Prevalence and incidence of locomotive syndrome components and its association with disability.

• Project/Area Number: 23390172
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: The University of Tokyo
• Principal Investigator: YOSHIMURA Noriko 東京大学, 医学部附属病院, 准教授 (60240355)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Takao , 国立長寿医療センター研究所, 所長 (30154545) ; AKUNE Toru 東京大学, 医学部附属病院, 特任准教授 (60282662) ; OKA Hiroyuki 東京大学, 医学部附属病院, 特任助手 (60401064) ; MURAKI Shigeyuki 東京大学, 医学部附属病院, 特任助手 (40401070)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000); Fiscal Year 2013: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2011: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
• Keywords: 医療・福祉 / 老化 / 疫学 / ロコモティブシンドローム / 要介護 / 発生率 / 危険因子 / コホート研究 / 国際比較 / ゲノム / 国際情報交換(英国、香港） / 国際情報交換（英国、米国、香港）

Outline of Final Research Achievements

The prevalence of osteoporosis (OP) and osteoarthritis (OA), and the number of people affected with these diseases in Japan, were estimated in the population-based cohort study entitled research on osteoarthritis/osteoporosis against disability (ROAD). The annual cumulative incidences of osteoporosis at lumbar spine L2-4 and the femoral neck were 0.76%/y and 1.83%/y, respectively. The cumulative incidences of knee osteoarthritis (KOA) and lumbar spondylosis were 3.3%/y and 11.4%/y, respectively. After assessing the associations among the diseases causing disability, including musculoskeletal diseases, metabolic syndrome (MS) components, and cognitive impairment, it was found that the occurrence of KOA significantly increased according to the number of MS components present. Similarly, mild cognitive impairment significantly increased the risk of occurrence of KOA.

Research Products

• [Journal Article] Prevalence and distribution of intervertebral disc degeneration over the entire spine in a population-based cohort: the Wakayama Spine Study. (2014)
  • Author(s): Teraguchi M, Yoshimura N, Hashizume H, Muraki S, Yamada H, Minamide A, Oka H, Ishimoto Y, Nagata K, Kagotani R, Takiguchi N, Akune T, Kawaguchi H, Nakamura K, Yoshida M
  • Journal Title: Osteoarthritis Cartilage Volume: 22 Issue: 1 Pages: 104-110
  • DOI: 10.1016/j.joca.2013.10.019
  • Peer Reviewed
• [Journal Article] Prevalence and progression of the radiographic ossification of posterior longitudinal ligament and its associated factors in the Japanese populations: A 3-year follow-up of the ROAD study. (2014)
  • Author(s): Yoshimura N, Nagata K, Muraki S, Oka H, Yoshida M, Enyo Y, Kagotani R, Hashizume H, Yamada H, Ishimoto Y, Teraguchi M, Tanaka S, Kawaguchi H, Toyama Y, Nakamura K, Akune T
  • Journal Title: Osteoporos Int Volume: 25 Issue: 3 Pages: 1089-1098
  • DOI: 10.1007/s00198-013-2489-0
  • Peer Reviewed
• [Journal Article] Prevalence of knee pain, lumbar pain and its co-existence in Japanese men and women: The Longitudinal Cohorts of Motor System Organ (LOCOMO) study (2014)
  • Author(s): Yoshimura N, Akune T, Fujiwara S, Nishiwaki Y, Shimizu Y, Yoshida H, Sudo A, Omori G, Yoshida M, Shimokata H, Suzuki T, Muraki S, Oka H, Nakamura K
  • Journal Title: J Bone Miner Metab Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Exercise habits during middle age are associated with lower prevalence of sarcopenia: the ROAD study. (2014)
  • Author(s): Akune T, Muraki S, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Yoshimura N
  • Journal Title: Osteoporos Int Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Incidence of disability and its associated factors in Japanese men and women: The Longitudinal Cohorts of Motor System Organ (LOCOMO) study. (2014)
  • Author(s): Yoshimura N, Akune T, Fujiwara S, Shimizu Y, Yoshida H, Nishiwaki Y, Sudo A, Omori G, Yoshida M, Shimokata H, Suzuki T, Muraki S, Oka H, Nakamura K
  • Journal Title: J Bone Miner Metab Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Consuming breakfast and exercising longer during high school increases bone mineral density in young Japanese men. (2013)
  • Author(s): Ishimoto Y, Yoshida M, Nagata K, Yamada H, Hashizume H, Yoshimura N
  • Journal Title: J Bone Miner Metab Volume: 31 Issue: 3 Pages: 329-336
  • DOI: 10.1007/s00774-012-0415-8
  • Peer Reviewed
• [Journal Article] Impact of nutrition on muscle mass, strength, and performance in older adults. (2013)
  • Author(s): Mithal A, Boonen S, Bonjour J-P, Burckhardt P, Degens H, Hajj Fuleihan G El, Josse R, Lips P, Morales Torres J, Rizzoli R, Yoshimura N, Wahl DA, Cooper C, Dawson-Hughes B for the IOF CSA Nutrition Working Group
  • Journal Title: Osteoporos Int Volume: 24 Issue: 5 Pages: 1555-1566
  • DOI: 10.1007/s00198-012-2236-y
  • Peer Reviewed
• [Journal Article] Associations between radiographic lumbar spinal stenosis and clinical symptoms in the general population: The Wakayama Spine Study. (2013)
  • Author(s): Ishimoto Y
  • Journal Title: Osteoarthritis and Cartilage Volume: 印刷中 Issue: 6 Pages: 783-788
  • DOI: 10.1016/j.joca.2013.02.656
  • Peer Reviewed
• [Journal Article] Profiles of vitamin D insufficiency and deficiency in Japanese men and women: association with biological, environmental, and nutritional factors and coexisting disorders: the ROAD study. (2013)
  • Author(s): Yoshimura N, Muraki S, Oka H, Morita M, Yamada H, Tanaka S, Kawaguchi H, Nakamura K, Akune T
  • Journal Title: Osteoporos Int Volume: 24 Issue: 11 Pages: 2775-2787
  • DOI: 10.1007/s00198-013-2372-z
  • Peer Reviewed / Open Access
• [Journal Article] Risk factors for falls in a longitudinal population-based cohort study of Japanese men and women: The ROAD Study. (2013)
  • Author(s): Muraki S
  • Journal Title: Bone Volume: 52 Issue: 1 Pages: 516-523
  • DOI: 10.1016/j.bone.2012.10.020
  • Peer Reviewed
• [Journal Article] Physical performance, bone and joint diseases, and incidence of falls in Japanese men and women (2012)
  • Author(s): Muraki S, Akune T, Oka H, Ishimoto Y, Nagata K, Yoshida M, Tokimura F, Nakamura K, Kawaguchi H, Yoshimura N
  • Journal Title: A longitudinal cohort study. Osteoporosis Int (inpress) Volume: 21(Epub ahead of print) Issue: 2 Pages: 459-466
  • DOI: 10.1007/s00198-012-1967-0
  • Peer Reviewed
• [Journal Article] Does mild cognitive impairment affect the occurrence of radiographic knee osteoarthritis? A 3-year follow-up in the ROAD study. (2012)
  • Author(s): Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Tanaka S, and Akune T
  • Journal Title: BMJ Open (in press) Volume: 2 Issue: 6 Pages: 2001520-2001520
  • DOI: 10.1136/bmjopen-2012-001520
  • Peer Reviewed
• [Journal Article] Accumulation of metabolic risk factors such as overweight, hypertension, dyslipidaemia, and impaired glucose tolerance raises the risk of occurrence and progression of knee osteoarthritis: a 3-year follow-up of the ROAD study. (2012)
  • Author(s): Yoshimura N
  • Journal Title: Osteoarthritis Cartilage Volume: 20 Issue: 11 Pages: 1217-1226
  • DOI: 10.1016/j.joca.2012.06.006
  • Peer Reviewed
• [Journal Article] Incidence and risk factors for radiographic knee osteoarthritis and knee pain in Japanese men and women: a longitudinal population-based cohort study. (2012)
  • Author(s): Muraki S, Tokimura F
  • Journal Title: Arthritis Rheum. Volume: 64(5) Issue: 5 Pages: 1147-56
  • DOI: 10.1002/art.33508
  • Peer Reviewed
• [Journal Article] Incidence and risk factors for radiographic lumbar spondylosis and lower back pain in Japanese men and women: the ROAD study. (2012)
  • Author(s): Muraki S, Tokimura F
  • Journal Title: Osteoarthritis Cartilage. Volume: 20(7) Issue: 7 Pages: 712-8
  • DOI: 10.1016/j.joca.2012.03.009
  • Peer Reviewed
• [Journal Article] C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes (2012)
  • Author(s): Hirata M, Kugimiya F, Fukai A, Saito T, Yano F, Ikeda T, Mabuchi A, Sapkota BR, Akune T, Nishida N, Yoshimura N, Nakagawa T, Tokunaga K, Nakamura K, Chung U, Kawaguchi H
  • Journal Title: Human Molecular Genetics 21, 1111-1123, 2012 Volume: 21 Pages: 1111-1123
  • Peer Reviewed
• [Journal Article] Capacity of endogenous sex steroids to predict bone loss in Japanese men : 10-year follow-up of the Taiji Cohort Study (2011)
  • Author(s): Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T
  • Journal Title: J Bone Miner Metab Volume: 29 Pages: 96-102
  • NAID: 10029023846
  • Peer Reviewed
• [Journal Article] Prevalence and correlates of regional pain and associated disability in Japanese workers (2011)
  • Author(s): Matsudaira K, Palmer KT, Reading I, Hirai M, Yoshimura N, Coggon D
  • Journal Title: Occup Environ Med Volume: 68 Pages: 191-196
  • Peer Reviewed
• [Journal Article] Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22 (2011)
  • Author(s): Evangelou E, Valdes AM, Kerkhof HJ, Styrkarsdottir U, Zhu Y, Meulenbelt I, Lories RJ, Karassa FB, Tylzanowski P, Bos SD; arcOGEN Consortium, Akune T, Arden NK, Carr A, Chapman K, Cupples LA, Dai J, Deloukas P, Doherty M, Doherty S, Engstrom G, Gonzalez A, Halldorsson BV, Hammond CL, Hart DJ, Helgadottir H, Hofman A, Ikegawa S, Ingvarsson T, Jiang Q, Jonsson H, Kaprio J, Kawaguchi H, Kisand K, Kloppenburg M, Kujala UM, Lohmander LS, Loughlin J, Luyten FP, Mabuchi A, McCaskie A, Nakajima M, Nilsson PM, Nishida N, Ollier WE, Panoutsopoulou K, van de Putte T, Ralston SH, Rivadeneira F, Saarela J, Schulte-Merker S, Shi D, SlagboomPE, Sudo A, Tamm A, Tamm A, Thorleifsson G, Thorsteinsdottir U, Tsezou A, Wallis GA, Wilkinson JM, Yoshimura N, Zeggini E, Zhai G, Zhang F, Jonsdottir I, Uitterlinden AG, Felson DT, van Meurs JB, Stefansson K, Ioannidis JP, Spector TD
  • Journal Title: Ann Rheum Dis Volume: 70 Pages: 349-355
  • Peer Reviewed
• [Journal Article] Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis : the TREAT-OA consortium (2011)
  • Author(s): Kerkhof HJ, Meulenbelt I, Akune T, Arden NK, Aromaa A, Bierma-Zeinstra SM, Carr A, Cooper C, Dai J, Doherty M, Doherty SA, Felson D, Gonzalez A, Gordon A, Harilainen A, Hart DJ, Hauksson VB, Heliovaara M, Hofman A, Ikegawa S, Ingvarsson T, Jiang Q, Jonsson H, Jonsdottir I, Kawaguchi H, Kloppenburg M, Kujala UM, Lane NE, Leino-Arjas P, Lohmander LS, Luyten FP, Malizos KN, Nakajima M, Nevitt MC, Pols HA, Rivadeneira F, Shi D, Slagboom E, Spector TD, Stefansson K, Sudo A, Tamm A, Tamm AE, Tsezou A, Uchida A, Uitterlinden AG, Wilkinson JM, Yoshimura N, Valdes AM, van Meurs JB
  • Journal Title: Osteoarthritis Cartilage Volume: 19 Pages: 254-264
  • Peer Reviewed
• [Journal Article] Association of knee osteoarthritis with the accumulation of metabolic risk factors such as overweight, hypertension, dyslipidemia, and impaired glucose tolerance in Japanese men and women : the ROAD study (2011)
  • Author(s): Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T
  • Journal Title: J Rheumatol Volume: 38 Pages: 921-930
  • Peer Reviewed
• [Journal Article] Secular trends in the incidence of hip and other osteoporotic fractures (2011)
  • Author(s): Cooper C, Cole ZA, Holroyd CR, Earl SC, Harvey NC, Dennison EM, Melton LJ, Cummings SR, Kanis JA ,the IOF CSA Working Group on Fracture Epidemiology (Adachi J, Borgstrom F, Dimai HP, Clark P, Lau E, Lewiecki EM, Lips P, Lorenc R, McCloskey E, Ortolani S, Papaioannou A, Silverman S, Wahl DA, Yoshimura N)
  • Journal Title: Osteoporos Int Volume: 22 Pages: 1277-1288
  • Peer Reviewed
• [Journal Article] Health-related quality of life in subjects with low back pain and knee pain in a population-based cohort study of Japanese men : the ROAD study (2011)
  • Author(s): Muraki S, Akune T, Oka H, Enyo Y, Yoshida M, Saika A, Suzuki T, Yoshida H, Ishibashi H, Tokimura F, Yamamoto S, Nakamura K, Kawaguchi H, Yoshimura N
  • Journal Title: Spine (Phila Pa 1976) Volume: 36 Pages: 1312-1319
  • Peer Reviewed
• [Journal Article] Association of occupational activity with joint space narrowing and osteophytosis in the medial compartment of the knee : the ROAD study (2011)
  • Author(s): Muraki S, Oka H, Akune T, Enyo Y, Yoshida M, Nakamura K, Kawaguchi H, Yoshimura N
  • Journal Title: Osteoarthritis Cartilage Volume: 19 Pages: 840-846
  • Peer Reviewed
• [Journal Article] Changes in serum levels of biochemical markers of bone turnover over 10 years among Japanese men and women : associated factors and birth-cohort effect ; the Taiji study (2011)
  • Author(s): Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T
  • Journal Title: J Bone Miner Metab Volume: 29 Pages: 699-708
  • Peer Reviewed
• [Journal Article] Biochemical markers of bone turnover as predictors for occurrence of osteoporosis and osteoporotic fractures in men and women : Ten-year follow-up of the Taiji cohort study (2011)
  • Author(s): Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T
  • Journal Title: Mod Rheumatol Volume: 21 Pages: 608-620
  • Peer Reviewed
• [Journal Article] Reference values for hand grip strength, muscle mass, walking time, and one-leg standing time as indices for locomotive syndrome and associated disability : The second survey of the ROAD study (2011)
  • Author(s): Yoshimura N, Oka H, Muraki S, Akune T, Hirabayashi N, Matsuda S, Nojiri T, Hatanaka K, Ishimoto Y, Nagata K, Yoshida M, Tokimura F, Kawaguchi H, Nakamura K
  • Journal Title: J Orthop Sci Volume: 16 Pages: 768-777
  • Peer Reviewed
• [Journal Article] Association of vitamin D status with knee pain and radiographic knee osteoarthritis (2011)
  • Author(s): Muraki S, Dennison E, Jameson K, Boucher BJ, Akcune T, Yoshimura N, Judge A, Arden NK, Javaid K, Cooper C
  • Journal Title: Osteoarthritis Cartilage Volume: 19 Pages: 1301-1306
  • Peer Reviewed
• [Journal Article] Independent association of joint space narrowing and osteophyte formation at the knee with health-related quality of life in Japan : A cross-sectional study (2011)
  • Author(s): Muraki S, Oka H, Akune T, En-Yo Y, Yoshida M, Suzuki T, Yoshida H, Ishibashi H, Tokimura F, Yamamoto S, Nakamura K, Kawaguchi H, Yoshimura N
  • Journal Title: Arthritis Rheum Volume: 63 Pages: 3859-3864
  • Peer Reviewed
• [Journal Article] Prevalence of falls and its association with knee osteoarthritis and lumbar spondylosis as well as knee and lower back pain in Japanese men and women (2011)
  • Author(s): Muraki S, Akune T, Oka H, En-Yo Y, Yoshida M, Nakamura K, Kawaguchi H, Yoshimura N
  • Journal Title: Arthritis Care Res Volume: 63 Pages: 1425-1431
  • Peer Reviewed
• [Presentation] Osteoarthritis: Assessment of clinical and structural outcomes (2013)
  • Author(s): Yoshimura N
  • Organizer: IOF Regionals-4th Asia-Pacific Osteoporosis Meeting
  • Place of Presentation: Hong Kong
  • Invited
• [Presentation] Higher levels of serum 25(OH)D prevents the occurrence of osteoporosis, but deteriorates knee osteoarthritis: The ROAD study. (2013)
  • Author(s): Yoshimura N, Muraki S, Oka H, Nakamura K, Tanaka S, Kawaguchi H, Akune T
  • Organizer: European Congress on Osteoporosis and Osteoarthritis
  • Place of Presentation: Romei, Italy
• [Presentation] Higher levels of serum 25(OH)D prevents the occurrence of osteoporosis, but deteriorates knee osteoarthritis: A 3-year follow-up of the ROAD study. (2013)
  • Author(s): Yoshimura N, Muraki S, Oka H, Nakamura K, Tanaka S, Kawaguchi H, Akune T
  • Organizer: 2nd Joint Meeting of the International Bone and Mineral Society (IBMS) and the Japanese Society for Bone and Mineral Research (JSBMR)
  • Place of Presentation: Kobe, Japan
• [Presentation] Risk Factors for Multiple Falls in Japanese Men and Women: The ROAD Study. (2013)
  • Author(s): Muraki S, Akune T, Tanaka S, Kawaguchi H, Nakamura, K, Oka H, Yoshimura N
  • Organizer: 2nd Joint Meeting of the International Bone and Mineral Society (IBMS) and the Japanese Society for Bone and Mineral Research (JSBMR)
  • Place of Presentation: Kobe, Japan
• [Presentation] Prevalence of sarcopenia and its association with exercise habits in the elderly of Japanese population-based cohorts (2013)
  • Author(s): Muraki S, Akune T, Tanaka S, Kawaguchi H, Nakamura K, Oka H, Yoshimura N
  • Organizer: IOF Regionals-4th Asia-Pacific Osteoporosis Meeting
  • Place of Presentation: Hong Kong
• [Presentation] Accumulation of metabolic risk factors raises the risk of occurrence and progression of knee osteoarthritis: the ROAD study. (2012)
  • Author(s): Yoshimura N
  • Organizer: Annual European Congress of Rheumatology (EULAR) 2012
  • Place of Presentation: Berlin, Germany
• [Presentation] Mild Cognitive Impairment Increases The Risk of Knee Osteoarthritis: A 3-Year Follow-Up in The ROAD Study. (2012)
  • Author(s): Yoshimura N
  • Organizer: IOF Regionals - 3rd Asia-Pacific Osteoporosis Meeting
  • Place of Presentation: Kuala Lumpur, Malaysia
• [Presentation] Physical Performance, Bone and Joint Diseases, and Incidence of Falls in Japanese Men and women: The ROAD Study. (2012)
  • Author(s): Muraki S
  • Organizer: IOF Regionals - 3rd Asia-Pacific Osteoporosis Meeting
  • Place of Presentation: Kuala Lumpur, Malaysia
• [Presentation] Accumulation of metabolic risk factors such as overweight, hypertension, dyslipidemia, and impaired glucose intolerance raises the risk of occurence and progression of knee osteooarthritis : A 3-year follow-up of the ROAD Study (2012)
  • Author(s): Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T
  • Organizer: IOF-ECCEO 2012
  • Place of Presentation: Bordeaux, France
• [Presentation] Prevalence of cervical cord compression and its relations to physical signs and performances in a Japanese population-based cohort : The ROAD-MRI Study (2011)
  • Author(s): Nagata K, Yoshida M, Hashizume H, Yamada H, Ishimoto Y, Takiguchi N, Muraki S, Oka H, Akune T, Yoshimura N
  • Organizer: The 8th Combined Congress of the Spine and Pediatric Sections, Asia Pacific Orthopaetic Association (APOA)
  • Place of Presentation: Gifu, Japan
• [Presentation] The prevalence of lumbar spinal stenosis using MRI in a local cohort : The ROAD-MRI Study (2011)
  • Author(s): Ishimoto Y, Yamada H, Hashizume H, Nagata K, Takiguchi N, Yoshida M, Muraki S, Oka H, Akune T, Yoshimura N
  • Organizer: The 8th Combined Congress of the Spine and Pediatric Sections, Asia Pacific Orthopaetic Association (APOA)
  • Place of Presentation: Gifu, Japan
• [Presentation] The Prevalence of the lumbar spinal stenosis with Mobile MRI in a population-based cohort : The Road-MRI Study (2011)
  • Author(s): Ishimoto Y, Yoshida M, Yamada H, Nagata K, Hashizume H, Takiguchi N, Shigeyuki M, Oka H, Akune T, Yoshimura N
  • Organizer: Annual Meeting of the International Society for the Study of the Lumbar Spine (ISSLS)
  • Place of Presentation: Gothenburg, Sweden
• [Presentation] Role of neuromuscular function in predicting the occurrence of disability : The ROAD study (2011)
  • Author(s): Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T
  • Organizer: IEA World Congress of Epidemiology
  • Place of Presentation: Edinburgh, Scotland
• [Presentation] Vitamin D insufficiency and deficiency as a risk factor for fast bone loss among elderly men and women : The ROAD study (2011)
  • Author(s): Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T
  • Organizer: The 2nd Asia-Pacific Osteoporosis and Bone Meeting
  • Place of Presentation: Gold Coast, Australia
• [Presentation] Risk factors for multiple falls in a longitudinal population-based cohort study in Japan : the ROAD study (2011)
  • Author(s): Muraki S, Akune T, Oka H, Nakamura K, Kawaguchi H, Yoshimura N
  • Organizer: The 2nd Asia-Pacific Osteoporosis and Bone Meeting
  • Place of Presentation: Gold Coast, Australia
• [Presentation] Risk factors for the incidence and progress rate of radiographic knee osteoarthritis in Japanese men and women : the ROAD study (2011)
  • Author(s): Muraki S, Akune T, Oka H, Nakamura K, Kawaguchi H, Yoshimura N
  • Organizer: Osteoarthritis Research Society International (OARSI) 2011 World Congress on Osteoarthritis
  • Place of Presentation: San Diego, USA
• [Presentation] Incidence and risk factors for radiographic lumbar spondylosis : the ROAD study (2011)
  • Author(s): Muraki S, Akune T, Oka H, Nakamura K, Kawaguchi H, Yoshimura N
  • Organizer: Osteoarthritis Research Society International (OARSI) 2011 World Congress on Osteoarthritis
  • Place of Presentation: San Diego, USA
• [Presentation] Vitamin D Insufficiency and Occurrence of Osteoporosis and Disability : the ROAD study (2011)
  • Author(s): Yoshimura N, Muraki M, Oka H, Kawaguchi H, Nakamura K, Akune T
  • Organizer: The 33rd Annual Meeting of the American Society for Bone and Mineral Research (ASBMR)
  • Place of Presentation: San Diego, USA
• [Presentation] Incidence of multiple falls and risk factors in a longitudinal population-based cohort study in Japan : the ROAD study (2011)
  • Author(s): Muraki S, Akune T, Oka H, Nakamura K, Kawaguchi H, Yoshimura N
  • Organizer: The 33rd Annual Meeting of the American Society for Bone and Mineral Research (ASBMR)
  • Place of Presentation: San Diego, USA
• [Book] ロコモティブシンドローム (2014)
  • Author(s): 吉村典子(分担執筆）
  • Publisher: メディカルレビュー社
• [Book] 変形性膝関節症の運動療法ガイド－保存的治療から術後リハまで (2014)
  • Author(s): 吉村典子(分担執筆）
  • Publisher: 日本医事新報社
• [Book] II. 骨粗鬆症の疫学 2. 骨折の疫学 3) 非脊椎骨折（大腿骨頚部骨折を除く）「骨粗鬆症診療ハンドブック改訂５版」 (2012)
  • Author(s): 吉村典子
  • Publisher: 医薬ジャーナル社
• [Book] ロコモティブシンドロームの疫学．ロコモティブシンドロームと栄養 (2012)
  • Author(s): 吉村典子
  • Publisher: 建帛社
• [Book] 機能性食品素材の骨と軟骨への応用 (2011)
  • Author(s): 吉村典子、岡敬之
  • Publisher: 変形性関節症:大規模住民調査ROADから
• [Book] 骨粗鬆症の予防と治療ガイドライン2011年版(骨粗鬆症の予防と治療ガイドライン作成委員会(代表折茂肇)編) (2011)
  • Author(s): 吉村典子
  • Publisher: 骨粗鬆症の疫学