| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2015: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Outline of Final Research Achievements |
Based on our finding that secretory leukocyte protease inhibitor (SLPI) was involved in differentiative switches between bronchiolar stem cells and differentiated lung cells, we investigated the downstream signals of SLPI. As a result, we identified a molecule that induced de-differentiation to bronchiolar stem cells in the signaling pathway of SLPI, and hereafter referred to it as bronchiolar progenitor factor (BPF). Administration of recombinant BPF protein ameliorated naphthalene-induced lung inflammation. These results suggest that the differentiative switches between bronchiolar stem cells and differentiated lung cells may be a useful target to develop a novel strategy for inflammatory lung diseases.
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