Association between pericardial fat volume and subclinical atherosclerosis in Japanese men: a 7-year follow-up study

• Project/Area Number: 23390174
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Teikyo University (2013-2014); Shiga University of Medical Science (2011-2012)
• Principal Investigator: OHKUBO Takayoshi 帝京大学, 医学部, 教授 (60344652)
• Co-Investigator(Kenkyū-buntansha): FUJIYOSHI Akira 滋賀医科大学, 医学部, 准教授 (10567077) ; KADOTA Aya 滋賀医科大学, アジア疫学研究センター, 特任准教授 (60546068) ; UESHIMA Hirotsugu 滋賀医科大学, アジア疫学研究センター, 特任教授 (70144483) ; MIURA Katsuyuki 滋賀医科大学, 医学部, 教授 (90257452)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000); Fiscal Year 2012: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
• Keywords: 社会医学 / 循環器・高血圧 / 疫学 / 心異所性脂肪 / コホート研究 / 心臓CT / 潜在性動脈硬化

Outline of Final Research Achievements

We investigated the association between pericardial fat volume and metabolic or subclinical atherosclerosis factors in Japanese men in a general population. Pericardial fat volume was significantly associated with barometers of obesity, such as BMI, waist circumstance, visceral fat and so on. Pericardial fat volume was significantly associated with triglyceride and inversely associated with HDL. Pericardial fat volume has increased significantly during the follow-up period. The patients with a history of myocardial infarction had higher volume of pericardial fat. Smoking status at baseline was not associated with pericardial fat volume but Δ pericardial fat volume of current smokers were higher than that of no-smokers. Alcohol drinking was not associated with pericardial fat.

Research Products

• [Journal Article] High-density lipoprotein particle concentration and subclinical atherosclerosis of the carotid arteries in Japanese men. (2015)
  • Author(s): Maryam Zaid, Akira Fujiyoshi, Katsuyuki Miura, Robert D. Abbott, Tomonori Okamura, Naoyuki Takashima, Sayuki Torii, Yoshino Saito, Takashi Hisamatsu, Naoko Miyagawa, Takayoshi Ohkubo, Aya Kadota, Akira Sekikawa, Hiroshi Maegawa, Yasuyuki Nakamura, Kenichi Mitsunami, Hirotsugu Ueshima, For the SESSA Research group.
  • Journal Title: Atherosclerosis. Volume: 239(2) Pages: 444-450
  • Peer Reviewed / Open Access
• [Journal Article] Cross-sectional comparison of coronary artery calcium scores between Caucasian men in the United States and Japanese men in Japan: the multi-ethnic study of atherosclerosis and the Shiga epidemiological study of subclinical atherosclerosis. (2014)
  • Author(s): Fujiyoshi A, Miura K, Ohkubo T, Kadowaki T, Kadowaki S, Zaid M, Hisamatsu T, Sekikawa A, Budoff MJ, Liu K, Ueshima H; SESSA Research Group; MESA Research Group.
  • Journal Title: Am J Epidemiol Volume: 180 Issue: 6 Pages: 590-8
  • DOI: 10.1093/aje/kwu169
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Lipoprotein particle profiles compared with standard lipids in association with coronary artery calcification in the general Japanese population. (2014)
  • Author(s): Takashi Hisamatsu、Akira Fujiyoshi、Katsuyuki Miura、Takayoshi Ohkubo、Aya Kadota、 Sayaka Kadowaki、Takashi Kadowaki、Takashi Yamamoto、Naoko Miyagawa、Maryam Zaid、Sayuki Torii、Naoyuki Takashima、Yoshitaka Murakami、Tomonori Okamura、Minoru Horie、Hirotsugu Ueshima; for the SESSA Research Group.
  • Journal Title: Atherosclerosis. Volume: 236(2) Pages: 237-243
  • Peer Reviewed / Open Access
• [Journal Article] Carotid Intima-Media Thickness and Plaque in Apparently Healthy Japanese Individuals with an Estimated 10-Year Absolute Risk of CAD Death According to the Japan Atherosclerosis Society(JAS)Guidelines 2012: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA). (2013)
  • Author(s): Aya Kadota, Katsuyuki Miura, Tomonori Okamura, Akira Fujiyoshi, Takayoshi Ohkubo, Takashi Kadowaki, Naoyuki Takashima, Takashi Hisamatsu, Yasuyuki Nakamura, Fumiyoshi Kasagi, Hiroshi Maegawa, Aatsunori Kashiwagi, Hirotsugu Ueshima.
  • Journal Title: J Atheroscler Thromb. Volume: 20(10) Pages: 755-766
  • NAID: 130004444645
  • Peer Reviewed
• [Presentation] Association of unrecognized myocardial infarction with silent cerebral lesions in elderly Japanese (2015)
  • Author(s): Takashi Hisamatsu, Katsuyuki Miura, Akira Fujiyoshi, Takayoshi Ohkubo, Akihiko Shiino, Kazuhiko Nozaki, Sayuki Torii, Sentaro Suzuki, Kiyoshi Murata, Hirotsugu Ueshima; for the SESSA Research Group.
  • Organizer: 第40回日本脳卒中学会総会、STROKE2015
  • Place of Presentation: 広島
  • Year and Date: 2015-03-26 – 2015-03-29
• [Presentation] The association of brachial-ankle Pulse Wave Velocity and estimated glomerular filtration rate with albuminuria among general Japanese. (2015)
  • Author(s): Aya Kadota, Katsuyuki Miura, Takayoshi Ohkubo, Takashi Hisamatsu, Akira Fujiyoshi, Naoyuki Takashima,Tomonori Okamura, and Hirotsugu Ueshima for the SESSA Research Group.
  • Organizer: 83rd EAS Congress Glasgow
  • Place of Presentation: グラスゴー／イギリス
  • Year and Date: 2015-03-22 – 2015-03-25
• [Presentation] Lifetime Cigarette Smoking is Associated with Increased Indices of Abdominal Obesity Independent of Body Mass Index: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) (2014)
  • Author(s): Akira Fujiyoshi, Katsuyuki Miura, Sayaka Kadowaki, Aya Kadota, Takayoshi Ohkubo, Naoko Miyagawa, Takashi Hisamatsu, Yoshino Saitoh, Sayuki Torii, Itsuko Miyazawa, Kenichi Mitsunami, Hiroshi Maegawa, Kiyoshi Murata, Hirotsugu Ueshima, For the SESSA Research group
  • Organizer: AHA EPI/NPAM2014
  • Place of Presentation: サンフランシスコ/アメリカ
• [Presentation] 日本人男性における心臓周囲脂肪と肥満指標との関連：滋賀潜在性動脈硬化研究(SESSA) (2013)
  • Author(s): 宮澤伊都子、大久保孝義、三浦克之、藤吉朗、門脇紗也佳、宮川尚子、高嶋直敬、斉藤祥乃、鳥居さゆ希、久松隆史、門田文、前川聡、上島弘嗣 for the SESSA Research Group
  • Organizer: 第49回日本循環器病予防学会・日本循環器管理研究協議会総会
  • Place of Presentation: 金沢
• [Presentation] 地域住民男性における生涯喫煙量と内臓脂肪との関連：SESSA研究 (2013)
  • Author(s): 藤吉朗、三浦克之、門脇紗也佳、門田文、大久保孝義、宮川尚子、久松隆史、齋藤祥乃、鳥居さゆ希、宮澤伊都子、三ッ浪 健一、前川 聡、村田喜代史、上島弘嗣 for SESSA Research Group
  • Organizer: 第34回日本肥満学会
  • Place of Presentation: 東京
• [Presentation] Association between Pulse Wave Velocity and Coronary Artery Calcification in a general Japanese male population: SESSA (2013)
  • Author(s): Sayuki Torii, Takayoshi Ohkubo, Akira Fujiyoshi, Aya Kadota, Naoyuki Takashima, Sayaka Kadowaki, Takashi Hisamatsu, Yoshino Saitoh, Naoko Miyagawa, Maryam Zaid,Yoshitaka Murakami, Katsuyuki Miura, Hirotsugu Ueshima, Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) Research Group.
  • Organizer: 81st EAS Congress
  • Place of Presentation: リヨン/フランス
• [Presentation] Lipoprotein Particle Profiles by Nuclear Magnetic Resonance, Standard Lipids and Coronary Artery Calcification in a Japanese General Population: the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) (2013)
  • Author(s): Takashi Hisamatsu, Katsuyuki Miura, Takayoshi Ohkubo, Akira Fujiyoshi, Aya Kadota, Sayaka Kadowaki, Takashi Yamamoto, Naoko Miyagawa, Maryam Zaid, Naoyuki Takashima, Tomonori Okamura, Minoru Horie, Hirotsugu Ueshima, For the SESSA Research Group
  • Organizer: 第45回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 東京
• [Presentation] Lipoprotein-associated Phospholipase A2 Related to the Risk of Subclinical Carotid Atherosclerosis in a General Male Japanese (2012)
  • Author(s): Hirotsugu Ueshima, et.al., for the SESSA Research Group
  • Organizer: XVI International Symposium on Atherosclerosis
  • Place of Presentation: ジドニー/オーストラリア
  • Year and Date: 2012-03-28
• [Presentation] Coronary artery calcification is not uncommon among apparently healthy Japanese men and women : results from the Shiga Epidemiological Study of (2012)
  • Author(s): Akira Fujiyoshi, et al, for the SESSA Research Group
  • Organizer: XVI International Symposium on Atherosclerosis
  • Place of Presentation: シドニー/オーストラリア
  • Year and Date: 2012-03-28
• [Presentation] Subclinical Atherosclerosis of Carotid Arteries among Apparently Healthy Japanese Men and Women : The Shiga Epidemiological Study of Subclinical (2012)
  • Author(s): Aya Kadota, et.Al., for the SESSA Research Group
  • Organizer: XVI International Symposium on Atherosclerosis
  • Place of Presentation: シドニー/オーストラリア
  • Year and Date: 2012-03-28
• [Presentation] 冠動脈石灰化は日本人一般集団の男女でもまれではない:SESSA研究 (2012)
  • Author(s): 藤吉朗, 他, SESSAリサーチグループ
  • Organizer: 第76日本循環器学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2012-03-17
• [Presentation] 日米地域住民対象コホートにおけるCTによる冠動脈石灰化スコアの比較可能性検討 (2011)
  • Author(s): 藤吉朗、門脇崇、門脇紗也佳、関川暁、大久保孝義、三浦克之、上島弘嗣, 他
  • Organizer: 7回日本循環器病予防学会・日本循環器管理研究協議会総会
  • Place of Presentation: 福岡
  • Year and Date: 2011-06-03
• [Presentation] Coronary calcification and estimated 10 year-absolute risk for CHD death using the NIPPON DATA80 Risk Assessment Chart: The Shiga Epidemiological Study of Subclinical Atherosclerosis
  • Author(s): Akira Fujiyoshi et al
  • Organizer: 第44回日本動脈硬化学会
  • Place of Presentation: 福岡
• [Presentation] 一般男性集団における脈波伝播速度と冠動脈石灰化との関連
  • Author(s): 鳥居さゆ希、大久保孝義、藤吉朗、他 SESSA研究グループ
  • Organizer: 第35回日本高血圧学会総会
  • Place of Presentation: 名古屋
• [Presentation] Non-HDL Cholesterol is Strongly Associated with Coronary Artery Calcification in a General Japanese Population: SESSA
  • Author(s): Akira Fujiyoshi, Katsuyuki Miura, Takayoshi Ohkubo, et al
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Cross-Sectional Comparison of Coronary Artery Calcium Prevalence between Japan and the US: The Multi-Ethnic Study of Atherosclerosis (MESA) and the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)
  • Author(s): Akira Fujiyoshi, Katsuyuki Miura, Takayoshi Ohkubo, et al
  • Organizer: AHA Epidemiology and Prevention/Nutrition, Physical Activity and Metabolism
  • Place of Presentation: ニューオーリンズ/アメリカ
• [Presentation] The relationship of serum marine-derived n-3 fatty acids and carotid intima-media thickness among general Japanese men: the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)
  • Author(s): Aya Kadota, et al
  • Organizer: AHA Epidemiology and Prevention/Nutrition, Physical Activity and Metabolism
  • Place of Presentation: ニューオーリンズ/アメリカ