| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2013: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Research Abstract |
Although the origin of cancer cells remains mostly unsolved at present, it appears reasonable to assume that long-lived tissue stem/progenitor cells can accumulate genetic alterations and hence could be the origin of tumor cells. Whether the stepwise accumulation of genetic alterations on originally normal hepatic stem/progenitor cells contributes to the development of tumor cells, however, remains unknown. We demonstrated that engrafted hepatic progenitor cells played a role in the origin of liver tumors, including both hepatocellular carcinoma and cholangiocellular carcinoma, through the accumulation of somatic mutations in a variety of target genes.
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