Elucidation of the cardiovascular disease by the innovative three-dimensional proteome analytical method
Project/Area Number |
23390204
|
Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Circulatory organs internal medicine
|
Research Institution | The University of Tokyo |
Principal Investigator |
SUZUKI Toru 東京大学, 医学部附属病院, 准教授 (90359620)
|
Co-Investigator(Kenkyū-buntansha) |
AIZAWA Kenichi 東京大学, 医学部附属病院, 特任助教 (70436484)
|
Project Period (FY) |
2011-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2011: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
|
Keywords | 循環器・高血圧 / 蛋白質 / プロテオーム / ストレス / トランスレーショナル・リサーチ / トランスレーショナル・リサーチ |
Research Abstract |
We analyzed innovative three-dimensional proteome in consideration of the diachronic analysis that was necessary for the elucidation of the cardiovascular disease in this study. We performed the bioactive examination based on methodology of the disease proteome analysis about a disease-related factor and checked participation in disease condition of a patient. Our initial clinical experience shows that it is strongly associated with presence of restenosis. Reduced levels of the amino-terminal processed peptide, BNP(5-32), relative to BNP(3-32) (as the index parameter BNP[5-32]/BNP[3-32] ratio), were seen in patients with restenosis. In addition, we added examination about the generation mechanism of this disease-related factor and got the knowledge that certain protease participated in. We will consider what kind of activity this protease has in blood and will aim at the condition of a patient elucidation of the cardiovascular disease in future.
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Report
(4 results)
Research Products
(48 results)
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[Journal Article] Inverse correlations between serum ADAMTS13 levels and systolic blood pressure, pulse pressure, and serum C-reactive protein levels observed at a general health examination in a Japanese population : a cross-sectional study2013
Author(s)
Enokoku K, Ikeda H, Kato R, Kume Y, Yoshida H, Ono T, Aizawa K, Suzuki T, Yamzaki T, Yatomi Y
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Journal Title
Clin. Chim. Acta
Volume: 421
Pages: 147-151
Related Report
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[Journal Article] Stroke and outcomes in patients with acute type A aortic dissection.2013
Author(s)
Bossone E, Corteville DC, Harris KM, Suzuki T, Fattori R, Hutchison S, Ehrlich MP, Pyeritz RE, Steg PG, Greason K, Evangelista A, Kline-Rogers E, Montgomery DG, Isselbacher EM, Nienaber CA, Eagle KA.
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Journal Title
Circulation
Volume: 128
Issue: 11_suppl_1
DOI
Related Report
Peer Reviewed
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[Journal Article] Extent of preoperative false lumen thrombosis does not influence long-term survival in patients with acute type a aortic dissection.2013
Author(s)
Larsen M, Bartnes K, Tsai TT, Eagle KA, Evangelista A, Nienaber CA, Suzuki T, Fattori R, Froehlich JB, Hutchison S, Sundt TM, Januzzi JL, Isselbacher EM, Montgomery DG, Myrmel T
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Journal Title
J Am Heart Assoc
Volume: 2
Issue: 4
DOI
Related Report
Peer Reviewed
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