Developing successful immunomodulatory therapies against ventricular remodeling after myocardial infarction
| Project/Area Number |
23390217
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Keio University |
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Principal Investigator |
SANO MOTOAKI 慶應義塾大学, 医学部, 准教授 (30265798)
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| Co-Investigator(Renkei-kenkyūsha) |
YAN Xiaoxiang 慶應義塾大学, 医学部, 大学院生 (90594979)
ANZAI Atsushi 慶應義塾大学, 医学部, 助教 (50528164)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2011: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Keywords | 心筋梗塞 / 心不全 / 免疫 / 肺水腫 / NK細胞 / 好中球 / IL-10 / 線維化 / 樹状細胞 / リンパ球 / マクロファージ |
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| Research Abstract |
Left ventricular (LV) remodeling leads to chronic heart failure and is a main determinant of morbidity and mortality after myocardial infarction (MI). Mice with DC ablation showed deteriorated LV function and remodeling concomitant with enhanced expression of IL-1beta, IL-18, and TNF-alpha, prolonged extracellular matrix degradation, marked infiltration of proinflammatory monocytes. A deficiency of gamma-delta T cells improved survival, limiting infarct expansion and fibrosis in noninfarcted myocardium and alleviating LV dilatation and systolic dysfunction after MI. IL-17A-producing gamma-delta T cells promotes sustained infiltration of neutrophils and macrophages, , aggravating cardiomyocyte death, and enhancing fibroblast proliferation. Depletion of NK cells from mice exhibited severe respiratory. Adoptive transfer of NK cells from wild-type mice, but not from IL-10 knockout mice, into the NK cell-depleted mice rescued the respiratory phenotype.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Lung natural killer cells play a major counter-regulatory role in pulmonary vascular hyperpermeability after myocardial infarction2014
Author(s)
Yan X, Hegab AE, Endo J, Anzai A, Matsuhashi T, Katsumata Y, Ito K, Yamamoto T, Betsuyaku T, Shinmura K, Shen W, Vivier E, Fukuda K, Sano M
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Journal Title
Circ Res
Volume: 114(4)
Issue: 4
Pages: 637-49
DOI
Related Report
Peer Reviewed
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[Journal Article] Temporal dynamics of cardiac immune cell accumulation following a cute myocardial infarction2013
Author(s)
Yan X, Anzai A, Katsumata Y, Matsuhashi T, Ito K, Endo J, Yamamoto T, Takeshima A, Shinmura K, Shen W, Fukuda K, Sano M
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Journal Title
Journal of Molecular and Cellular Cardiology
Volume: 62
Pages: 24-35
DOI
Related Report
Peer Reviewed
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[Presentation] Dendritic Cell is an Immunoprotective Regulator in Post-Infarction Healing and Left Ventricular Remodeling2011
Author(s)
Anzai A, Anzai T, Nagai S, Maekawa Y, Sano M, Yoshikawa T, Koyasu S, Ogawa S, Fukuda K
Organizer
American Heart Association-Scientific Sessions
Place of Presentation
Orlando, Florida, USA
Year and Date
2011-11-15
Related Report
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