Clarifying the pathogenesis of chronic hepatitis C through comprehensive genetic analyses of the virus and host using next-generation sequencer

• Project/Area Number: 23390195
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: University of Yamanashi
• Principal Investigator: ENOMOTO Nobuyuki 山梨大学, 医学工学総合研究部, 教授 (20251530)
• Co-Investigator(Kenkyū-buntansha): MAEKAWA Shinya 山梨大学, 医学工学総合研究部, 講師 (70397298)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000); Fiscal Year 2013: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2012: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2011: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
• Keywords: HCV / HCC / 次世代シークエンス / プロテアーゼ阻害剤 / NS5A阻害剤 / コア蛋白 / ISDR / インターフェロン / リバビリン / 次世代シークエンシング

Research Abstract

Hepatitis C virus has been considered to exist in a host as a complex mixture of various viral mutant subpopulations called as "quasispecies". However, analyzing viral quasispecies and its role in the pathogenesis of hepatitis has been difficult due to the technical limitation. In this study, through introducing the revolutionary technology of next-generation sequencing, we disclosed that the quasispecies state and its dynamics had a significant association with antiviral therapies as well as hepatocarcinogenesis.

Research Products

• [Journal Article] Once-daily simeprevir in combination with pegylated-interferon and ribavirin : a new horizon in the era of direct-acting antiviral agent therapy for chronic hepatitis C (2014)
  • Author(s): Maekawa S, Enomoto N
  • Journal Title: J Gastroenterol Volume: 49(1) Pages: 163-4
  • Peer Reviewed
• [Journal Article] Once-daily simeprevir in combination with pegylated-interferon and ribavirin: a new horizon in the era of direct-acting antiviral agent therapy for chronic hepatitis C. (2014)
  • Author(s): Maekawa S, Enomoto N
  • Journal Title: J Gastroenterol. Volume: 49(1) Issue: 12 Pages: 163-164
  • DOI: 10.1371/journal.pone.0082299
  • Peer Reviewed
• [Journal Article] Inhibitory effects of caffeic Acid phenethyl ester derivatives on replication of hepatitis C virus (2013)
  • Author(s): Shen H, Yamashita A, Nakakoshi M, Yokoe H, Sudo M, Kasai H, Tanaka T, Fujimoto Y, Ikeda M, Kato N, Sakamoto N, Shindo H, Maekawa S, Enomoto N, Tsubuki M, Moriishi K
  • Journal Title: PLoS One Volume: 17;8(12)
  • Peer Reviewed
• [Journal Article] Association of splenic MR elastographic findings with gastroesophageal varices in patients with chronic liver disease (2013)
  • Author(s): Morisaka H, Motosugi U, Ichikawa S, Sano K, Ichikawa T, Enomoto N
  • Journal Title: J Magn Reson Imaging
  • Peer Reviewed
• [Journal Article] Changes in plasma vascular endothelial growth factor at 8 weeks after sorafenib administration as predictors of survival for advanced hepatocellular carcinoma (2013)
  • Author(s): Tsuchiya K, Asahina Y, Matsuda S, Muraoka M, Nakata T, Suzuki Y, Tamaki N, Yasui Y, Suzuki S, Hosokawa T, Nishimura T, Ueda K, Kuzuya T, Nakanishi H, Itakura J, Takahashi Y, Kurosaki M, Enomoto N, Izumi N
  • Journal Title: Cancer Volume: 15;120(2) Pages: 229-37
  • Peer Reviewed
• [Journal Article] Deep-sequencing analysis of the association between the quasispecies nature of the hepatitis C virus core region and disease progression (2013)
  • Author(s): Miura M, Maekawa S, Takano S, Komatsu N, Tatsumi A, Asakawa Y, Shindo K, Amemiya F, Nakayama Y, Inoue T, Sakamoto M, Yamashita A, Moriishi K, Enomoto N
  • Journal Title: J Virol Volume: 87(23) Pages: 12541-51
  • Peer Reviewed
• [Journal Article] Genetic variation near interleukin 28B and the risk of hepatocellular carcinoma in patients with chronic hepatitis C (2013)
  • Author(s): Asahina Y, Tsuchiya K, Nishimura T, Muraoka M, Suzuki Y, Tamaki N, Yasui Y, Hosokawa T, Ueda K, Nakanishi H, Itakura J, Takahashi Y, Kurosaki M, Enomoto N, Nakagawa M, Kakinuma S, Watanabe M, Izumi N
  • Journal Title: J Gastroenterol
  • Peer Reviewed
• [Journal Article] MR-based measurements of portal vein flow and liver stiffness for predicting gastroesophageal varices (2013)
  • Author(s): Morisaka H, Motosugi U, Ichikawa T, Sano K, Ichikawa S, Araki T, Enomoto N
  • Journal Title: Magn Reson Med Sci Volume: 12(2) Pages: 77-86
  • NAID: 10031183920
  • Peer Reviewed
• [Journal Article] Presence of a hypovascular hepatic nodule showing hypointensity on hepatocyte-phase image is a risk factor for hypervascular hepatocellular carcinoma (2013)
  • Author(s): Ichikawa S, Ichikawa T, Motosugi U, Sano K, Morisaka H, Enomoto N, Matsuda M, Fujii H, Araki T
  • Journal Title: J Magn Reson Imaging Volume: 39(2) Pages: 293-7
  • Peer Reviewed
• [Journal Article] Impaired brain activity in cirrhotic patients with minimal hepatic encephalopathy : Evaluation by near-infrared spectroscopy (2013)
  • Author(s): Nakanishi H, Kurosaki M, Nakanishi K, Tsuchiya K, Noda T, Tamaki N, Yasui Y, Hosokawa T, Ueda K, Itakura J, Anami K, Asahina Y, Enomoto N, Higuchi T, Izumi N
  • Journal Title: Hepatol Res
  • Peer Reviewed
• [Journal Article] Clinical efficacy of combination therapy with ME3738 and pegylated interferon-alpha-2a in patients with hepatitis C virus genotype 1 (2013)
  • Author(s): Saibara T, Enomoto N, Kaneko S, Chayama K, Sata M, Imawari M, Onishi S, Okita K
  • Journal Title: Hepatol Res
  • Peer Reviewed
• [Journal Article] α-fetoprotein levels after interferon therapy and risk of hepatocarcinogenesis in chronic hepatitis C (2013)
  • Author(s): Asahina Y, Tsuchiya K, Nishimura T, Muraoka M, Suzuki Y, Tamaki N, Yasui Y, Hosokawa T, Ueda K, Nakanishi H, Itakura J, Takahashi Y, Kurosaki M, Enomoto N, Nakagawa M, Kakinuma S, Watanabe M, Izumi N
  • Journal Title: Hepatology Volume: 58(4) Pages: 1253-62
  • Peer Reviewed
• [Journal Article] IL-28B (IFN-λ3) and IFN-α synergistically inhibit HCV replication (2013)
  • Author(s): Shindo H, Maekawa S, Komase K, Miura M, Kadokura M, Sueki R, Komatsu N, Shindo K, Amemiya F, Nakayama Y, Inoue T, Sakamoto M, Yamashita A, Moriishi K, Enomoto N
  • Journal Title: J Viral Hepat Volume: 20(4) Pages: 281-9
  • Peer Reviewed
• [Journal Article] Model incorporating the ITPA genotype identifies patients at high risk of anemia and treatment failure with pegylated-interferon plus ribavirin therapy for chronic hepatitis C (2013)
  • Author(s): Kurosaki M, Tanaka Y, Nishida N, Sakamoto N, Enomoto N, Matsuura K, Asahina Y, Nakagawa M, Watanabe M, Sakamoto M, Maekawa S, Tokunaga K, Mizokami M, Izumi N
  • Journal Title: J Med Virol Volume: 85(3) Pages: 449-58
  • Peer Reviewed
• [Journal Article] Serum RANTES level influences the response to pegylated interferon and ribavirin therapy in chronic hepatitis C (2013)
  • Author(s): Komase K, Maekawa S, Miura M, Sueki R, Kadokura M, Shindo H, Shindo K, Amemiya F, Nakayama Y, Inoue T, Sakamoto M, Yamashita A, Moriishi K, Enomoto N
  • Journal Title: Hepatol Res Volume: 43(8) Pages: 865-75
  • NAID: 10031194591
  • Peer Reviewed
• [Journal Article] Bayesian prediction for liver fibrosis staging : combined use of elastography and serum fibrosis markers (2013)
  • Author(s): Motosugi U, Ichikawa T, Araki T, Matsuda M, Fujii H, Enomoto N
  • Journal Title: Hepatology Volume: 58(1) Pages: 450-1
  • Peer Reviewed
• [Journal Article] Liver stiffness measured by magnetic resonance elastography as a risk factor for hepatocellular carcinoma : a preliminary case-control study (2013)
  • Author(s): Motosugi U, Ichikawa T, Koshiishi T, Sano K, Morisaka H, Ichikawa S, Enomoto N, Matsuda M, Fujii H, Araki T
  • Journal Title: Eur Radiol Volume: 23(1) Pages: 156-62
  • Peer Reviewed
• [Journal Article] Inhibitory effects of caffeic Acid phenethyl ester derivatives on replication of hepatitis C virus. (2013)
  • Author(s): Shen H, Yamashita A, Nakakoshi M, Yokoe H, Sudo M, Kasai H, Tanaka T, Fujimoto Y, Ikeda M, Kato N, Sakamoto N, Shindo H, Maekawa S, Enomoto N, Tsubuki M, Moriishi K.
  • Journal Title: PLoS One. Volume: 17 Issue: 1 Pages: 163-164
  • DOI: 10.1007/s00535-013-0926-7
  • Peer Reviewed
• [Journal Article] Association of splenic MR elastographic findings with gastroesophageal varices in patients with chronic liver disease. (2013)
  • Author(s): Morisaka H, Motosugi U, Ichikawa S, Sano K, Ichikawa T, Enomoto N
  • Journal Title: J Magn Reson Imaging. Volume: Nov 14 Issue: 1 Pages: 117-124
  • DOI: 10.1002/jmri.24505
  • Peer Reviewed
• [Journal Article] Changes in plasma vascular endothelial growth factor at 8 weeks after sorafenib administration as predictors of survival for advanced hepatocellular carcinoma. (2013)
  • Author(s): Tsuchiya K, Asahina Y, Matsuda S, Muraoka M, Nakata T, Suzuki Y, Tamaki N, Yasui Y, Suzuki S, Hosokawa T, Nishimura T, Ueda K, Kuzuya T, Nakanishi H, Itakura J, Takahashi Y, Kurosaki M, Enomoto N, Izumi N.
  • Journal Title: Cancer. Volume: 15;120(2) Issue: 2 Pages: 229-237
  • DOI: 10.1002/cncr.28384
  • Peer Reviewed
• [Journal Article] Deep-sequencing analysis of the association between the quasispecies nature of the hepatitis C virus core region and disease progression. (2013)
  • Author(s): Miura M, Maekawa S, Takano S, Komatsu N, Tatsumi A, Asakawa Y, Shindo K, Amemiya F, Nakayama Y, Inoue T, Sakamoto M, Yamashita A, Moriishi K, Enomoto N.
  • Journal Title: J Virol. Volume: 87(23) Issue: 23 Pages: 12541-12551
  • DOI: 10.1128/jvi.00826-13
  • Peer Reviewed
• [Journal Article] Genetic variation near interleukin 28B and the risk of hepatocellular carcinoma in patients with chronic hepatitis C. (2013)
  • Author(s): Asahina Y, Tsuchiya K, Nishimura T, Muraoka M, Suzuki Y, Tamaki N, Yasui Y, Hosokawa T, Ueda K, Nakanishi H, Itakura J, Takahashi Y, Kurosaki M, Enomoto N, Nakagawa M, Kakinuma S, Watanabe M, Izumi N.
  • Journal Title: J Gastroenterol. Volume: Jul 17
  • Peer Reviewed
• [Journal Article] MR-based measurements of portal vein flow and liver stiffness for predicting gastroesophageal varices. (2013)
  • Author(s): Morisaka H, Motosugi U, Ichikawa T, Sano K, Ichikawa S, Araki T, Enomoto N
  • Journal Title: Magn Reson Med Sci. Volume: 12(2) Pages: 77-86
  • NAID: 10031183920
  • Peer Reviewed
• [Journal Article] Presence of a hypovascular hepatic nodule showing hypointensity on hepatocyte-phase image is a risk factor for hypervascular hepatocellular carcinoma. (2013)
  • Author(s): Ichikawa S, Ichikawa T, Motosugi U, Sano K, Morisaka H, Enomoto N, Matsuda M, Fujii H, Araki T.
  • Journal Title: J Magn Reson Imaging. Volume: 39(2) Issue: 2 Pages: 293-297
  • DOI: 10.1002/jmri.24164
  • Peer Reviewed
• [Journal Article] Impaired brain activity in cirrhotic patients with minimal hepatic encephalopathy: evaluation by near infrared spectroscopy. (2013)
  • Author(s): Nakanishi H,Asahina Y, Izumi N et al
  • Journal Title: Hepatol Res Volume: in press Issue: 3 Pages: 319-326
  • DOI: 10.1111/hepr.12127
  • Peer Reviewed
• [Journal Article] Clinical efficacy of combination therapy with ME3738 and pegylated interferon-alpha-2a in patients with hepatitis C virus genotype 1. (2013)
  • Author(s): Saibara T, Enomoto N, Kaneko S, Chayama K, Sata M, Imawari M, Onishi S, Okita K.
  • Journal Title: Hepatol Res. Volume: Apr 19 Issue: 4 Pages: 410-419
  • DOI: 10.1111/hepr.12139
  • Peer Reviewed
• [Journal Article] α-fetoprotein levels afterinterferon therapy and risk of hepatocarcinogenesis in chronic hepatitis C (2013)
  • Author(s): Asahina Y, Tsuchiya K, Nishimura T, Muraoka M, Suzuki Y, Tamaki N, Yasui Y, Hosokawa T, Ueda K, Nakanishi H, Itakura J, Takahashi Y, Kurosaki M, Enomoto N, Nakagawa M, Kakinuma S, Watanabe M,Izumi N
  • Journal Title: Hepatology Volume: (in press) Issue: 4 Pages: 1253-1262
  • DOI: 10.1002/hep.26442
  • Peer Reviewed
• [Journal Article] IL-28B (IFN-λ3) and IFN-α synergistically inhibit HCV replication. (2013)
  • Author(s): Shindo H
  • Journal Title: J Viral Hepat. Volume: 20 Issue: 4 Pages: 281-289
  • DOI: 10.1111/j.1365-2893.2012.01649.x
  • Peer Reviewed
• [Journal Article] Model incorporating the ITPA genotype identifies patients at high risk of anemia and treatment failure with pegylated-interferon plus ribavirin therapy for chronic hepatitis C. (2013)
  • Author(s): Kurosaki M, Sakamoto N, Asahina Y, Izumi N et al
  • Journal Title: J Med Virol Volume: 85 Issue: 3 Pages: 449-458
  • DOI: 10.1002/jmv.23497
  • Peer Reviewed
• [Journal Article] Serum RANTES level influences the response to pegylated interferon and ribavirin therapy in chronic hepatitis C. (2013)
  • Author(s): Komase K, Maekawa S, Miura M, Sueki R, Kadokura M, Shindo H, Shindo K, Amemiya F, Nakayama Y, Inoue T, Sakamoto M, Yamashita A, Moriishi K, Enomoto N
  • Journal Title: Hepatol Res. Volume: 43(8) Issue: 8 Pages: 865-875
  • DOI: 10.1111/hepr.12032
  • NAID: 10031194591
  • Peer Reviewed
• [Journal Article] Magnetic resonance elastography for staging liver fibrosis in chronic hepatitis C (2012)
  • Author(s): Ichikawa S, Motosugi U, Ichikawa T, Sano K, Morisaka H, Enomoto N, Matsuda M, Fujii H, Araki T
  • Journal Title: Magn Reson Med Sci Volume: 11(4) Pages: 291-7
  • NAID: 10031145229
  • Peer Reviewed
• [Journal Article] RETRY Study Group. Retreatment with peginterferon α-2a + ribavirin in patients who failed previous peginterferon α-2b + ribavirin combination therapy (2012)
  • Author(s): Ueda T, Tsuchiya K, Hashimoto S, Inoue T, Enomoto N, Inao M, Tanaka A, Kaito M, Imazeki F, Nishiguchi S, Mochida S, Yokosuka O, Yatsuhashi H, Izumi N, Kudo M
  • Journal Title: Dig Dis Volume: 30(6) Pages: 554-60
  • Peer Reviewed
• [Journal Article] Inhibition of both protease and helicase activities of hepatitis C virus NS3 by an ethyl acetate extract of marine sponge Amphimedon sp (2012)
  • Author(s): Fujimoto Y, Salam KA, Furuta A, Matsuda Y, Fujita O, Tani H, Ikeda M, Kato N, Sakamoto N, Maekawa S, Enomoto N, de Voogd NJ, Nakakoshi M, Tsubuki M, Sekiguchi Y, Tsuneda S, Akimitsu N, Noda N, Yamashita A, Tanaka J, Moriishi K
  • Journal Title: PLoS One Volume: 7(11)
  • Peer Reviewed
• [Journal Article] Correlation between pretreatment viral sequences and the emergence of lamivudine resistance in hepatitis B virus infection (2012)
  • Author(s): Sueki R, Maekawa S, Miura M, Kadokura M, Komase K, Shindo H, Kanayama A, Ohmori T, Shindo K, Amemiya F, Nakayama Y, Uetake T, Inoue T, Sakamoto M, Enomoto N
  • Journal Title: J Med Virol Volume: 84(9) Pages: 1360-1360
  • Peer Reviewed
• [Journal Article] Inhibition of hepatitis C virus replication and viral helicase by ethyl acetate extract of the marine feather star Alloeocomatella polycladia (2012)
  • Author(s): Yamashita A, Salam KA, Furuta A, Matsuda Y, Fujita O, Tani H, Fujita Y, Fujimoto Y, Ikeda M, Kato N, Sakamoto N, Maekawa S, Enomoto N, Nakakoshi M, Tsubuki M, Sekiguchi Y, Tsuneda S, Akimitsu N, Noda N, Tanaka J, Moriishi K
  • Journal Title: Mar Drugs Volume: 10(4) Pages: 744-61
  • Peer Reviewed
• [Journal Article] Retreatment with peginterferon α-2a + ribavirin in patients who failed previous peginterferon α-2b + ribavirin combination therapy. (2012)
  • Author(s): Ueda T
  • Journal Title: Dig Dis. Volume: 30(6) Issue: 6 Pages: 554-560
  • DOI: 10.1159/000343064
  • Peer Reviewed
• [Journal Article] Inhibition of both protease and helicase activities of hepatitis C virus NS3 by an ethyl acetate extract of marine sponge Amphimedon sp. (2012)
  • Author(s): Fujimoto Y
  • Journal Title: PLoS One. Volume: 7 Issue: 11 Pages: 744-761
  • DOI: 10.1371/journal.pone.0048685
  • Peer Reviewed
• [Journal Article] Inhibition of Hepatitis C Virus Replication and Viral Helicase by Ethyl Acetate Extract of the Marine Feather Star Alloeocomatella polycladia (2012)
  • Author(s): Yamashita A, Maekawa S, et al
  • Journal Title: Mar.Drugs Volume: 10 Issue: 4 Pages: 744-761
  • DOI: 10.3390/md10040744
  • Peer Reviewed
• [Journal Article] Comprehensive analysis for viral elements and interleukin-28B polymorphisms in response to pegylated interferon plus ribavirin therapy in hepatitis C virus 1B infection. (2012)
  • Author(s): Maekawa S
  • Journal Title: Hepatology. Volume: 56(5) Issue: 5 Pages: 1611-1621
  • DOI: 10.1002/hep.25826
  • Peer Reviewed
• [Journal Article] Causes of Thrombocytopenia in Chronic Hepatitis C Viral Infection (2012)
  • Author(s): Osada M
  • Journal Title: Clin Appl Thromb Hemost Volume: 12(Epub ahead of print) Issue: 3 Pages: 272-280
  • DOI: 10.1177/1076029611429124
  • Peer Reviewed
• [Journal Article] Analysis of viral amino acids sequences and the IL28B SNP influencing the development of hepatocellular carcinoma in chronic hepatitis (2011)
  • Author(s): Miura M, Maekawa S, Kadokura M, Sueki R, Komase K, Shindo H, Ohmori T, Kanayama A, Shindo K, Amemiya F, Nakayama Y, Kitamura T, Uetake T, Inoue T, Sakamoto M, Okada S, Enomoto N
  • Journal Title: Hepatol Int
  • Peer Reviewed
• [Journal Article] Characterization of naturally occurring protease inhibitor-resistance mutations in genotype 1b hepatitis C virus patients (2011)
  • Author(s): Shindo H, Maekawa S, Komase K, Kadokura M, Sueki R, Miura M, Shindo K, Amemiya F, Kitamura T, Nakayama Y, Uetake T, Inoue T, Sakamoto M, Okada S, Asahina Y, Izumi N, Honda M, Kaneko S, Enomoto N
  • Journal Title: Hepatol Int
  • Peer Reviewed
• [Journal Article] Analysis of the complete open reading frame of genotype 2b hepatitis C virus in association with the response to peginterferon and ribavirin therapy (2011)
  • Author(s): Kadokura M, Maekawa S, Sueki R, Miura M, Komase K, Shindo H, Amemiya F, Uetake T, Inoue T, Sakamoto M, Nakagawa M, Sakamoto N, Watanabe M, Enomoto N
  • Journal Title: PLoS One Volume: 6(9)
  • Peer Reviewed
• [Journal Article] Analysis of the complete open reading frame of hepatitis C virus in genotype 2a infection reveals critical sites influencing the response to peginterferon and ribavirin therapy (2011)
  • Author(s): Kadokura M, Maekawa S, Sueki R, Miura M, Komase K, Shindo H, Amemiya F, Uetake T, Inoue T, Sakamoto M, Nakagawa M, Sakamoto N, Watanabe M, Enomoto N
  • Journal Title: Hepatol Int
  • Peer Reviewed
• [Journal Article] A new method for induced fit docking (GENIUS) and its application to virtual screening of novel HCV NS3-4A protease inhibitors (2011)
  • Author(s): Takaya D, Yamashita A, Kamijo K, Gomi J, Ito M, Maekawa S, Enomoto N, Sakamoto N, Watanabe Y, Arai R, Umeyama H, Honma T, Matsumoto T, Yokoyama S
  • Journal Title: Bioorg Med Chem
  • Peer Reviewed
• [Journal Article] PERFECT Study Group. Cancer preventive effect of pegylated interferon α-2b plus ribavirin in a real-life clinical setting in Japan : PERFECT interim analysis (2011)
  • Author(s): Watanabe S, Enomoto N, Koike K, Izumi N, Takikawa H, Hashimoto E, Moriyasu F, Kumada H, Imawari M
  • Journal Title: Hepatol Res Volume: 41(10) Pages: 955-964
  • Peer Reviewed
• [Journal Article] Pre-treatment prediction of response to pegylated-interferon plus ribavirin for chronic hepatitis C using genetic polymorphism in IL28B and viral factors (2011)
  • Author(s): Kurosaki M, Tanaka Y, Nishida N, Sakamoto N, Enomoto N, Honda M, Sugiyama M, Matsuura K, Sugauchi F, Asahina Y, Nakagawa M, Watanabe M, Sakamoto M, Maekawa S, Sakai A, Kaneko S, Ito K, Masaki N, Tokunaga K, Izumi N, Mizokami M
  • Journal Title: J Hepatol Volume: 54(3) Pages: 439-48
  • Peer Reviewed
• [Journal Article] Association of gene expression involving innate immunity and genetic variation in IL28B with antiviral response (2011)
  • Author(s): Asahina Y, Tsuchiya K, Muraoka M, Tanaka K, Suzuki Y, Tamaki N, Hoshioka Y, Yasui Y, Katoh T, Hosokawa T, Ueda K, Nakanishi H, Itakura J, Takahashi Y, Kurosaki M, Enomoto N, Nitta S, Sakamoto N, Izumi N
  • Journal Title: Hepatology
  • Peer Reviewed
• [Journal Article] Relationship between polymorphisms of the inosine triphosphatase gene and anaemia or outcome after treatment with pegylated interferon and ribavirin (2011)
  • Author(s): Kurosaki M, Tanaka Y, Tanaka K, Suzuki Y, Hoshioka Y, Tamaki N, Kato T, Yasui Y, Hosokawa T, Ueda K, Tsuchiya K, Kuzuya T, Nakanishi H, Itakura J, Takahashi Y, Asahina Y, Matsuura K, Sugauchi F, Enomoto N, Nishida N, Tokunaga K, Mizokami M, Izumi N
  • Journal Title: Antivir Ther Volume: 16(5) Pages: 685-94
  • Peer Reviewed
• [Journal Article] Staging liver fibrosis by using liver-enhancement ratio of gadoxetic acid-enhanced MR imaging : comparison with aspartate aminotransferase-to-platelet ratio index (2011)
  • Author(s): Motosugi U, Ichikawa T, Oguri M, Sano K, Sou H, Muhi A, Matsuda M, Fujii H, Enomoto N, Araki T
  • Journal Title: Magn Reson Imaging Volume: 29(8) Pages: 1047-52
  • Peer Reviewed
• [Journal Article] Expression of keratin 19 is related to high recurrence of hepatocellular carcinoma after radiofrequency ablation (2011)
  • Author(s): Tsuchiya K, Komuta M, Yasui Y, Tamaki N, Hosokawa T, Ueda K, Kuzuya T, Itakura J, Nakanishi H, Takahashi Y, Kurosaki M, Asahina Y, Enomoto N, Sakamoto M, Izumi N
  • Journal Title: Oncology Volume: 80(3-4) Pages: 278-88
  • Peer Reviewed
• [Journal Article] Genome-wide association study identified ITPA/DDRGK1 variants reflecting thrombocytopenia in pegylated interferon and ribavirin therapy for chronic hepatitis C (2011)
  • Author(s): Tanaka Y, Kurosaki M, Nishida N, Sugiyama M, Matsuura K, Sakamoto N, Enomoto N, Yatsuhashi H, Nishiguchi S, Hino K, Hige S, Itoh Y, Tanaka E, Mochida S, Honda M, Hiasa Y, Koike A, Sugauchi F, Kaneko S, Izumi N, Tokunaga K, Mizokami M
  • Journal Title: Hum Mol Genet Volume: 20(17) Pages: 3507-16
  • Peer Reviewed
• [Journal Article] Will there be an HCV meeting in 2020? Summary of the 17th international meeting on hepatitis C virus and related viruses (2011)
  • Author(s): Wakita T, Suzuki T, Evans MJ, Shimotohno K, Chayama K, Matsuura Y, Hijikata M, Moriishi K, Seya T, Enomoto N, Koike K, Kato N, Kanto T, Hotta H
  • Journal Title: Gastroenterology Volume: 141(1)
  • Peer Reviewed
• [Journal Article] Outcome of hypovascular hepatic nodules revealing no gadoxetic acid uptake in patients with chronic liver disease (2011)
  • Author(s): Motosugi U, Ichikawa T, Sano K, Sou H, Onohara K, Muhi A, Amemiya F, Enomoto N, Matsuda M, Fujii H, Araki T
  • Journal Title: J Magn Reson Imaging Volume: 34(1) Issue: 1 Pages: 88-94
  • DOI: 10.1002/jmri.22630
  • Peer Reviewed
• [Journal Article] Analysis of viral amino acids sequences and the IL28B SNP influencing the development of hepatocellular carcinoma in chronic hepatitis C (2011)
  • Author(s): Miura M, Maekawa S, et.al
  • Journal Title: Hepatol Int. Volume: 6 Issue: 1 Pages: 386-396
  • DOI: 10.1007/s12072-011-9307-6
  • Peer Reviewed
• [Journal Article] Characterization of naturally occurring protease inhibitor-resistance mutations in genotype 1b hepatitis C virus patients (2011)
  • Author(s): Honda M, (他17名, 16番目)
  • Journal Title: Hepatol Int Epub ahead of print Volume: 2 Issue: 2 Pages: 482-490
  • DOI: 10.1007/s12072-011-9306-7
  • Peer Reviewed
• [Journal Article] A new method for induced fit docking (GENIUS) and its application to virtual screening of novel HCV NS3-4A protease inhibitors (2011)
  • Author(s): Takaya D, Sakamoto N, et al.
  • Journal Title: Bioorganic & Medicinal Chemistry Volume: 19(22) Issue: 22 Pages: 6892-6905
  • DOI: 10.1016/j.bmc.2011.09.023
  • Peer Reviewed
• [Journal Article] Analysis of the complete open reading frame of genotype 2b hepatitis C virus in association with the response to peginterferon and ribavirin therapy (2011)
  • Author(s): Kadokura M, Nakagawa M, Sakamoto N, Watanabe M, et al.
  • Journal Title: PLoS One Volume: 6(9) Issue: 9 Pages: e24514-e24514
  • DOI: 10.1371/journal.pone.0024514
  • Peer Reviewed
• [Journal Article] Will there be an HCV meeting in 2020? Summary of the 17th international meeting on hepatitis C virus and related viruses (2011)
  • Author(s): Wakita T, Suzuki T, Evans MJ, Shimotohno K, Chayama K, Matsuura Y, Hijikata M, Moriishi K, Seya T, Enomoto N, Koike K, Kato N, Kanto T, Hotta H
  • Journal Title: Gastroenterology Volume: 141 Issue: 1 Pages: 1-5
  • DOI: 10.1053/j.gastro.2011.05.027
  • Peer Reviewed
• [Journal Article] Analysis of the complete open reading frame of hepatitis C virus in genotype 2a infection reveals critical sites influencing the response to peginterferon and ribavirin therapy (2011)
  • Author(s): Kadokura M
  • Journal Title: Hepatol Int Volume: 5 Pages: 789-799
  • Peer Reviewed
• [Journal Article] PERFECT Study Group. Cancer preventive effect of pegylated interferon α-2b plus ribavirin in a real-life clinical setting in Japan : PERFECT interim analysis (2011)
  • Author(s): Watanabe S
  • Journal Title: Hepatol Res Volume: 41 Issue: 10 Pages: 955-964
  • DOI: 10.1111/j.1872-034x.2011.00847.x
  • Peer Reviewed
• [Journal Article] Genome-wide association study identified ITPA/DDRGK1 variants reflecting thrombocytopenia in pegylated interferon and ribavirin therapy for chronic hepatitis C (2011)
  • Author(s): Tanaka Y, Sakamoto N, et al.
  • Journal Title: Human Molecular Genetics Volume: 20(17) Issue: 17 Pages: 3507-3516
  • DOI: 10.1093/hmg/ddr249
  • Peer Reviewed