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Nested case-control study on the effects of prenatal exposure to PCBs

Research Project

Project/Area Number 23390158
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionTohoku University

Principal Investigator

NAKAI Kunihiko  東北大学, 医学(系)研究科(研究院), 教授 (00291336)

Co-Investigator(Kenkyū-buntansha) TATSUTA Nozomi  東北大学, 大学院・医学系研究科, 助教 (40547709)
KUROKAWA Naoyuki  宮城教育大学, 教育学部, 講師 (30431505)
佐藤 洋  東北大学, 大学院・医学系研究科, 名誉教授 (40125571)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2011: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Keywordsコホート内症例対照研究 / ポリ塩化ビフェニル / 胎児期ばく露 / 神経行動学 / 出生コホート調査 / 知能検査 / 環境保健 / 神経行動学的指標 / 環境由来化学物質 / コホート調査 / 小児発達 / KーABC / 環境 / 有害化学物質 / 分析化学 / 神経科学 / 環境政策 / コホート内症例対照 / 周産期ばく露
Research Abstract

Environmental exposures to polychlorinated biphenyls (PCBs) have been suggested as a risk factor for neurobehavioral development in children. A nested case-control study was performed to investigate the association between the cognitive outcome at 42 months and the prenatal exposures to PCB and DDE. The Tohoku Study of Child Development cohort contains cord blood samples collected at the delivery of healthy pregnant women of the Tohoku district of east Japan. The cognitive score was assessed with the Kaufman Assessment Battery for Children (K-ABC). After adjusting with maternal IQ, maternal age, gestational days, maternal fish intake, plasma omega-3/omega-6 polyunsaturated fatty acids, and others, no statistically significant association with the cognitive and simultaneous processing scores was seen for any PCB and DDE.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (13 results)

All 2013 2012

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (8 results)

  • [Journal Article] 魚介類摂取と化学物質曝露のリスク2013

    • Author(s)
      仲井邦彦
    • Journal Title

      脂質栄養学

      Volume: 22巻 Pages: 7-15

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of Kyoto Scale of Psychological Development and Bayley Scales of Infant Development second edition among Japanese infants2013

    • Author(s)
      Tatsuta N, Suzuki K, Nakai K, Hosokawa T, Satoh H
    • Journal Title

      Journal of Special Education Research

      Volume: 2巻 Pages: 17-24

    • NAID

      130004673120

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increase in accumulation of polychlorinated biphenyls in offspring mouse brain via maternal coexposure to methylmercury and polychlorinated biphenyls2013

    • Author(s)
      Miyuki Iwai-Shimada, et. al.
    • Journal Title

      The Journal of Toxicological Sciences

      Volume: 38 Issue: 5 Pages: 689-696

    • DOI

      10.2131/jts.38.689

    • NAID

      10031191727

    • ISSN
      0388-1350, 1880-3989
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of Kyoto Scale of Psychological Development and Bayley Scales of Infant Development second edition among Japanese infants2013

    • Author(s)
      Tatsuta N, Suzuki K, Nakai K, Hosokawa T, Satoh H.
    • Journal Title

      Journal of Special Education Research

      Volume: 2 Pages: 189-196

    • NAID

      130004673120

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prenatal exposures to environmental chemicals and birth order as risk Factors for child behavior problems2012

    • Author(s)
      Tatsuta, N., Nakai, K., Murata, K., et al
    • Journal Title

      Environmental Health

      Volume: 114 Pages: 47-52

    • DOI

      10.1016/j.envres.2012.02.001

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 環境由来化学物質の男性精子への影響2013

    • Author(s)
      仲井邦彦、有馬隆博、松村徹、佐藤晶子
    • Organizer
      第22回環境化学討論会
    • Place of Presentation
      府中市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 周産期PCB ばく露による出生児の発達への影響2012

    • Author(s)
      仲井邦彦, 龍田希, 岩井美幸, 阿部和眞, 村田勝敬, 細川徹, 佐藤洋
    • Organizer
      第21回環境化学討論会
    • Place of Presentation
      松山市
    • Related Report
      2013 Final Research Report
  • [Presentation] 臍帯血PCB 濃度を決定する要因の検討2012

    • Author(s)
      阿部和眞, 仲井邦彦, 龍田希, 中村朋之, 岩井美幸, 黒川修行, 柳沼梢, 村田勝敬, 坂本峰至, 佐藤洋
    • Organizer
      第21回環境化学討論会
    • Place of Presentation
      松山市
    • Related Report
      2013 Final Research Report
  • [Presentation] 食物由来の環境化学物質とその曝露による子どもの健康影響2012

    • Author(s)
      仲井邦彦
    • Organizer
      第66回日本栄養・食糧学会大会
    • Place of Presentation
      仙台市
    • Related Report
      2013 Final Research Report
  • [Presentation] 東北沿岸部における小児出生コホート調査の到達点と東日本大震災被災地としての課題2012

    • Author(s)
      仲井邦彦
    • Organizer
      第82回日本衛生学会総会
    • Place of Presentation
      京都市
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] 周産期PCBばく露による出生児の発達への影響2012

    • Author(s)
      仲井邦彦
    • Organizer
      第21回環境化学討論会
    • Place of Presentation
      松山市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 臍帯血PCB濃度を決定する要因の検討2012

    • Author(s)
      阿部和眞
    • Organizer
      第21回環境化学討論会
    • Place of Presentation
      松山市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 食物由来の環境化学物質とそのばく露による子どもの健康影響2012

    • Author(s)
      仲井邦彦
    • Organizer
      第66回日本栄養・食糧学会大会
    • Place of Presentation
      仙台市
    • Related Report
      2012 Annual Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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