other

All Journal Article (35 results) (of which Peer Reviewed: 25 results,  Open Access: 1 results) Presentation (47 results) (of which Invited: 15 results) Book (4 results) Remarks (2 results)

  • [Journal Article] Opto-activation of locus coeruleus neurons evokes bidirectional changes in thermal nociception in rats2014

    • Author(s)
      Hickey L, Li Y, Fyson S, Watson T, Perrins R, Hewinson J, Teschemacher A, Furue H, Lumb B, Pickering AE.
    • Journal Title

      J Neurosci

      Volume: 34(12) Issue: 12 Pages: 4148-4160

    • DOI

      10.1523/jneurosci.4835-13.2014

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Systemic dexmedetomidine augments inhibitory synaptic transmission in the superficial dorsal horn through activation of descending noradrenergic control : an in vivo patch-clamp analysis of analgesic mechamisms2014

    • Author(s)
      Funai Y, Pickering AE, Uta D, Nishikawa K, Mori T, Asada A, Imoto K and Furue H
    • Journal Title

      Pain

      Volume: 155(3) Issue: 3 Pages: 617-628

    • DOI

      10.1016/j.pain.2013.12.018

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] S100A6 (calcyclin) is a novel marker of neural stem cells and astrocyte precursors in the subgranular zone of the adult mouse hippocampus.2014

    • Author(s)
      Yamada J, Jinno S.
    • Journal Title

      Hippocampus

      Volume: 24 Issue: 1 Pages: 89-101

    • DOI

      10.1002/hipo.22207

    • Related Report
      2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 下行性制御機構:セロトニン系、ノルアドレナリン系2014

    • Author(s)
      古江秀昌
    • Journal Title

      日本医師会雑誌

      Volume: 14(特別号1)

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 脊髄における侵害受容機構2014

    • Author(s)
      古江秀昌、歌大介、秋元望
    • Journal Title

      ファインケミカル

      Volume: 43(1) Pages: 17-21

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Systemic alpha-2 agonist administration facilitates inhibitory synaptic transmission in the rat spinal dorsal horn mediated through alpha-1 adorenoceptors2013

    • Author(s)
      Funai Y, Nishikawa K, Mori T, Asada A, Imoto K and Furue H
    • Journal Title

      Pain Res

      Volume: 28(3) Pages: 145-153

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vivo patch-clamp analysis of visceral spinal sensory synaptic transmission and spinal control of lower urinary tract function2013

    • Author(s)
      Hakozaki A, Imoto K, Hayashi Y, Kawatani M and Furue H
    • Journal Title

      Pain Res

      Volume: 28(3) Pages: 155-165

    • NAID

      10031203273

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 中枢性の痛覚抑制機構2013

    • Author(s)
      古江秀昌
    • Journal Title

      ペインクリニック

      Volume: 34(8) Pages: 1091-1099

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] Spatio-temporal differences in perineuronal net expression in the mouse hippocampus, with reference to parvalbumin2013

    • Author(s)
      Yamada J, Jinno S
    • Journal Title

      Neurosci

      Volume: 253 Pages: 368-79

    • DOI

      10.1016/j.neuroscience.2013.08.061

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel objective classification of reactive microglia following hypoglossal axotomy using hierarchical cluster analysis2013

    • Author(s)
      Yamada J, Jinno S
    • Journal Title

      J Comp Neurol

      Volume: 521 Issue: 5 Pages: 1184-201

    • DOI

      10.1002/cne.23228

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuroligin-1 controls synaptic abundance of NMDA-type glutamate receptors through extracellular coupling2013

    • Author(s)
      Fukazawa Y(他10名)
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 110 Issue: 2 Pages: 725-730

    • DOI

      10.1073/pnas.1214718110

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vivo patch-clamp analysis of visceral spinal sensory synaptic transmission and spinal control of lower urinary tract function.2013

    • Author(s)
      Hakozaki A
    • Journal Title

      Pain Research

      Volume: in press

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Systemic alpha-2 agonist administration facilitates inhibitory synaptic transmission in the rat spinal dorsal horn mediated through alpha-1 adorenoceptors.2013

    • Author(s)
      Funai Y
    • Journal Title

      Pain Research

      Volume: in press

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo patch-clamp recording from locus coeruleus neurons in the rat brainstem2012

    • Author(s)
      Sugiyama D, Hur SW, Pickering AE, Kase D, Kim SJ, Kawamata M, Imoto K, Furue H
    • Journal Title

      Journal of Physiology

      Volume: (in press) Issue: 10 Pages: 2225-2231

    • DOI

      10.1113/jphysiol.2011.226407

    • NAID

      120007108244

    • Related Report
      2013 Final Research Report 2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of 5-HT receptor subtypes enhancing inhibitory transmission in the rat spinal dorsal horn in vitro2012

    • Author(s)
      Xie DJ, Uta D, Feng PY, Wakita M, Shin MC, Furue H and Yoshimura M
    • Journal Title

      Mol Pain

      Volume: 8(1) Pages: 58-58

    • DOI

      10.1186/1744-8069-8-58

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Noradrenaline2012

    • Author(s)
      Furue H and Kato G
    • Journal Title

      Bone Joint Nerve

      Volume: 2(2) Pages: 231-237

    • NAID

      40020261097

    • Related Report
      2013 Final Research Report
  • [Journal Article] 下行性ノルアドレナリン痛覚抑制機構とその活動制御2012

    • Author(s)
      古江秀昌, 杉山大介, 川真田樹人, 舟井優介
    • Journal Title

      麻酔

      Volume: 61(増刊)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Upregulation of calcium binding protein, S100A6, in activated astrocytes is linked to glutamate toxicity2012

    • Author(s)
      Yamada J, Jinno S
    • Journal Title

      Neurosci

      Volume: 226 Pages: 119-129

    • DOI

      10.1016/j.neuroscience.2012.08.068

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intra-synapse-type and inter-synapse-type relationships between synapticsize and AMPAR expression2012

    • Author(s)
      Fukazawa Y
    • Journal Title

      Current Opinion Neurobiology

      Volume: 22 Issue: 3 Pages: 1-7

    • DOI

      10.1016/j.conb.2012.01.006

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Application of an optogenetic byway for perturbing neuronal activity via glialphotostimulation.2012

    • Author(s)
      T. Sasaki. K. Beppu, K. Tanaka, Y. Fukazawa, R. Shigemoto, K. Matsui
    • Journal Title

      Proceedings National Academy of Sciences of the USA

      Volume: 109 Issue: 50 Pages: 20720-20725

    • DOI

      10.1073/pnas.1213458109

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Light-evoked somatosensory perception of transgenic rats which express channelrhodopsin-2 in dorsal root ganglion cells2012

    • Author(s)
      Ji Z-G, Ito S, Honjoh T, Ohta H, Ishizuka T, Fukazawa Y, Yawo H
    • Journal Title

      PLoS ONE

      Volume: 7 Issue: 3 Pages: e32699-e32699

    • DOI

      10.1371/journal.pone.0032699

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mechanisms underlying signal filtering at a multi-synapse contact2012

    • Author(s)
      Budisantoso T, Matsui K, Kamasawa N, Fukazawa Y, Shigemoto R
    • Journal Title

      Journal of Neuroscience

      Volume: 32 Issue: 7 Pages: 2357-2376

    • DOI

      10.1523/jneurosci.5243-11.2012

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Noradrenaline2012

    • Author(s)
      Furue H
    • Journal Title

      Bone Joint Nerve

      Volume: 2 Pages: 231-237

    • NAID

      40020261097

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 下行性ノルアドレナリン痛覚抑制機構とその活動制御2012

    • Author(s)
      古江 秀昌
    • Journal Title

      麻酔

      Volume: 61

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Noradrenaline2012

    • Author(s)
      Furue H, Kato G
    • Journal Title

      Bone Joint Nerve

      Volume: (in press)

    • NAID

      40020261097

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Actions of TRPA1 on excitatory synaptic transmission in substantia gelatinosa of the adult rat spinal cord2012

    • Author(s)
      Uta D., et al
    • Journal Title

      The Journal of Functional Diagnosis of the Spinal Cord

      Volume: 33 Pages: 24-29

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 悪性骨腫瘍性疼痛マウスにける脊髄興奮性入力の可塑的変化2012

    • Author(s)
      柳澤義和, et al
    • Journal Title

      脊髄機能診断学

      Volume: 33 Pages: 8-17

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Using comparative anatomy in the axotomy model to identify distinct roles for microglia and astrocytes in synaptic stripping2012

    • Author(s)
      Jinno S, Yamada J
    • Journal Title

      Neuron Glia Biology

      Volume: 5 Issue: 1 Pages: 1-12

    • DOI

      10.1017/s1740925x11000135

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid S-nitrosylation of actin by NO-generating donors and in inflammatory pain model mice.2011

    • Author(s)
      Lu J, Katano T, Uta D, Furue H and ItoS
    • Journal Title

      Mol Pain7

      Volume: 101(1-13) Pages: 101-101

    • DOI

      10.1186/1744-8069-7-101

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo patch-clamp analysis of descending noradrenergic controls of spinal nociceptive transmission2011

    • Author(s)
      Sugiyama D, Imoto K, Kawamata M and Furue H
    • Journal Title

      Pain Res

      Volume: 26(1) Pages: 1-9

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vivo patch-clamp analysis of descending noradrenergic controls of spinal nociceptive transmission2011

    • Author(s)
      Sugiyama D., et al
    • Journal Title

      Pain Research

      Volume: 26 Pages: 1-9

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Alterations in neuronal survival and glial reactions after axotomy by ceftriaxone and minocycline in the mouse hypoglossal nucleus2011

    • Author(s)
      Yamada J, Jinno S
    • Journal Title

      Neuroscience letters

      Volume: 504 Issue: 3 Pages: 295-300

    • DOI

      10.1016/j.neulet.2011.09.051

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential involvement of perineuronal astrocytes and microglia in synaptic stripping after hypoglossal axotomy2011

    • Author(s)
      Yamada J, Nakanishi H, Jinno S
    • Journal Title

      Neuroscience

      Volume: 182 Pages: 1-10

    • DOI

      10.1016/j.neuroscience.2011.03.030

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regional and laminar differences in antigen profiles and spatial distributions of a strocytes in the mouse hippocampus, with reference to aging2011

    • Author(s)
      Jinno S
    • Journal Title

      Neuroscience

      Volume: 180 Pages: 41-52

    • DOI

      10.1016/j.neuroscience.2011.02.013

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NMDA Receptors in Hippocampal GABAergic Synapses and Their Role in Nitric Oxide Signaling2011

    • Author(s)
      Szabadits, E.; Cserep, C.; Szonyi, A., et al
    • Journal Title

      Journal of Neuroscience

      Volume: 31(16) Issue: 16 Pages: 5893-5904

    • DOI

      10.1523/jneurosci.5938-10.2011

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 痒みの脊髄シナプス伝達と下行性抑制機構2014

    • Author(s)
      古江秀昌 歌大介
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 光による神経の活動制御と髄節を越える痛みの抑制2013

    • Author(s)
      古江秀昌
    • Organizer
      第3回運動器疾患の新しい疼痛治療を考える会
    • Place of Presentation
      和歌山
    • Year and Date
      2013-06-08
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 生理学からみた鎮痛・発痛メカニズム2013

    • Author(s)
      古江秀昌
    • Organizer
      第6回日本運動器疼痛学会, ランチョンセミナ
    • Place of Presentation
      神戸
    • Related Report
      2013 Final Research Report
  • [Presentation] Endogeneous control of pain transmission. 1st CU-NIPS Symposium "Frontier in Physiological Sciences Research : From Basic Research to Diseases and Treatments"2013

    • Author(s)
      Furue H and Imoto K
    • Organizer
      シンポジウム
    • Place of Presentation
      Bangkok, Thailand
    • Related Report
      2013 Final Research Report
  • [Presentation] In vivo spinal inhibitory synaptic responses evoked by optoactivation of descending noxious inhibitory system2013

    • Author(s)
      Furue H, Koga K, Imoto
    • Organizer
      The 11th Korea-Japan Joint Symposium of Brain Sciences, and Cardiac and Smooth Muscles, シンポジウム
    • Place of Presentation
      浜松
    • Related Report
      2013 Final Research Report
  • [Presentation] In vivo analysis of spinal GABAergic inhibition of nociceptive transmission2013

    • Author(s)
      Furue H
    • Organizer
      第90回日本生理学会大会, シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] pinal GABAergic Excitation by Optogenetic Activation of Descending Noradrenergic System2013

    • Author(s)
      Furue H
    • Organizer
      5th Asian Pain Symposium
    • Place of Presentation
      Okazaki Conference Center (Okazaki, Aichi)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 生理学からみた鎮痛・発痛メカニズム2013

    • Author(s)
      古江秀昌
    • Organizer
      第6回日本運動器疼痛学会(ランチョンセミナー・招待講演)
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Endogeneous control of pain transmission2013

    • Author(s)
      Furue H and Imoto K
    • Organizer
      1st Chulalongkorn University-National Institute for Physiological Sciences Symposium
    • Place of Presentation
      Chulalongkorn University (Bangkok, Thailand)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] In vivo spinal inhibitory synaptic responses evoked by optoactivation of descending noxious inhibitory system2013

    • Author(s)
      Furue H, Koga K and Imoto K
    • Organizer
      The 11th Japan-Korea joint symposium of Brain Sicences, and Cardiac and Smooth Muscle Scienses
    • Place of Presentation
      Act City Congress Center (Hamamatsu, Shizuoka)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] In vivo analysis of spinal GABAergic inhibition of nociceptive transmission.2013

    • Author(s)
      Furue H
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京 タワーホール船堀
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 活動電位と痛覚伝達2013

    • Author(s)
      古江 秀昌
    • Organizer
      第90回日本生理学会
    • Place of Presentation
      東京 タワーホール船堀
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] In vivo analysis of synaptic responses evoked in parasympathetic preganglionic neurons in the rat lumbosacral spinal cord.2013

    • Author(s)
      Hakozaki A
    • Organizer
      第90回日本生理学会
    • Place of Presentation
      東京 タワーホール船堀
    • Related Report
      2012 Annual Research Report
  • [Presentation] 局所麻酔薬レボブピバカンのeNav1.8チャネルに対する作用2013

    • Author(s)
      Kawatsu R
    • Organizer
      第90回日本生理学会
    • Place of Presentation
      東京 タワーホール船堀
    • Related Report
      2012 Annual Research Report
  • [Presentation] Firing pattern and morphorlogical analysis of substantia gelatinosa neurons receiving TRPA1-expressing afferents in rat spinal dorsal horn.2013

    • Author(s)
      Uta D
    • Organizer
      第90回日本生理学会
    • Place of Presentation
      東京 タワーホール船堀
    • Related Report
      2012 Annual Research Report
  • [Presentation] Enhancement of colorectal motility by dopamine through an activation of lumbo-sacral defection center in rats.2013

    • Author(s)
      Ikeda A
    • Organizer
      第90回日本生理学会
    • Place of Presentation
      東京 タワーホール船堀
    • Related Report
      2012 Annual Research Report
  • [Presentation] Full visualization of single trigeminal ganglion neurons.2013

    • Author(s)
      Tonomura S
    • Organizer
      第90回日本生理学会
    • Place of Presentation
      東京 タワーホール船堀
    • Related Report
      2012 Annual Research Report
  • [Presentation] In vivo patch clamp analysis of spinal modultaion of nociceptice synaptic transmission by optoactivation of the locus coeruleus2012

    • Author(s)
      Furue H
    • Organizer
      NIPS International Workshop 2012, Central Neuroplasticity in Sensory-Emotional Link
    • Place of Presentation
      Aichi
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 神経生理学からみた内因性痛覚抑制機序とその減弱による疼痛発現機序2012

    • Author(s)
      古江秀昌
    • Organizer
      日本麻酔科学会第59回学術集会
    • Place of Presentation
      兵庫
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] In vivo patch-clamp analysis of pontospinal descending inhibitory control of pain2012

    • Author(s)
      Furue H
    • Organizer
      第89回日本生理学会大会, シンポジウム
    • Place of Presentation
      長野
    • Related Report
      2013 Final Research Report
  • [Presentation] In vivoパッチクランプ法を用いた脊髄における内臓知覚シナプス伝達および下部尿路中枢性制御機構の解析法の開発2012

    • Author(s)
      箱崎 敦志
    • Organizer
      第59回中部日本生理学会
    • Place of Presentation
      愛知 岡崎カンファレンスセンター
    • Related Report
      2012 Annual Research Report
  • [Presentation] 内因性の痛みの抑制と鍼による鎮痛機構2012

    • Author(s)
      古江 秀昌
    • Organizer
      生体制御学会第261回定例講習会
    • Place of Presentation
      愛知 岡崎カンファレンスセンター
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 痛みの局所麻酔薬による分離遮断と内因性の鎮痛機構2012

    • Author(s)
      古江 秀昌
    • Organizer
      岡崎歯科医師会月例会学術講演会
    • Place of Presentation
      愛知 岡崎歯科医師総合センター
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] In vivo patch clamp analysis of spinal synaptic responses evoked by optoactivation of the locus coeruleus.2012

    • Author(s)
      Furue H
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      愛知 名古屋国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] In vivo patch-clamp analysis of spinal neuronal control if the lower urinary tract function.2012

    • Author(s)
      Hakozaki A
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      愛知 名古屋国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] In vivo spinal synaptic responses and scratching behaviors evoked by cutaneous serotonin applocation.2012

    • Author(s)
      Uta D
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      愛知 名古屋国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] In vivo patch clamp analysis of spinal modulation of nociceptive synaptic transmission by optoactivation of the locus coeruleus.2012

    • Author(s)
      Furue H
    • Organizer
      NIPS international workshop 2012 - Central neuroplasticity in sensory-emotion linlk
    • Place of Presentation
      愛知 岡崎カンファレンスセンター
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] In vivo spinal synaptic responses and scratching behaviors evoked by cutaneous 5-HT application.2012

    • Author(s)
      Uta D
    • Organizer
      NIPS international workshop 2012 - Central neuroplasticity in sensory-emotion linlk
    • Place of Presentation
      愛知 岡崎カンファレンスセンター
    • Related Report
      2012 Annual Research Report
  • [Presentation] 下部尿路中枢制御機構解明のためのin vivoパッチクランプ法の開発2012

    • Author(s)
      古江 秀昌
    • Organizer
      第19回日本排尿機能学会
    • Place of Presentation
      愛知 名古屋国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] 腰仙髄脊髄副交感神経核ニューロンにおける後根誘起シナプス応答の解析2012

    • Author(s)
      箱崎 敦志
    • Organizer
      第19回日本排尿機能学会
    • Place of Presentation
      愛知 名古屋国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] Systemically administered alpha-2 agonists facilitate inhibitory synaptic transmission in the rat spinal dorsal horn via alpha-1 adrenoceotors.2012

    • Author(s)
      Funai Y
    • Organizer
      第34回日本疼痛学会
    • Place of Presentation
      熊本 熊本市国際交流会館
    • Related Report
      2012 Annual Research Report
  • [Presentation] In vivo patch-clamp analysis of local anesthetic actions on rat spinal nociceptive synaptic transmission.2012

    • Author(s)
      Uta D
    • Organizer
      第34回日本疼痛学会
    • Place of Presentation
      熊本 熊本市国際交流会館
    • Related Report
      2012 Annual Research Report
  • [Presentation] In vivo patch-clamp analysis of visceral nociceptive synaptic transmission and the spinal control of lower urinary tract function.2012

    • Author(s)
      Hakozaki A
    • Organizer
      第34回日本疼痛学会
    • Place of Presentation
      熊本 熊本市国際交流会館
    • Related Report
      2012 Annual Research Report
  • [Presentation] 神経生理学からみた内因性痛覚抑制機序とその源弱による疼痛発現機序2012

    • Author(s)
      古江 秀昌
    • Organizer
      日本麻酔科学会第59回学術集会
    • Place of Presentation
      兵庫 神戸ポートピアホテル
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] A novel antinociceptive mechanism of systemically administered dexmedetomidine via the activation of noradrenergic desending inhibitory system.2012

    • Author(s)
      Funai Y
    • Organizer
      日本麻酔科学会第59回学術集会
    • Place of Presentation
      兵庫 神戸ポートピアホテル
    • Related Report
      2012 Annual Research Report
  • [Presentation] CCL-1の疼痛発現との連関、および神経細胞ーグリア細胞連関の解明2012

    • Author(s)
      秋元 望
    • Organizer
      第14回ブレインサイエンス研究会
    • Place of Presentation
      鹿児島 霧島国際ホテル
    • Related Report
      2012 Annual Research Report
  • [Presentation] 下部尿路機能の中枢性制御機構解明のためのin vivoパッチクランプ法の開発2012

    • Author(s)
      箱崎 敦志
    • Organizer
      第14回ブレインサイエンス研究会
    • Place of Presentation
      鹿児島 霧島国際ホテル
    • Related Report
      2012 Annual Research Report
  • [Presentation] In vivo patch-clamp analysis of pontospinal descending inhibitory control of pain2012

    • Author(s)
      Furue H.
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本分化会館(長野県)(シンポジウム)
    • Related Report
      2011 Annual Research Report
  • [Presentation] In vivo patch-clamp recording from rat locus coeruleus neurons2012

    • Author(s)
      Sugiyama D.
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本分化会館(長野県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] In vivo patch-clamp recording technique to investigate neuronal control of the lower urinary tract functions2012

    • Author(s)
      Furue H.
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本分化会館(長野県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Excitatory effect of a pruritogen serortonin-induced itching on synaptic transmission in adult rat spinal dorsal horn neurons in vivo2012

    • Author(s)
      Uta D.
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本分化会館(長野県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] In vivo whole-cell patch-clamp analysis of synaptic responses evoked in locus coeruleus neurons in the rat brainstem2011

    • Author(s)
      Sugiyama D.
    • Organizer
      The 41st Annual Meeting of the Society of Neuroscience
    • Place of Presentation
      Washington D.C.(USA)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Systemic injection. of alpha-2adrenergic agonist enhances inhibitory synaptic transmission in the rat superficial dorsal horn in vivo2011

    • Author(s)
      Funai Y.
    • Organizer
      The 41st Annual Meeting of the Society of Neuroscience
    • Place of Presentation
      Washington D.C.(USA)
    • Related Report
      2011 Annual Research Report
  • [Presentation] In vivo patch-clamp analysis of puriceptive and nociceptive transmission in the adult rat spinal dorsal horn2011

    • Author(s)
      Uta D.
    • Organizer
      The 41st Annual Meeting of the Society of Neuroscience
    • Place of Presentation
      Washington D.C.(USA)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Sensitization of TRPV1 receptors expressed at the central end of C afferents following inflammation2011

    • Author(s)
      Yoshimura M.
    • Organizer
      The 41st Annual Meeting of the Society of Neuroscience
    • Place of Presentation
      Washington D.C.(USA)
    • Related Report
      2011 Annual Research Report
  • [Presentation] In vivo patch-clamp recording analysis of serotonin-induced itching on synaptic transmission in substantia gelatinosa neurons2011

    • Author(s)
      Uta D.
    • Organizer
      第34回日本神経科学会大会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] In vivo spinal GABAergic excitation by optogenetic activation of descending noradrenergic neurons in the locus coeruleus

    • Author(s)
      Furue H
    • Organizer
      Korean Pain Research Consortium
    • Place of Presentation
      Richell hotel (Andong, Korea)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] In vivo blind patch-clamp recording technique. In : Patch Clamp Techniques: From Beginning to Advanced Protocols. (Springer Protocols Handbooks)2012

    • Author(s)
      Furue H
    • Publisher
      Springer-Verlag, Japan
    • Related Report
      2013 Final Research Report
  • [Book] Patch Clamp Techniques : From Beginning to Advanced Protocols2012

    • Author(s)
      Furue H
    • Publisher
      Springer-Verlag(in press)
    • Related Report
      2011 Annual Research Report
  • [Book] In vivo ブラインドパッチ法. In; 最新パッチクランプ実験技術法2011

    • Author(s)
      古江秀昌
    • Publisher
      吉岡書店, 京都
    • Related Report
      2013 Final Research Report
  • [Book] 最新パッチクランプ実験技術法2011

    • Author(s)
      古江秀昌
    • Total Pages
      274
    • Publisher
      吉岡書店
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.nips.ac.jp/huinfo/

    • Related Report
      2013 Final Research Report
  • [Remarks] 生理学研究所神経シグナル研究部門古江ホームページ

    • URL

      http://www.nips.ac.jp/~furue/index.html

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2011-04-06   Modified: 2019-07-29  

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