Elucidation of inflammatory network underlying the pathogenesis of atrial fibrillation
Project/Area Number |
23390213
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Circulatory organs internal medicine
|
Research Institution | The University of Tokyo (2013) Osaka University (2011-2012) |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
KOMURO Issei 東京大学, 医学系研究科, 教授 (30260483)
|
Project Period (FY) |
2011-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2011: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
|
Keywords | 分子心臓病態学 / 肥満細胞 / リモデリング / スタチン / 細胞・組織 / 循環器・高血圧 / ストレス / 生体分子 |
Research Abstract |
Endothelin-1 (ET-1) is profoundly involved in the activation of mast cells in hemodyamically stressed atria. ET-1-induced secretion of monocyte chemotactic protein-1 (MCP-1) from activated mast cells enhances migration of macrophages, and consequently promotes atrial remodeling. HMG-CoA reductase pitavastatin inhibits ET-1-triggered activation of mast cells and up-regulation of fibrogenic PDGF-A in atria, and thereby prevents atrial remodeling and inducibility of atrial fibrillation. These results suggest that application of statins may be a promising approach to achieve upstream prevention of atrial fibrillation in stressed hearts.
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Report
(4 results)
Research Products
(103 results)
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[Journal Article] Novel regulation of cardiac metabolism and homeostasis by the adrenomedullin-receptor activity-modifying protein 2 system2013
Author(s)
Yoshizawa T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Iesato Y, Koyama T, Uetake R, Yang, L, Yamauchi A, Tanaka M, Toriyama Y, Igarashi K, Nakada T, Kashihara T, Yamada M, Kawakami H, Nakanishi H, Taguchi R, Nakanishi T, Akazawa H, Shindo T.
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Journal Title
Hypertension
Volume: 61
Pages: 341-351
Related Report
Peer Reviewed
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[Journal Article] Notch activation mediates angiotensin II-induced vascular remodeling by promoting proliferation and migration of vascular smooth muscle cells2013
Author(s)
Ozasa Y, Akazawa H, Qin Y, Tateno K, Ito K, Kudo-Sakamoto Y, Yano M, Yabumoto C, Naito AT, Oka T, Lee JK, Minamino T, Nagai T, Kobayashi Y, Komuro I
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Journal Title
Hypertens Res
Volume: 36
Pages: 859-865
Related Report
Peer Reviewed
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[Journal Article] High incidence of Aggregatibacter actinomycetemcomitans infection in patients with cerebral infarction and diabetic renal failure : A cross-sectional study2013
Author(s)
Murakami M, Suzuki J, Yamazaki S, Ikezoe M, Matsushima R, Ashigaki N, Aoyama N, Kobayashi N, Wakayama K, Akazawa H, Komuro I, Izumi Y, Isobe M
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Journal Title
BMC Infect Dis
Volume: 13
Pages: 557-557
Related Report
Peer Reviewed
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[Journal Article] Novel regulation pf cardiac metabolism and homeostasis by the adrenomedullin- receptor activity-modifying protein 2 system2013
Author(s)
Takahiro Yoshizawa, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Ichikawa-Shindo, Hisaka Kawate, Yasuhiro Iesato, Teruhide Koyama, Ryuichi Uetake, Lei Yang, Akihiro Yamauchi, Megumu Tanaka, Yuichi Toriyama, Kyoko Igarashi, Tsutomu Nakada, Toshihide Kashihara, Mitsuhiko Yamada, Hayato Kawakami, Hiroki Nakanishi, Ryo Taguchi, Tsuyoshi Nakanishi, Hiroshi Akazawa, Takayuki Shindo
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Journal Title
Hypertension
Volume: 61
Issue: 2
Pages: 341-351
DOI
Related Report
Peer Reviewed
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[Journal Article] Valsartan, independently of AT1 receptor or PPARγ, suppresses LPS-induced macrophage activation and improves insulin resistance in co-cultured adipocytes2012
Author(s)
Iwashita M, Sakoda H, Kushiyama A, Fujishiro M, Ohno H, Nakatsu Y, Fukushima T, Kumamoto S, Tsuchiya Y, Kikuchi T, Kurihara H, Akazawa H, Komuro I, Kamata H, Nishimura F, Asano T
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Journal Title
Am J Physiol Endocrinol Metab
Volume: 302
Related Report
Peer Reviewed
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[Journal Article] Agonist-independent constitutive activity of angiotensin II receptor promotes cardiac remodeling in mice2012
Author(s)
Yasuda N, Akazawa H, Ito K, Shimizu I, Kudo-Sakamoto Y, Yabumoto C, Yano M, Yamamoto R, Ozasa Y, Minamino T, Naito AT, Oka T, Shiojima I, Tamura K, Umemura S, Paradis P, Nemer M, Komuro I
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Journal Title
Hypertension
Volume: 59
Pages: 627-633
Related Report
Peer Reviewed
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[Journal Article] Complement C1 q activates canonical Wnt signaling and promotes aging-related phenotypes2012
Author(s)
Naito AT, Sumida T, Nomura S, Liu ML, Higo T, Nakagawa A, Okada K, Sakai T, Hashimoto A, Hara Y, Shimizu I, Zhu W, Toko H, Katada A, Akazawa H, Oka T, Lee JK, Minamino T, Nagai T, Walsh K, Kikuchi A, Matsumoto M, Botto M, Shiojima I, Komuro I
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Journal Title
Cell
Volume: 149
Pages: 1298-1313
Related Report
Peer Reviewed
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[Journal Article] Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes2012
Author(s)
Naito AT, Sumida T, Nomura S, Liu ML, Higo T, Nakagawa A, Okada K, Sakai T, Hashimoto A, Hara Y, Shimizu I, Zhu W, Toko H, Katada A, Akazawa H, Oka T, Lee JK, Minamino T, Nagai T, Walsh K, Kikuchi A, Matsumoto M, Botto M, Shiojima I, Komuro I
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Journal Title
Cell
Volume: 149
Issue: 6
Pages: 1298-1313
DOI
Related Report
Peer Reviewed
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[Journal Article] Valsartan, independently of AT1 receptor or PPARγ, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes.2012
Author(s)
Iwashita M, Sakoda H, Kushiyama A, Fujishiro M, Ohno H, Nakatsu Y, Fukushima T, Kumamoto S, Tsuchiya Y, Kikuchi T, Kurihara H, Akazawa H, Komuro I, Kamata H, Nishimura F, Asano T.
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Journal Title
American Journal of Physiology - Endocrinology and Metabolism
Volume: 302
Issue: 3
Pages: 286-296
DOI
Related Report
Peer Reviewed
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[Journal Article] Ryanodine receptor type 2 is required for the development of pressure overload-induced cardiac hypertrophy2011
Author(s)
Zou Y, Liang Y, Zhou N, Ma H, Guan A, Gong H, Sun A, Wang P, Niu Y, Jiang H, Takano H, Toko H, Yao A, Takeshima H, Akazawa H, Shiojima I, Wang Y, Komuro I, Ge J
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Journal Title
Hypertension
Volume: 58
Pages: 1099-110
Related Report
Peer Reviewed
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[Journal Article] A crucial role of activin A-mediated growth hormone suppression in mouse and human heart failure2011
Author(s)
Fukushima N, Matsuura K, Akazawa H, Honda A, Nagai T, Takahashi T, Seki A, Murasaki KM, Shimizu T, Yamato M, Okano T, Kasanuki H, Hagiwara N, Komuro I
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Angiotensin II type 1 receptor signaling regulates feeding behavior through anorexigenic corticotropin-releasing hormone in hypothalamus2011
Author(s)
Yamamoto, R. Akazawa, H. Fujihara, H. Ozasa, Y. Yasuda, N. Ito, K. Kudo, Y. Qin, Y. Ueta, Y. & Komuro, I
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Journal Title
Journal of Biological Chemistry
Volume: 286(24)
Issue: 24
Pages: 21458-21465
DOI
Related Report
Peer Reviewed
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[Journal Article] A crucial role of activin A-mediated growth hormone suppression in mouse and human heart failure2011
Author(s)
Fukushima N, Matsuura K, Akazawa H, Honda A, Nagai T, Takahashi T, Seki A, Murasaki KM, Shimizu T, Okano T, Hagiwara N, Komuro I
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Journal Title
PLoS One
Volume: 6
Issue: 12
Pages: e27901-e27901
DOI
Related Report
Peer Reviewed
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