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Environmental factors and genetic factors related to adolescent physical and mental health

Research Project

Project/Area Number 23390173
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene and public health
Research InstitutionUniversity of Yamanashi

Principal Investigator

YAMAGATA Zentaro  山梨大学, 総合研究部, 教授 (10210337)

Co-Investigator(Renkei-kenkyūsha) SUZUKI Kohta  山梨大学, 大学院総合研究部, 准教授 (90402081)
TANAKA Taichiro  東邦大学, 保健管理センター, 准教授 (70402740)
KONDO Naoki  東京大学, 医学系研究科, 准教授 (20345705)
SATO Miri  山梨大学, 大学院総合研究部, 助教 (10535602)
Project Period (FY) 2011-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords思春期 / 肥満 / 高血圧 / メンタルヘルス / 出生コホート研究 / マルチレベルモデル / ネット依存 / DOHaD / マルチレベル解析 / 出生コホート / ゲノム
Outline of Final Research Achievements

The environmental and genetic factors related to adolescent health were analyzed using a birth cohort data set from fetal period to 14 years old including 2464 children with multilevel models. The following are results.1) Multiple developmental patterns in children were identified.2)Children born to mothers who stopped smoking before or during early pregnancy had appropriate fetal and childhood growth.3) Time of sleep at 3 years of age is risk of adolescent obesity. 4)We found that malocclusion, especially lower crowding, was associated with headache in a population-based sample of adolescents. 5) The timing of pubertal growth is involved in the process of hypertension development in people with a family history of hypertension. 6) The risk factors of depression during adolescent were the desire to lose weight, Orthostatic Dysregulation, internet addiction. University of Yamanashi and Koshu City were concluded an agreement to continue this data analysis for health promotion of citizen.

Report

(6 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (29 results)

All 2016 2015 2014 2013 2012 Other

All Journal Article (10 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 9 results,  Open Access: 2 results,  Acknowledgement Compliant: 5 results) Presentation (19 results) (of which Int'l Joint Research: 2 results,  Invited: 5 results)

  • [Journal Article] Pubertal timing and a family history of hypertension: Prospective cohort study.2016

    • Author(s)
      Zheng W, Suzuki K, Sato M, Yokomichi H, Shinohara R, Yamagata Z.
    • Journal Title

      Pediatr Int.

      Volume: 58 Issue: 4 Pages: 284-289

    • DOI

      10.1111/ped.12821

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Childhood growth trajectories according to combinations of pregestational weight status and maternal smoking during pregnancy: a multilevel analysis2015

    • Author(s)
      Suzuki K, Sato M, Zheng W, Shinohara R, Yokomichi H, Yamagata Z
    • Journal Title

      PLoS One

      Volume: 10(2) Issue: 2 Pages: e0118538-e0118538

    • DOI

      10.1371/journal.pone.0118538

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Childhood growth trajectories according to combinations of pregestational weight status and maternal smoking during pregnancy: A multilevel analysis2015

    • Author(s)
      Kohta Suzuki, Miri Sato, Wei Zheng, Ryoji Shinohara, Hiroshi Yokomichi, Zentaro Yamagata
    • Journal Title

      PLoS ONE

      Volume: 10

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Maternal smoking during pregnancy and infancy growth: A covariance structure analysis2015

    • Author(s)
      Wei Zheng, Kohta Suzuki, Ryoji Shinohara, Miri Sato, Hiroshi Yokomichi, Zentaro Yamagata
    • Journal Title

      Journal of Epidemiology

      Volume: 25 Pages: 44-49

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Adolescent growth in overweight and non-overweight children in Japan: a multilevel analysis2014

    • Author(s)
      Wei Zheng, Kohta Suzuki, Miri Sato, Hiroshi Yokomichi, Ryoji Shinohara, Zentaro Yamagata
    • Journal Title

      Paediatric and Perinatal Epidemiology

      Volume: 28 Pages: 263-269

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Association between malocclusion and headache among 12- to 15-year-old adolescents: a population-based study2014

    • Author(s)
      Komazaki Y, Fujiwara T, Ogawa T, Sato M, Suzuki K, Yamagata Z, Moriyama K
    • Journal Title

      Community Dent Oral Epidemiol

      Volume: 42 Pages: 572-580

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 発達研究における出生コホート研究の意義(第33回日本社会精神医学会@東京:シンポジウム3「わが国におけるこころの発達コホート研究の将来展望」)2014

    • Author(s)
      山縣然太朗
    • Journal Title

      日本社会精神医学会雑誌

      Volume: 23 Pages: 366-371

    • Related Report
      2014 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] Multilevel longitudinal analysis of sex differences in height gain and growth rate changes in Japanese school-aged children2013

    • Author(s)
      Zheng W,Suzuki K,Yokomichi H,Sato M,Yamagata Z.
    • Journal Title

      Journal of Epidemiology

      Volume: 23 Pages: 275-279

    • NAID

      10031183193

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differences in the effect of maternal smoking during pregnancy for childhood overweight before and after 5 years of age2013

    • Author(s)
      Kohta Suzuki
    • Journal Title

      Journal of Obstetrics and Gynaecology Research

      Volume: 39(5) Issue: 5 Pages: 914-921

    • DOI

      10.1111/jog.12025

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Developmental trajectories of body mass index among Japanese children and impact of maternal factors during pregnancy2012

    • Author(s)
      Chiyori Haga
    • Journal Title

      PLoS One

      Volume: 7(12) Issue: 12 Pages: 1-10

    • DOI

      10.1371/journal.pone.0051896

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 小学校6年間における視力低下の発症時期およびリスクの検討 甲州プロジェクト 生存時間分析2016

    • Author(s)
      野田北斗,鈴木孝太,佐藤美理,山縣然太朗
    • Organizer
      日本疫学会
    • Place of Presentation
      米子コンベンションセンター(鳥取県米子市)
    • Year and Date
      2016-01-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 地域を基盤にした生涯にわたる健康づくりとソーシャル・キャピタル2015

    • Author(s)
      山縣然太朗
    • Organizer
      日本地域看護学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2015-08-02
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] The association betwween depressive status and internet addiction in puberty: A community-based cohort study2015

    • Author(s)
      Miri Sato, Kohta Suzuki, Ryouji Shinohara, Sonoko Mizorogi, Zentaro Yamagata
    • Organizer
      European congress of epidemiology
    • Place of Presentation
      Maastricht(The Netherlands)
    • Year and Date
      2015-06-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Attitudes toward genetic research on children in Japan2015

    • Author(s)
      Zentaro Yamagata, Kaori Muto
    • Organizer
      European Society of Human Genetics
    • Place of Presentation
      Glasgow(Scotland)
    • Year and Date
      2015-06-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 日本における子どもに対する遺伝子研究に関する意識とインフォームド・コン2015

    • Author(s)
      山縣然太朗
    • Organizer
      日本小児科学会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2015-04-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] Macrosomia is one of risk factors for dental caries in 3-year-old infants in Japan2014

    • Author(s)
      Zentaro Yamagata, Hiroshi Yokomichi, Kohta Suzuki, Taichiro Tanaka
    • Organizer
      20th IEA World Congress of Epidemiology (International Epidemiological Association)
    • Place of Presentation
      Anchorage, Alaska (USA)
    • Year and Date
      2014-08-17 – 2014-08-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] Community-based screening program to detect pre-school children with developmental disorders2014

    • Author(s)
      Miri Sato, Kohta Suzuki, Masao Aihara, Zentaro Yamagata
    • Organizer
      20th IEA World Congress of Epidemiology (International Epidemiological Association)
    • Place of Presentation
      Anchorage, Alaska (USA)
    • Year and Date
      2014-08-17 – 2014-08-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] Effects of the Great East Japan Earthquake on perinatal outcomes2014

    • Author(s)
      Kohta Suzuki, Zentaro Yamagata, Miyuki Kawado, Shuji Hashimoto
    • Organizer
      20th IEA World Congress of Epidemiology (International Epidemiological Association)
    • Place of Presentation
      Anchorage, Alaska (USA)
    • Year and Date
      2014-08-17 – 2014-08-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] The influence of infancy weight gain on patterns of adolescent growth in Japanese children2014

    • Author(s)
      Wei Zheng, Kohta Suzuki, Miri Sato, Hiroshi Yokomichi, Ryoji Shinohara, Zentaro Yamagata
    • Organizer
      47th Annual SER Meeting(Society for Epidemiologic Research)
    • Place of Presentation
      Seattle, Washington (USA)
    • Year and Date
      2014-06-24 – 2014-06-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] A life-table analysis to explore factors associated with selective study participation in the national birth cohort in Japan2014

    • Author(s)
      Kohta Suzuki, Zentaro Yamagata, Ichiro Tsuji
    • Organizer
      47th Annual SER Meeting(Society for Epidemiologic Research)
    • Place of Presentation
      Seattle, Washington (USA)
    • Year and Date
      2014-06-24 – 2014-06-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] The effects of interaction between maternal smoking and household income on birth weight in Japan2014

    • Author(s)
      Kohta Suzuki, Zentaro Yamagata, Ichiro Tsuji
    • Organizer
      SPER 27th Annual Meeting(Society for Pediatric and Perinatal Epidemiologic Research)
    • Place of Presentation
      Seattle, Washington (USA)
    • Year and Date
      2014-06-23 – 2014-06-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] The association between body image and change in depressive symptoms during the pubertal period among non-obese children in Japan: Multilevel analysis2014

    • Author(s)
      Miri Sato, Kohta Suzuki, Zentaro Yamagata
    • Organizer
      SPER 27th Annual Meeting(Society for Pediatric and Perinatal Epidemiologic Research)
    • Place of Presentation
      Seattle, Washington (USA)
    • Year and Date
      2014-06-23 – 2014-06-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] Childhood growth trajectories by combinations of maternal weight status before pregnancy and maternal smoking during pregnancy: A multilevel analysis2013

    • Author(s)
      Kohta Suzuki, Miri Sato, Zentaro Yamagat
    • Organizer
      SPER 26th Annual Meeting(Society for Pediatric and Perinatal Epidemiologic Research)
    • Place of Presentation
      パークプラザホテル(ボストン、米国)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Association of individual social skills and classroom connectedness with depressive symptoms in puberty2013

    • Author(s)
      Miri Sato, Kohta Suzuki, Zentaro Yamagata
    • Organizer
      SPER 26th Annual Meeting(Society for Pediatric and Perinatal Epidemiologic Research)
    • Place of Presentation
      パークプラザホテル(ボストン、米国)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Difference in pubertal height gain trajectories based on gender and childhood body mass index: A multilevel analysis2013

    • Author(s)
      Wei Zheng, Kohta Suzuki, Miri Sato, Zentaro Yamagata
    • Organizer
      46th Annual SER Meeting(Society for Epidemiologic Research)
    • Place of Presentation
      パークプラザホテル(ボストン、米国)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 親子保健のタバコ問題2013

    • Author(s)
      山縣然太朗
    • Organizer
      第8回日本禁煙科学会学術総会
    • Place of Presentation
      高崎健康科学大学(群馬県前橋市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Combination of birth cohort studies and neuroscience research2012

    • Author(s)
      Zentaro Yamagata
    • Organizer
      Japan Neuroscience Society
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 大規模出生コホート研究と脳科学研究の連携2012

    • Author(s)
      山縣然太朗
    • Organizer
      日本生物学的精神医学会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 日本における小児生活習慣病対策に関する政策と課題

    • Author(s)
      山縣然太朗
    • Organizer
      国際小児保健研究会
    • Place of Presentation
      広島工業大学(広島県広島市)
    • Related Report
      2013 Annual Research Report
    • Invited

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Published: 2011-04-06   Modified: 2019-07-29  

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