| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2011: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Research Abstract |
Endothelin-1 (ET-1) is profoundly involved in the activation of mast cells in hemodyamically stressed atria. ET-1-induced secretion of monocyte chemotactic protein-1 (MCP-1) from activated mast cells enhances migration of macrophages, and consequently promotes atrial remodeling. HMG-CoA reductase pitavastatin inhibits ET-1-triggered activation of mast cells and up-regulation of fibrogenic PDGF-A in atria, and thereby prevents atrial remodeling and inducibility of atrial fibrillation. These results suggest that application of statins may be a promising approach to achieve upstream prevention of atrial fibrillation in stressed hearts.
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