| Budget Amount *help |
¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
The author conducted the following experiments to establish the pharmacotherapy for treating psychogenic fever and to elucidate its possible mechanisms. 1. After exposing Wistar rats to 21 daily 1-hr social defeat stresses, they showed about 0.5℃ higher abdominal temperature (Ta) than the Ta of the control rats. This increase was attenuated by repeated intraperitoneal injection of fluvoxamine, a selective serotonin reuptake inhibitor, suggesting the usefulness of fluvoxamine as one of the treatment of psychogenic fever induced by chronic stress. 2. Acute stress-induced hyperthermia is attenuated by single administration of diazepam. Fos expression pattern within the brain was compared between rats exposed to acute stress and those exposed to stress and diazepam treatment. The Fos expression pattern was also compared with those treated by lipopolysaccharide, a model of infectious fever.
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