|Budget Amount *help
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
We proposed the definition of sarcopenia and sarcopenic obesity. Three aspects of sarcopenic obesity, 1) metabolic abnormality, 2) functional change, and 3) causality, were investigated.
1) Metabolic abnormality; Sarcopenic obesity is associated with insulin resistance, leptin resistance, and adiponectin paradox. Sarcopenia is also involved in the BNP resistance observed in obese subjects.
2) Functional changes; Sarocopenia was related to frailty, arterial stiffness, central blood pressure and end organ damages. 3)Causalty; Several candidate genes for sarcopenia were identified including KCNQ1 and CHD13. We demonstrated ectopic fat infiltration in the skeletal muscle in cardiotoxin injury model of ob/ob and KKAy mouse. Causal relationship between sarcopenic obesity and cardiovascular events will be followed in longitudinal study.