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Evaluation of arginase as an inflammatory biomarker.

Research Project

Project/Area Number 23390163
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionOkayama University

Principal Investigator

OGINO Keiki  岡山大学, 医歯(薬)学総合研究科, 教授 (70204104)

Co-Investigator(Kenkyū-buntansha) WANG Da-hong  岡山大学, 大学院・医歯薬学総合研究科, 講師 (90294404)
TAKAHASHI Hidekazu  山口大学, 大学院・医学系研究科, 講師 (90450402)
KUBO Masayuki  岡山大学, 大学院・医歯薬学総合研究科, 助教 (60420519)
OUCHI Kazunobu  川崎医科大学, 医学部, 教授 (80351899)
OBASE Yasushi  川崎医科大学, 医学部, 講師 (40399762)
MATSUI Hideki  岡山大学, 大学院・医歯薬学総合研究科, 教授 (30157234)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2013: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2012: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Keywords予防医学 / アレルギー / アルギナーゼ / バイオマーカー / 喘息 / 糖尿病 / 肥満 / 一酸化窒素 / アルギナーゼI / L-アルギニン / 酸化ストレス / 呼気NO / IgE / インスリン / アルギニン / 炎症バイオマーカー / hsCRP / ELISA
Research Abstract

The availability of arginase as a biomarker for asthma, diabetes, and obesity was evaluated. In asthmatic patients, the relationship among arginase and physiological factors was investigated using a multivariable analysis. Given that the concentration of serum arginase had a positive correlation with hs-CRP, exhaled nitric oxide, NOx, and 3-nitrotyrosine, it is likely that arginase is available as a biomarker. In obese model mice, the expression of arginase was upregulated, in proportion as increase of body weight and blood glucose. Nitrite may contribute to prevention of diabetes, because the concentration of insulin was downregulated with nitrite.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (34 results)

All 2014 2013 2012 2011 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results,  Open Access: 2 results) Presentation (20 results) Book (2 results)

  • [Journal Article] Associations of serum retinol, α-tocopherol, and γ-tocopherol with biomarkers among healthy Japanese men2014

    • Author(s)
      Zou Y, Wang DH, Sakano N, Sato Y, Iwanaga S, Taketa K, Kubo M, Takemoto K, Masatomi C, Inoue K, Ogino K
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: Vol.11 Issue: 2 Pages: 1647-1660

    • DOI

      10.3390/ijerph110201647

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of serum arginase I with L-arginine, 3-nitrotyrosine, and exhaled nitric oxide in healthy Japanese worker2014

    • Author(s)
      Ogino K, Wang DH, Kubo M, Obase Y, Setiawan H, Yan F, Takahashi H, Zhang R, Tsukiyama Y, Yoshida J, Zou Y
    • Journal Title

      Free Radical Research

      Volume: Vol. 48 Issue: 2 Pages: 137-145

    • DOI

      10.3109/10715762.2013.842979

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of serum arginase I as an oxidative stress biomarker in a healthy Japanese population using a newly established ELISA2013

    • Author(s)
      Ogino K, Murakami I, Wang DH, Tsukiyama Y, Takahashi H, Kubo M, Sakano N, Setiawan H, Bando M, Ohmoto Y
    • Journal Title

      Clinical Biochemistry

      Volume: Vol. 46 Issue: 16-17 Pages: 1717-1722

    • DOI

      10.1016/j.clinbiochem.2013.08.012

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] omparison of serum ferritin and oxidative stress biomarkers between Japanese workers with and without metabolic syndrome2013

    • Author(s)
      Iwanaga S, Sakano N, Taketa K, Takahashi N, Wang DH, Takahashi H, Kubo M, Miyatake N, Ogino K
    • Journal Title

      Obesity Research & Clinical Practice

      Volume: (in press) Issue: 3 Pages: 271-282

    • DOI

      10.1016/j.orcp.2013.01.003

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship between ceruloplasmin and oxidative biomarkers including ferritin among healthy Japanese2013

    • Author(s)
      Inoue Kiyomi, Ogino Keiki; Sakano Noriko; Wang Da-Hong; Yoshida Junko; Akazawa Yuji; Kanbara Sakiko; Kubo Masayuki; Takahashi Hidekazu
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 52 Issue: 2 Pages: 160-166

    • DOI

      10.3164/jcbn.12-122

    • NAID

      130004466707

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of urinary hydrogen peroxide as an oxidative stress biomarker in a healthy Japanese population2013

    • Author(s)
      Sato Yoshie; Ogino Keiki; Sakano Noriko; Wang,Da-Hong; Yoshida Junko; Akazawa Yuji; kanbara Sakiko; Inoue Kiyomi; Kubo Masayuki; Takahashi Hidekazu
    • Journal Title

      Free Radical Research

      Volume: 47(3) Issue: 3 Pages: 181-191

    • DOI

      10.3109/10715762.2012.759218

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of arginase ameliorates experimental ulcerative colitis in mice2013

    • Author(s)
      Akazawa Y, Kubo M, Zhang R, Matsumoto K, Yan F, Setiawan H, Takahashi H, Fujikura Y, Ogino K
    • Journal Title

      Free Radical Research

      Volume: Vol. 47 Issue: 3 Pages: 137-145

    • DOI

      10.3109/10715762.2012.756980

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-inflammatory effect of arginase inhibitor and corticosteroid on airway allergic reactions in a Dermatophogoides farinae-induced NC/Nga mouse model2013

    • Author(s)
      Ogino K, Kubo M, Takahashi H, Zhang R, Zou Y, Fujikura Y
    • Journal Title

      Inflammation

      Volume: Vol. 36 Issue: 1 Pages: 141-151

    • DOI

      10.1007/s10753-012-9529-3

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of nitric oxide generation by up-regulated arginase I in rat spinal cord injury2012

    • Author(s)
      Imagama T, Ogino K, Takemoto K, Kato Y, Kataoka H, Suzuki H, Ran Z, Setiawan H, Fujikura Y, Taguchi T
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 51 Issue: 1 Pages: 68-75

    • DOI

      10.3164/jcbn.D-11-00011

    • NAID

      130004879289

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inflammatory airway responses by nasal inoculation of suspended particulate matter in NC/Nga mice2012

    • Author(s)
      Ogino K, Takahashi N, Kubo M, Takeuchi A, Nakagiri M, Fujikura Y
    • Journal Title

      Environmental Toxicology

      Volume: (in press) Issue: 6 Pages: 642-654

    • DOI

      10.1002/tox.21791

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] High serum arginase I in asthma : its correlation with high-sensitivity C-reactive protein2011

    • Author(s)
      Ogino K
    • Journal Title

      J Asthma

      Volume: 48 Pages: 1-7

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of serum arginase I with oxidative stress in a healthy population2011

    • Author(s)
      Ogino K
    • Journal Title

      Free Radic Res

      Volume: 45 Pages: 147-155

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 男性労働者における血中抗酸化ビタミンと血中バイオマーカーとの関連性について2013

    • Author(s)
      鄒宇, 汪達紘, 坂野紀子, 佐藤美恵, 久保正幸, 竹本圭, 荻野景規
    • Organizer
      第57回中国四国合同産業衛生学会
    • Place of Presentation
      香川県社会福祉総合センター (香川)
    • Year and Date
      2013-12-08
    • Related Report
      2013 Final Research Report
  • [Presentation] 職業従事者におけるストレスに関するスコアと生活習慣及び血液バイオマーカーとの関連性についての検討2013

    • Author(s)
      三宅優紀, 高橋秀和, 久保正幸, 汪達紘, 佐藤美恵, 吉田純子, 張燃, 築山依果, 鄒宇, 舟久保徳美, 叶欽霞, 石井香代子, 井上清美, 荻野景規
    • Organizer
      第86回日本産業衛生学会学術総会
    • Place of Presentation
      ひめぎんホール (愛媛)
    • Year and Date
      2013-05-17
    • Related Report
      2013 Final Research Report
  • [Presentation] 肥満マウスモデルにおける血中アルギナーゼ活性およびアルギニン量の変化2013

    • Author(s)
      高橋秀和, 中田信也, 張燃, ヘリ・セティアワン, 村上育郎, 久保正幸, 荻野景規
    • Organizer
      第83回日本衛生学会学術総会
    • Place of Presentation
      金沢大学 鶴間キャンパス (石川)
    • Year and Date
      2013-03-25
    • Related Report
      2013 Final Research Report
  • [Presentation] 職業従事者におけるストレスに関するスコアと生活習慣及び血液バイオマーカーとの関連性についての検討2013

    • Author(s)
      三宅優紀, 髙橋秀和, 久保正幸, 汪達紘, 佐藤美恵, 吉田純子, 張燃, 築山依果, 鄒宇, 舟久保徳美, 叶欽霞, 石井香代子, 井上清美, 荻野景規
    • Organizer
      第86回日本産業衛生学会学術総会
    • Place of Presentation
      愛媛県
    • Related Report
      2013 Annual Research Report
  • [Presentation] 男性労働者における血中抗酸化ビタミンと血中バイオマーカーとの関連性について2013

    • Author(s)
      鄒宇, 汪達紘, 坂野紀子, 佐藤美恵, 久保正幸, 竹本圭, 荻野景規
    • Organizer
      第57回中国四国合同産業衛生学会
    • Place of Presentation
      香川県
    • Related Report
      2013 Annual Research Report
  • [Presentation] 企業従事者における抗酸化炎症バイオマーカーセルロプラスミンに関する研究2012

    • Author(s)
      井上清美, 坂野紀子, 佐藤美恵, 汪達紘, 久保正幸, 高橋秀和, 宮武伸行, 荻野景規
    • Organizer
      第56回中国四国合同産業衛生学会
    • Place of Presentation
      岡山大学 創立五十周年記念館 (岡山)
    • Year and Date
      2012-12-09
    • Related Report
      2013 Final Research Report
  • [Presentation] 企業健診受診者における酸化ストレスバイオマーカーと動脈硬化および冠動脈疾患リスクについて2012

    • Author(s)
      佐藤美恵, 荻野景規, 坂野紀子, 汪達紘, 吉田純子, 赤澤裕二, 神原咲子, 井上清美, 久保正幸, 高橋秀和
    • Organizer
      第56回中国四国合同産業衛生学会
    • Place of Presentation
      岡山大学 創立五十周年記念館 (岡山)
    • Year and Date
      2012-12-09
    • Related Report
      2013 Final Research Report
  • [Presentation] セルロプラスミンは抗酸化炎症バイオマーカーの一種か?2012

    • Author(s)
      井上清美, 坂野紀子, 佐藤美恵, 久保正幸, 汪達紘, 高橋秀和, 宮武伸行, 荻野景規
    • Organizer
      第10回日本予防医学会学術総会
    • Place of Presentation
      広島大学 霞キャンパス広仁会館 (広島)
    • Year and Date
      2012-11-25
    • Related Report
      2013 Final Research Report
  • [Presentation] 健診受診者における尿中過酸化水素について2012

    • Author(s)
      佐藤美恵, 荻野景規, 坂野紀子, 汪達紘, 吉田純子, 赤澤裕二, 神原咲子, 井上清美, 久保正幸, 高橋秀和
    • Organizer
      第10回日本予防医学会学術総会
    • Place of Presentation
      広島大学霞キャンパス広仁会館 (広島)
    • Year and Date
      2012-11-25
    • Related Report
      2013 Final Research Report
  • [Presentation] 新しい炎症性バイオマーカー『アルギナーゼI』と酸化ストレス2012

    • Author(s)
      荻野景規
    • Organizer
      第82回日本衛生学会総会
    • Place of Presentation
      京都大学 吉田キャンパス (京都)
    • Year and Date
      2012-03-25
    • Related Report
      2013 Final Research Report
  • [Presentation] 新しい炎症性バイオマーカー『アルギナーゼI』と酸化ストレス2012

    • Author(s)
      荻野景規
    • Organizer
      第82回日本衛生学会総会
    • Place of Presentation
      京都
    • Year and Date
      2012-03-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] 呼気NO とその調節因子2011

    • Author(s)
      荻野景規
    • Organizer
      第3回日本安定同位体・生体ガス医学応用学会大会
    • Place of Presentation
      東邦大学医療センター大森病院5 号館地下1 階臨床講堂 (東京)
    • Year and Date
      2011-11-04
    • Related Report
      2013 Final Research Report
  • [Presentation] 呼気NOとその調節因子2011

    • Author(s)
      荻野景規
    • Organizer
      第3回日本安定同位体・生体ガス医学応用学会大会特別講演
    • Place of Presentation
      東京
    • Year and Date
      2011-11-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 健康成人及び喘息患者における血清3-nitrotyrosine の疫学的評価2011

    • Author(s)
      荻野景規, 高橋紀子, ヘリ・セティアワン, 赤澤裕二, 高橋秀和, 汪達紘
    • Organizer
      第17回MPO 研究会シンポジウム
    • Place of Presentation
      アークホテル熊本(熊本)
    • Year and Date
      2011-10-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 健康成人及び喘息患者における血清3-nitrotyrosineの疫学的評価2011

    • Author(s)
      荻野景規
    • Organizer
      第17回MPO研究会シンポジウム
    • Place of Presentation
      熊本
    • Year and Date
      2011-10-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 肥満マウスモデルにおける血中アルギナーゼ活性およびアルギニン量の変化

    • Author(s)
      髙橋秀和
    • Organizer
      第83回日本衛生学会学術総会
    • Place of Presentation
      金沢大学鶴間キャンパス(石川県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 企業健診受診者における酸化ストレスバイオマーカーと動脈硬化および冠動脈疾患リスクについて

    • Author(s)
      佐藤美恵
    • Organizer
      第56回中国四国合同産業衛生学会
    • Place of Presentation
      岡山大学 創立五十周年記念館(岡山県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 企業従事者における抗酸化炎症バイオマーカーセルロプラスミンに関する研究

    • Author(s)
      井上清美
    • Organizer
      第56回中国四国合同産業衛生学会
    • Place of Presentation
      岡山大学 創立五十周年記念館(岡山県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 健診受診者における尿中過酸化水素について

    • Author(s)
      佐藤美恵
    • Organizer
      第10回日本予防医学会学術総会
    • Place of Presentation
      広島大学 霞キャンパス広仁会館(広島県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] セルロプラスミンは抗酸化炎症バイオマーカーの一種か?

    • Author(s)
      井上清美
    • Organizer
      第10回日本予防医学会学術総会
    • Place of Presentation
      広島大学 霞キャンパス広仁会館(広島県)
    • Related Report
      2012 Annual Research Report
  • [Book] Studies on Pediatric Disorders (Chapter Title : Analytical Procedures for Nitrative/Nitrosative Stress)2014

    • Author(s)
      Kubo M and Ogino K
    • Publisher
      Springer(in press)
    • Related Report
      2013 Final Research Report
  • [Book] Studies on Pediatric Disorders2014

    • Author(s)
      Masayuki Kubo, Keiki Ogino
    • Publisher
      Springer
    • Related Report
      2013 Annual Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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