| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2013: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2012: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2011: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Research Abstract |
DIC (blood coagulation occurring in vessels) is an important prognostic factor in a severe lung injury called acute respiratory distress syndrome (ARDS). A retrospective study demonstrated that KL-6/MUC1 having a selectin ligand (SLAK) can predict the onset of DIC in ARDS. The SLAK had the better sensitivity and specificity for prediction of mortality than previously known factors and thus is a good prognostic biomarker in ARDS. During investigation on the mechanism for the synthesis of the molecules, we demonstrated that KL-6 could be expressed in mice expressing the human MUC1, although KL-6 is never expressed in mice. We also demonstrated that KL-6 could be a biomarker in mouse models of acute lung injury and bleomycin pulmonary fibrosis by using this transgenic mouse.
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