| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2011: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
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| Research Abstract |
NGAL KO mice exhibited worsening of adenine nephropathy. 80% of blood NGAL was derived from leukocytes, while urinary NGAL was mainly synthesized by the kidney. In chronic kidney disease, urinary NGAL was partly bound to polyIg receptor or a2-macroglobulin, and showed correlation with severity of renal pathologic changes. Under high fat diet, NGAL KO mice showed resistance against obesity. Hemodialysis patients having low blood NGAL levels showed increased risk to have malnutrition and to develop severe infection. Treatment of WT mice with LPS induced brain inflammation, reduced motor activity and recognition impairment, and these chnges were ameliorated in KO mice. NGAL expression was increased in BAL fluid and lung biopsy samples from patients with idiopathic pulmonary fibrosis.
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