• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Application of Fourier transformation-linear ion trap mass spectrometers to forensic medicine

Research Project

Project/Area Number 23390183
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Legal medicine
Research InstitutionNagoya University

Principal Investigator

ISHII Akira  名古屋大学, 医学(系)研究科(研究院), 教授 (30252175)

Co-Investigator(Kenkyū-buntansha) ZAITSU Kei  名古屋大学, 医学系研究科, 准教授 (30700546)
NASU Tamie  中部大学, 生命健康科学部, 教授 (10020794)
HANAJIRI Ruri (KIKURA Ruri)  国立医薬品食品衛生研究所, 生薬部, 室長 (10224916)
SENO Hiroshi  愛知医科大学, 医学部, 教授 (50236113)
HATTORI Hideki  愛知医科大学, 医学部, 准教授 (30107817)
OGAWA Tadashi  愛知医科大学, 医学部, 助教 (50559937)
KANEKO Rina  名古屋大学, 医学系研究科, 助教 (70367697)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2013: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2011: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Keywords法中毒学 / 質量分析 / オービトラップ / 飛行時間型質量分析計 / 自然毒 / アマニチン / 合成カンナビノイド / ミフェプリストン / タンデム質量分析 / 飛行時間型 / 代謝物 / UPLC-MS-MS / Orbitrap / Q-TOF / 法医学 / 中毒学 / 分析化学
Research Abstract

The purpose of the project is to develop application methods for identifying and quantitating various drugs and toxins using a Fourier transformation-linear ion trap mass spectrometer, shared in the Faculty. However, under the available LC conditions optimized to proteomic analysis, sufficient separation and reproducibility were not obtained. We thus purchased a quadrupole-time of flight mass spectrometer (Q-TOFMS); further experiments were rendered using this (liquid chromatography) LC-Q-TOFMS system.
Using the LC-Q-TOFMS system, amanitins in urine samples were sufficiently separated; the calibration curves showed good linearity in the range of 1 - 5,000 ng/ml. This system has enabled sensitive detection and identification of various synthetic cannabinoids and mifepristone, and their metabolites with high sensitivity. We are now constructing a screening system of 53 natural toxins. Hence, LC-Q-TOFMS will be a useful tool in analyzing various compounds in forensic toxicology.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (157 results)

All 2014 2013 2012 2011

All Journal Article (82 results) (of which Peer Reviewed: 80 results,  Open Access: 1 results) Presentation (69 results) (of which Invited: 5 results) Book (6 results)

  • [Journal Article] Recently abused synthetic cathinones, α-pyrrolidinophenone derivatives : a review of their pharmacology, acute toxicity, and metabolism2014

    • Author(s)
      Zaitsu K, Katagi M, Tsuchihasi H, Ishii A
    • Journal Title

      Forensic Toxicol

      Volume: 32 Pages: 1-8

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] High-throughput analysis of ramelteon, agomelatine and melatonin in human plasma by ultra-performance liquid chromatography-tandem mass spectrometry2014

    • Author(s)
      Ogawa T, Iwai M, Hattori H, Zaitsu K, Kumazawa T, Ishii A, Suzuki O, Seno H
    • Journal Title

      Forensic Toxicol

      Volume: 32 Pages: 126-131

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Metabolism of the newly encountered drug α-pyrrolidino- valerophenone in humans : identification and quantitation of urinary metabolites2014

    • Author(s)
      Shima N, Katagi M, Kamata H, Matsuta S, Sasaki K, Kamata T, Nishioka H, Miki A, Tastuno M, Zaitsu K, Ishii A, Sato T, Tsuchihashi H, Suzuki K
    • Journal Title

      Forensic Toxicol

      Volume: 32 Pages: 59-67

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] ecently abused synthetic cathinones, α-pyrrolidinophenone derivatives: a review of their pharmacology, acute toxicity, and metabolism2014

    • Author(s)
      Kei Zaitsu, Munehiro Katagi, Hitoshi Tsuchihashi, Akira Ishii
    • Journal Title

      Forensic Toxicology

      Volume: 32 Issue: 1 Pages: 1-8

    • DOI

      10.1007/s11419-013-0218-1

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simultaneous and sensitive analysis of fourth-generation antidepressants in human plasma by ultra-performance liquid chromatography-tandem mass spectrometry2014

    • Author(s)
      Iwakura K, Ogawa T, Hattori H, Iwai M, Suzuki O, Nakagawa T
    • Journal Title

      Forensic Toxicology

      Volume: 23 Issue: 1 Pages: 30-38

    • DOI

      10.1007/s11419-013-0197-2

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metabolism of the newly encountered designer drug α-pyrrolidinovalerophenone in humans: identification and quantitation of urinary metabolites.2014

    • Author(s)
      Noriaki Shima, Munehiro Katagi, Hiroe Kamata, Shuntaro Matsuta, Keiko Sasaki, Tohru Kamata, Hiroshi Nishioka, Akihiro Miki, Michiaki Tatsuno, Kei Zaitsu, Akira Ishii, Takako Sato, Hitoshi Tsuchihashi, Koichi Suzuki
    • Journal Title

      Forensic Toxicology

      Volume: 32 Issue: 1 Pages: 59-67

    • DOI

      10.1007/s11419-013-0202-9

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-throughput analysis of ramelteon, agomelatine, and melatonin in human plasma by ultra-performance liquid chromatography-tandem mass spectrometry2014

    • Author(s)
      Tadashi Ogawa, Masae Iwai, Hideki Hattori, Kei Zaitsu, Takeshi Kumazawa, Akira Ishii, Osamu Suzuki, Hiroshi Seno
    • Journal Title

      Forensic Toxicology

      Volume: 32 Issue: 1 Pages: 126-131

    • DOI

      10.1007/s11419-013-0195-4

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in the prevalence of new psychoactive substances before and after the introduction of the generic scheduling of synthetic cannabinoids in Japan2014

    • Author(s)
      R. Kikura-Hanajiri, N. Uchiyama, M. Kawamura, Y. Goda
    • Journal Title

      Drug Test. Anal

      Volume: in press Issue: 7-8 Pages: 832-839

    • DOI

      10.1002/dta.1584

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two new synthetic cannabinoids, AM-2201 benzimidazole analog (FUBIMINA) and (4-methylpiperazin-1-yl)(1-pentyl-1H-indol-3-yl)methanone (MEPIRAPIM), and three phenethylamine derivatives, 25H-NBOMe 3,4,5-trimethoxybenzyl analog, 25B-NBOMe, and 2C-N-NBOMe, identified in illegal products2014

    • Author(s)
      N. Uchiyama, Y. Shimokawa, S. Matsuda, M. Kawamura, R. Kikura-Hanajiri, Y. Goda
    • Journal Title

      Forensic Toxicology

      Volume: 32 Issue: 1 Pages: 105-115

    • DOI

      10.1007/s11419-013-0217-2

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of two new-type designer drugs, a piperazine derivative MT-45 (I-C6) and a synthetic peptide Noopept (GVS-111), with a synthetic cannabinoid A-834735, a cathinone derivative 4-methoxy-α-PVP and a phenethylamine derivative 4-methylbuphedrine from illegal products2014

    • Author(s)
      N. Uchiyama, S. Matsuda, M. Kawamura, R. Kikura-Hanajiri, Y. Goda
    • Journal Title

      forensic Toxicology

      Volume: 32 Issue: 1 Pages: 9-18

    • DOI

      10.1007/s11419-013-0194-5

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Assessment of the reproductive toxicity of inhalation exposure to ethyl tertiary butyl ether in male mice with normal low active and inactive ALDH22014

    • Author(s)
      Weng Z, Ohtani K, Suda M, Yanagiba Y, Kawamoto T, Nakajima T, Wang RS
    • Journal Title

      Arch Toxicol

      Volume: 88 Issue: 4 Pages: 1007-1021

    • DOI

      10.1007/s00204-014-1192-z

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Trends in Asbestos and Non-asbestos Fibre Concentrations in the Lung Tissues of Japanese Patients with Mesothelioma2014

    • Author(s)
      Sakai K, Hisanaga N, Shibata E, Kamijima M, Ichihara G, Takeuchi Y, Nakajima T
    • Journal Title

      Ann Occup Hyg

      Volume: 58 Pages: 103-120

    • DOI

      10.1093/annhyg/met055

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Species and inter-individual differences in metabolic capacity of di(2-ethylhexyl) Phthalate (DEHP) between human and mouse livers2014

    • Author(s)
      Ito Y, Kamijima M,, Hasegawa C, Tagawa M, Kawai T, Miyake M, Hayashi Y, Naito H, Nakajima T
    • Journal Title

      Environ Health Prev Med

      Volume: 19 Issue: 2 Pages: 117-125

    • DOI

      10.1007/s12199-013-0362-6

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mass spectrometric differentiation of the isomers of mono-methoxyethylamphetamines and monomethoxydimethylamphetamines by GC/MS/MS2013

    • Author(s)
      Zaitsu K, Miyagawa H, Sakamoto Y, Matuta S, Tsuboi K, Nishioka H, Katagi M, Sato T, Tatsuno M, Tsuchihashi H, Suzuki K, Ishii A
    • Journal Title

      Forensic Toxicol

      Volume: 31 Pages: 292-300

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of new designer drugs and their legal status in Japan2013

    • Author(s)
      Kikura-Hanajiri R, Uchiyama N, Kawamura M, Ogata J, Goda Y
    • Journal Title

      Yakugaku Zasshi

      Volume: 122 Pages: 31-40

    • Related Report
      2013 Final Research Report
  • [Journal Article] URB-754 : a new class of designer drug and 12 synthetic cannabinoids detected in illegal products2013

    • Author(s)
      N. Uchiyama, M. Kawamura, R. Kikura-Hanajiri, Y. Goda
    • Journal Title

      Forensic Sci. Int

      Volume: 227 Pages: 21-32

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] High-fat-cholesterol diet-induced mainly necrosis fibrotic steatohepatities rats by suppressing caspase activity2013

    • Author(s)
      Yetti H, Naito H, Jia X, Shindo M, Taki H, Tamada H, Kitamori K, Hayashi Y, Ikeda K, Yamori Y, Nakajima T
    • Journal Title

      Life Sciences

      Volume: 93 Pages: 673-680

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mass spectrometric differentiation of the isomers of mono-methoxyethylamphetamines and mono-methoxydimethylamphetamines by GC/SM/MS2013

    • Author(s)
      Kei Zaitsu, Haruhiko Miyagawa, Yuki Sakamoto, Shuntaro Matsuta, Kento Tsuboi, Hiroshi Nishioka, Munehiro Katagi, Takako Sato, Michiaki Tatsuno, Hitoshi Tsuchihashi, Koichi Suzuki, Akira Ishii.
    • Journal Title

      Forensic Toxicology

      Volume: 31 Issue: 2 Pages: 292-300

    • DOI

      10.1007/s11419-013-0193-6

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Urinary excretion and metabolism of the newly encountered designer drug 3,4-dimethylmethcathinone in humans2013

    • Author(s)
      Noriaki Shima, Munehiro Katagi, Hiroe Kamata, Shuntaro Matsuta, Keiko Nakanishi, Kei Zaitsu, Tooru Kamata, Hiroshi Nishioka, Akihiro Miki, Michiaki Tatsuno, Takako Sato, Hitoshi. Tsuchihashi, Koichi Suzuki
    • Journal Title

      Forensic Toxicology

      Volume: 31 Issue: 1 Pages: 101-112

    • DOI

      10.1007/s11419-012-0172-3

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a simple one-pot extraction method for various drugs and metabolites of forensic interest in blood by modifying the QuEChERS method2013

    • Author(s)
      Shuntaro Matsuta, Keiko Nakanishi, Akihiro Miki, Kei Zaitsu, Noriaki Shima, Tooru Kamata, Hiroshi Nishioka, Munehiro Katagi, Michiaki Tatsuno, Kento Tsuboi, Hitoshi Tsuchihashi, Koichi Suzuki
    • Journal Title

      Forensic Science International

      Volume: 232 Issue: 1-3 Pages: 40-45

    • DOI

      10.1016/j.forsciint.2013.06.015

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simple and rapid assay method for simultaneous quantification of urinary nicotine and cotinine using micro-extraction by packed sorbent and gas chromatography-mass spectrometry2013

    • Author(s)
      Masae Iwai, Tadashi Ogawa, Hideki Hattori, Kei Zaitsu, Akira Ishii, Osamu Suzuki, Hiroshi Seno.
    • Journal Title

      Nagoya Journal of Medical Science

      Volume: 75 Pages: 255-261

    • NAID

      120005322406

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two new-type cannabimimetic quinolinyl carboxylates, QUPIC and QUCHIC, two new cannnabimimetic carboxamide derivatives, ADB-FUBINACA and ADBICA, and five synthetic cannabinoids detected with a thiophene derivative, α-PVT, and an opioid receptor agonist, AH-7921, in illegal products2013

    • Author(s)
      N. Uchiyama, S. Matsuda, M. Kawamura, R. Kikura-Hanjiri, Y. Goda
    • Journal Title

      Forensic Toxicology

      Volume: 31 Issue: 2 Pages: 223-240

    • DOI

      10.1007/s11419-013-0182-9

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] URB-754: a new class of designer drug and 12 synthetic cannabinoids detected in illegal products2013

    • Author(s)
      N. Uchiyama, M. Kawamura, R. Kikura-Hanajiri, Y. Goda
    • Journal Title

      10.1016/j.forsciint.2012.08.047

      Volume: 227 Pages: 21-31

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New cannabimimetic indazole derivatives, N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-pentyl-1H-indazole-3-carboxamide (AB-PINACA) and N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide (AB-FUBINACA), identified as designer drugs in illegal products2013

    • Author(s)
      N. Uchiyama, S. Matsuda, D. Wakana, R. Kikura-Hanajiri, Y. Goda
    • Journal Title

      Forensic Toxicology

      Volume: 31 Issue: 1 Pages: 93-100

    • DOI

      10.1007/s11419-012-0171-4

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in the prevalence of synthetic cannabinoids and cathinone derivatives in Japan until early 20122013

    • Author(s)
      R. Kikura-Hanajiri, N. Uchiyama, M. Kawamura, Y. Goda
    • Journal Title

      Forensic Toxicology

      Volume: 31 Issue: 1 Pages: 44-53

    • DOI

      10.1007/s11419-012-0165-2

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification and quantitation of JWH-213, a cannabimimetic indole, as a designer drug in an herbal product.2013

    • Author(s)
      K. Takahashi, N. Uchiyama, T. Fukiwake, T. Hasegawa, M. Saijou, Y. Motoki, R. Kikura-Hanajiri, Y. Goda
    • Journal Title

      Forensic Toxicology

      Volume: 31 Issue: 1 Pages: 145-150

    • DOI

      10.1007/s11419-012-0161-6

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of new designer drugs and their legal status in Japan2013

    • Author(s)
      R. Kikura-Hanajiri, N. Uchiyama, M. Kawamura, J. Ogata, Y. Goda
    • Journal Title

      Yakugaku Zasshi

      Volume: 133 Pages: 31-40

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
  • [Journal Article] Sex differences in metabolism of trichloroethylene and trichloroethanol in guinea pigs2013

    • Author(s)
      Hibino Y, Wang H, Naito H, Zhao N, Wang D, Jia X, Li H, Song X, Liu L, Huang Y, Ito Y, Huang H, Kamijima M, Nakajima T
    • Journal Title

      J Occup Health

      Volume: 55 Pages: 443-449

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Occupational trichloroethylene hypersensitivity syndrome: Human herpesvirus 6 reactivation and rash phenotypes2013

    • Author(s)
      Kamijima M, Wang H, Yamanoshita O, Ito Y, Xia L, Yanagiba Y, Chen C, Okamura A, Huang Z, Qiu X, Song X, Cai T, Liu L, Ge Y, Deng Y, Naito H, Yoshikawa T, Tohyama M, Li L, Huang H, Nakajima T
    • Journal Title

      J. Occup Health

      Volume: 72 Issue: 3 Pages: 443-449

    • DOI

      10.1016/j.jdermsci.2013.07.003

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ubchronic exposure to ethyl tertiary butyl ether resulting in genetic damage in Aldh2 knockout mice2013

    • Author(s)
      Weng Z,Suda M,Ohtani K,Mei N,Kawamoto T,Nakajima T,Wang RS
    • Journal Title

      Toxicology

      Volume: 311 Issue: 3 Pages: 107-114

    • DOI

      10.1016/j.tox.2013.06.005

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exposure to DEHP decreased four fatty acid levels in plasma of prepartum mice.2013

    • Author(s)
      Nakashima R, Hayashi Y, Khalequzzaman M, Jia X, Wang D, Naito H, Ito Y, Kamijima M, Gonzalez FJ, Nakajima T
    • Journal Title

      Toxicology

      Volume: 309 Pages: 1489-1504

    • DOI

      10.1016/j.tox.2013.04.010

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced carcinogenicity by coexposure to arsenic and iron and a novel remediation system for the elements in well drinking water.2013

    • Author(s)
      Kumasaka YM, et al.
    • Journal Title

      Arch Toxicol.

      Volume: 87 Issue: 3 Pages: 439-447

    • DOI

      10.1007/s00204-012-0964-6

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Difference in urinary arsenic metabolites between diabetic and non-diabetic subjects in Bangladesh2013

    • Author(s)
      Saika Nizam
    • Journal Title

      Int. J. Environ. Res. Public Health

      Volume: 10 Issue: 3 Pages: 1006-1019

    • DOI

      10.3390/ijerph10031006

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A rapid and simultaneous analysis of theophylline and its metabolites in human whole blood by ultra-performance liquid chromatography-tandem mass spectrometry2012

    • Author(s)
      Ogawa T, Hattori T, Iwai M, Ito K, Itakura K, Ishii A, Suzuki O, Seno H
    • Journal Title

      Forensic Toxicol

      Volume: 30 Pages: 142-148

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] New analytical method for sensitive quantification of urinary 3-methyl-4-nitrophenol to assess fenitrothion exposure in general population and occupational sprayers2012

    • Author(s)
      Okamura A, Saito I, Ueyama J, Ito Y, Nakajima T, Kamijima M
    • Journal Title

      Toxicol Lett

      Volume: 210 Pages: 220-224

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differences in metabolite burden of di(2-ethylhexyl)phthalate in pregnant and postpartum dams and their offspring in relation to drug-metabolizing enzymes in mice2012

    • Author(s)
      Hayashi Y, Ito Y, Yanagiba Y, Kamijima M, Naito H, Nakajima T
    • Journal Title

      Arch Toxicol

      Volume: 86 Pages: 563-569

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Simple and rapid analysis of amatoxins using UPLC-MS-MS2012

    • Author(s)
      Nomura M, Suzuki Y, Kaneko R, Ogawa T, Hattori H, Seno H, Ishii A
    • Journal Title

      Forensic Toxicol

      Volume: 30 Pages: 185-192

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A rapid and simultaneous analysis of theophylline and its metabolites in human whole blood by ultra-performance liquid chromatography tandem mass spectrometry2012

    • Author(s)
      Ogawa T, Hattori H, Iwai M, Ito K, Iwakura K, Ishii A, Suzuki O, Seno H
    • Journal Title

      Forensic Toxicol

      Volume: 30(2) Pages: 142-148

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The modulation of hepatic adenosine triphosphate and inflammation by eicosapentaenoic acid during severe fibrotic progression in the SHRSP5/Dmcr rat model2012

    • Author(s)
      Jia X, Naito H, Yetti H, Tamada H, Kitamori K, Hayashi Y, Yamagishi N, Wang D, Yanagiba Y, Ito Y, Wang J, Tanaka N, Ikeda K, Yamori Y, Nakajima T
    • Journal Title

      Life Sci

      Volume: 90(23-24) Pages: 934-43

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Simple and rapid analysis of amatoxins using UPLC-MS-MS2012

    • Author(s)
      Mina Nomura
    • Journal Title

      Forensic Toxicology

      Volume: 30 Pages: 185-192

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxidative polymerization behavior of diphenylamine with bridged structure2012

    • Author(s)
      Hideki Hayashi
    • Journal Title

      International Journal of Polymer Analysis and Characterization

      Volume: 17 Issue: 3 Pages: 189-198

    • DOI

      10.1080/1023666x.2012.653890

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A rapid and simultaneous analysis of theophylline and its metabolites in human whole blood by ultra-performance liquid chromatography tandem mass spectrometry2012

    • Author(s)
      Tadashi Ogawa
    • Journal Title

      Forensic Toxicology

      Volume: 30 Issue: 2 Pages: 142-148

    • DOI

      10.1007/s11419-012-0133-x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecularly imprinted solid-phase extraction for the selective determination of methamphetamine, amphetamine, and methylenedioxyphenylalkylamine designer drugs in human whole blood by gas chromatography-mass spectrometry2012

    • Author(s)
      Takeshi Kumazawa
    • Journal Title

      Journal of Separational Sciences

      Volume: 35 Issue: 5-6 Pages: 726-733

    • DOI

      10.1002/jssc.201100924

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] URB-754: a new class of designer drug and 12 synthetic cannabinoids detected in illegal products2012

    • Author(s)
      Nahoko Uchiyama
    • Journal Title

      Forensic Science International

      Volume: 227 Issue: 1-3 Pages: 21-32

    • DOI

      10.1016/j.forsciint.2012.08.047

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA sequence analyses of blended herbal products including synthetic cannabinoids as designer drugs2012

    • Author(s)
      Jun Ogata
    • Journal Title

      Forensic Science International

      Volume: 227 Issue: 1-3 Pages: 33-41

    • DOI

      10.1016/j.forsciint.2012.09.006

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of two new-type synthetic cannabinoids, N-(1-adamantyl)-1-pentyl-1H-indole-3-carboxamide (APICA) and N-(1-adamantyl)-1-pentyl-1H-indazole-3-carboxamide (APINACA), and detection of five synthetic cannabinoids, AM-1220, AM-2233, AM-1241 CB-13 (CRA-13) and AM-1248, as designer drugs in illegal products2012

    • Author(s)
      Nahoko Uchiyama
    • Journal Title

      Forensic Toxicology

      Volume: 30 Issue: 2 Pages: 114-125

    • DOI

      10.1007/s11419-012-0136-7

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of synthetic cannabinoids on electroencephalogram power spectra in rats2012

    • Author(s)
      Uchiyama N, Kikura-Hanajiri R, Matsumoto N, Huang ZL, Goda Y, Urade Y.
    • Journal Title

      Forensic Sci Int

      Volume: 215(1-3) Issue: 1-3 Pages: 179-183

    • DOI

      10.1016/j.forsciint.2011.05.005

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modulation of ammonium perfluorooctanoate-induced hepatic damage by genetically different PPARαin mice.2012

    • Author(s)
      Nakagawa T, Ramdhan DH, Tanaka N, Naito H, Tamada H, Ito Y, Li YF, Hayashi Y, Yamagishi N, Yanagiba Y, Aoyama T, Gonzalez FJ, Nakajima T
    • Journal Title

      Arch Toxicol

      Volume: 86 Issue: 1 Pages: 63-74

    • DOI

      10.1007/s00204-011-0704-3

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of novel rat model for high-fat and high-cholesterol diet-induced steatohepatitis and severe fibrosis progression in SHRSP5/Dmcr.2012

    • Author(s)
      Kitamori K
    • Journal Title

      Environ Health Prev Med.

      Volume: May;17(3) Issue: 3 Pages: 173-82

    • DOI

      10.1007/s12199-011-0235-9

    • NAID

      10030616942

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differences in metabolite burden of di(2-ethylhexy)phthalate in pregnant and postpartum dams and their offspring in relation to drug-metabolizing enzymes in mice2012

    • Author(s)
      Hayashi Y
    • Journal Title

      Arch Toxicol

      Volume: (印刷中)(in press) Issue: 4 Pages: 563-569

    • DOI

      10.1007/s00204-011-0790-2

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential genotoxic effects of subchronic exposure to ethyl tertiary butyl ether in the livers of Aldh2 knockout and wild-type mice.2012

    • Author(s)
      Wang Z, Suda M, Ohtani K, Mei N, Kawamoto T, Nakajima T, Wang RS
    • Journal Title

      Archives of Toxicology

      Volume: 86 Issue: 4 Pages: 675-682

    • DOI

      10.1007/s00204-011-0779-x

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Incidence of young onset insulin-requiring diabetes mellitus among 18- to 30-year-olds in Dhaka, Bangladesh (1994-2003)2012

    • Author(s)
      Saika Nizam
    • Journal Title

      Nagoya Journal of Medical Sciences

      Volume: 74 Pages: 149-156

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simultaneous changes in high-fat and high-cholesterol diet-induced steat ohepatitis and severe fibrosis and those underlying molecular mechanisms in novel SHRSP5/Dmcr rat2012

    • Author(s)
      Moriya T
    • Journal Title

      Environ Health Prev Med

      Volume: (印刷中)(in press) Issue: 6 Pages: 444-456

    • DOI

      10.1007/s12199-012-0273-y

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evidence for diazinon-mediated inhibition of cis-permethrin metabolism and its effects on reproductive toxicity in adult male mice2012

    • Author(s)
      Dong Wang
    • Journal Title

      Reproductive Toxicology

      Volume: 34 Issue: 4 Pages: 489-497

    • DOI

      10.1016/j.reprotox.2012.07.007

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plasticizers may activate human hepatic peroxisome proliferator-activated receptor α less than that of a mouse but may activate constitutive androstane receptor in liver2012

    • Author(s)
      Ito Y, Nakamura T, Yanagiba Y, Ramdhan DH, Yamagishi N, Naito H, Kamijima M, Gonzalez FJ, Nakajima T
    • Journal Title

      PPAR Res

      Volume: 2012824 Pages: 1-11

    • DOI

      10.1155/2012/201284

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of nanoparticle-rich diesel exhaust on testicular and hippocampus steroidogenesis in male rats.2012

    • Author(s)
      Nozomi Yamagishi
    • Journal Title

      Inharation Toxicology

      Volume: 24 Issue: 8 Pages: 459-467

    • DOI

      10.3109/08958378.2012.688225

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Upregulation of Calprotectin and Downregulation of Retinol Binding Protein in the Serum of Workers with Trichloroethylene-Induced Hypersensitivity Dermatitis2012

    • Author(s)
      Zhenlie Huang
    • Journal Title

      Journal of Occupational Health

      Volume: 54 Pages: 299-309

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The modulation of hepatic adenosine triphosphate and inflammation by eicosapentaenoic acid during severe fibrotic progression in the SHRSP5/Dmcr rat model.2012

    • Author(s)
      Jia X
    • Journal Title

      Life Sci.

      Volume: Jun 14;90(23-24) Issue: 23-24 Pages: 934-43

    • DOI

      10.1016/j.lfs.2012.04.029

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Barium inhibits arsenic-mediated apoptotic cell death in human squamous cell carcinoma cells.2012

    • Author(s)
      Yajima I, et al.
    • Journal Title

      Arch Toxicol.

      Volume: 86 Issue: 6 Pages: 961-973

    • DOI

      10.1007/s00204-012-0848-9

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A rapid and simultaneous analysis of theophylline and its metabolites in human whole blood with ultra-performance liquid chromatography tandem mass spectrometry2012

    • Author(s)
      Ogawa T, et al
    • Journal Title

      Forensic Toxicology

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid enantiomeric separation and simultaneous determination of phenethylamines by ultra high performance liquid chromatography with fluorescence and mass spectrometric detection : application to the analysis of illicit drugs distributed in the Japanese market and biological samples2012

    • Author(s)
      Inagaki S, et al
    • Journal Title

      Drug Test Anal

      Volume: (In press) Issue: 12 Pages: 1001-1008

    • DOI

      10.1002/dta.1327

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of synthetic cannabinoids on electroencephalogram power spectra in rats2012

    • Author(s)
      Uchiyama N, et al
    • Journal Title

      Forensic Sci.Int.

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modulation of ammonium perfluorooctanoate-induced hepatic damage by geneti cally different PPARα in mice2012

    • Author(s)
      Nakagawa T, et al
    • Journal Title

      Arch.Toxicol.

      Volume: 86 Pages: 63-74

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-through-put and simultaneous analysis of eight central-acting muscle relaxants in human plasma by ultra-performance liquid chromategraphy- tandem mass spectrometry in the positive and negative modes2011

    • Author(s)
      Ogawa T, Hattori H, Kaneko R, Ito K, Iwai M, Mizutani Y, Arinobu T, Ishii A, Seno H
    • Journal Title

      Anal. Bioanal. Chem

      Volume: 400 Pages: 1959-1965

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a novel cannabimimetic phenylacetylindole, cannabi- piperidiethanone, as a designer drug in a herbal product and its affinity for cannabinoid CB1 and CB2 receptors2011

    • Author(s)
      Uchiyama N, Kikura-Hanajiri R and Goda Y
    • Journal Title

      Chem. Pharm. Bull

      Volume: 59 Pages: 1203-5

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chiral analyses of dextromethorphan/ levomethorphan and their metabolites in rat and human samples using LC-MS/MS2011

    • Author(s)
      Kikura-Hanajiri R, Kawamura M, Miyajima A, Sunouchi M, Goda Y
    • Journal Title

      Anal Bioanal Chem

      Volume: 400(1) Pages: 165-174

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tamada H, Gonzalez FJ, Nakajima T. Ammonium perfluorooctanoate may cause testosterone reduction by adversely affecting testis in relation to PPARα2011

    • Author(s)
      Li Y, Ramdhan DH, Naito H, Yamagishi N, Ito Y, Hayashi Y, Yanagiba Y, Okamura A, Tamada H, Gonzalez FJ, Nakajima T
    • Journal Title

      Toxicol Lett

      Volume: 205 Pages: 265-72

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] New analytical method for sensitive quantification of urinary 3-methyl-4-nitrophenol to assess fenitrothion exposure in general population and occupational sprayers. Toxicol Lett2011

    • Author(s)
      Ai Okamura, et al
    • Journal Title

      Toxicology Letters

      Volume: 210(in press) Issue: 2 Pages: 220-224

    • DOI

      10.1016/j.toxlet.2011.10.008

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-throughput and simultaneous analysis of eight central-acting muscle relaxants in human plasma by ultra-performance liquid chroma-tography-mass spectrometry in the positive and negative modes2011

    • Author(s)
      Ogawa T, et al
    • Journal Title

      Anal.Bioanal.Chem.

      Volume: 400 Pages: 1959-1965

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a novel cannabimimetic phenylacetylindole, cannabipiperidiethan one, as a designer drug in a herbal product and its affinity for cannabinoid CB1 and CB2 receptors2011

    • Author(s)
      Uchiyama N, et al
    • Journal Title

      Chem.Pharm.Bull.

      Volume: 59 Pages: 1203-1205

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simultaneous determination of N-benzylpiperazine and 1-(3-trifluoroinethylphenyl) piperazine in rat plasma by HPLC-fluorescence detection and its application to monitoring of these drugs2011

    • Author(s)
      Wada M, et al
    • Journal Title

      Biomed.Chromatogr.

      Volume: 26 Pages: 21-25

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isomeric analysis of synthetic cannabinoids detected as designer drugs2011

    • Author(s)
      Uchiyama N, et al
    • Journal Title

      Yakugaku Zasshi

      Volume: 131 Pages: 1141-1147

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chiral analyses of dextromethorphan/levomethorphan and their metabolites in rat and human samples using LC-MS/MS2011

    • Author(s)
      Kikura-Hanajiri R, et al
    • Journal Title

      Anal.Bioanal.Chem.

      Volume: 400 Pages: 165-174

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HPLC determination of methylphenidate and its metabolite, ritalinic acid, by high-performance liquid chromatography with peroxyoxalate chemiluminescence detection2011

    • Author(s)
      Wada M, et al
    • Journal Title

      Anal.Bioanal.Chem.

      Volume: 400 Pages: 387-393

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Methylone and Monoamine Transporters : Correlation with Toxicity2011

    • Author(s)
      Sogawa C, et al
    • Journal Title

      Current Neuropharmacol

      Volume: 9 Pages: 58-62

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Discovery of indole alkaloids with cannabinoid CB1 receptor antagonistic activity2011

    • Author(s)
      Kitajima M, et al
    • Journal Title

      Bioorg.Med.Chem.Lett.

      Volume: 21 Pages: 1962-1964

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simple and rapid screening for methamphetamine, 3,4-methylenedioxy-methamphetamine (MDMA) and their metabolites in urine using DART (Direct Analysis in Real Time)-TOFMS2011

    • Author(s)
      Kawamura M, et al
    • Journal Title

      Yakugaku Zasshi

      Volume: 131 Pages: 827-833

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Survey of current trends in the abuse of psychotropic substances and plants in Japan2011

    • Author(s)
      Kikura-Hanajiri R, et al
    • Journal Title

      Legal Med

      Volume: 13 Pages: 109-115

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ammonium perfluorooctanoate may cause testosterone reduction by adversely a ffecting testis in relation to PPARα2011

    • Author(s)
      Li Y, et al
    • Journal Title

      Toxicol.Lett.

      Volume: 205 Pages: 265-272

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of nanoparticle-rich-diesel exhaust on steroidogenesis in rats and the mechanism underlying such effects2011

    • Author(s)
      Yamagishi N, et al
    • Journal Title

      Nihon Eiseigaku Zasshi

      Volume: 66 Pages: 434-437

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exposure to nanoparticle-rich diesel exhaust may cause liver damage2011

    • Author(s)
      Ito Y, et al
    • Journal Title

      Nihon Eiseigaku Zasshi

      Volume: 66 Pages: 634-642

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of subchronic inhalation exposure to ethyl tertiary butyl ether on splenocytes in mice2011

    • Author(s)
      Li Q, et al
    • Journal Title

      Int.J.Immunophathol.Pharmacol.

      Volume: 24 Pages: 837-847

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] The emerging of new synthetic cannabinoids and their binding affinities at the cnnnabinoid CB1 and CB2 receptors2013

    • Author(s)
      R. Kikura-Hanajiri, N. Uchiyama, M. Kawamura and Y. Goda
    • Organizer
      SOFT 2013 Annual Meeting
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2013-10-30
    • Related Report
      2013 Final Research Report
  • [Presentation] MS-MS でミフェプリストンが検出された嬰児の1 剖検例2013

    • Author(s)
      石井晃, 財津桂, 吉本高士, 山本敏充, 小川匡之, 服部秀樹, 妹尾洋
    • Organizer
      第38回日本医用マススペクトル学会年会.神戸産業振興ホール
    • Place of Presentation
      神戸市
    • Year and Date
      2013-09-26
    • Related Report
      2013 Final Research Report
  • [Presentation] High-resolution mass spectrometry and accurate mass measurement of synthetic cannabinoids and their metabolites in human biological specimens by LC/Q-TOFMS2013

    • Author(s)
      Zaitsu K, Yoshimoto T, Yamamoto T, Ogawa T, Hattori H, Matsumoto T, Hisatsune K, Katagi M, Tsuchihashi H, Ishii A
    • Organizer
      The 51st Annual Meeting of the International Association of Forensic Toxicologists
    • Place of Presentation
      Funchal, Portugal
    • Year and Date
      2013-09-05
    • Related Report
      2013 Final Research Report
  • [Presentation] Simultaneous and sensitive analysis of fourth-generation antidepressants in human plasma by ultraperformance liquid chromatography-tandem mass spectrometry2013

    • Author(s)
      Ogawa T, Iwakura K, Hattori H, Iwai M, Suzuki O, Nakagawa T, Seno H
    • Organizer
      The 51st Annual Meeting of the International Association of Forensic Toxicologists
    • Place of Presentation
      Funchal, Portugal
    • Year and Date
      2013-09-03
    • Related Report
      2013 Final Research Report
  • [Presentation] Determination of MAM-2201 and its metabolites in a fatal case and the binding affinities of MAM-2201 at the cannabinoid CB1 and CB2 receptors2013

    • Author(s)
      R. Kikura-Hanajiri, M. Kawamura, S. Kanno, T. Nagai, M. Takada, T. Mukai and Y. Goda
    • Organizer
      51th Annual Meeting of the International Association of Rorensic Toxicologists
    • Place of Presentation
      Funchal, Portugal
    • Year and Date
      2013-09-03
    • Related Report
      2013 Final Research Report
  • [Presentation] LC-Q-TOF-MSによる生体試料中合成カンナビノイド及び代謝物の分析2013

    • Author(s)
      財津桂, 吉本高士, 山本敏充, 鎌田徹, 片木宗弘, 小川匡之, 服部秀樹, 佐藤貴子, 土橋 均, 鈴木廣一, 石井晃
    • Organizer
      日本法中毒学会第32年会
    • Place of Presentation
      さわやかちば県民プラザ 柏市
    • Year and Date
      2013-07-06
    • Related Report
      2013 Final Research Report
  • [Presentation] 合成カンナビノイド摂取後に死亡した一事例2013

    • Author(s)
      石井晃, 吉本高士, 財津桂, 伊藤雅文, 山本敏充
    • Organizer
      第97次日本法医学会学術全国集会
    • Place of Presentation
      ロイトン札幌, 札幌市
    • Year and Date
      2013-06-28
    • Related Report
      2013 Final Research Report
  • [Presentation] LC/MS/MS による合成カンナビノイドJWH-073 のラット尿中代謝物の推定2013

    • Author(s)
      財津桂, 片木宗弘, 鎌田徹, 志摩典明, 吉本高士, 山本敏充, 土橋均, 鈴木廣一, 石井晃
    • Organizer
      第97次日本法医学会学術全国集会
    • Place of Presentation
      ロイトン札幌, 札幌市
    • Year and Date
      2013-06-27
    • Related Report
      2013 Final Research Report
  • [Presentation] High-resolution mass spectrometry and accurate mass measurement of synthetic cannabinoids and their metabolites in human biological specimens by LC/Q-TOFMS2013

    • Author(s)
      Kei Zaitsu, Takashi Yoshimoto, Toshimichi Yamamoto, Tadashi Ogawa, Hideki Hattori, Tomohiro Matsumoto, Kazuaki Hisatsune, Munehiro Katagi, Hitoshi Tsuchihashi, Akira Ishii
    • Organizer
      The 51st Annual Meeting of the International Association of Forensic Toxicologists.
    • Place of Presentation
      Funchal, Portugal
    • Related Report
      2013 Annual Research Report
  • [Presentation] Simultaneous and sensitive analysis of fourth-generation antidepressants in human plasma by ultra-performance liquid chromatography-tandem mass spectrometry2013

    • Author(s)
      Ogawa T, Iwakura K, Hattori H, Iwai M, Suzuki O, Nakagawa T, Seno H
    • Organizer
      The 51st Annual Meeting of the International Association of Forensic Toxicologists.
    • Place of Presentation
      Funchal, Portugal
    • Related Report
      2013 Annual Research Report
  • [Presentation] Effects of cannabinoids on the neuronal responses in the mouse amygdala analyzed by voltage-sensitive dye imaging2013

    • Author(s)
      K. Hara, Tomomi Fujieda, T. Irie, H. Miwa, J. Oka, T. Shirao, R. Kikura-Hanajiri, Y. Goda, M. Kurihara, Y. Sekino
    • Organizer
      Neuro 2013
    • Place of Presentation
      Kyoto International Conference Center, Kyoto, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] Determination of MAM-2201 and its metabolites in a fatal case and the binding affinities of MAM-2201 at the cannabinoid CB1 and CB2 receptors. 51th Annual Meeting of the International Association of Rorensic Toxicologists2013

    • Author(s)
      R. Kikura-Hanajiri, M. Kawamura, S. Kanno, T. Nagai, M. Takada, T. Mukai and Y. Goda
    • Organizer
      The 51st Annual Meeting of the International Association of Forensic Toxicologists.
    • Place of Presentation
      Funchal, Portugal
    • Related Report
      2013 Annual Research Report
  • [Presentation] wo new designer drugs, MT-45 (I-C6) and Noopept (GVS-111), detected with a synthetic cannabinoid A-834735 in illegal products2013

    • Author(s)
      N. Uchiyama, S. Matsuda, M. Kawamura, R. Kikura-Hanajiri, Y. Goda
    • Organizer
      The 51st Annual Meeting of the International Association of Forensic Toxicologists
    • Place of Presentation
      Funchal, Portugal
    • Related Report
      2013 Annual Research Report
  • [Presentation] urvey of the emergence of erectile dysfunction medicines and their related compounds adulterated to health food products in Japan for the last decade2013

    • Author(s)
      K. Saisho, R. Kikura-Hanajiri, Y. Goda
    • Organizer
      The 51st Annual Meeting of the International Association of Forensic Toxicologists.
    • Place of Presentation
      Funchal, Portugal
    • Related Report
      2013 Annual Research Report
  • [Presentation] A fatal case after smoking herb containing a synthetic cannabinoid MAM-22012013

    • Author(s)
      S. Kanno, R. Kikura-Hanajiri, M. Sagi, T. Nagai, S. Chiba, H. Takeshita, M. Takada, M. Kawamura, Y. Goda, T. Mukai
    • Organizer
      The 51st Annual Meeting of the International Association of Forensic Toxicologists.
    • Place of Presentation
      Funchal, Portugal
    • Related Report
      2013 Annual Research Report
  • [Presentation] "Midi-6"システムが有用であったパラフィンブロックからの親子鑑定例2013

    • Author(s)
      山本敏充, 吉本高士, 広重優二, 財津 桂, 石井 晃
    • Organizer
      第97次日本法医学会学術全国集会
    • Place of Presentation
      ロイトン札幌、札幌市
    • Related Report
      2013 Annual Research Report
  • [Presentation] トリプル四重極型GC-MS/MSによる法薬毒物の高感度スクリーニングと確認分析2013

    • Author(s)
      坪井健人, 土橋 均, 財津 桂, 片木宗広, 松田駿太郎, 佐藤貴子, 阿部俊太郎, 岩田美佐, 石井 晃, 鈴木廣一
    • Organizer
      第97次日本法医学会学術全国集会
    • Place of Presentation
      ロイトン札幌、札幌市
    • Related Report
      2013 Annual Research Report
  • [Presentation] LC/MS/MSによる合成カンナビノイドJWH-073のラット尿中代謝物の推定2013

    • Author(s)
      財津桂,片木宗弘,鎌田徹,志摩典明,吉本高士,山本敏充,土橋均,鈴木廣一,石井晃
    • Organizer
      第97次日本法医学会学術全国集会
    • Place of Presentation
      ロイトン札幌、札幌市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 合成カンナビノイド摂取後に死亡した一事例2013

    • Author(s)
      石井 晃, 吉本高士, 財津 桂, 伊藤雅文, 山本敏充
    • Organizer
      第97次日本法医学会学術全国集会
    • Place of Presentation
      ロイトン札幌、札幌市
    • Related Report
      2013 Annual Research Report
  • [Presentation] GC/MS/MS による違法ドラッグ異性体識別法の検討2013

    • Author(s)
      財津 桂、松田駿太朗、志摩典明、西岡 裕、片木宗弘、吉本高士、山本敏充、坪井健人、 土橋 均、鈴木廣一、石井 晃
    • Organizer
      日本法中毒学会第 32 年会
    • Place of Presentation
      さわやかちば県民プラザ、柏市
    • Related Report
      2013 Annual Research Report
  • [Presentation] LC-Q-TOF-MS による生体試料中合成カンナビノイド及び 代謝物の分析.2013

    • Author(s)
      財津 桂、吉本高士、山本敏充、鎌田 徹、片木宗弘、小川匡之、服部秀樹、佐藤貴子、 土橋 均、鈴木廣一、石井 晃.
    • Organizer
      日本法中毒学会第 32 年会
    • Place of Presentation
      さわやかちば県民プラザ、柏市
    • Related Report
      2013 Annual Research Report
  • [Presentation] UPLC-MS-MSを用いたヒト血漿中第四世代抗うつ薬の高感度一斉分析2013

    • Author(s)
      小川匡之, 岩倉賢也, 服部秀樹, 岩井雅枝, 鈴木 修, 中川 隆, 妹尾 洋
    • Organizer
      日本法中毒学会第 32 年会
    • Place of Presentation
      さわやかちば県民プラザ、柏市
    • Related Report
      2013 Annual Research Report
  • [Presentation] GC-MS/MS を用いたナフトイルインドール系薬物の包括的検出2013

    • Author(s)
      宮川 治彦, 坂本 雄紀, 松田 駿太朗, 鎌田 徹, 西岡 裕, 片木 宗弘, 財津 桂, 石井 晃, 坪井 健人, 土橋 均, 鈴木 廣一
    • Organizer
      日本法中毒学会第 32 年会
    • Place of Presentation
      さわやかちば県民プラザ、柏市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 2012 年度に実施した違法ドラッグ製品の流通実態調査結果について2013

    • Author(s)
      内山 奈穂子,松田 諭,花尻(木倉)瑠理,合田 幸広
    • Organizer
      日本法中毒学会第 32 年会
    • Place of Presentation
      さわやかちば県民プラザ、柏市
    • Related Report
      2013 Annual Research Report
  • [Presentation] MS-MSでミフェプリストンが検出された嬰児の1剖検例2013

    • Author(s)
      石井 晃, 財津 桂, 吉本高士, 山本敏充, 小川匡之, 服部秀樹, 妹尾 洋
    • Organizer
      第38回日本医用マススペクトル学会年会
    • Place of Presentation
      神戸市産業振興センター、神戸市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 高血圧は高コレステロール食による非アルコール性脂肪性肝炎進展のリスクとなるか2013

    • Author(s)
      那須民江他
    • Organizer
      第72回日本公衆衛生学会総会
    • Place of Presentation
      三重県総合文化センター、津市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 非アルコール性脂肪性肝疾患モデル(SHRSP5/Dmcr)の病態メカニズム2013

    • Author(s)
      那須民江
    • Organizer
      消費生活科学研究所講演会
    • Place of Presentation
      金城学院大学、名古屋市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 特定健診・特定保健指導の現状と課題について2013

    • Author(s)
      那須民江他
    • Organizer
      第86回日本産業衛生学会総会
    • Place of Presentation
      愛媛ひめぎんホール、松山市
    • Related Report
      2013 Annual Research Report
  • [Presentation] フタル酸エステルの生殖・次世代影響の健康リスク評価に関する総合研究2013

    • Author(s)
      那須民江
    • Organizer
      平成25年度食品健康影響評価技術研究成果発表会
    • Place of Presentation
      食品安全委員会、東京都港区
    • Related Report
      2013 Annual Research Report
  • [Presentation] いわゆる「脱法ハーブ」使用者生体試料からの薬物分析例2013

    • Author(s)
      花尻(木倉)瑠理
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 2012年度買い上げ違法ドラッグ製品から検出された新規流通デザイナードラッグ成分の同定2013

    • Author(s)
      内山奈穂子
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 大麻種子1粒からのISSR法による系統識別2013

    • Author(s)
      緒方 潤
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 妊娠期プラスチック可塑剤曝露の次世代影響―マウスの発達段階の影響の違いについて2013

    • Author(s)
      那須民江
    • Organizer
      第83回日本衛生学会学術総会
    • Place of Presentation
      金沢大学(金沢)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] フタル酸ジ-2-エチルヘキシルの尿中代謝物プロファイルにおけるPPARαの関与.2013

    • Author(s)
      伊藤由起
    • Organizer
      第83回日本衛生学会学術総会
    • Place of Presentation
      金沢大学(金沢)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 高脂肪食摂取によるラット肝炎・線維化は肝臓内の特定の胆汁酸の蓄積と関連がある2013

    • Author(s)
      賈 小芳
    • Organizer
      第83回日本衛生学会学術総会
    • Place of Presentation
      金沢大学(金沢)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 高脂肪・コレステロール食により誘導されるSHRSP5/Dmcrラット肝障害の性差2013

    • Author(s)
      イエッティフスナ
    • Organizer
      第83回日本衛生学会学術総会
    • Place of Presentation
      金沢大学(金沢)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 高脂肪食摂取による2系統ラットの肝線維化進展の差は胆汁酸組成の変化が関連する2013

    • Author(s)
      内藤久雄
    • Organizer
      第83回日本衛生学会学術総会
    • Place of Presentation
      金沢大学(金沢)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 非アルコール性脂肪性肝炎モデル動物SHRSP5/Dmcrにおける死亡の蓄積と摂取の関連2013

    • Author(s)
      玉田葉月
    • Organizer
      第83回日本衛生学会学術総会
    • Place of Presentation
      金沢大学(金沢)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 高分解能高精度 LC-MS/MS を用いたα-アマニチンとβ-アマニチンの分析およびピクロトキシンの分析2012

    • Author(s)
      多田美保, 服部秀樹, 小川匡之, 石井晃
    • Organizer
      第37回日本医用マススペクトル学会年会
    • Place of Presentation
      ウィンクあいち, 名古屋市
    • Year and Date
      2012-10-25
    • Related Report
      2013 Final Research Report
  • [Presentation] UPLC-MS-MSによる体液中アマニチン類の分析2012

    • Author(s)
      石井晃, 野村美奈, 鈴木雄大, 金子理奈, 小川匡之, 服部秀樹, 妹尾洋
    • Organizer
      第96次日本法医学会学術全国集会.アクトシティ浜松
    • Place of Presentation
      浜松市
    • Year and Date
      2012-06-08
    • Related Report
      2013 Final Research Report
  • [Presentation] Changes in the trends of the abuse of designer drugs and their legal status in Japan2012

    • Author(s)
      Kikura-Hanajiri R, Uchiyama N, Kawamura M, Goda Y
    • Organizer
      2012 NIDA International Forum -New and Emerging Psychoactive Substances : Second Interdisciplinary Forum-
    • Place of Presentation
      Palm Springs, California, USA
    • Year and Date
      2012-06-08
    • Related Report
      2013 Final Research Report
  • [Presentation] Survey of the trend in the abuse of designer drugs in Japan from 2002 to 20112012

    • Author(s)
      Kikura-Hanajiri R, Kawamura M, Uchiyama N, Goda Y
    • Organizer
      The 50th Annual Meeting of TIAFT
    • Place of Presentation
      Hamamatsu, Japan
    • Year and Date
      2012-06-07
    • Related Report
      2013 Final Research Report
  • [Presentation] Simple and simultaneous analysis of eight new antidepressants in human plasma samples using UPLC-MS-MS2012

    • Author(s)
      Ishii A, Suzuki Y, Yasuda T, Nomura M, Hattori H, Ishii A, Seno H
    • Organizer
      The 50th Annual Meeting of TIAFT
    • Place of Presentation
      Hamamatsu, Japan
    • Year and Date
      2012-06-06
    • Related Report
      2013 Final Research Report
  • [Presentation] 違法ドラッグを取り巻く国内外における現状と規制について2012

    • Author(s)
      花尻(木倉)瑠理
    • Organizer
      日本薬学会第132年会一般シンポジウム
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] The trends of the abuse of designer drugs and their legal status in Japan2012

    • Author(s)
      Kikura-Hanajiri R, et al
    • Organizer
      The first International Conference on Novel Psychoactive Compounds
    • Place of Presentation
      Budapest, Hungary
    • Year and Date
      2012-03-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] High-throughput determination of barbiturates in human plasma using on-line column-switching ultra fast liquid chromatography-tandem mass spectrometry2012

    • Author(s)
      Xiao-Peng Lee
    • Organizer
      The 50th Annual Meeting of TIAFT
    • Place of Presentation
      アクトシティ浜松(浜松)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Simple and simultaneous analysis of eight new antidepressants in human plasma samples using UPLC-MS-MS2012

    • Author(s)
      Akira Ishii
    • Organizer
      The 50th Annual Meeting of TIAFT
    • Place of Presentation
      アクトシティ浜松(浜松)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Simultaneous analysis of peripheral muscle relaxants in whole blood by ultra-performance liquid chromatography tandem mass spectrometry2012

    • Author(s)
      Tadashi Ogawa
    • Organizer
      The 50th Annual Meeting of TIAFT
    • Place of Presentation
      アクトシティ浜松(浜松)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Survey of the trend in the abuse of designer drugs in Japan from 2002 to 20112012

    • Author(s)
      Ruri Kikura-Hanajiri
    • Organizer
      The 50th Annual Meeting of TIAFT
    • Place of Presentation
      アクトシティ浜松(浜松)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Identification of two new adamantly amide type synthetic cannabinoids, APICA and APINACA, and detection of newly distributed designer drugs in illegal products being sold in Japan2012

    • Author(s)
      Nahoko Uchiyama
    • Organizer
      The 50th Annual Meeting of TIAFT
    • Place of Presentation
      アクトシティ浜松(浜松)
    • Related Report
      2012 Annual Research Report
  • [Presentation] The botanical origins of blend herbal products (“Spice”-like products) containing synthetic cannabinoids2012

    • Author(s)
      Jun Ogata
    • Organizer
      The 50th Annual Meeting of TIAFT
    • Place of Presentation
      アクトシティ浜松(浜松)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Changes in the trends of the abuse of designer drugs and their legal status in Japan2012

    • Author(s)
      Ruri Kikura-Hanajiri
    • Organizer
      2012 NIDA International Forum
    • Place of Presentation
      PalmSprings, CA (USA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] UPLC-MS-MSによる体液中アマニチン類の分析2012

    • Author(s)
      石井 晃
    • Organizer
      第96次日本法医学会学術全国集会
    • Place of Presentation
      アクトシティ浜松(浜松)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 高分解能高精度 LC-MS/MS を用いたα-アマニチンとβ-アマニチンの分析およびピクロトキシンの分析2012

    • Author(s)
      多田美保
    • Organizer
      第37回日本医用マススペクトル学会年会
    • Place of Presentation
      ウィンクあいち(名古屋)
    • Related Report
      2012 Annual Research Report
  • [Presentation] UPLC-MS/MS を用いたヒト血漿中メラトニン受容体作動薬の迅速・一斉分析2012

    • Author(s)
      小川匡之
    • Organizer
      第37回日本医用マススペクトル学会年会
    • Place of Presentation
      ウィンクあいち(名古屋)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 「脱法ドラッグ」の流通実態と指定薬物制度について2012

    • Author(s)
      花尻(木倉)瑠理
    • Organizer
      平成24年度アルコール・薬物依存関連学会合同学術総会
    • Place of Presentation
      札幌コンベンションセンター(札幌)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 指定薬物について2012

    • Author(s)
      花尻(木倉)瑠理
    • Organizer
      第49回全国薬事指導協議会総会
    • Place of Presentation
      鯉城会館(広島)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 指定薬物制度と違法ドラッグ流通実態の変化について2012

    • Author(s)
      花尻(木倉)瑠理
    • Organizer
      第49回全国衛生化学技術協議会
    • Place of Presentation
      環境保健センター(高松)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Determination of a synthetic cannabinoid, JWH-018 and its metabolites in raturine and hair samples using UPLC-MS/MS2011

    • Author(s)
      Kikura-Hanajiri R, et al
    • Organizer
      SOFT-TIAFT 2011
    • Place of Presentation
      San Francisco, CA
    • Year and Date
      2011-09-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] Sensitive determination of amatoxins using UPLC-MS-MS. Joint Meeting of SOFT and TIAFT2011

    • Author(s)
      Ishii A, Nomura M, Suzsuki Y, Kaneko R, Ogawa T, Hattori H, Seno H
    • Organizer
      Program and Abstracts
    • Place of Presentation
      San Francisco CA, USA
    • Year and Date
      2011-09-28
    • Related Report
      2013 Final Research Report
  • [Presentation] Sensitive determination of amatoxins using UPLC-MS-MS2011

    • Author(s)
      Ishii A, et al
    • Organizer
      SOFT-TIAFT 2011
    • Place of Presentation
      San Francisco, CA
    • Year and Date
      2011-09-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Identification of newly distributed designer drugs, synthetic cannabinoids and cathinone derivatives, in Japan2011

    • Author(s)
      Uchiyama N, et al
    • Organizer
      SOFT-TIAFT 2011
    • Place of Presentation
      San Francisco, CA
    • Year and Date
      2011-09-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Inducibility of CYP1A by linuron in primary cultured human hepatocytes2011

    • Author(s)
      Sunouchi W, et al
    • Organizer
      EUROTOX 2011
    • Place of Presentation
      Paris, Francce
    • Year and Date
      2011-08-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] 法医学からみた急性中毒死について2011

    • Author(s)
      石井晃
    • Organizer
      第33回日本中毒学会総会・学術集会
    • Place of Presentation
      ソフトピアジャパン, 大垣市
    • Year and Date
      2011-07-30
    • Related Report
      2013 Final Research Report
  • [Presentation] 法医学からみた急性中毒死について2011

    • Author(s)
      石井晃
    • Organizer
      第33回日本中毒学会総会
    • Place of Presentation
      大垣(招待講演)
    • Year and Date
      2011-07-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] 法医鑑定における薬毒物分析-LC-MS-MS を中心として-2011

    • Author(s)
      石井晃
    • Organizer
      第25回日本医用マススペクトル学会東海支部講演会
    • Place of Presentation
      名古屋大学医学部, 名古屋市
    • Year and Date
      2011-07-09
    • Related Report
      2013 Final Research Report
  • [Presentation] 法医鑑定における薬毒物分析-LC-MS-MSを中心として-2011

    • Author(s)
      石井晃
    • Organizer
      第25回日本医用マススペクトル学会東海支部講演会
    • Place of Presentation
      名古屋(招待講演)
    • Year and Date
      2011-07-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] Survey of current trends in the abuse of psychotropic substances and plants in Japan2011

    • Author(s)
      Kikura-Hanajiri R, et al
    • Organizer
      First international multidisciplinary forum on new drugs
    • Place of Presentation
      Lisbon, Portugal
    • Year and Date
      2011-05-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] Drug Control in Japan-Designated Substances-2011

    • Author(s)
      Kikura-Hanajiri R, et al
    • Organizer
      First international multidisciplinary forum on new drugs
    • Place of Presentation
      Lisbon, Portugal
    • Year and Date
      2011-05-11
    • Related Report
      2011 Annual Research Report
  • [Book] Encyclopedia of Toxicology2014

    • Author(s)
      Nakajima T,Yanagiba Y
    • Total Pages
      2000
    • Publisher
      Elsevier
    • Related Report
      2013 Annual Research Report
  • [Book] Trichloroethylene: Toxicity and Health Risks2014

    • Author(s)
      Kamijima M, Wang H, Yamanoshita O,Ito Y,T Nakajima
    • Total Pages
      245
    • Publisher
      Springer
    • Related Report
      2013 Annual Research Report
  • [Book] 法医学における質量分析.医用質量分析ハンドブック2013

    • Author(s)
      石井晃, 財津桂
    • Total Pages
      190
    • Publisher
      診断と治療社
    • Related Report
      2013 Final Research Report
  • [Book] 法医鑑定における薬毒物の質量分析.医用質量分析ハンドブック2013

    • Author(s)
      財津桂, 石井晃
    • Total Pages
      190
    • Publisher
      診断と治療社
    • Related Report
      2013 Final Research Report
  • [Book] 医用質量分析ガイドブック2013

    • Author(s)
      石井 晃, 財津 桂
    • Total Pages
      190
    • Publisher
      診断と治療社
    • Related Report
      2013 Annual Research Report
  • [Book] 医用質量分析ガイドブック2013

    • Author(s)
      財津 桂, 石井 晃
    • Total Pages
      190
    • Publisher
      診断と治療社
    • Related Report
      2013 Annual Research Report

URL: 

Published: 2011-04-06   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi