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Gene-environmental interaction for common arrhythmias based on GWAS data

Research Project

Project/Area Number 23390205
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionTokyo Medical and Dental University

Principal Investigator

FURUKAWA Tetsushi  東京医科歯科大学, 難治疾患研究所, 教授 (80251552)

Co-Investigator(Renkei-kenkyūsha) SASANO Tetsuo  東京医科歯科大学, 大学院・医歯学総合研究科, 准教授 (00466898)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2012: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2011: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Keywords分子心臓病態学 / 不整脈 / 心房細動 / 心室細動 / ゲノム / 遺伝子多型 / 心血管疾患 / 全ゲノム相関解析 / 突然死 / 遺伝子 / 心臓突然死 / GWAS / 遺伝子変異 / 炎症 / 酸化ストレス
Research Abstract

Understanding of arrhythmias has been substantially advanced by gene mutation analysis in familiar arrhythmia syndromes and studies of ionic channels with the patch-clamp technique in cell-level. The remaining major problem in arrhythmia research is the understanding and therapeutic strategy for atrial and ventricular fibrillation. On the other hand, genome-wide-association study (GWAS) is a comprehensive, un-biased approach and could reveal novel pathways leading to diseases. Thus, we performed biological functional analysis for genes that had been newly identified in GWAS of atrial and ventricular fibrillation. In atrial fibrillation, we found one strong genetic risk related to trigger mechanism, and multiple weak genetic risks related to maintenance mechanism. In ventricular fibrillation, we found that a defective transcription factor expressed in the His-Purkinje system causes exercise-induced idiopathic ventricular fibrillation.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (98 results)

All 2014 2013 2012 2011 Other

All Journal Article (14 results) (of which Peer Reviewed: 14 results) Presentation (70 results) (of which Invited: 13 results) Book (14 results)

  • [Journal Article] The generation of induced pluripotent stem cells from a patient with KCNH2 G603D, without LQT2 disease associated symptom2013

    • Author(s)
      Okata S, Yuasa S, Yamane T, Furukawa T, Fukuda K
    • Journal Title

      J. Med. Dent. Sci

      Volume: 60 Pages: 17-22

    • NAID

      130006943948

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Non-genomic action of sex steroid hormones and cardiac repolarization2013

    • Author(s)
      Kurokawa J, Furukawa T
    • Journal Title

      Biol. Pharm. Bul

      Volume: 36 Pages: 8-12

    • NAID

      130003361360

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of an hERG activator, ICA-1 05574, on electrophysilogical properties of canine hearts2013

    • Author(s)
      Asayama M, Kurokawa J, Shirakawa K, Okuyama H, Kagawa T, Okada J, Sugiura S, Hisada T, Furukawa T
    • Journal Title

      J. Pharmacol. Sci

      Volume: 121 Pages: 1-8

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Region- and condition-dependence of the membrane and Ca2+ clocks in the sinus node2013

    • Author(s)
      Kurokawa J, Furukawa T
    • Journal Title

      Circ. J

      Volume: 76 Pages: 293-294

    • NAID

      10030035264

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of an hERG activator, ICA-105574, on electriphysiological properties of canine hearts2013

    • Author(s)
      Asayama M
    • Journal Title

      Journal of Pharmacological Science

      Volume: 121 Pages: 1-8

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Disease characterization using LQTS-specific induced pluripotent stem cells2012

    • Author(s)
      Egashira T, Yuasa S, Suzuki T, Aizawa Y, Yamanaka H, Matsuhashi T, Ohno Y, Tohyama S, Okata S, Seki T, Kuroda Y, Yae K, Hashimoto H, Tanaka T, Hattori F, Sato T, Miyoshi S, Takatsuki S, Murata M, Kurokawa J, Furukawa T, Makita N, Aiba T, Shimizu W, Horie M, Kamiya K, Kodama I, Ogawa S, Fukuda K
    • Journal Title

      Cardiovasc. Res

      Volume: 95 Pages: 419-429

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Meta analysis in the AFGen consortium identifies six novel loci for atrial fibrillation2012

    • Author(s)
      Ellinor PT, Lunetta KL, Albert CM, Glazer NL, Ritchie MD, Smith AV, Arking DE, Mü ller M, Krijthe BP, Lubitz SA, Bis JC, Chung MK, M, Ozaki K, Roberts JD, Smith JG, Pfeufer A, Sinner MF, Lohman K, Ding J, Smith NL, Smith JD, Rienstra M, Rice KM, Van Wagoner DR, Magnani JW, Wakili R, Clauss S, Rotter J, Steinbeck G, Launer LJ, Davies RW, Borkovich M, Harris TB, Lin H, Vö lker U, Vö lzke H, Milan DJ, Hofman A, Boerwinkle E, Chen LY, Soliman EZ, Voight BF, Li G, Chakravarti A, Kubo M, Tedrow U, Rose LM, Ridker PM, Conen D, Tsunoda T, Furukawa T, Sotoodehnia N, Xu S, Kamatani N, Levy D, Nakamura Y, Parvez B, Mahida S, Furie KL, Rosand J, Muhammad R, Psaty BM, Meitinger T, Perz S, Wichmann HE, Witteman JCM, Kao WHL, Kathiresan S, Roden DM, Uitterlinden AG, Rivadeneira F, McKnight B, Sjö gren M, Newman AB, Liu Y, Gollob MH, Melander O, Tanaka T, Stricker BHC, Felix SB, Alonso A, Darbar D, Barnard J, Chasman D, Heckbert SR, Benjamin EJ, Gudnason V, Kä ä b S
    • Journal Title

      Nat. Genet

      Volume: 44 Pages: 670-675

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Meta-analysis identifies six new susceptibility loci for atrial fibrillation2012

    • Author(s)
      Ellinor PT
    • Journal Title

      Nature Genetics

      Volume: 44 Issue: 6 Pages: 670-675

    • DOI

      10.1038/ng.2261

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stretch of atrial myocytes stimulates recruitment of macrophages via ATP released through gap-junction channels2012

    • Author(s)
      Oishi S
    • Journal Title

      Journal of Pharmacological Science

      Volume: 120 Pages: 296-304

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Disease characterization using LQTS-specific induced pluripotent stem cells2012

    • Author(s)
      Egashira T
    • Journal Title

      Cardiovascular Research

      Volume: 95 Pages: 419-429

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Region- and condition-dependence of the membrane and Ca2+ clocks in the sinus node2012

    • Author(s)
      Kurokawa J, Furukawa T
    • Journal Title

      Circulation Journal

      Volume: 76 Pages: 293-294

    • NAID

      10030035264

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Circulating KCNH2 current-activating factor in patients with heart failure and ventricular tachyarrhythmia2011

    • Author(s)
      Sugiyama H, Nakamura K, Morita H, Akagi S, Tani Y, Katayama Y, Nishii N, Miyoshi T, Nagase S, Kohno K, Kusano FK, Ohe T, Kurokawa J, Furukawa T, Ito H
    • Journal Title

      PLoS ONE

      Volume: 6

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Atrial fibrillation and inflammation2011

    • Author(s)
      Furukawa T, Oishi S, Sasano T
    • Journal Title

      Nihon Yakurigaku Zasshi

      Volume: 138 Pages: 192-195

    • NAID

      10029896339

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Circulating KCNH2 current-activating factor in patients with heart failure and ventricular tachyarrhythmia2011

    • Author(s)
      Siguyama H, Nakamura K, Morita H, Akagi S, Tani Y, Katayama Y, Nishii N, Miyoshi T, Nagase S, Kohno K, Kusano FK, Ohe T, Kurokawa J, Furukawa T, Ito H
    • Journal Title

      PLoS ONE

      Volume: 6

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] パネキシンの心房・心室における異なった役割2014

    • Author(s)
      古川哲史
    • Organizer
      一般シンポジウムS14"心疾患と炎症応答"日本薬学会第134年会
    • Place of Presentation
      熊本
    • Year and Date
      2014-03-29
    • Related Report
      2013 Final Research Report
  • [Presentation] Genetic defects in a His-Purkinje system-specific transcription factor as a cause of J wave syndrome. In Symposium 3 "J-wave syndrome and related electrical disorders"2014

    • Author(s)
      Sasano T, Koizumi A, Kimura W, Nogami A, Fukamizu S, Sakurada H, Hirao K, Isobe M, Kimura A, Miyamoto Y, Shimizu W, Miura N, Furukawa T
    • Organizer
      The 78th Annual Scientific Meeting of the Japanese Circulation Society
    • Year and Date
      2014-03-23
    • Related Report
      2013 Final Research Report
  • [Presentation] Effect of SNP on 9q22 (rs6479562) on the progression from paroxysmal atrial fibrillation to persistent atrial fibrillation2014

    • Author(s)
      Sekigawa M, Satoh A, Nitta J, Sato Y, Honda Y, Kuroda S, Kanoh M, Suzuki M, Inaba O, Muramatsu K, Yamato T, Matsumura Y, Asakawa K, Ebana Y, Furukawa T, Hirao K, Isobe M
    • Organizer
      The 78th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      Tokyo
    • Year and Date
      2014-03-23
    • Related Report
      2013 Final Research Report
  • [Presentation] Na+ channel beta-subunit affects the phenotype in long QT syndrome type 3 and Brugada syndrome induced pluripotent stem cell-derived cardiomyocytes2014

    • Author(s)
      Okata S, Yuasa S, Suzuki T, Egashira T, Kuroda Y, Tanaka A, Makita N, Kurokawa J, Furukawa T, Fukuda K
    • Organizer
      The 78th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      Tokyo
    • Year and Date
      2014-03-22
    • Related Report
      2013 Final Research Report
  • [Presentation] The relationship between the single nucleotide polymorphism rs2634073 and arrhythmogenic superior vena cava in the patients with atrial fibrillation2014

    • Author(s)
      Sato A, Honda Y, Sato Y, Kuroda S, Kanoh M, Sekigawa M, Suzuki M, Inaba O, Muramatsu K, Yamato T, Matsumura Y, Nitta J, Asakawa K, Ebana Y, Furukawa T
    • Organizer
      The 78th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      Tokyo
    • Year and Date
      2014-03-22
    • Related Report
      2013 Final Research Report
  • [Presentation] Arrhythmogenicity of the superior vena cava and common single nucleotide polymorphisms in patients with paroxysmal atrial fibrillation2014

    • Author(s)
      Takahashi Y, Ebana Y, Hayashi T, Miwa N, Masumura M, Goto K, Sakakibara A, Itoh J, Ohmi T, Ohno M, Katoh R, Nozato T, Satoh Y, Furukawa T, Hirao K, Isobe M
    • Organizer
      The 78th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      Tokyo
    • Year and Date
      2014-03-22
    • Related Report
      2013 Final Research Report
  • [Presentation] Sex hormones on ventricular electrophysiology2014

    • Author(s)
      Furukawa T
    • Organizer
      The 2014 Annual Scientific Meeting
    • Place of Presentation
      Taipei, Tanwan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] High-fat diet increases vulnerability to atrial arrhythmia by conduction disturbance via microRNA2014

    • Author(s)
      Takahashi K, Sasano T, Koizumi A, Sugiyama K, Furukawa T, Isobe M
    • Organizer
      The 78th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      東京国際フォーラム、東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Genome-wide association study (GWAS) for a cardiac arrhythmia, atrial fibrillation2014

    • Author(s)
      Furukawa T, Ebana Y, Nogami A, Nitta J, Kobayashi K, Mokura M, Takahashi Y, Hachiya H, Miyazaki S, Nakamura H, Hirao K, Isobe M, Ozaki K, Kubo M, Tanaka T
    • Organizer
      The 78th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      東京国際フォーラム、東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Disease modeling using iPS cells2014

    • Author(s)
      Furukawa T, Okata S, Yuasa S, Suzuki T, Makita N, Kurokawa J, Egashira T, Yamakawa H, Seki T, Aizawa T, Hashimoto H, Kuroda Y, Tanaka A, Yae K, Murata M, Aiba T, Shimizu W, Horie M, Kodama I, Ogawa S, Fukuda K
    • Organizer
      The 78th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      東京国際フォーラム、東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Impact of SNP on IL6R (rs7514452) for age at onset of atrial fibrillation2014

    • Author(s)
      Sato Y, Satoh A, Nitta J, Honda Y, Kuroda S, Sekigawa M, Kanoh M, Suzuki M, Inaba O, Muramatsu K, Yamato T, Matsumura Y, Asakawa K, Ebana Y, Furukawa T, Hirao K, Isobe M
    • Organizer
      The 78th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      東京国際フォーラム、東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Impact of SNP on 1q24 (rsrs593479) in PRRX1 for the age at onset of atrial fibrillation2014

    • Author(s)
      Sato Y, Satoh A, Nitta J, Honda Y, Kuroda S, Sekigawa M, Kanoh M, Suzuki M, Inaba O, Muramatsu K, Yamato T, Matsumura Y, Asakawa K, Ebana Y, Furukawa T, Hirao K, Isobe M
    • Organizer
      The 78th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      東京国際フォーラム、東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Arrhythmogenicity of the superior vena cava and common single nucleotide polymorphisms in patients with paroxysmal atrial fibrillation2014

    • Author(s)
      Takahashi Y, Ebana Y, Hayashi T, Miwa N, Masumura M, Goto K, Sakakibara A, Itoh J, Ohmi T, Ohno M, Katoh R, Nozato T, Satoh Y, Furukawa T, Hirao K, Isobe M
    • Organizer
      The 78th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      東京国際フォーラム、東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] The relationship between the single nucleotide polymorphism rs2634073 and arrhythmogenic superior vena cava in the patients with atrial fibrillation2014

    • Author(s)
      Sato A, Honda Y, Sato Y, Kuroda S, Kanoh M, Sekigawa M, Suzuki M, Inaba O, Muramatsu K, Yamato T, Matsumura Y, Nitta J, Asakawa K, Ebana Y, Furukawa T.
    • Organizer
      The 78th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      東京国際フォーラム、東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Na+ channel beta-subunit affects the phenotype in long QT syndrome type 3 and Brugada syndrome induced pluripotent stem cell-derived cardiomyocytes2014

    • Author(s)
      Okata S, Yuasa S, Suzuki T, Egashira T, Kuroda Y, Tanaka A, Makita N, Kurokawa J, Furukawa T, Fukuda K
    • Organizer
      The 78th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      東京国際フォーラム、東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Effect of SNP on 9q22 (rs6479562) on the progression from paroxysmal atrial fibrillation to persistent atrial fibrillation2014

    • Author(s)
      Sekigawa M, Satoh A, Nitta J, Sato Y, Honda Y, Kuroda S, Kanoh M, Suzuki M, Inaba O, Muramatsu K, Yamato T, Matsumura Y, Asakawa K, Ebana Y, Furukawa T, Hirao K, Isobe M
    • Organizer
      The 78th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      東京国際フォーラム、東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Genetic defects in a His-Purkinje system-specific transcription factor as a cause of J wave syndrome.2014

    • Author(s)
      Sasano T, Koizumi A, Kimura W, Nogami A, Fukamizu S, Sakurada H, Hirao K, Isobe M, Kimura A, Miyamoto Y, Shimizu W, Miura N, Furukawa T
    • Organizer
      The 78th Annual Scientific Meeting of the Japanese Circulation Society,
    • Place of Presentation
      東京国際フォーラム、東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] パネキシンの心房・心室における異なった役割2014

    • Author(s)
      古川哲史
    • Organizer
      日本薬学会
    • Place of Presentation
      ホテル日航熊本、熊本
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Localized cAMP signaling in the heart regarding a cross-talk with a non-genomic pathway of progesterone receptors2013

    • Author(s)
      Kodama M, Goryoda S, Tomida T, Furukawa T, Kurokawa J
    • Organizer
      The 2ndHD Physiology International Symposium
    • Place of Presentation
      丸の内マイプラザホール、東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Functional optimization of commercially available human induced pluripotent stem cell-derived cardiomyocytes for evaluation of drug-induced QT prolongation2013

    • Author(s)
      Min L, Kanda Y, Ashihara T, Sekino Y, Furukawa T, Kurokawa J
    • Organizer
      The 2ndHD Physiology International Symposium
    • Place of Presentation
      丸の内マイプラザホール、東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] The Cutting Edge of Cardiac Arrhythmia Genomics – Channelopathy, GWAS, and Beyond GWAS2013

    • Author(s)
      Furukawa T
    • Organizer
      第28回日本不整脈学会年会
    • Place of Presentation
      グランプリホテル新高輪、東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Contractile behaviors of human-induced pluripotent stem cell-derived cardiomyocyte monolayers evaluated with an image-based analysis using motion vector prediction technique: A comparison with extracellular electrophysiology2013

    • Author(s)
      Hayakawa T, Kunihiro T, Ando T, Unno H, Kobayashi S, Matsui E, Yada H, Kanda Y, Kurokawa J, Furukawa T
    • Organizer
      13th annual meeting of Safety Pharmacology Society
    • Place of Presentation
      Rotterdam,Netherland
    • Related Report
      2013 Annual Research Report
  • [Presentation] ヒトiPS由来心筋を用いた心毒性評価系の構築2013

    • Author(s)
      黒川洵子、李敏、諫田泰成、関野祐子、古川哲史
    • Organizer
      第30回日本心電学会学術集会
    • Place of Presentation
      リンクスステーションホテル青森、青森
    • Related Report
      2013 Annual Research Report
  • [Presentation] ゲノム研究から見えてきた心房細動発現メカニズム2013

    • Author(s)
      古川哲史
    • Organizer
      第30回日本心電学会学術集会
    • Place of Presentation
      リンクスステーションホテル青森、青森
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Human ES- and iPS-derived cardiomyocytes. A comparative electrophysiological syudy2013

    • Author(s)
      Lopez-Redondo F
    • Organizer
      57th Biophysical Society Annual Meeting
    • Place of Presentation
      Philadelphia
    • Related Report
      2012 Annual Research Report
  • [Presentation] Involvement of PDE2 in a localized regulation of the L-type Ca2+ channels by progesterone2013

    • Author(s)
      Kurokawa J
    • Organizer
      57th Biophysical Society Annual Meeting
    • Place of Presentation
      Philadelphia
    • Related Report
      2012 Annual Research Report
  • [Presentation] Localization of a non-genomic pathway of cardiac progesterone receptors2013

    • Author(s)
      Goryoda S
    • Organizer
      第86回日本薬理学会大会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] パネキシンと心房リモデリング、心房細動2013

    • Author(s)
      古川哲史
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      船堀
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Ionic mechanism for sex difference in cardiac arrhythmias2013

    • Author(s)
      古川哲史
    • Organizer
      第77回日本循環器学会大会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] During the transdifferentiation from mesenchyme to cardiomyocyte, atrial fibrillation associated locus 4q25 enhanced PITX2c expression to interact with its promoter2013

    • Author(s)
      Ebana Y
    • Organizer
      第77回日本循環器学会大会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] A SNP in 4p15.2 was identified as a novel atrial fibrillation associated locus through the GWAS in Japanese population2013

    • Author(s)
      Ebana Y
    • Organizer
      第77回日本循環器学会大会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヒトiPS由来心筋の電気生理学的性質におよぼす分化誘導時間の影響2012

    • Author(s)
      黒川洵子、遠山周吾、村田光繁、古川哲史、福田恵一
    • Organizer
      第132回日本薬学会年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Atrial fibrillation-associated locus 4q25 has the cis-regulatory function toward the neighboring PITX2 gene2012

    • Author(s)
      Ebana Y, Ozaki K, Tanaka T, Isobe M, Furukawa T
    • Organizer
      The 76^<th> Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      福岡
    • Year and Date
      2012-03-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] A variant in locus of caveolin 1 confers atrial fibrillation anf left atrial enlargement2012

    • Author(s)
      Ebana Y, Makita S, Hirao K, Arai H, Isobe M, Furukawa T
    • Organizer
      The 76^<th> Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      福岡
    • Year and Date
      2012-03-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Genetic deletion of Nos1ap enhanced cardiac impairment and death on oxidative stress induced by doxorubicin2012

    • Author(s)
      Sasano T, Tsuchiya J, Okamura T, Katou N, Hirao K, Isobe M, Furukawa T
    • Organizer
      The 76^<th> Annual Scientific Meeting of the Japanese circulation Society
    • Place of Presentation
      福岡
    • Year and Date
      2012-03-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Scna1a mutant knock-in mouse revealed sudden unexpected death in epilepsy (SUDEP) in Dravet syndrome as cardiac arrhythmia origin2012

    • Author(s)
      Sasano T, Horigome Y, Koizumi A, Takahashi Y, Ogiwara I, Furukawa T
    • Organizer
      The 76^<th> Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      福岡
    • Year and Date
      2012-03-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Polymorphisms on atrial fibrillation-associated locus 4q25 could accelerate the disease onset and the recurrence after pulmonary vein isolation2012

    • Author(s)
      Ebana Y, Hachiya H, Inaba O, Nitta J, Swawabe M, Nogami A, Takahashi A, Nakamura H, Hirao K, Isobe M, Furukawa T
    • Organizer
      The 76^<th> Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      福岡
    • Year and Date
      2012-03-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 心筋L型カルシウム電流に対するジヒドロテストステロンの非ゲノム作用の性差に対する交感神経系刺激の関与2012

    • Author(s)
      Fernando Lopez-Redondo, 黒川洵子、古川哲史
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都
    • Year and Date
      2012-03-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] ATP放出抑制はマウス圧負荷モデル心房における催不整脈性を抑制する2012

    • Author(s)
      大石咲子、笹野哲郎、古川哲史
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都
    • Year and Date
      2012-03-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Genetically engineered mouse model for arrhythmia research2012

    • Author(s)
      Furukawa T
    • Organizer
      5th APHRS
    • Place of Presentation
      Taipei
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] High-throughput genotyping technology in the future study of atrial fibrillation2012

    • Author(s)
      Furukawa T
    • Organizer
      5th APHRS
    • Place of Presentation
      Taipei
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Use of iPS-derived cardia myocytes for arrhythmia research2012

    • Author(s)
      Furukawa T
    • Organizer
      5th APHRS
    • Place of Presentation
      Taipei
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 炎症と不整脈2012

    • Author(s)
      古川哲史
    • Organizer
      第29回日本心電学会学術集会
    • Place of Presentation
      千葉
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 構造から読み解くNa+チャネル機能2012

    • Author(s)
      古川哲史
    • Organizer
      第29回日本心電学会学術集会
    • Place of Presentation
      千葉
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 次世代の不整脈研究2012

    • Author(s)
      古川哲史
    • Organizer
      第29回日本心電学会学術集会
    • Place of Presentation
      千葉
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 心房細動のゲノムワイド関連研究で同定されたGene Xに関する機能解析2012

    • Author(s)
      小島聖美
    • Organizer
      第29回日本心電学会学術集会
    • Place of Presentation
      千葉
    • Related Report
      2012 Annual Research Report
  • [Presentation] 心房細動関連遺伝子座4q25の遺伝子多型によるPITX2遺伝子発現の制御2012

    • Author(s)
      江花有亮
    • Organizer
      第29回日本心電学会学術集会
    • Place of Presentation
      千葉
    • Related Report
      2012 Annual Research Report
  • [Presentation] Evaluation of contractile behavior of human iPS cell-derived cardiomyocytes based on motion vector prediction method2012

    • Author(s)
      Hayakawa T
    • Organizer
      第39回日本毒性学会
    • Place of Presentation
      仙台
    • Related Report
      2012 Annual Research Report
  • [Presentation] Contractile behavior of human-induced pluripotent stem cell-derivced cardiomyocyte monolayers evaluated with an image-based analysis using motion vector prediction technique: a comparison with extracellular electrophysiology2012

    • Author(s)
      Hayakawa T
    • Organizer
      Safety Pharmacology Society 12th Annual Meeting
    • Place of Presentation
      Phoenix
    • Related Report
      2012 Annual Research Report
  • [Presentation] 新規心臓転写因子による心臓細胞運命決定と機能的な心臓再生2012

    • Author(s)
      森田唯加
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] マウス胎児心臓における冠血管走行の性差2011

    • Author(s)
      児玉昌美、萩原理生、有馬勇一郎、西山功一、栗原裕基、古川哲史、黒川洵子
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Stretch-induced ATP release from atrial myocytes as a trigger of inflammation and atrial tachyarrhythmias2011

    • Author(s)
      Furukawa T, Oishi S, Sasano T
    • Organizer
      The 28^<th> Annual Meeting of the International Society for Heart Research Japanese Section
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2011-12-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] Genetics deletion of transcription factor in cardiac conduction system mimicked early repolarization syndrome in mouse2011

    • Author(s)
      Sasano T, Koizumi A, Kimura W, Miura N, Hirao K, Isobe M, Furukawa T
    • Organizer
      The 28^<th> Annual Meeting of the International Society for Heart Research Japanese Section
    • Place of Presentation
      東京
    • Year and Date
      2011-12-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] NOS1AP deletion enhanced ventricular arrhythmogenicity and cardiac death in pressure overloaded conduction2011

    • Author(s)
      Sasano S, Hirao K, Okamura T, Kato N, Isobe M, Furukawa T
    • Organizer
      The 28^<th> Annual Meeting of the International Society for Heart Research Japanese Section
    • Place of Presentation
      東京
    • Year and Date
      2011-12-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] Hyperthermia-induced arrhythmias and sudden death in mouse model of Dravet syndrome2011

    • Author(s)
      Sasano T, Horigome Y, Takahashi Y, Ogiwara I, Isobe M, Furukawa T
    • Organizer
      The 28^<th> Annual Meeting of the International Society for Heart Research Japanese Section
    • Place of Presentation
      東京
    • Year and Date
      2011-12-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] Hyperthermia-induced ventricular tachycardia and sudden cardiac death in mouse model of Dravet syndrome2011

    • Author(s)
      Sasano T, Horigome Y, Takahashi Y, Ogiwara I, Furukawa T
    • Organizer
      4^<th> Asia Pacific Heart Rhythm Society scientific Session (APHRS 2011), 26^<th> Annual Scientific Session of tne Japanese Heart Rhythm Society, 28^<th> Annual Scientific Session of the Japanese Society of Electrophysiology
    • Place of Presentation
      福岡
    • Year and Date
      2011-09-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] Genetic risks of atrial fibrillation in Japan2011

    • Author(s)
      Furukawa T
    • Organizer
      4^<th> Asia Pacific Heart Rhythm Society scientific Session (APHRS 2011), 26^<th> Annual Scientific Session of the Japanese Heart Rhythm Society, 28^<th> Annual Scientific Session of the Japanese Society of Electrophysiology
    • Place of Presentation
      福岡(招待講演)
    • Year and Date
      2011-09-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] A variant in locus of caveolin 1 confers atrial fibrillation and left atrial enlargement2011

    • Author(s)
      Kishihara Y, Ebana Y, Hachiya H, Hirao K, Isobe M, Furukawa T
    • Organizer
      4^<th> Asia Pacific Heart Rhythm Society scientific Session (APHRS 2011), 26^<th> Annual Scientific Session of the Japanese Heart Rhythm Society, 28^<th> Annual Scientific Session of the Japanese Society of Electrophysiology
    • Place of Presentation
      福岡
    • Year and Date
      2011-09-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Non-genomic regulation of K+ and Ca2+ channels by sex hormones2011

    • Author(s)
      Furukawa T
    • Organizer
      4^<th> Asia Pacific Heart Rhythm Society scientific Session (APHRS 2011), 26^<th> Annual Scientific Session of the Japanese Heart Rhythm Society, 28^<th> Annual Scientific Session of the Japanese Society of Electrophysiology
    • Place of Presentation
      福岡(招待講演)
    • Year and Date
      2011-09-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] J wave syndrome-early repolarization or delayed depolarization?2011

    • Author(s)
      Furukawa T
    • Organizer
      4^<th> Asia Pacific Heart Rhythm Society scientific Session (APHRS 2011), 26^<th> Annual Scientific Session of the Japanese Heart Rhythm Society, 28^<th> Annual Scientific Session of the Japanese Society of Electrophysiology
    • Place of Presentation
      福岡(招待講演)
    • Year and Date
      2011-09-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] Atrial fibrillation-associated locus 4q25 has the cis-regulatory function toward the neighboring genes2011

    • Author(s)
      Ebana Y, Hachiya H, Hirao K, Isobe M, Furukawa T
    • Organizer
      4^<th> Asia Pacific Heart Rhythm Society scientific Session (APHRS 2011), 26^<th> Annual Scientific Session of the Japanese Heart Rhythm Society, 28^<th> Annual Scientific Session of the Japanese Society of Electrophysiology
    • Place of Presentation
      福岡
    • Year and Date
      2011-09-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] NOS1AP destruction enhanced susceptibility to oxidative stress in doxorubicin-induced cardiomyopathy2011

    • Author(s)
      Tsuchiya J, Sasano T, Okamura T, Kato N, Furukawa T
    • Organizer
      4^<th> Asia Pacific Heart Rhythm Society scientific Session (APHRS 2011), 26^<th> Annual Scientific Session of the Japanese Heart Rhythm Society, 28^<th> Annual Scientific Session of the Japanese Society of Electrophysiology
    • Place of Presentation
      福岡
    • Year and Date
      2011-09-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] Genetic destruction of transcription factor in His-Purkinje system mimicked J wave syndrome in mouse2011

    • Author(s)
      Koizumi A, Sasano T, Kimura W, Miura N, Furukawa T
    • Organizer
      4^<th> Asia Pacific Heart Rhythm Society scientific Session (APHRS 2011), 26^<th> Annual Scientific Session of the Japanese Heart Rhythm Society, 28^<th> Annual Scientific Session of the Japanese Society of Electrophysiology
    • Place of Presentation
      福岡
    • Year and Date
      2011-09-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] Electrophysiological characterization of cardiomyocyte-like cells differentiated from human iPS cells2011

    • Author(s)
      Furukawa T
    • Organizer
      The 75^<th> Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      横浜(招待講演)
    • Year and Date
      2011-08-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] Extracellular ATP released through pannexin-2 mediates infiltration of macrophage in stretched atrium2011

    • Author(s)
      Sasano T, Oishi S, Furukawa T
    • Organizer
      The 75^<th> Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      横浜
    • Year and Date
      2011-08-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] Contribution of Irx3 on His-Purkinje system (HPS) conduction and arrhythm ogeneity-A possible animal model for HPS-oriented arrhythmias2011

    • Author(s)
      Koizumi A, Sasano T, Miura N, Furukawa T
    • Organizer
      The 75^<th> Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      横浜
    • Year and Date
      2011-08-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] Genetic deletion of NOS1AP sensitized to sudden cardiac death after trasn verse aortic constriction2011

    • Author(s)
      Sasano T, Matsubara S, Tamura S, Isobe M, Furukawa T
    • Organizer
      The 75^<th> Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      横浜
    • Year and Date
      2011-08-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] hERGを標的とする薬物安全性評価システムの問題点と対策2011

    • Author(s)
      古川哲史
    • Organizer
      第38回日本トキシコロジー学術年会
    • Place of Presentation
      横浜(招待講演)
    • Year and Date
      2011-07-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Characterization of human induced pluripotent stem cell-derived cardiomyocytes2011

    • Author(s)
      李敏、黒川洵子、諌田泰成、関野祐子、古川哲史
    • Organizer
      第124回日本薬理学会関東部会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 心筋プロゲステロン受容体を介した性ホルモン非ゲノム経路の細胞内局在化機構

    • Author(s)
      五領田小百合, 児玉昌美,冨田太一郎,黒羽笑加,鈴木岳史,古川哲史,黒川洵子
    • Organizer
      日本薬理学会第129回関東部会
    • Place of Presentation
      順天堂大学、東京
    • Related Report
      2013 Annual Research Report
  • [Book] そうだったのか!臨床に役立つ心血管ゲノム医学2014

    • Author(s)
      古川哲史
    • Total Pages
      204
    • Publisher
      メディカル・サイエンス・インターナショナル
    • Related Report
      2013 Annual Research Report
  • [Book] そうだったのか!臨床に役立つ心血管ゲノム医学2013

    • Author(s)
      古川哲史
    • Publisher
      メディカル・サイエンス・インターナショナル社
    • Related Report
      2013 Final Research Report
  • [Book] そうだったのか!臨床に役立つ循環薬理学2013

    • Author(s)
      古川哲史
    • Publisher
      メディカル・サイエンス・インターナショナル社
    • Related Report
      2013 Final Research Report
  • [Book] Ion Channel Expression and Function of iPSC-derived Cardiomyocytes. In : Cardiac Regeneration using Stem Cells. (eds.) Keiichi Fukuda, Shinsuke Yuasa2013

    • Author(s)
      Tetsushi Furukawa
    • Publisher
      CRC Press
    • Related Report
      2013 Final Research Report
  • [Book] Cardiac Regeneration using Stem Cells2013

    • Author(s)
      Tetsushi Furukawa
    • Total Pages
      366
    • Publisher
      CRC Press
    • Related Report
      2013 Annual Research Report
  • [Book] 不整脈概論2013

    • Author(s)
      古川哲史
    • Total Pages
      421
    • Publisher
      メジカル・ビュー
    • Related Report
      2012 Annual Research Report
  • [Book] そうだったのか!臨床に役立つ循環薬理学2013

    • Author(s)
      古川哲史
    • Total Pages
      203
    • Publisher
      メディカル・サイエンス・インターナショナル
    • Related Report
      2012 Annual Research Report
  • [Book] そうだったのか!臨床に役立つ不整脈基礎2012

    • Author(s)
      中谷晴昭, 古川哲史, 山根禎一
    • Publisher
      メディカル・サイエンス・インターナショナル社
    • Related Report
      2013 Final Research Report
  • [Book] Sex and gender difference in pharmacology2012

    • Author(s)
      Kurokawa J
    • Total Pages
      378
    • Publisher
      Springer-Verlag
    • Related Report
      2012 Annual Research Report
  • [Book] そうだったのか!臨床に役立つ不整脈の基礎2012

    • Author(s)
      中谷晴昭
    • Total Pages
      199
    • Publisher
      メディカル・サイエンス・インターナショナル
    • Related Report
      2012 Annual Research Report
  • [Book] 新しい経口抗凝固薬、どう使う?2012

    • Author(s)
      古川哲史
    • Total Pages
      162
    • Publisher
      日本医事新報社
    • Related Report
      2012 Annual Research Report
  • [Book] 不整脈学2012

    • Author(s)
      古川哲史
    • Total Pages
      614
    • Publisher
      南江堂
    • Related Report
      2012 Annual Research Report
  • [Book] 目からウロコの心電図2011

    • Author(s)
      古川哲史
    • Publisher
      ライフメディ コム社
    • Related Report
      2013 Final Research Report
  • [Book] 目からウロコの心電図2011

    • Author(s)
      古川哲史
    • Total Pages
      129
    • Publisher
      ライフメディコム
    • Related Report
      2011 Annual Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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