Analysis of hepatocarcinogenesis based on gender and mitochondrial biogenesis
| Project/Area Number |
23390201
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
HINO Keisuke 川崎医科大学, 医学部, 教授 (80228741)
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| Co-Investigator(Kenkyū-buntansha) |
IKEDA Masanori 岡山大学, 医歯(薬)学総合研究科, 准教授 (30315767)
KISHI Fumio 川崎医科大学, 医学部, 教授 (40153077)
KORENAGA Masaaki 川崎医科大学, 医学部, 准教授 (70420536)
NISHINA Sohji 川崎医科大学, 医学部, 講師 (70550961)
HARA Yuichi 川崎医科大学, 医学部, 講師 (60550952)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2012: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2011: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Keywords | ミトコンドリア / 酸化ストレス / 肝発がん / C型肝炎ウイルス / 性差 / Ｃ型肝炎ウイルス / 肝細胞癌 / mitophagy / Parkin / 活性酸素種 / autophagy / エストロゲン |
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| Research Abstract |
Oxidative stress plays an important role in hepatocarcinogenesis. Hepatitis C virus (HCV) is well known to induce the production of reactive oxygen species (ROS). In the present study we have shown that hepatitis C virus (HCV) core protein suppresses mitophagy (mitochondrial quality control) , which may lead to continuous induction of ROS production and inhibition of mitochondrial biogenesis. We also demonstrated that hepatic oxidative stress was augumented in ovariectomized transgenic mice expressing the HCV polyprotein by attenuation of antioxidant potential through inhibition of AMPK/PGC-1alpha signaling. These results may account in part for the mechanisms by which HCV-infected women are at high risk for HCC development when some period had passed after menopause.
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Report
(4 results)
Research Products
(51 results)
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[Journal Article] New susceptibility and resistance HLA-DP alleles to HBV-related diseases identified by a trans-ethnic association study in Asia.2014
Author(s)
Nishida N, Sawai H, Kashiwase K, Minami M, Sugiyama M, Seto WK, Yuen MF, Posuwan N, Poovorawan Y, Ahn SH, Han KH, Matsuura K, Tanaka Y, Kurosaki M, Asahina Y, Izumi N, Kang JK, （省略）, Tokunaga K, and Mizokami M
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Journal Title
PLoS One
Volume: 9
Issue: 2
Pages: e86449-e86449
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] New susceptibility and resistance HLA-DP alleles to HBV-related diseases identified by a trans-ethnic association study in Asia.2014
Author(s)
Nishida N, Sawai H, Kashiwase K, Minami M, Sugiyama M, Seto WK, Yuen MF, Posuwan N, Poovorawan Y, Ahn SH, Han KH, Matsuura K, Tanaka Y, Kurosaki M, Asahina Y, Izumi N, Yamamoto K, Sakaida I, Murawaki Y, Itoh Y, Tamori A, Orito E, Honda M, Kaneko S, Mita E, Hino K, Tokunaga K, Mizokami M, et al
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Treatment of nonalcoholic steatohepatitis with vitamins E and C: a pilot study2013
Author(s)
Kawanaka M, Nishino K, Suehiro M, Goto D, Urata N, Oka T, Kawamoto H, Nakamura H, Yodoi J, Hino K, Yamada G
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Journal Title
Hepatic Medicine: Evidence and Research
Volume: 5
Pages: 11-16
Related Report
Peer Reviewed
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[Presentation] The hepatitis C virus core protein suppresses mitophagy by affecting Parkin
Author(s)
Yuichi Hara, Izumi Yanatori , Masanori Ikeda, Sohji Nishina, Yasuyuki Tomiyama, Fumio Kishi, Kazunori Toida, Nobuyuki Kato, Kazuaki Chayama , Keisuke Hino
Organizer
Cell Symposium Mitochondria:from Signaling to Disease
Place of Presentation
Sheraton Lisboa, Lisbon, Portugal
Related Report
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[Presentation] Hepatitis C virus core protein suppresses mitophagy by interacting with Parkin
Author(s)
Yuhichi Hara, Izumi Yanatori, EmiKiyokage, Sohji Nishina, Yasuyuki Tomiyama, Kazunori Toida, Masanori Ikeda, Fumio Kishi, Nobuyuki Kato, Keisuke Hino
Organizer
The 64th Annual Meeting of the American Association for the Study of Liver Diseases
Place of Presentation
WALTER E. Washington Convention Center Washington,DC.US
Related Report
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