Role of fibroblast growth factors in pathogenesis of lung cancer

• Project/Area Number: 23390218
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Keio University
• Principal Investigator: BETSUYAKU Tomoko 慶應義塾大学, 医学部, 教授 (60333605)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2012: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
• Keywords: 線維芽細胞増殖因子 / 肺癌 / 幹細胞 / 繊維芽細胞増殖因子

Outline of Final Research Achievements

Recent progress is remarkable in molecular target therapy of lung cancer. The signaling of fibroblast growth factor (FGF) signaling has been interested in many cancers including lung cancer. We have developed the mouse model of lung adenocarcinoma by overexpressing FGF9 in lung epithelial specific manner. Using that model, we have investigated the molecular mechanism of FGF9-induced lung cancer by identified the putative receptor of this pathway. We have also tested the several potential drugs as novel FGFR targeting therapy. We have also characterized the patients of lung cancer with overexpression of FGF9.

Research Products

• [Journal Article] Multiple roles of extracellular fibroblast growth factors in lung cancer cells (2015)
  • Author(s): Suzuki T, Yasuda H, Funaishi K, Arai D, Ishioka K, Ohgino K, Tani T, Hamamoto J, Ohashi A, Naoki K, Betsuyaku T, Soejima K
  • Journal Title: Int J Oncol Volume: 46 Issue: 1 Pages: 423-429
  • DOI: 10.3892/ijo.2014.2718
  • Peer Reviewed / Open Access
• [Journal Article] Characterization of the cell of origin and propagation potential of the fibroblast growth factor 9-induced mouse model of lung adenocarcinoma (2014)
  • Author(s): Arai D, Hegab AE, Soejima K, Kuroda A, Ishioka K, Yasuda H, Naoki K, KagawaS, Hamamoto J, Yin Y, Ornitz DM, Betsuyaku T S,
  • Journal Title: J Pathol Volume: 235 Issue: 4 Pages: 593-605
  • DOI: 10.1002/path.4486
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Expression of fibroblast growth factor 9 is associated with poor prognosis in patients with resected non-small cell lung cancer. (2014)
  • Author(s): Ohgino K, Soejima K, Yasuda H, Hayashi Y, Hamamoto J, Naoki K, Arai D, Ishioka K, Sato T, Terai H, Ikemura S, Yoda S, Tani T, Kuroda A, Betsuyaku T.
  • Journal Title: Lung Cancer Volume: 83 Issue: 1 Pages: 90-6
  • DOI: 10.1016/j.lungcan.2013.10.016
  • Peer Reviewed
• [Journal Article] Rapid induction of lung adenocarcinoma by fibroblast growth factor 9 signaling through FGF receptor 3. (2013)
  • Author(s): Yin Y, Betsuyaku T, Garbow JR, Miao J, Govindan R, Ornitz DM.
  • Journal Title: Cancer Res Volume: 73 Issue: 18 Pages: 5730-41
  • DOI: 10.1158/0008-5472.can-13-0495
  • Peer Reviewed
• [Presentation] Several components affect the in vitro sphere formation of airway epithelial stem cells (2014)
  • Author(s): Ahmed E. Hegab, Daisuke Arai, Aoi Kuroda, Kenzo Soejima, Tomoko Betsuyaku.
  • Organizer: American Thoracic Society annaul meeting
  • Place of Presentation: San Diego
• [Presentation] Effects of fibroblast growth factor (FGF) 9 on mouse tracheal stem cells (2013)
  • Author(s): Ahmed E. Hegab
  • Organizer: American Thoracic Society
  • Place of Presentation: Philadelphia, PA, USA
  • Invited
• [Presentation] Propagation potential of fibroblast growth factor (FGF) 9-induced lung tumors (2013)
  • Author(s): Daisuke Arai
  • Organizer: American Thoracic Society
  • Place of Presentation: Philadelphia, PA, USA
• [Presentation] Featured Lecture: IPF and COPD; common origins and features? (2012)
  • Author(s): Tomoko Betsuyaku
  • Organizer: The conference MLC - Perspectives 2020: Emerging Trends in Pulmonary Medicine
  • Place of Presentation: Munich, Germany
  • Invited