Examination of the pathogenesis of epigenetics of virus infection for allergic diseases and development of preventive methods for it
Project/Area Number |
23390160
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Hygiene
|
Research Institution | Kanazawa University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
HITOMI Yoshiaki 金沢大学, 医学系, 准教授 (70231545)
KAMBAYASHI Yasuhiro 金沢大学, 医学系, 講師 (20345630)
SUGANUMA Narufumi 高知大学, 医歯学系, 教授 (50313747)
FUKUTOMI Yuma 独立行政法人国立病院機構(相模原病院臨床研究センター), 診断・治療薬開発研究室, 室長 (30463110)
|
Project Period (FY) |
2011-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2013: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2011: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
|
Keywords | アレルギー / エピジェネティクス / RSウイルス / 妊娠 / メチル化 / 感作 / アレルゲン / 分子疫学 / 気管支喘息 / RSウイルス / microRNA / Respiratory syncytial (RS)ウイルス / インフルエンザウイルス |
Research Abstract |
The infection of virus such as respiratory syncytial virus is involved in pathogenesis of allergy during prenatal and postnatal infants, although the interaction between candidate genes and virus infection remains to be elucidated. We demonstrated hypomethylation of CpG islands produced by virus infection in IL4RA gene in splenic cells for postpartum infants from pregnant model mouse. Epidemiologic study showed the hypomethylation of CpG islands in in IL4RA gene in monocytes in cord blood of pregnant patients with asthma sensitized by house dust. These results suggest expression of IL4RA gene in just new born infants is produced by infection of RS virus.
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Report
(4 results)
Research Products
(77 results)
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[Journal Article] Antipsychotics for delirium in the general hospital setting in consecutive 2453 inpatients : a prospective observational study2014
Author(s)
Hatta K, Kishi Y, Wada K, Odawara T, Takeuchi T, Shiganami T, Tsuchida K, Oshima Y, Uchimura N, Akaho R, Watanabe A, Taira T, Nishimura K, Hashimoto N, Usui C, Nakamura H
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Journal Title
Int J Geriatr Psychiatry
Volume: 29(3)
Issue: 3
Pages: 253-262
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[Journal Article] Clinical impacts of albuminuria and glomerular filtration rate on renal, cardiovascular events, and all-cause mortality in Japanese patients with type 2 diabetes.2014
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Wada T, Haneda M, Furuichi K, Babazono T, Yokoyama H, Iseki K, Araki SI, Ninomiya T, Hara S, Suzuki Y, Iwano M, Kusano E, Moriya T, Satoh H, Nakamura H, Shimizu M, Toyama T, Hara A, Makino H; The Research Group of Diabetic Nephropathy, Ministry of Health, Labour, and Welfare of Japan
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Clin Exp Nephrol
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Issue: 4
Pages: 613-620
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[Journal Article] The possibility that requiring high-dose olanzapine cannot be explained by pharmacokinetics in the treatment of acute-phase schizophrenia2013
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Hatta K, Takebayashi H, Sudo Y, Katayama S, Kasuya M, Shirai Y, Morikawa F, Nakase R, Nakamura M, Ito S, Kuga H, Nakamura M, Ohnuma T, Usui C, Nakamura H, Hirata T, Sawa Y, for the JAST study group
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Journal Title
Psychiatry Res
Volume: 210(2)
Issue: 2
Pages: 396-401
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[Journal Article] Vulnerability to traumatic stress in fibromyalgia patients : 19 months follow-up after the Great East Japan Disaster2013
Author(s)
Usui C, Hatta K, Aratani S, Yagishita N, Nishioka K, Itoh K, Yamano Y, Nakamura H, Asukai N, Nakajima T, Nishioka K
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Arthritis Research & Therapy
Volume: 15(5)
Issue: 5
Pages: R130-R130
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[Journal Article] The Japanese version of the modified ACR preliminary diagnostic criteria for fibromyalgia and the fibromyalgia symptom scale : reliability and validity2013
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Usui C, Hatta K, Aratani S, Yagishita N, Nishioka K, Kanazawa T, Itoh K, Yamano Y, Nakamura H, Nakajima T, Nishioka K
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Mod Rheumatol
Volume: 23(5)
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Pages: 846-850
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[Journal Article] Epidemiological study on the involvements of environmental factors and allergy in child mental health using autism spectrum questionnaire.2013
Author(s)
Shibata A, Hitomi Y, Kambayashi Y, Hibino Y, Yamazaki M, Mitoma J, Asakura H, Hayashi K, Otaki N, Sagara T, Nakamura H
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Res Autism Spectr Disord.
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[Journal Article] Cellular heat acclimation regulates cell growth, cell morphology, mitogen-activated protein kinase activation, and expression of aquaporins in mouse fibroblast cells2012
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Sugimoto N, Shido O, Matsuzaki K, Ohno-Shosaku T, Hitomi Y, Tanaka M, Sawaki T, Fujita Y, Kawanami T, Masaki Y, Okazaki T, Nakamura H, Koizumi S, Yachie A and Umehara H
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Cell Physiol Biochem.
Volume: 30
Issue: 2
Pages: 450-457
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[Journal Article] Phosphodiesterase Inhibitors Suppress Lactobacillus casei Cell-Wall-Induced NF-κB and MAPK Activations and Cell Proliferation through Protein Kinase A-or Exchange Protein Activated by cAMP-Dependent Signal Pathway2012
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Saito T, Sugimoto N, Ohta K, Shimizu T, Ohtani K, Nakayama Y, Nakamura T, Hitomi Y, Nakamura H, Koizumi S, Yachie A
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Journal Title
The Scientific World Journal
Volume: 2012
Pages: 748572-748572
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[Presentation] アスピリンが好塩基球のIgE 依存的活性化に及ぼす影響2013
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第20回日本免疫毒性学会学術大会
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東海大学代々木キャンパス(東京都)
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2013-09-13
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第22回体力・栄養・免疫学会大会
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いこいの村 能登半島(石川県
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2012-08-26
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[Presentation] 要介護高齢者におけるアルツハイマー疾患と骨折の合併による生活動作能力の低下2012
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第22回体力・栄養・免疫学会大会
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2012-08-25
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[Presentation] 能登における新しい予防医学・疫学の展開2012
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2012-08-25
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第22回体力・栄養・免疫学会大会
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いこいの村 能登半島(石川県)
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2012-08-25
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第82回日本衛生学会学術総会
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