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Association between pericardial fat volume and subclinical atherosclerosis in Japanese men: a 7-year follow-up study

Research Project

Project/Area Number 23390174
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Epidemiology and preventive medicine
Research InstitutionTeikyo University (2013-2014)
Shiga University of Medical Science (2011-2012)

Principal Investigator

OHKUBO Takayoshi  帝京大学, 医学部, 教授 (60344652)

Co-Investigator(Kenkyū-buntansha) FUJIYOSHI Akira  滋賀医科大学, 医学部, 准教授 (10567077)
KADOTA Aya  滋賀医科大学, アジア疫学研究センター, 特任准教授 (60546068)
UESHIMA Hirotsugu  滋賀医科大学, アジア疫学研究センター, 特任教授 (70144483)
MIURA Katsuyuki  滋賀医科大学, 医学部, 教授 (90257452)
Project Period (FY) 2011-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2012: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Keywords社会医学 / 循環器・高血圧 / 疫学 / 心異所性脂肪 / コホート研究 / 心臓CT / 潜在性動脈硬化
Outline of Final Research Achievements

We investigated the association between pericardial fat volume and metabolic or subclinical atherosclerosis factors in Japanese men in a general population. Pericardial fat volume was significantly associated with barometers of obesity, such as BMI, waist circumstance, visceral fat and so on. Pericardial fat volume was significantly associated with triglyceride and inversely associated with HDL. Pericardial fat volume has increased significantly during the follow-up period. The patients with a history of myocardial infarction had higher volume of pericardial fat. Smoking status at baseline was not associated with pericardial fat volume but Δ pericardial fat volume of current smokers were higher than that of no-smokers. Alcohol drinking was not associated with pericardial fat.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (21 results)

All 2015 2014 2013 2012 2011 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (17 results)

  • [Journal Article] High-density lipoprotein particle concentration and subclinical atherosclerosis of the carotid arteries in Japanese men.2015

    • Author(s)
      Maryam Zaid, Akira Fujiyoshi, Katsuyuki Miura, Robert D. Abbott, Tomonori Okamura, Naoyuki Takashima, Sayuki Torii, Yoshino Saito, Takashi Hisamatsu, Naoko Miyagawa, Takayoshi Ohkubo, Aya Kadota, Akira Sekikawa, Hiroshi Maegawa, Yasuyuki Nakamura, Kenichi Mitsunami, Hirotsugu Ueshima, For the SESSA Research group.
    • Journal Title

      Atherosclerosis.

      Volume: 239(2) Pages: 444-450

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cross-sectional comparison of coronary artery calcium scores between Caucasian men in the United States and Japanese Men in Japan: The multi-ethnic study of atherosclerosis and the Shiga epidemiological study of subclinical atherosclerosis2014

    • Author(s)
      Fujiyoshi A, Miura K, Ohkubo T, Kadowaki T, Kadowaki S, Zaid M, Hisamatsu T, Sekikawa A, Budoff MJ, Liu K, Ueshima H; SESSA Research Group; MESA Research Group.
    • Journal Title

      Am J Epidemiol

      Volume: 180 Issue: 6 Pages: 590

    • DOI

      10.1093/aje/kwu169

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Lipoprotein particle profiles compared with standard lipids in association with coronary artery calcification in the general Japanese population.2014

    • Author(s)
      Takashi Hisamatsu、Akira Fujiyoshi、Katsuyuki Miura、Takayoshi Ohkubo、Aya Kadota、 Sayaka Kadowaki、Takashi Kadowaki、Takashi Yamamoto、Naoko Miyagawa、Maryam Zaid、Sayuki Torii、Naoyuki Takashima、Yoshitaka Murakami、Tomonori Okamura、Minoru Horie、Hirotsugu Ueshima; for the SESSA Research Group.
    • Journal Title

      Atherosclerosis.

      Volume: 236(2) Pages: 237-243

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Carotid Intima-Media Thickness and Plaque in Apparently Healthy Japanese Individuals with an Estimated 10-Year Absolute Risk of CAD Death According to the Japan Atherosclerosis Society(JAS)Guidelines 2012: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA).2013

    • Author(s)
      Aya Kadota, Katsuyuki Miura, Tomonori Okamura, Akira Fujiyoshi, Takayoshi Ohkubo, Takashi Kadowaki, Naoyuki Takashima, Takashi Hisamatsu, Yasuyuki Nakamura, Fumiyoshi Kasagi, Hiroshi Maegawa, Aatsunori Kashiwagi, Hirotsugu Ueshima.
    • Journal Title

      J Atheroscler Thromb.

      Volume: 20(10) Pages: 755-766

    • NAID

      130004444645

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Association of unrecognized myocardial infarction with silent cerebral lesions in elderly Japanese2015

    • Author(s)
      Takashi Hisamatsu, Katsuyuki Miura, Akira Fujiyoshi, Takayoshi Ohkubo, Akihiko Shiino, Kazuhiko Nozaki, Sayuki Torii, Sentaro Suzuki, Kiyoshi Murata, Hirotsugu Ueshima; for the SESSA Research Group.
    • Organizer
      第40回日本脳卒中学会総会、STROKE2015
    • Place of Presentation
      広島
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] The association of brachial-ankle Pulse Wave Velocity and estimated glomerular filtration rate with albuminuria among general Japanese.2015

    • Author(s)
      Aya Kadota, Katsuyuki Miura, Takayoshi Ohkubo, Takashi Hisamatsu, Akira Fujiyoshi, Naoyuki Takashima,Tomonori Okamura, and Hirotsugu Ueshima for the SESSA Research Group.
    • Organizer
      83rd EAS Congress Glasgow
    • Place of Presentation
      グラスゴー/イギリス
    • Year and Date
      2015-03-22 – 2015-03-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Lifetime Cigarette Smoking is Associated with Increased Indices of Abdominal Obesity Independent of Body Mass Index: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)2014

    • Author(s)
      Akira Fujiyoshi, Katsuyuki Miura, Sayaka Kadowaki, Aya Kadota, Takayoshi Ohkubo, Naoko Miyagawa, Takashi Hisamatsu, Yoshino Saitoh, Sayuki Torii, Itsuko Miyazawa, Kenichi Mitsunami, Hiroshi Maegawa, Kiyoshi Murata, Hirotsugu Ueshima, For the SESSA Research group
    • Organizer
      AHA EPI/NPAM2014
    • Place of Presentation
      サンフランシスコ/アメリカ
    • Related Report
      2013 Annual Research Report
  • [Presentation] 日本人男性における心臓周囲脂肪と肥満指標との関連:滋賀潜在性動脈硬化研究(SESSA)2013

    • Author(s)
      宮澤伊都子、大久保孝義、三浦克之、藤吉朗、門脇紗也佳、宮川尚子、高嶋直敬、斉藤祥乃、鳥居さゆ希、久松隆史、門田文、前川聡、上島弘嗣 for the SESSA Research Group
    • Organizer
      第49回日本循環器病予防学会・日本循環器管理研究協議会総会
    • Place of Presentation
      金沢
    • Related Report
      2013 Annual Research Report
  • [Presentation] 地域住民男性における生涯喫煙量と内臓脂肪との関連:SESSA研究2013

    • Author(s)
      藤吉朗、三浦克之、門脇紗也佳、門田文、大久保孝義、宮川尚子、久松隆史、齋藤祥乃、鳥居さゆ希、宮澤伊都子、三ッ浪 健一、前川 聡、村田喜代史、上島弘嗣 for SESSA Research Group
    • Organizer
      第34回日本肥満学会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Association between Pulse Wave Velocity and Coronary Artery Calcification in a general Japanese male population: SESSA2013

    • Author(s)
      Sayuki Torii, Takayoshi Ohkubo, Akira Fujiyoshi, Aya Kadota, Naoyuki Takashima, Sayaka Kadowaki, Takashi Hisamatsu, Yoshino Saitoh, Naoko Miyagawa, Maryam Zaid,Yoshitaka Murakami, Katsuyuki Miura, Hirotsugu Ueshima, Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) Research Group.
    • Organizer
      81st EAS Congress
    • Place of Presentation
      リヨン/フランス
    • Related Report
      2013 Annual Research Report
  • [Presentation] Lipoprotein Particle Profiles by Nuclear Magnetic Resonance, Standard Lipids and Coronary Artery Calcification in a Japanese General Population: the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)2013

    • Author(s)
      Takashi Hisamatsu, Katsuyuki Miura, Takayoshi Ohkubo, Akira Fujiyoshi, Aya Kadota, Sayaka Kadowaki, Takashi Yamamoto, Naoko Miyagawa, Maryam Zaid, Naoyuki Takashima, Tomonori Okamura, Minoru Horie, Hirotsugu Ueshima, For the SESSA Research Group
    • Organizer
      第45回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Lipoprotein-associated Phospholipase A2 Related to the Risk of Subclinical Carotid Atherosclerosis in a General Male Japanese2012

    • Author(s)
      Hirotsugu Ueshima, et.al., for the SESSA Research Group
    • Organizer
      XVI International Symposium on Atherosclerosis
    • Place of Presentation
      ジドニー/オーストラリア
    • Year and Date
      2012-03-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Coronary artery calcification is not uncommon among apparently healthy Japanese men and women : results from the Shiga Epidemiological Study of2012

    • Author(s)
      Akira Fujiyoshi, et al, for the SESSA Research Group
    • Organizer
      XVI International Symposium on Atherosclerosis
    • Place of Presentation
      シドニー/オーストラリア
    • Year and Date
      2012-03-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Subclinical Atherosclerosis of Carotid Arteries among Apparently Healthy Japanese Men and Women : The Shiga Epidemiological Study of Subclinical2012

    • Author(s)
      Aya Kadota, et.Al., for the SESSA Research Group
    • Organizer
      XVI International Symposium on Atherosclerosis
    • Place of Presentation
      シドニー/オーストラリア
    • Year and Date
      2012-03-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 冠動脈石灰化は日本人一般集団の男女でもまれではない:SESSA研究2012

    • Author(s)
      藤吉朗, 他, SESSAリサーチグループ
    • Organizer
      第76日本循環器学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2012-03-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 日米地域住民対象コホートにおけるCTによる冠動脈石灰化スコアの比較可能性検討2011

    • Author(s)
      藤吉朗、門脇崇、門脇紗也佳、関川暁、大久保孝義、三浦克之、上島弘嗣, 他
    • Organizer
      7回日本循環器病予防学会・日本循環器管理研究協議会総会
    • Place of Presentation
      福岡
    • Year and Date
      2011-06-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Coronary calcification and estimated 10 year-absolute risk for CHD death using the NIPPON DATA80 Risk Assessment Chart: The Shiga Epidemiological Study of Subclinical Atherosclerosis

    • Author(s)
      Akira Fujiyoshi et al
    • Organizer
      第44回日本動脈硬化学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] 一般男性集団における脈波伝播速度と冠動脈石灰化との関連

    • Author(s)
      鳥居さゆ希、大久保孝義、藤吉朗、他 SESSA研究グループ
    • Organizer
      第35回日本高血圧学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] Non-HDL Cholesterol is Strongly Associated with Coronary Artery Calcification in a General Japanese Population: SESSA

    • Author(s)
      Akira Fujiyoshi, Katsuyuki Miura, Takayoshi Ohkubo, et al
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] Cross-Sectional Comparison of Coronary Artery Calcium Prevalence between Japan and the US: The Multi-Ethnic Study of Atherosclerosis (MESA) and the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)

    • Author(s)
      Akira Fujiyoshi, Katsuyuki Miura, Takayoshi Ohkubo, et al
    • Organizer
      AHA Epidemiology and Prevention/Nutrition, Physical Activity and Metabolism
    • Place of Presentation
      ニューオーリンズ/アメリカ
    • Related Report
      2012 Annual Research Report
  • [Presentation] The relationship of serum marine-derived n-3 fatty acids and carotid intima-media thickness among general Japanese men: the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)

    • Author(s)
      Aya Kadota, et al
    • Organizer
      AHA Epidemiology and Prevention/Nutrition, Physical Activity and Metabolism
    • Place of Presentation
      ニューオーリンズ/アメリカ
    • Related Report
      2012 Annual Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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