Role of the myocyte-derived secreted factor in ischemic heart disease
Project/Area Number |
23390207
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Circulatory organs internal medicine
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Research Institution | Nagoya University |
Principal Investigator |
OUCHI NORIYUKI 名古屋大学, 医学(系)研究科(研究院), 寄附講座教授 (00595514)
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Co-Investigator(Kenkyū-buntansha) |
OHASHI Koji 名古屋大学, 医学系研究科, 寄附講座助教 (10595515)
SHIBATA Rei 名古屋大学, 医学系研究科, 特任講師 (70343689)
MUROHARA Toyoaki 名古屋大学, 医学系研究科, 教授 (90299503)
|
Project Period (FY) |
2011-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2011: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
|
Keywords | 分子心臓病態学 / 虚血性心疾患 |
Research Abstract |
We found that follistatin-like 1 (Fstl1) is protective against acute cardiac injury following ischemia-reperfusion (I/R). Administration of Fstl1 led to reduction of myocardial infarct size following I/R in vivo, which was accompanied by attenuation of inflammatory response and apoptosis in the ischemic heart. Furthermore, Fstl1 attenuated inflammatory reaction and apoptosis in cardiac myocytes by its ability to activate AMP-activated protein kinase pathway and inhibit bone morphogenetic protein-4 signaling pathway.
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Report
(4 results)
Research Products
(44 results)
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[Journal Article] Transcriptional regulation of an insulin-sensitizing adipokine adipolin/CTRP12 in adipocytes by Krüppel-like factor 152013
Author(s)
Enomoto T, Ohashi K, Shibata R, Kambara T, Uemura Y, Yuasa D, Kataoka Y, Miyabe M, Matsuo K, Joki Y, Hayakawa S, Hiramatsu-Ito M, Ito M, Murohara T, Ouchi N
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Journal Title
PLoS One
Volume: 8(12)
Pages: e83183
DOI
Related Report
Peer Reviewed
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[Journal Article] Adiponectin-mediated modulation of lymphatic vessel formation and lymphedema2013
Author(s)
Shimizu Y, Shibata R, Ishii M, Ohashi K, Kambara T, Uemura Y, Yuasa D, Kataoka Y, Kihara S, Murohara T, Ouchi N
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Journal Title
J Am Heart Assoc
Volume: 2
Pages: e000438
DOI
Related Report
Peer Reviewed
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[Journal Article] Therapeutic Reendothelialization by Induced Pluripotent Stem Cells After Vascular Injury2013
Author(s)
Yamamoto T, Shibata R, Ishii M, Kanemura N, Kito T, Suzuki H, Miyake H, Maeda K, Tanigawa T, Ouchi N, Murohara T
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Journal Title
Arterioscler Thromb Vasc Biol
Volume: 33
Pages: 2218-21
DOI
Related Report
Peer Reviewed
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[Journal Article] iPS cell sheets created by a novel magnetite tissue engineering method for reparative angiogenesis2013
Author(s)
Kito T, Shibata R, Ishii M, Suzuki H, Himeno T, Kataoka Y, Yamamura Y, Yamamoto T, Nishio N, Ito S, Numaguchi Y, Tanigawa T, Yamashita JK, Ouchi N, Honda H, Isobe K, Murohara T
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Journal Title
Sci Rep
Volume: 3
Pages: 1418
DOI
Related Report
Peer Reviewed
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[Journal Article] Adipose-derived factor CTRP9 attenuates vascular smooth muscle cell proliferation and neointimal formation2013
Author(s)
Uemura Y, Shibata R, Ohashi K, Enomoto T, Kambara T, Yamamoto T, Ogura Y, Yuasa D, Joki Y, Matsuo K, Miyabe M, Kataoka Y, Murohara T, Ouchi N
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Journal Title
FASEB J
Volume: 27
Pages: 25-33
DOI
Related Report
Peer Reviewed
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[Journal Article] iPS cell sheets created by a novel magnetite tissue engineering method for reparative angiogenesis.2013
Author(s)
Kito T, Shibata R, Ishii M, Suzuki H, Himeno T, Kataoka Y, Yamamura Y, Yamamoto T, Nishio N, Ito S, Numaguchi Y, Tanigawa T, Yamashita JK, Ouchi N, Honda H, Isobe K, Murohara T.
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Journal Title
Sci Rep.
Volume: 3
Pages: 1418
DOI
Related Report
Peer Reviewed
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[Journal Article] Therapeutic reendothelialization by induced pluripotent stem cells after vascular injury.2013
Author(s)
Yamamoto T, Shibata R, Ishii M, Kanemura N, Kito T, Suzuki H, Miyake H, Maeda K, Tanigawa T, Ouchi N, Murohara T.
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Journal Title
Arterioscler Thromb Vasc Biol.
Volume: 33
Pages: 2218-2221
DOI
Related Report
Peer Reviewed
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[Journal Article] Adiponectin-mediated modulation of lymphatic vessel formation and lymphedema.2013
Author(s)
Shimizu Y, Shibata R, Ishii M, Ohashi K, Kambara T, Uemura Y, Yuasa D, Kataoka Y, Kihara S, Murohara T, Ouchi N.
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Journal Title
J Am Heart Assoc.
Volume: 2
Pages: e000438
DOI
Related Report
Peer Reviewed
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[Journal Article] Transcriptional regulation of an insulin-sensitizing adipokine adipolin/CTRP12 in adipocytes by Kruppel-like factor 15.2013
Author(s)
Enomoto T, Ohashi K, Shibata R, Kambara T, Uemura Y, Yuasa D, Kataoka Y, Miyabe M, Matsuo K, Joki Y, Hayakawa S, Hiramatsu-Ito M, Ito M, Murohara T, Ouchi N.
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Journal Title
PLoS One.
Volume: 8
Pages: e83183
DOI
Related Report
Peer Reviewed
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[Journal Article] Therapeutic impact of follistatin-like 1 on myocardial ischemic injury in preclinical animal models2012
Author(s)
Ogura Y, Ouchi N, Ohashi K, Shibata R, Kataoka Y, Kambara T, Kito T, Maruyama S, Yuasa D, Matsuo K, Enomoto T, Uemura Y, Miyabe M, Ishii M, Yamamoto T, Shimizu Y, Walsh K, Murohara T
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Journal Title
Circulation
Volume: 126
Pages: 1728-38
DOI
Related Report
Peer Reviewed
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[Journal Article] CTRP9 protects against myocardial injury following ischemia-reperfusion through AMPK-dependent mechanism2012
Author(s)
Kambara T, Ohashi K, Shibata R, Ogura Y, Maruyama S, Enomoto T, Uemura Y, Shimizu Y, Yuasa D, Matsuo K, Miyabe M, Kataoka Y, Murohara T, Ouchi N
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Journal Title
J Biol Chem
Volume: 287
Pages: 18965-73
DOI
Related Report
Peer Reviewed
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[Journal Article] Fat-derived factor omentin stimulates endothelial cell function and ischemia-induced revascularization via an endothelial nitric oxide synthase-dependent mechanism2012
Author(s)
Maruyama S, Shibata R, Kikuchi R, Izumiya Y, Rokutanda T, Araki S, Kataoka Y, Ohashi K, Daida H, Kihara S, Ogawa H, Murohara T, Ouchi N
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Journal Title
J Biol Chem
Volume: 287
Pages: 408-17
DOI
Related Report
Peer Reviewed
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[Journal Article] CTRP9 protects against myocardial injury following ischemia-reperfusion through AMPK-dependent mechanism.2012
Author(s)
Kambara T, Ohashi K, Shibata R, Ogura Y, Maruyama S, Enomoto T, Uemura Y, Shimizu Y, Yuasa D, Matsuo K, Miyabe M, Kataoka Y, Murohara T, Ouchi N.
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Journal Title
J Biol Chem.
Volume: 287
Pages: 18965-73
DOI
Related Report
Peer Reviewed
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[Journal Article] Therapeutic impact of follistatin-like 1 on myocardial ischemic injury in preclinical animal models.2012
Author(s)
Ogura Y, Ouchi N, Ohashi K, Shibata R, Kataoka Y, Kambara T, Kito T, Maruyama S, Yuasa D, Matsuo K, Enomoto T, Uemura Y, Miyabe M, Ishii M, Yamamoto T, Shimizu Y, Walsh K, Murohara T.
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Journal Title
Circulation
Volume: 126
Pages: 1728-38
DOI
Related Report
Peer Reviewed
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[Journal Article] Adipose-derived factor CTRP9 attenuates vascular smooth muscle cell proliferation and neointimal formation.2012
Author(s)
Uemura Y, Shibata R, Ohashi K, Enomoto T, Kambara T, Yamamoto T, Ogura Y, Yuasa D, Joki Y, Matsuo K, Miyabe M, Kataoka Y, Murohara T, Ouchi N.
-
Journal Title
FASEB J.
Volume: 27
Pages: 25-33
DOI
Related Report
Peer Reviewed
-
[Journal Article] Fat-derived factor omentin stimulates endothelial cell function and ischemia-induced revascularization via an endothelial nitric oxide synthase-dependent mechanism.2012
Author(s)
Maruyama S, Shibata R, Kikuchi R, Izumiya Y, Rokutanda T, Araki S, Kataoka Y, Ohashi K, Daida H, Kihara S, Ogawa H, Murohara T, Ouchi N.
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Journal Title
J Biol Chem.
Volume: 287
Pages: 408-417
DOI
Related Report
Peer Reviewed
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[Presentation] アディポサイトカインと心血管病2013
Author(s)
大内乗有, 柴田玲, 大橋浩二, 室原豊明
Organizer
第17回日本心血管内分泌代謝学会学術集会
Place of Presentation
千里ライフサイエンスセンター(豊中市)大阪
Year and Date
2013-11-22
Related Report
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[Presentation] アディポサイトカインと心血管病
Author(s)
大内乗有 柴田玲 大橋浩二 室原豊明
Organizer
第17回日本心血管内分泌代謝学会学術集会
Place of Presentation
千里ライフサイエンスセンター(豊中市)
Related Report
Invited
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