Innovative therapeutic strategies: Cellular reprogramming of gastrointestinal cancer stem and host cells.

• Project/Area Number: 23390199
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Osaka University
• Principal Investigator: ISHII Hideshi 大阪大学, 医学(系)研究科(研究院), 教授 (10280736)
• Co-Investigator(Kenkyū-buntansha): MORI Masaki 大阪大学, 大学院・医学系研究科, 教授 (70190999)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000); Fiscal Year 2013: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2012: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
• Keywords: 癌幹細胞 / マイクロRNA / ニッチ / 消化器癌

Research Abstract

By utilizing small compounds, we examined the effects of cellular reprogramming, which is supposed useful to suppression and eradication of human intractable malignancies including gastrointestinal cancers. Our data indicated that it is possible to reprogram cells to pluripotency by direct transfection of double-stranded miRNAs as a combination for immune cells ,too. It holds significant potential for biomedical research and regenerative medicine. We examined the underlying mechanism of synthesized, or virus-mediated miRNA-based reprogramming and the possible application for cancer cell reprogramming as a novel therapeutic approach. It is expected that pharmacogenomics of targeting reprogramming machineries sensitize cancer cell populations that were largely refractory to conventional chemotherapy. These novel approaches are beneficial for cancer research and may open an avenue to clinical treat gastrointestinal cancers that are difficult to cure.

Research Products

• [Journal Article] SSEA-3 as a novel amplifying cancer cell surface marker in colorectal cancers (2013)
  • Author(s): Suzuki, Y., Haraguchi, N., Takahashi, H., Uemura, M., Nishimura, J., Hata, T., Takemasa, I., Mizushima, T., Ishii, H., Doki, Y., Mori, M., Yamamoto, H
  • Journal Title: Int. J. Oncol Volume: 42(1) Pages: 161-167
• [Journal Article] Depletion of Jarid1b induces cellular senescence in human colorectal cancer (2013)
  • Author(s): Ohta, K., Haraguchi, N., Kano, Y., Kagawa, Y., Konno, M., Nishikawa, S., Hamabe, A., Hasegawa, S., Ogawa, H., Fukusumi, T., Uemura, M., Nishimura, J., Hata, T., Takemasa, I., Nishimura, T., Noguchi, Y., Ozaki, M., Kudo, T., Sakai, D., Satoh, T., Fukami, M., Ishii, M., Yamamoto, H., Doki, Y., Mori, M., Ishii, H
  • Journal Title: Int. J. Oncol Volume: 42(4) Pages: 1212-1218
• [Journal Article] The rs6983267 SNP Is Associated with MYC Transcription Efficiency, Which Promotes Progression and Worsens Prognosis of Colorectal Cancer (2013)
  • Author(s): Takatsuno, Y., Mimori, K., Yamamoto, K., Sato, T., Niida, A., Inoue, H., Imoto, S., Kawano, S., Yamaguchi, R., Toh, H., Iinuma, H., Ishimaru, S., Ishii, H., Suzuki, S., Tokudome, S., Watanabe, M., Tanaka, J.I., Kudo, S.E., Mochizuki, H., Kusunoki, M., Yamada, K., Shimada, Y., Moriya, Y., Miyano, S., Sugihara, K., Mori, M
  • Journal Title: Ann. Surg. Oncol Volume: 20(4) Pages: 1395-1402
• [Journal Article] Jumonji/Arid1b (Jarid1b) protein modulates human esophageal cancer cell growth (2013)
  • Author(s): Kano, Y., Konno, M., Ohta, K., Haraguchi, N., Nishikawa, S., Kagawa, Y., Hamabe, A., Hasegawa, S., Ogawa, H., Fukusumi, T., Noguchi, Y., Ozaki, M., Kudo, T., Sakai, D., Satoh, T., Ishii, M., Mizohata, E., Inoue, T., Mori, M., Doki, Y., Ishii, H
  • Journal Title: Mol. Clin. Oncol Volume: 1(4) Pages: 753-757
• [Journal Article] The REV7 subunit of DNA polymerase ζ is essential for primordial germ cell maintenance in the mouse (2013)
  • Author(s): Watanabe, N., Mii, S., Asai, N., Asai, M., Niimi, K., Ushida, K., Kato, T., Enomoto, A., Ishii, H., Takahashi, M., Murakumo, Y
  • Journal Title: J. Biol. Chem Volume: 288(15) Pages: 10459-10471
• [Journal Article] Effect of in vivo administration of reprogramming factors in the mouse liver (2013)
  • Author(s): Tomokuni, A., Eguchi, H., Hoshino, H., Dewi, DL., Nishikawa, S., Kano, Y., Miyoshi, N., Tojo, A., Kobayashi, S., Gotoh, N., Hinohara, K., Fusaki, N., Saito, T., Suemizu, H., Wada, H., Kobayashi, S., Marubashi, S., Tanemura, M., Doki, Y., Mori, M., Ishii, H., Nagano, H
  • Journal Title: Oncol. Lett Volume: 6(2) Pages: 323-328
• [Journal Article] Aldehyde dehydrogenase high gastric cancer stem cells are resistant to chemotherapy (2013)
  • Author(s): Nishikawa, S., Konno, M., Hamabe, A., Hasegawa, S., Kano, Y., Ohta, K., Fukusumi, T., Sakai, D., Kudo, T., Haraguchi, N., Satoh, T., Takiguchi, S., Mori, M., Doki, Y., Ishii, H
  • Journal Title: Int. J. Oncol Volume: 42(4) Pages: 1437-1442
• [Journal Article] CD49f-positive cell population efficiently enriches colon cancer-initiating cells (2013)
  • Author(s): Haraguchi, N., Ishii, H., Mimori, K., Ohta, K., Uemura, M., Nishimura, J., Hata, T., Takemasa, I., Mizushima, T., Yamamoto, H., Doki, Y., Mori, M
  • Journal Title: Int. J. Oncol Volume: 43(2) Pages: 425-430
• [Journal Article] Adipose-derived mesenchymal stem cells and regenerative medicine (2013)
  • Author(s): Konno, M., Hamabe, A., Hasegawa, S., Ogawa, H., Fukusumi, T., Nishikawa, S., Ohta, K., Kano, Y., Ozaki, M., Noguchi, Y., Sakai, D., Kudoh, T., Kawamoto, K., Eguchi, H., Satoh, T., Tanemura, M., Nagano, H., Doki, Y., Mori, M., Ishii, H
  • Journal Title: Dev. Growth Differ Volume: 55(3) Pages: 309-318
• [Journal Article] SSEA-3 as a novel amplifying cancer cell surface marker in colorectal cancers. (2013)
  • Author(s): Suzuki, Y., Haraguchi, N., Takahashi, H., Uemura, M., Nishimura, J., Hata, T., Takemasa, I., Mizushima, T., Ishii, H., Doki, Y., Mori, M., Yamamoto, H.
  • Journal Title: Int. J. Oncol. Volume: 42 Pages: 161-167
  • DOI: 10.3892/ijo.2012.1713
  • Peer Reviewed
• [Journal Article] Depletion of Jarid1b induces cellular senescence in human colorectal cancer. (2013)
  • Author(s): Ohta, K., Haraguchi, N., Kano, Y., Kagawa, Y., Konno, M., Nishikawa, S., Hamabe, A., Hasegawa, S., Ogawa, H., Fukusumi, T., Uemura, M., Nishimura, J., Hata, T., Takemasa, I., Nishimura, T., Noguchi, Y., Ozaki, M., Kudo, T., Sakai, D., Satoh, T., Fukami, M., Ishii, M., Yamamoto, H., Doki, Y., Mori, M., Ishii, H.
  • Journal Title: Intern. J. Oncol. Volume: 42 Issue: 4 Pages: 1212-1218
  • DOI: 10.3892/ijo.2013.1799
  • Peer Reviewed
• [Journal Article] The rs6983267 SNP Is Associated with MYC Transcription Efficiency, Which Promotes Progression and Worsens Prognosis of Colorectal Cancer. (2013)
  • Author(s): Takatsuno Y
  • Journal Title: Ann Surg Oncol Volume: 20 Issue: 4 Pages: 1395-402
  • DOI: 10.1245/s10434-012-2657-z
  • Peer Reviewed
• [Journal Article] Jumonji/Arid1b (Jarid1b) protein modulates human esophageal cancer cell growth. (2013)
  • Author(s): Kano, Y., Konno, M., Ohta, K., Haraguchi, N., Nishikawa, S., Kagawa, Y., Hamabe, A., Hasegawa, S., Ogawa, H., Fukusumi, T., Noguchi, Y., Ozaki, M., Kudo, T., Sakai, D., Satoh, T., Ishii, M., Mizohata, E., Inoue, T., Mori, M., Doki, Y., Ishii, H.
  • Journal Title: Mol．Clin. Oncol. Volume: 1 Issue: 4 Pages: 753-757
  • DOI: 10.3892/mco.2013.127
  • Peer Reviewed
• [Journal Article] The REV7 subunit of DNA polymerase ζ is essential for primordial germ cell maintenance in the mouse. (2013)
  • Author(s): Watanabe, N., Mii, S., Asai, N., Asai, M., Niimi, K., Ushida, K., Kato, T., Enomoto, A., Ishii, H., Takahashi, M., Murakumo, Y.
  • Journal Title: J. Biol. Chem. Volume: 288 Issue: 15 Pages: 10459-10471
  • DOI: 10.1074/jbc.m112.421966
  • Peer Reviewed
• [Journal Article] Effect of in vivo administration of reprogramming factors in the mouse liver. (2013)
  • Author(s): 6） Tomokuni, A., Eguchi, H., Hoshino, H., Dewi, DL., Nishikawa, S., Kano, Y., Miyoshi, N., Tojo, A., Kobayashi, S., Gotoh, N., Hinohara, K., Fusaki, N., Saito, T., Suemizu, H., Wada, H., Kobayashi, S., Marubashi, S., Tanemura, M., Doki, Y., Mori, M.,et.al.
  • Journal Title: Oncol Lett. Volume: 6 Issue: 2 Pages: 323-328
  • DOI: 10.3892/ol.2013.1418
  • Peer Reviewed
• [Journal Article] Aldehyde dehydrogenase high gastric cancer stem cells are resistant to chemotherapy. (2013)
  • Author(s): Nishikawa, S., Konno, M., Hamabe, A., Hasegawa, S., Kano, Y., Ohta, K., Fukusumi, T., Sakai, D., Kudo, T., Haraguchi, N., Satoh, T., Takiguchi, S., Mori, M., Doki,Y., Ishii, H.
  • Journal Title: Int. J. Oncol. Volume: 42 Issue: 4 Pages: 1437-1442
  • DOI: 10.3892/ijo.2013.1837
  • Peer Reviewed
• [Journal Article] CD49f-positive cell population efficiently enriches colon cancer-initiating cells. (2013)
  • Author(s): Haraguchi, N., Ishii, H., Mimori, K., Ohta, K., Uemura, M., Nishimura, J., Hata, T., Takemasa, I., Mizushima, T., Yamamoto, H., Doki, Y., Mori, M.
  • Journal Title: Int J Oncol. Volume: 43 Issue: 2 Pages: 425-430
  • DOI: 10.3892/ijo.2013.1955
  • Peer Reviewed
• [Journal Article] Adipose-derived mesenchymal stem cells and regenerative medicine. (2013)
  • Author(s): Konno, M., Hamabe, A., Hasegawa, S., Ogawa, H., Fukusumi, T., Nishikawa, S., Ohta, K., Kano, Y., Ozaki, M., Noguchi, Y., Sakai, D., Kudoh, T., Kawamoto, K., Eguchi, H., Satoh, T., Tanemura, M., Nagano, H., Doki, Y., Mori, M., Ishii, H.
  • Journal Title: Dev. Growth Differ. Volume: 55 Issue: 3 Pages: 309-318
  • DOI: 10.1111/dgd.12049
  • Peer Reviewed
• [Journal Article] Down-regulation of miR-125a-3p in human gastric cancer and its clinicopathological significance (2012)
  • Author(s): Hashiguchi, Y., Nishida, N., Mimori, K., Sudo, T., Tanaka, F., Shibata, K., Ishii, H., Mochizuki, H., Hase, K., Doki, Y., Mori, M
  • Journal Title: Int. J. Oncol Volume: 40(5) Pages: 1477-1482
• [Journal Article] MicroRNA-10b is a prognostic indicator in colorectal cancer and confers resistance to the chemotherapeutic agent 5-fluorouracil in colorectal cancer cells (2012)
  • Author(s): Nishida, N., Yamashita, S., Mimori, K., Sudo, T., Tanaka, F., Shibata, K., Yamamoto, H., Ishii, H., Doki, Y., Mori, M
  • Journal Title: Ann. Surg. Oncol Volume: 19(9) Pages: 3065-3071
• [Journal Article] Overexpression of PFTK1 predicts resistance to chemotherapy in patients with oesophageal squamous cell carcinoma (2012)
  • Author(s): Miyagaki, H., Yamasaki, M., Miyata, H., Takahashi, T., Kurokawa, Y., Nakajima, K., Takiguchi, S., Fujiwara, Y., Ishii, H., Tanaka, F., Mori, M., Doki, Y
  • Journal Title: Br. J. Cancer Volume: 106(5) Pages: 947-954
• [Journal Article] Increased risk for CRC in diabetic patients with the nonrisk allele of SNPs at 8q24 (2012)
  • Author(s): Ishimaru, S., Mimori, K., Yamamoto, K., Inoue, H., Imoto, S., Kawano, S., Yamaguchi, R., Sato, T., Toh, H., Iinuma, H., Maeda, T., Ishii, H., Suzuki, S., Tokudome, S., Watanabe, M., Tanaka, J., Kudo, S.E., Sugihara, K., Hase, K., Mochizuki, H., Kusunoki, M., Yamada, K., Shimada, Y., Moriya, Y., Barnard, G.F., Miyano, S., Mori, M
  • Journal Title: Ann. Surg. Oncol Volume: 19(9) Pages: 2853-2858
• [Journal Article] Copy number loss of FBXW7 is related to gene expression and poor prognosis in esophageal squamous cell carcinoma (2012)
  • Author(s): Yokobori, T., Mimori, K., Iwatsuki, M., Ishii, H., Tanaka, F., Sato, T., Toh, H., Sudo, T., Iwaya, T., Tanaka, Y., Onoyama, I., Kuwano, H., Nakayama, K.I., Mori, M
  • Journal Title: Int. J. Oncol Volume: 41(1) Pages: 253-259
• [Journal Article] Genotoxic therapy stimulates error-prone DNA repair in dormant hepatocellular cancer stem cells (2012)
  • Author(s): Nishikawa, S., Ishii, H., Haraguchi, N., Kano, Y., Fukusumi, T., Ohta, K., Ozaki, M., Sakai, D., Satoh, T., Nagano, H., Doki, Y., Mori, M
  • Journal Title: Exp. Ther. Med Volume: 3(6) Pages: 959-962
• [Journal Article] Absence of CD71 transferrin receptor characterizes human gastric adenosquamous carcinoma stem cells (2012)
  • Author(s): Ohkuma, M., Haraguchi, N., Ishii, H., Mimori, K., Tanaka, F., Kim, H.M., Shimomura, M., Hirose, H., Yanaga, K., Mori, M
  • Journal Title: Ann. Surg. Oncol Volume: 19(4) Pages: 1357-1364
• [Journal Article] Increased CD13 expression reduces reactive oxygen species, promoting survival of liver cancer stem cells via an epithelial-mesenchymal transition-like phenomenon (2012)
  • Author(s): Kim, H.M., Haraguchi, N., Ishii, H., Ohkuma, M., Okano, M., Mimori, K., Eguchi, H., Yamamoto, H., Nagano, H., Sekimoto, M., Doki, Y., Mori, M
  • Journal Title: Ann. Surg. Oncol Volume: 19
• [Journal Article] Microarray analysis of colorectal cancer stromal tissue reveals upregulation of two oncogenic microRNA clusters (2012)
  • Author(s): Nishida, N., Nagahara, M., Sato, T., Mimori, K., Sudo, T., Tanaka, F., Shibata, K., Ishii, H., Sugihara, K., Doki, Y., Mori, M
  • Journal Title: Clin. Cancer Res Volume: 18(11) Pages: 3054-3070
• [Journal Article] Transcriptome study of dormant gastrointestinal cancer stem cells (2012)
  • Author(s): Nishikawa, S., Dewi, D.L., Ishii, H., Konno, M., Haraguchi, N., Kano, Y., Fukusumi, T., Ohta, K., Noguchi, Y., Ozaki, M., Sakai, D., Satoh, T., Doki, Y., Mori, M
  • Journal Title: Int. J. Oncol Volume: 41(3) Pages: 979-984
• [Journal Article] Dicer 1, ribonuclease type III modulates a reprogramming effect in colorectal cancer cells (2012)
  • Author(s): Dewi, D.L., Ishii, H., Haraguchi, N., Nishikawa, S., Kano, Y., Fukusumi, T., Ozaki, M., Saito, T., Sakai, D., Satoh, T., Doki, Y., Mori, M
  • Journal Title: Int. J. Mol. Med Volume: 29(6) Pages: 1060-1064
• [Journal Article] Hypoxia and TP53 deficiency for induced pluripotent stem cell-like properties in gastrointestinal cancer (2012)
  • Author(s): Hoshino, H., Nagano, H., Haraguchi, N., Nishikawa, S., Tomokuni, A., Kano, Y., Fukusumi, T., Saito, T., Osaki, M., Sakai, D., Satoh, T., Eguchi, H., Sekimoto, M., Doki, Y., Mori, M., Ishii, H
  • Journal Title: Int. J. Oncol Volume: 40(5) Pages: 1423-1430
• [Journal Article] Down-regulation of miR-125a-3p in human gastric cancer and its clinicopathological significance (2012)
  • Author(s): Yojiro Hashiguchi, Naohiro Nishida, Koshi Mimori, Tomoya Sudo, Fumiaki Tanaka, Kohei Shibata, Hideshi Ishii, Hidetaka Mochizuki, Kazuo Hase, Yuichiro Doki, Masaki Mori
  • Journal Title: Int J Oncol Volume: 40(5) Pages: 1477-82
  • DOI: 10.3892/ijo.2012.1363
  • Peer Reviewed
• [Journal Article] MicroRNA-10b is a Prognostic Indicator in Colorectal Cancer and Confers Resistance to the Chemotherapeutic Agent 5-Fluorouracil in Colorectal Cancer Cells (2012)
  • Author(s): Naohiro Nishida, Shinya Yamashita, Koshi Mimori, Tomoya Sudo, Fumiaki Tanaka, Kohei Shibata, Hirofumi Yamamoto, Hideshi Ishii, Yuichiro Doki, Masaki Mori
  • Journal Title: ANNALS OF SURGICAL ONCOLOGY Volume: (Epub) Issue: 9 Pages: 10-10
  • DOI: 10.1245/s10434-012-2246-1
  • Peer Reviewed
• [Journal Article] Overexpression of PFTK1 predicts resistance to chemotherapy in patients with oesophageal squamous cell carcinoma. (2012)
  • Author(s): Miyagaki, H.,et.al
  • Journal Title: Br. J. Cancer Volume: 106 Issue: 5 Pages: 947-954
  • DOI: 10.1038/bjc.2012.35
  • Peer Reviewed
• [Journal Article] Increased Risk for CRC in Diabetic Patients with the Nonrisk Allele of SNPs at 8q24 (2012)
  • Author(s): Ishimaru S, Iinuma H, et al
  • Journal Title: Ann Surg Oncol Volume: 21(in press) Issue: 9 Pages: 21-21
  • DOI: 10.1245/s10434-012-2278-6
  • Peer Reviewed
• [Journal Article] Copy number loss of FBXW7 is related to gene expression and poor prognosis in esophageal squamous cell carcinoma (2012)
  • Author(s): Mar ; 113(2): 204-9. 2. Yokobori T, Mimori K, Iwatsuki M, Ishii H, Tanaka F, Sato T, Toh H, Sudo T, Iwaya T, Tanaka Y, Onoyama I, Kuwano H, Nakayama KI, Mori M.
  • Journal Title: Int J Oncol Volume: 41(1) Pages: 253-9
  • DOI: 10.3892/ijo.2012.1436
  • Peer Reviewed
• [Journal Article] Genotoxic therapy stimulates error-prone DNA repair in dormant hepatocellular cancer stem cells. (2012)
  • Author(s): Nishikawa, S.,et.al
  • Journal Title: Exp. Ther. Med Volume: 3 Pages: 959-962
  • Peer Reviewed
• [Journal Article] Absence of CD71 transferrin receptor characterizes human gastric adenosquamous carcinoma stem cells (2012)
  • Author(s): Ohkuma M, Haraguchi N, Ishii H, Mimori K, Tanaka F, Kim HM, Shimomura M, Hirose H, Yanaga K, Mori M.
  • Journal Title: Ann Surg Oncol Volume: 19(4) Issue: 4 Pages: 1357-64
  • DOI: 10.1245/s10434-011-1739-7
  • Peer Reviewed
• [Journal Article] Microarray Analysis of Colorectal Cancer Stromal Tissue Reveals Upregulation of Two Oncogenic miRNA Clusters (2012)
  • Author(s): Nishida N, Nagahara M, Sato T, Mimori K, Sudo T, Tanaka F, et al
  • Journal Title: Clinical Cancer Reserch Volume: (Epub) Issue: 11 Pages: 3054-3070
  • DOI: 10.1158/1078-0432.ccr-11-1078
  • Peer Reviewed
• [Journal Article] Transcriptome study of dormant gastrointestinal cancer stem cells. (2012)
  • Author(s): Nishikawa, S.,et.al
  • Journal Title: Int. J. Oncol Volume: 41 Issue: 3 Pages: 979-984
  • DOI: 10.3892/ijo.2012.1531
  • Peer Reviewed
• [Journal Article] Dicer 1, ribonuclease type III modulates a reprogramming effect in colorectal cancer cells (2012)
  • Author(s): Dewi DL, Ishii H, Haraguchi N, Nishikawa S, Kano Y, Fukusumi T, Ozaki M, Saito T, Sakai D, Satoh T, Doki Y, Mori M.
  • Journal Title: Int J Mol Med Volume: 29(6) Pages: 1060-4
  • DOI: 10.3892/ijmm.2012.945
  • Peer Reviewed
• [Journal Article] Hypoxia and TP53 deficiency for induced pluripotent stem cell-like properties in gastrointestinal cancer (2012)
  • Author(s): Hoshino H, Nagano H, Haraguchi N, Nishikawa S, Tomokuni A, Kano Y, Fukusumi T, Saito T, Ozaki M, Sakai D, Satoh T, Eguchi H, Sekimoto M, Doki Y, Mori M, Ishii H.
  • Journal Title: Int J Oncol Volume: 40(5) Pages: 1423-30
  • DOI: 10.3892/ijo.2012.1346
  • Peer Reviewed
• [Journal Article] MicroRNA-125a-5p is an independent prognostic factor in gastric cancer, and inhibits the proliferation of human gastric cancer cells in combination with trastuzumab (2011)
  • Author(s): Nishida, N., Mimori, K., Fabbri, M., Yokobori, T., Sudo, T., Tanaka, F., Shibata, K., Ishii, H., Doki, Y., Mori, M
  • Journal Title: Clin. Cancer Res Volume: 1;17(9) Pages: 2725-2733
• [Journal Article] Gain-of-function oncogenic mutations in TP53 enhance defined factor-mediated cellular reprogramming (2011)
  • Author(s): Moon, JH., Ishii, H., Dewi, D.L., Kano, Y., Yamamoto, K., Nishikawa, S., Fujiwara, Y., Doki, Y., Mori, M
  • Journal Title: Nat. Preceding Pages: 1-15
• [Journal Article] Significance of Lgr5(+ve) Cancer Stem Cells in the Colon and Rectum (2011)
  • Author(s): Takahashi, H., Ishii, H., Nishida, N., Takemasa, I., Mizushima, T., Ikeda, M., Yokobori, T., Mimori, K., Yamamoto, H., Sekimoto, M., Doki, Y., Mori, M
  • Journal Title: Ann. Surg. Oncol Volume: 18(4) Pages: 1166-1174
• [Journal Article] STC2 : A Predictive Marker for Lymph Node Metastasis in Esophageal Squamous-Cell Carcinoma (2011)
  • Author(s): Kita, Y., Mimori, K., Iwatsuki, M., Yokobori, T., Ieta, K., Tanaka, F., Ishii, H., Okumura, H., Natsugoe, S., Mori, M
  • Journal Title: Ann. Surg. Oncol Volume: 18(1) Pages: 261-272
• [Journal Article] The significance of PITX2 overexpression in human colorectal cancer (2011)
  • Author(s): Hirose, H., Ishii, H., Mimori, K., Tanaka, F., Takemasa, I., Mizushima, T., Ikeda, M., Yamamoto, H., Sekimoto, M., Doki, Y., Mori, M
  • Journal Title: Ann. Surg. Oncol Volume: 18(10) Pages: 3005-3012
• [Journal Article] Increased CD13 Expression Reduces Reactive Oxygen Species, Promoting Survival of Liver Cancer Stem Cells via an Epithelial-Mesenchymal Transition-like Phenomenon (2011)
  • Author(s): Kim HM, Haraguchi N, Ishii H, Ohkuma M, Okano M, Mimori K, Eguchi H, Yamamoto H, Nagano H, Sekimoto M, Doki Y, Mori M.
  • Journal Title: Ann Surg Oncol Volume: 31 Issue: S3 Pages: 539-548
  • DOI: 10.1245/s10434-011-2040-5
  • Peer Reviewed
• [Journal Article] The future prospects and subject of the liver cancer stem cells study for the clinical application (2011)
  • Author(s): Haraguchi N., Ishii H., Nagano H., Doki Y., Mori M.
  • Journal Title: Gastroenterology Volume: (Epub)
  • Peer Reviewed
• [Journal Article] MicroRNA-125a-5p is an independent prognostic factor in gastric cancer, and inhibits the proliferation of human gastric cancer cells in combination with trastuzumab (2011)
  • Author(s): Nishida N, Mimori K, Fabbri M, Yokobori T, Sudo T, Tanaka F, Shibata K, Ishii H, Doki Y, Mori M.]
  • Journal Title: Clin Cancer Res Volume: 17(9) Issue: 9 Pages: 2725-33
  • DOI: 10.1158/1078-0432.ccr-10-2132
  • Peer Reviewed
• [Journal Article] Combination use of anti-CD133 antibody and SSA lectin can effectively enrich cells with high tumorigenicity (2011)
  • Author(s): MoriwakiK、Okudo K, Miyoshi E, et al
  • Journal Title: Cancer Science Volume: 102 Issue: 6 Pages: 1164-1170
  • DOI: 10.1111/j.1349-7006.2011.01923.x
  • NAID: 10029294388
  • Peer Reviewed
• [Journal Article] Gain-of-function oncogenic mutations in TP53 enhance defined factor-mediated cellular reprogramming (2011)
  • Author(s): Moon JH., Ishii H., Dewi DL., Kano Y., Yamamoto K., Nishikawa S., Fujiwara Y., Doki Y., Mori M.
  • Journal Title: Nat Preceding Volume: －
  • DOI: 10.1038/npre.2011.5681.1
  • Peer Reviewed
• [Journal Article] Significance of Lgr5(+ ve) cancer stem (2011)
  • Author(s): Takahashi H, Ishii H, Nishida N, Takemasa I, Mizushima T, Ikeda M, Yokobori T, Mimori K, Yamamoto H, Sekimoto M, Doki Y, Mori M.
  • Journal Title: cells in the colon and rectum Ann Surg Oncol Volume: 18(4) Issue: 4 Pages: 1166-74
  • DOI: 10.1245/s10434-010-1373-9
  • Peer Reviewed
• [Journal Article] STC2 : A Predictive Marker for Lymph Node Metastasis in Esophageal Squamous-Cell Carcinoma (2011)
  • Author(s): Kita Y, Mimori K, Iwatsuki M, Yokobori T, Ieta K, Tanaka F, Ishii H, Okumura H, Natsugoe S, Mori M.
  • Journal Title: Ann Surg Oncol Volume: 18(1) Issue: 1 Pages: 261-72
  • DOI: 10.1245/s10434-010-1271-1
  • Peer Reviewed
• [Journal Article] The Significance of PTTX2 Overexpression in Human Colorectal Cancer (2011)
  • Author(s): Hirose Hajime, Ishii Hideshi, Mimori Koshi, et al
  • Journal Title: ANNALS OF SURGICAL ONCOLOGY Volume: 18 Issue: 10 Pages: 3005-3012
  • DOI: 10.1245/s10434-011-1653-z
  • Peer Reviewed
• [Journal Article] Identification of recurrence-related microRNAs in the bone marrow of breast cancer patients. (2010)
  • Author(s): Ota D, Mimori K, Yokobori T, Iwatsuki M, Kataoka A, Masuda N, Ishii H, Ohno S, Mori M.
  • Journal Title: Int J Oncol 38 Volume: 38(4) Issue: 4 Pages: 955-962
  • DOI: 10.3892/ijo.2011.926
  • Peer Reviewed
• [Presentation] 難治性消化器癌に対する革新的医療技術の創出 (2013)
  • Author(s): 石井秀始, 土岐祐一郎, 森正樹
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2013-10-05
• [Presentation] 難治性消化器癌を克服する新しい創薬展開 (2013)
  • Author(s): 石井秀始
  • Organizer: 第23回日本サイトメトリー学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2013-06-22
• [Presentation] 難治性消化器癌に対する革新的医療技術の創出 (2013)
  • Author(s): 石井秀始、土岐 祐一郎、森 正樹
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（神奈川県）
• [Presentation] 癌幹細胞研究の現状と展望 (2013)
  • Author(s): 石井秀始
  • Organizer: 第23回日本サイトメトリー学会学術集会
  • Place of Presentation: 日本医科大学橘桜会館（東京都）
• [Presentation] 難治性消化器癌を克服する新しい創薬展開 (2013)
  • Author(s): 石井秀始
  • Organizer: 第23回日本サイトメトリー学会学術集会
  • Place of Presentation: 日本医科大学橘桜会館（東京都）
• [Presentation] Cancer stem cell research for innovative cell-modifying technologies (2012)
  • Author(s): 石井秀始
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2012-10-19
• [Presentation] 先端医療 : がん幹細胞理論に基づく新規治療開発 (2012)
  • Author(s): 石井秀始
  • Organizer: 第10回日本臨床腫瘍学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2012-07-28
• [Presentation] Leucine-rich repeat-containing G-protein-coupled receptor５（Lgr５）のヒト腸管における発現解析 (2012)
  • Author(s): 浜部敦史 他13名
  • Organizer: 第２３回日本消化器癌発生学会総会
  • Place of Presentation: ルネッサンスリゾートナルト（徳島県）
• [Presentation] 胃癌幹細胞の同定とその生物学的解析 (2012)
  • Author(s): 西川晋平 他14名
  • Organizer: 第２３回日本消化器癌発生学会総会
  • Place of Presentation: ルネッサンスリゾートナルト（徳島県）
• [Presentation] Cancer stem cell research for innovative cell-modifying technologies (2012)
  • Author(s): 石井秀始
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 国立京都国際会館（京都府）
• [Presentation] 先端医療：がん幹細胞理論に基づく新規治療開発 (2012)
  • Author(s): 石井秀始
  • Organizer: 第10回日本臨床腫瘍学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府）
• [Presentation] Induced Pluripotent Stem Cell Reprogramming for Innovative Cell-Modifying Technology in Cancer (2012)
  • Author(s): 石井秀始
  • Organizer: 第33回日本炎症・再生医学会シンポジウム
  • Place of Presentation: ホテル日航福岡（福岡県）
• [Presentation] 肝臓癌幹細胞の分離・同定と治療標的化へ向けた検討 (2011)
  • Author(s): 原口直紹, 石井秀始, 永野浩昭, 土岐祐一郎, 森正樹
  • Organizer: 第21回日本サイトメトリー学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2011-06-26
• [Presentation] 肝臓癌幹細胞の分離・同定と治療標的化へ向けた検討 (2011)
  • Author(s): 原口直紹, 石井秀始, 永野浩昭, 土岐祐一郎, 森正樹
  • Organizer: 第21回日本サイトメトリー学会学術集会
  • Place of Presentation: 京都市国際交流会館(京都府)
  • Year and Date: 2011-06-26
• [Presentation] 肝細胞癌の再発・転移を制御するmicroRNA の探索 (2011)
  • Author(s): 友國晃, 三森功士, 和田浩志, 小林省吾, 丸橋繁, 江口英利, 種村匡弘, 石井秀始, 永野浩昭, 土岐祐一郎, 森正樹
  • Organizer: 第21回日本サイトメトリー学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2011-06-25
• [Presentation] 転移性大腸癌患者における骨髄中細胞の分画分析 (2011)
  • Author(s): 山下晋也, 石井秀始, 山本浩文, 三森功士, 友國晃, 西田尚弘, 原口直紹, 西村潤一, 竹政伊知郎, 水島恒和, 池田正孝, 関本貢嗣, 土岐祐一郎, 森正樹
  • Organizer: 第21回日本サイトメトリー学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2011-06-25
• [Presentation] 癌・固形腫瘍の診断・治療 (2011)
  • Author(s): 石井秀始, 大重秀行
  • Organizer: 第21回日本サイトメトリー学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2011-06-25
• [Presentation] 癌・固形腫瘍の診断・治療 (2011)
  • Author(s): 石井秀始、大重英行
  • Organizer: 第21回日本サイトメトリー学会学術集会
  • Place of Presentation: 京都市国際交流会館(京都府)
  • Year and Date: 2011-06-25
• [Presentation] 転移性大腸癌患者における骨髄中細胞の分画分析 (2011)
  • Author(s): 山下晋也, 石井秀始, 山本浩文, 三森功士, 友國晃, 西田尚弘, 原口直紹, 西村潤一, 竹政伊知郎, 水島恒和, 池田正孝, 関本貢嗣, 土岐祐一郎, 森正樹
  • Organizer: 第21回日本サイトメトリー学会学術集会
  • Place of Presentation: 京都市国際交流会館(京都府)
  • Year and Date: 2011-06-25
• [Presentation] 肝細胞癌の再発・転移を制御するmicroRNAの探索 (2011)
  • Author(s): 友國晃, 三森功士, 和田浩志, 小林省吾, 丸橋繁, 江口英利, 種村匡弘, 石井秀始, 永野浩昭, 土岐祐一郎, 森正樹
  • Organizer: 第21回日本サイトメトリー学会学術集会
  • Place of Presentation: 京都市国際交流会館(京都府)
  • Year and Date: 2011-06-25