| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2011: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Research Abstract |
The aim of this study is to detect the contribution of lymphatic vessels to lifestyle related disease.In obese type2 diabetic mice,pancreatic lymphatic vasculature was increased and VEGF-C expression was enhanced in islets.In vitro study showed that IL-1beta and TNF-alpha upregulated VEGF-C in pancreatic alpha cells and pancreatic beta cells.These results indicated that in diabetes and obesity,elevated inflammatory cytokine induce VEGF-C expression in islets,thereby pancreatic lymphatic vessels were increased.
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