| Project/Area Number |
23390163
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Okayama University |
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Principal Investigator |
OGINO Keiki 岡山大学, 医歯(薬)学総合研究科, 教授 (70204104)
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| Co-Investigator(Kenkyū-buntansha) |
WANG Da-hong 岡山大学, 大学院・医歯薬学総合研究科, 講師 (90294404)
TAKAHASHI Hidekazu 山口大学, 大学院・医学系研究科, 講師 (90450402)
KUBO Masayuki 岡山大学, 大学院・医歯薬学総合研究科, 助教 (60420519)
OUCHI Kazunobu 川崎医科大学, 医学部, 教授 (80351899)
OBASE Yasushi 川崎医科大学, 医学部, 講師 (40399762)
MATSUI Hideki 岡山大学, 大学院・医歯薬学総合研究科, 教授 (30157234)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2013: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2012: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Keywords | 予防医学 / アレルギー / アルギナーゼ / バイオマーカー / 喘息 / 糖尿病 / 肥満 / 一酸化窒素 / アルギナーゼI / L-アルギニン / 酸化ストレス / 呼気NO / IgE / インスリン / アルギニン / 炎症バイオマーカー / hsCRP / ELISA |
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| Research Abstract |
The availability of arginase as a biomarker for asthma, diabetes, and obesity was evaluated. In asthmatic patients, the relationship among arginase and physiological factors was investigated using a multivariable analysis. Given that the concentration of serum arginase had a positive correlation with hs-CRP, exhaled nitric oxide, NOx, and 3-nitrotyrosine, it is likely that arginase is available as a biomarker. In obese model mice, the expression of arginase was upregulated, in proportion as increase of body weight and blood glucose. Nitrite may contribute to prevention of diabetes, because the concentration of insulin was downregulated with nitrite.
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