Role of mutated hepatic progenitor cells on hepatocarcinogenesis
| Project/Area Number |
23390196
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kyoto University |
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Principal Investigator |
MARUSAWA HIROYUKI 京都大学, 医学(系)研究科(研究院), 講師 (80324630)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2013: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Keywords | 肝癌 / 遺伝子変異 / 前駆細胞 / 幹細胞 / AID / 肝前駆細胞 |
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| Research Abstract |
Although the origin of cancer cells remains mostly unsolved at present, it appears reasonable to assume that long-lived tissue stem/progenitor cells can accumulate genetic alterations and hence could be the origin of tumor cells. Whether the stepwise accumulation of genetic alterations on originally normal hepatic stem/progenitor cells contributes to the development of tumor cells, however, remains unknown. We demonstrated that engrafted hepatic progenitor cells played a role in the origin of liver tumors, including both hepatocellular carcinoma and cholangiocellular carcinoma, through the accumulation of somatic mutations in a variety of target genes.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Leptin receptor somatic mutations are frequent in HCV-infected cirrhotic liver and associated with hepatocellular carcinoma.2014
Author(s)
Ikeda A, Shimizu T, Matsumoto Y, Fujii Y, Eso Y, Inuzuka T, Mizuguchi A, Shimizu K, Hatano E, Uemoto S, Chiba T, Marusawa H
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Journal Title
Gastroenterology
Volume: 146
Issue: 1
Pages: 222-232
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] A model of liver carcinogenesis originating from hepatic progenitor cells with accumulation of genetic alterations.2014
Author(s)
Soo Ki Kim, Akihiro Nasu, Junji Komori, Takahiro Shimizu, Yuko Matsumoto, Yasuko Minaki, Kenji Kohno, Kazuharu Shimizu, Shinji Uemoto, Tsutomu Chiba, Hiroyuki Marusawa.
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Journal Title
International Journal of Cancer
Volume: 134
Issue: 5
Pages: 1067-76
DOI
Related Report
Peer Reviewed / Open Access
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