Signal networks among organ/tissue in the disorder of phosphate homeostasis

• Project/Area Number: 23390226
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: The University of Tokushima
• Principal Investigator: MIYAMOTO KENICHI 徳島大学, ヘルスバイオサイエンス研究部, 教授 (70174208)
• Co-Investigator(Kenkyū-buntansha): SEGAWA Hiroko 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (70325257) ; KIDO Shinsuke 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 特任助教 (30437652)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000); Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2012: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2011: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
• Keywords: リン利尿 / 腎臓 / 繊維芽細胞増殖因子２３ (FGF23) / 骨細胞 / FGF23 / Klotho / リン / 慢性腎臓病 / ビタミンD

Research Abstract

Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that plays an important role in phosphate (Pi) transport in the proximal tubular cells. Klotho forms a specific receptor complex with FGF receptor that transmits signaling of FGF23 in the distal tubules. FGF23/klotho signaling leads to down-regulation of sodium-dependent Pi cotransporter (NaPi-II ) in the proximal tubules. In the present study, we investigated the mechanisms of down-regulation of renal Pi transporter by FGF23/klotho system and the production of FGF23 in bone cells. We show that klotho expression in the proximal tubules is induced by several conditions. Furthermore, inactivation of NaPi-IIc by PKC is the first step of FGF23/klotho dependent down-regulation of the transporters. Thus, FGF23/klotho signaling in the kidney-bone axis is essential for Pi homeostasis.

Research Products

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• [Journal Article] Hepatectomy-Related Hypophosphatemia : A Novel Phosphaturic Factor in the Liver-Kidney Axis (2014)
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• [Journal Article] Molecular Mechanisms of Cadmium-Induced Fibroblast growth Factor 23 Upregulation in Osteoblast-Like Cells. (2014)
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• [Journal Article] Role of serine 249 of ezrin in the regulation of sodium-dependent phosphate transporter NaPi-IIa activity in renal proximal tubular cells (2013)
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• [Journal Article] Parathyroid hormone (1-34) counteracts the suppression of interleulin-11 expression by glucocorticoid in murine osteoblasts : a possible mechanism for stimulating osteoblast differentiation against glucocorticoid excess (2013)
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• [Journal Article] Ezrin, a membrane cytoskeletal cross-linker, is essential for the regulation of phosphate and calcium homeostasis (2013)
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• [Journal Article] Activation of a non-cAMP/PKA signaling pathway downstream of the PTH/PTHrP receptor is essential for a sustained hypophosphatemic response to PTH infusion in male mice (2013)
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• [Journal Article] Role of serine 249 of ezrin in the regulation of sodium-dependent phosphate transporter NaPi-IIa activity in renal proximal tubular cells. (2013)
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• [Journal Article] Updates on rickets and osteomalacia:the role of NaPi-2c/SLC34A3 and hypophosphataemic rickets. (2013)
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• [Journal Article] Ezrin, a membrane cytoskeletal cross-linker, is essential for the regulation of phosphate and calcium homeostasis (2013)
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• [Journal Article] Evoluation of 14 questions detecting malnutrition in newly hospitalized patients (2013)
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• [Journal Article] Fibroblast growth factor 23 mediates the phosphaturic actions of cadomium (2012)
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• [Journal Article] Identification and functional analysis of a splice variant of mouse sodium-dependent phosphate transporter Npt2c (2012)
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• [Journal Article] Inorganic phosphate homeostasis in sodium-dependent phosphate co-transporter Npt2b+/- mice (2011)
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• [Journal Article] Accumulation of orally administered quercetin in brain tissue and its antioxidative effects in rats (2011)
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• [Journal Article] Dietary Medium-Chain Triglycerides Attenuate Hepatic Lipid Deposition in Growing Rats with Protein Malnutrition (2011)
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• [Journal Article] Analysis of different complexes of type IIa sodium-dependent phosphate transporter in rat renal cortex using blue-native polyacrylamide gel electrophoresis (2011)
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• [Journal Article] Analysis of different complexes of type IIa sodium-dependent phosphate transporter in rat renal cortex using blue-native polyacrylamide gel electrophoresis (2011)
  • Author(s): Tanimura A, et al.
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  • NAID: 130004465236
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  • Author(s): Ishisaka A, et al
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• [Presentation] 栄養の吸収と代謝. (2014)
  • Author(s): 宮本賢一.
  • Organizer: 第34回メディコピア教育講演シンポジウム
  • Place of Presentation: 東京国際フォーラム（東京都）
  • Invited
• [Presentation] 骨細胞死滅マウスにおけるカルシウム／リン代謝異常機構について. (2014)
  • Author(s): 辰巳佐和子,藤田みゆき,藤井理,野村憲吾,木戸慎介,瀬川博子,宮本賢一.
  • Organizer: 第17回日本病態栄養学会年次学術集会
  • Place of Presentation: 大阪国際会議場（大阪府）
• [Presentation] リン過剰摂取が招く危険性と最新の代謝機構 (2014)
  • Author(s): 宮本賢一.
  • Organizer: 第22回北摂四医師会骨・内分泌・代謝研究会
  • Place of Presentation: 大阪医科大学（大阪府）
  • Invited
• [Presentation] リン代謝調節機序におけるNaPiトランスポーターの役割. (2014)
  • Author(s): 瀬川博子,宮本 賢一.
  • Organizer: 日本農芸化学会2014年度大会
  • Place of Presentation: 明治大学生田キャンパス（東京都）
  • Invited
• [Presentation] Hepatectomy Hypophosphatemia : A Novel Phosphaturic Factor in the Liver Kidney Axis (2013)
  • Author(s): Nomura K, Tatsumi S, Miyagawa A, Shiozaki Y, Sasaki S, Segawa H, Miyamoto K
  • Organizer: American Society of Nephrology
  • Place of Presentation: GeorgiaWorldCongressCenter, Atlanta, GA, USA
  • Year and Date: 2013-11-08
• [Presentation] Hepatectomy Hypophosphatemia:A Novel Phosphaturic Factor in the Liver Kidney Axis. (2013)
  • Author(s): Nomura K, Tatsumi S, Miyagawa A, Shiozaki Y, Sasaki S, Segawa H, Miyamoto K.
  • Organizer: American Society of Nephrology(第46会米国腎臓学会)
  • Place of Presentation: ｼﾞｮｰｼﾞｱ･ﾜｰﾙﾄﾞ･ｺﾝｸﾞﾚｽ･ｾﾝﾀｰ(USA)
• [Presentation] 骨細胞死滅マウスにおけるリン利尿促進機序について. (2013)
  • Author(s): 辰巳佐和子,釜谷達哉,宮本賢一.
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京国際フォーラム（東京都）
• [Presentation] リンの吸収と排泄の生体内調節. (2013)
  • Author(s): 瀬川博子,向井朋,森絢香,佐々木祥平,宮本賢一.
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京国際フォーラム（東京都）
• [Presentation] リン利尿におけるKlothoの役割. (2013)
  • Author(s): 佐々木祥平,瀬川博子,大西沙織,森絢香,向井朋,真鍋舞,日下祐里,木戸慎介,辰巳佐和子 宮本 賢一.
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京国際フォーラム（東京都）
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  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京国際フォーラム（東京都）
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  • Author(s): 野村憲吾,辰巳佐和子,宮川淳美,岡奈都紀,塩崎雄治,木戸慎介,瀬川博子,佐野光枝,福渡努, 柴田克己,宮本賢一.
  • Organizer: 第67回日本栄養・食糧学会大会
  • Place of Presentation: 名古屋大学東山キャンパス（愛知県）
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  • Author(s): 宮川淳美,辰巳佐和子,野村憲吾,木戸慎介,瀬川博子,宮本賢一.
  • Organizer: 第67回日本栄養・食糧学会大会
  • Place of Presentation: 名古屋大学東山キャンパス（愛知県）
• [Presentation] 慢性腎臓病に併存する骨ミネラル代謝障害（CKD-MBD）の発症並びに進展におけるFGF23の関与. (2013)
  • Author(s): 木戸慎介,越智美佐子,藤原真理奈,向井朋,塩崎雄治,瀬川博子,辰巳佐和子,宮本賢一.
  • Organizer: 第67回日本栄養・食糧学会大会
  • Place of Presentation: 名古屋大学東山キャンパス（愛知県）
• [Presentation] 骨とリン利尿因子. (2013)
  • Author(s): 辰巳佐和子,木戸慎介,瀬川博子,宮本賢一.
  • Organizer: 第58回日本透析医学会学術集会・総会
  • Place of Presentation: 福岡国際会議場（福岡県）
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  • Invited
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  • Author(s): 宮本賢一.
  • Organizer: 第12回徳島腎と薬剤研究会
  • Place of Presentation: ザグランドパレス徳島（徳島県）
  • Invited
• [Presentation] 食品添加物としてのリン：最近の話題. (2013)
  • Author(s): 宮本賢一.
  • Organizer: 第13回東京腎不全骨代謝研究会
  • Place of Presentation: 京王プラザホテル（東京都）
  • Invited
• [Presentation] 透析患者におけるリン管理と栄養摂取. (2013)
  • Author(s): 宮本賢一.
  • Organizer: 第45回西播透析医会
  • Place of Presentation: 姫路ｷｬｯｽﾙｸﾞﾗﾝｳ゛ｨﾘｵﾎﾃﾙ（兵庫県）
  • Invited
• [Presentation] 食道癌術後乳糜胸をオクトレオチドと低脂肪食の栄養治療で回復した一例. (2013)
  • Author(s): 大西律子,谷佳子,山田静恵,松村晃子,宮本賢一.
  • Organizer: 第60回日本栄養改善学会学術総会
  • Place of Presentation: 神戸国際会議場（兵庫県）
• [Presentation] 肝臓切除患者における低リン血症発症機序の解明. (2013)
  • Author(s): 辰巳佐和子,野村憲吾,大西律子,宮本賢一.
  • Organizer: 第60回日本栄養改善学会学術総会
  • Place of Presentation: 神戸国際会議場（兵庫県）
• [Presentation] 近位尿細管上皮細胞におけるNa+依存性無機リン酸輸送担体Npt2cの発現調節とVacuole形成. (2013)
  • Author(s): 塩崎雄治,瀬川博子,大西沙織,大井彰子,杉野紗貴子,簑島さくら,伊藤美紀子,木戸慎介,辰巳佐和子,宮本賢一.
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: パシフィコ横浜（神奈川県）
• [Presentation] 生体内リン代謝調節機構における唾液腺の関与. (2013)
  • Author(s): 生田かよ,瀬川博子,向井朋,佐々木祥平,森絢加,石川康子,上田乙也,堀場直,寺社下浩一,福島直,宮本賢一.
  • Organizer: 第86回日本生化学会大会.
  • Place of Presentation: パシフィコ横浜（神奈川県）
• [Presentation] Klothoによるリン代謝制御と老化 (2013)
  • Author(s): 瀬川博子,佐々木祥平,宮本賢一.
  • Organizer: 第43回日本腎臓学会西部学術大会
  • Place of Presentation: 松山全日空ホテル（愛媛県）
• [Presentation] 肝臓切除による無機リン酸恒常性破綻機構について. (2013)
  • Author(s): 野村憲吾,辰巳佐和子,宮川淳美,塩崎雄治,瀬川博子,宮本賢一.
  • Organizer: 第36回日本分子生物学会年会.
  • Place of Presentation: 神戸国際会議場（兵庫県）
• [Presentation] 肝臓切除に起因する低リン血漿発症機構の解明 (2013)
  • Author(s): 野村憲吾
  • Organizer: 第16回日本病態栄養学会年次学術集会
  • Place of Presentation: 国立京都国際会館（京都府）
• [Presentation] 腸管リン吸収における腸アルカリフォスファターゼの役割 (2013)
  • Author(s): 日下祐里
  • Organizer: 第16回日本病態栄養学会年次学術集会
  • Place of Presentation: 国立京都国際会館（京都府）
• [Presentation] 慢性腎臓病におけるFGF23産生亢進の分子機能解析 (2013)
  • Author(s): 木戸慎介
  • Organizer: 第16回日本病態栄養学会年次学術集会
  • Place of Presentation: 国立京都国際会館（京都府）
• [Presentation] 食道癌術後乳糜胸をオクトレオチドと低脂肪の栄養治療で回復した一例 (2013)
  • Author(s): 大西律子
  • Organizer: 第16回日本病態栄養学会年次学術集会
  • Place of Presentation: 国立京都国際会館（京都府）
• [Presentation] リンと栄養：各国の話題 (2013)
  • Author(s): 宮本 賢一
  • Organizer: 第15回日本腎不全看護学会学術集会・総会
  • Place of Presentation: 愛媛県民文化会館（愛媛県）
• [Presentation] Molecular mechanisms of cadmium (Cd) dependent fibroblast growth factor 23 secretion in bone (2012)
  • Author(s): Kido S, Fujiwara M, Nomura K, Sasaki S, Shiozaki Y, Segawa H, Tatsumi S, Miyamoto K
  • Organizer: Americal Society Nephrology, Kidney Week
  • Place of Presentation: San Diego Convention Center, CA, USA
  • Year and Date: 2012-11-02
• [Presentation] Mechanisms of hyperphosphatemia in the osteocyte-abelated mice (2012)
  • Author(s): Tatsumi S, Kamatani T, Nomura K, Yoshimi A, Shiozaki Y, Sasaki S, Manabe M, Kido S, Segawa H, Miyamoto K
  • Organizer: Americal Society Nephrology, Kidney Week
  • Place of Presentation: San Diego Convention Center, CA, USA
  • Year and Date: 2012-11-02
• [Presentation] Clinical consequences of gene mutations involved in renal phosphate transport (2012)
  • Author(s): Miyamoto K, Ohnishi S, Shiozaki Y, Segawa H, Tatsumi S
  • Organizer: International Symposium on Epithelial Barrier and Transport
  • Place of Presentation: Ritsumeikan University. Kusatsu, Shiga, Japan
  • Year and Date: 2012-09-16
• [Presentation] The role of salivary glands in phosphate homeostasis (2012)
  • Author(s): Mukai T, Segawa H, Sasaki S, (他9名)
  • Organizer: XVI International Congress on Nutrition and Metabolism in Renal Disease
  • Place of Presentation: Hilton Hawaian Village, Honolulu, Hawaii, USA
  • Year and Date: 2012-06-29
• [Presentation] Dietary inorganic phosphorus and intestinal peptide absorption (2012)
  • Author(s): Segawa H, Furutani J, Miyamoto K
  • Organizer: XVI International Congress on Nutrition and Metabolism in Renal Disease
  • Place of Presentation: Hilton Hawaian Village, Honolulu, Hawaii.USA
  • Year and Date: 2012-06-29
• [Presentation] Muscle atrophy in patients with CKD results from FGF23/Klotho-mediated suppression of Insulin/IGF-I signaling (2012)
  • Author(s): Kido S, Hashimoto Y, Segawa H, Tatsumi S, Miyamoto K
  • Organizer: XVI International Congress on Nutrition and Metabolism in Renal Disease
  • Place of Presentation: Hilton Hawaian Village, Honolulu, Hawaii, USA
  • Year and Date: 2012-06-27
• [Presentation] Phosphorus Management and Clinical Outcomes (2012)
  • Author(s): Miyamoto K
  • Organizer: XVI International Congress on Nutrition and Metabolism in Renal Disease
  • Place of Presentation: Hilton Hawaian Village, Honolulu, Hawaii, USA
  • Year and Date: 2012-06-26
• [Presentation] カドミウムと低リン血症 (2012)
  • Author(s): 宮本賢一
  • Organizer: 第82回日本衛生学会学術総会
  • Place of Presentation: 京都大学(京都府)(招待講演)
  • Year and Date: 2012-03-26
• [Presentation] カドミウム汚染によるリン代謝異常;骨軟化症発症機序およびバイオマーカーの探索 (2012)
  • Author(s): 藤原真里奈
  • Organizer: 第244回徳島医学会学術集会
  • Place of Presentation: 徳島大学(徳島県)
  • Year and Date: 2012-02-12
• [Presentation] 骨細胞とリン代謝 (2012)
  • Author(s): 釜谷達哉
  • Organizer: 第15回日本病態栄養学会年次学術集会
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2012-01-14
• [Presentation] カドミウム汚染によるリン代謝異常:骨軟化症発症機序の検討 (2012)
  • Author(s): 藤原真理奈
  • Organizer: 第15回日本病態栄養学会年次学術集会
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2012-01-14
• [Presentation] ナトリウム依存性リン酸トランスポーターNpt2bの新たな生理機能の解析 (2012)
  • Author(s): 向井朋
  • Organizer: 第15回日本病態栄養学会年次学術集会
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2012-01-14
• [Presentation] 糖尿病に併存する腎障害・骨障害の発症及び進展におけるFGF23の関与 (2012)
  • Author(s): 木戸慎介
  • Organizer: 第15回日本病態栄養学会年次学術集会
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2012-01-14
• [Presentation] リン代謝における腸管の役割 (2012)
  • Author(s): 宮本賢一
  • Organizer: 第15回日本病態栄養学会年次学術集会
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2012-01-14
• [Presentation] Muscle atrophy in patients with CKD results from FGF23/Klotho-mediated suppression of Insulin/IGF-I signaling (2012)
  • Author(s): Kido S
  • Organizer: XVI International Congress on Nutrition and Metabolism in Renal Disease 2012
  • Place of Presentation: ﾋﾙﾄﾝ・ﾊﾜｲｱﾝﾋﾞﾚｯｼﾞ（ｱﾒﾘｶ）
• [Presentation] The role of salivary glands in phosphate homeostasis (2012)
  • Author(s): Mukai T
  • Organizer: XVI International Congress on Nutrition and Metabolism in Renal Disease 2012
  • Place of Presentation: ﾋﾙﾄﾝ・ﾊﾜｲｱﾝﾋﾞﾚｯｼﾞ（ｱﾒﾘｶ）
• [Presentation] Dietary inorganic phosphorus and intestinal peptide absorption (2012)
  • Author(s): Segawa H
  • Organizer: XVI International Congress on Nutrition and Metabolism in Renal Disease 2012
  • Place of Presentation: ﾋﾙﾄﾝ・ﾊﾜｲｱﾝﾋﾞﾚｯｼﾞ(ｱﾒﾘｶ）
• [Presentation] hosphorus Management and Clinical Outcomes (2012)
  • Author(s): Miyamoto K
  • Organizer: XVI International Congress on Nutrition and Metabolism in Renal Disease 2012
  • Place of Presentation: ﾋﾙﾄﾝ・ﾊﾜｲｱﾝﾋﾞﾚｯｼﾞ（ｱﾒﾘｶ）
• [Presentation] Molecular mechanisms of cadmium (Cd) dependent fibroblast growth factor 23 secretion in bone (2012)
  • Author(s): Kido S
  • Organizer: American Society Nephrology
  • Place of Presentation: ｻﾝﾃﾞｨｴｺﾞｺﾝﾍﾞﾝｼｮﾝｾﾝﾀｰ（ｱﾒﾘｶ）
• [Presentation] The membrane cytoskeletal crosslinker ezrin is essential for the regulation of phosphate homeostasis in the kidney (2012)
  • Author(s): Hatano R
  • Organizer: American Society Nephrology
  • Place of Presentation: ｻﾝﾃﾞｨｴｺﾞｺﾝﾍﾞﾝｼｮﾝｾﾝﾀｰ（ｱﾒﾘｶ）
• [Presentation] Mechanisms of hyperphosphatemia in the osteocyte-abelated mice (2012)
  • Author(s): Tatsumi S
  • Organizer: American Society Nephrology
  • Place of Presentation: ｻﾝﾃﾞｨｴｺﾞｺﾝﾍﾞﾝｼｮﾝｾﾝﾀｰ（ｱﾒﾘｶ）
• [Presentation] Clinical consequences of gene mutations involved in renal phosphate transport (2012)
  • Author(s): Miyamoto K
  • Organizer: International Symposium on Epithelial Barrier and Transport 2012
  • Place of Presentation: 立命館大学（滋賀県）
• [Presentation] 生体内リン代謝調節機構における唾液腺の関与 (2012)
  • Author(s): 向井朋
  • Organizer: 第66回日本栄養・食糧学会大会
  • Place of Presentation: 東北大学（宮城県）
• [Presentation] 骨細胞と腎臓を結ぶリン代謝調節機序 (2012)
  • Author(s): 辰巳佐和子
  • Organizer: 第66回日本栄養・食糧学会大会
  • Place of Presentation: 東北大学（宮城県）
• [Presentation] 慢性腎臓病患者におけるFGF23産生亢進の分子機能解析 (2012)
  • Author(s): 木戸慎介
  • Organizer: 第66回日本栄養・食糧学会大会
  • Place of Presentation: 東北大学（宮城県）
• [Presentation] リン代謝調節機構 (2012)
  • Author(s): 瀬川博子
  • Organizer: 第55回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県）
• [Presentation] HHRHの原因遺伝子Na-Pi-llcによる細胞内vacuole形成について (2012)
  • Author(s): 大西沙織
  • Organizer: 第55回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県）
• [Presentation] カドミウム汚染によるリン代謝異常・骨軟化症発症機序の検討 (2012)
  • Author(s): 木戸慎介
  • Organizer: 第30回日本骨代謝学会学術集会
  • Place of Presentation: 京王プラザホテル（東京都）
• [Presentation] 腎臓切除後の低リン血症発症機構の解明 (2012)
  • Author(s): 野村憲吾
  • Organizer: 第45回日本栄養・食糧学会 中国・四国支部大会
  • Place of Presentation: 愛媛大学（愛媛県）
• [Presentation] 糖尿病合併症発症におけるFGF23/Klothoの関与 (2011)
  • Author(s): 橋本由衣
  • Organizer: 第44回日本栄養食糧学会中四国支部大会
  • Place of Presentation: 岡山県立大学(岡山県)
  • Year and Date: 2011-11-13
• [Presentation] Post-Hepatectomy Hypophosphatemia in Rats (2011)
  • Author(s): Nomura K, Tatsumi S, Shiozaki Y, Yamaguchi S, Kamatani T, Segawa H, Kido S, Miyamoto K
  • Organizer: J Am Soc Nephrol
  • Place of Presentation: Pennsylvania Convention Center in Philadelphia, USA
  • Year and Date: 2011-11-12
• [Presentation] Post-Hepatectomy Hypophosphatemia in Rats (2011)
  • Author(s): Kengo Nomura
  • Organizer: Ameriean Society of Nephrology
  • Place of Presentation: Pennsylvania Convention Center (Philadelphia)
  • Year and Date: 2011-11-12
• [Presentation] Role of Sodium-Dependent Phosphate(Pi)Transporter(Npt2b)on Salivary Pi Secretion (2011)
  • Author(s): Segawa H, Mukai T, Ohnishi S, Sasaki S, Ohi A, Kuwahara S, Kido S, Tatsumi S, Ishikawa Y, Ueda O, Horiba N, Jishage K, Fukushima N, Miyamoto K
  • Organizer: J Am Soc Nephrol
  • Place of Presentation: Pennsylvania Convention Center in Philadelphia, USA
  • Year and Date: 2011-11-11
• [Presentation] Role of Sodium-Dependent Phosphate (Pi) Transporter (Npt2b) on Salivary Pi Se (2011)
  • Author(s): Hiioko Segawa
  • Organizer: Ameriean Society of Nephrology
  • Place of Presentation: Pennsylvania Convention Center (Philadelphia)
  • Year and Date: 2011-11-11
• [Presentation] Molecular Consequences of the SLC34A3 Mutations of Hereditary Hypophosphatemic Rickets with Hypercalciuria(HHRH) (2011)
  • Author(s): Ohi A, Haito Sugino S, Ito M, Shiozaki Y, Nomura K, Kusaka Y, Sasaki S, Ohnishi S, Yamaguchi S, Kido S, Tatsumi S, Segawa H, Miyamoto K
  • Organizer: J Am Soc Nephrol
  • Place of Presentation: Pennsylvania Convention Center in Philadelphia, USA
  • Year and Date: 2011-11-10
• [Presentation] Molecular Consequences of the SLC34A3 Mutations of Hereditaiy Hypophosphatemic Rickets with Hypercalciuria (HHRH) (2011)
  • Author(s): Akiko Ohi
  • Organizer: Ameriean Society of Nephiology
  • Place of Presentation: Pennsylvania Convention Center (Philadelphia)
  • Year and Date: 2011-11-10
• [Presentation] Ezrin Is Essential for the Phosphate Reabeorption in the Renal Proximai T (2011)
  • Author(s): Ryo Hatano
  • Organizer: Ameriean Society of Nephiology
  • Place of Presentation: Pennsylvania Convention Center (Philadelphia)
  • Year and Date: 2011-11-10
• [Presentation] Hereditary nypophosphatemic rickets with hypercalciuria (HHRH)やFanconi's syndromeにおける低リン血症の分子機構解明 (2011)
  • Author(s): 大西沙織
  • Organizer: 第41回日本腎臓学会西部学術大会
  • Place of Presentation: あわぎんホール(徳島県)
  • Year and Date: 2011-09-30
• [Presentation] ナトリウム依存性リン酸トランスポーターNpt2bの新たな生理機能の解明 (2011)
  • Author(s): 向井朋
  • Organizer: 第41回日本腎臓学会西部学術大会
  • Place of Presentation: あわぎんホール(徳島県)
  • Year and Date: 2011-09-30
• [Presentation] Phospholipase C signaling through the PTH/PTHrP receptor is required for serum phosphate homeostasis but not for serum 1.25(OH)2D3 (2011)
  • Author(s): Jun Guo
  • Organizer: American Society for Bone and Mineral Research
  • Place of Presentation: San Diego (California)
  • Year and Date: 2011-09-16
• [Presentation] シナカルセト塩酸塩によるリン代謝 (2011)
  • Author(s): 辰已佐和子
  • Organizer: 第58回日本栄養改善学会学術総会
  • Place of Presentation: 広島国際会議場(広島県)
  • Year and Date: 2011-09-10
• [Presentation] 慢性腎臓病モデルラットにおけるリン摂取制限による血管内皮機能改善効果 (2011)
  • Author(s): 竹谷豊
  • Organizer: 第58回日本栄養改善学会学術総会
  • Place of Presentation: 広島国際会議場(広島県)
  • Year and Date: 2011-09-09
• [Presentation] レチノイン酸はIIb型リン酸トランスボークーNpt2b発根を抑制し小腸リン吸収を低下させろ (2011)
  • Author(s): 山本浩範
  • Organizer: 第29回日本骨代謝学会学術集会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2011-07-30
• [Presentation] リン制限食はアデニン誘発性CKDモデルラットにおける血管内皮機能障害を改善す (2011)
  • Author(s): 竹谷豊
  • Organizer: 第29回日本骨代謝学会学術集会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2011-07-30
• [Presentation] 敗血症時におけるリン代謝異常の分子メカニズムの解析 (2011)
  • Author(s): 山本浩範
  • Organizer: 第29回日本骨代謝学会学術集会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2011-07-28
• [Presentation] イタイイタイ病に見られる骨障害の発症・進展におけるFGF23の関与 (2011)
  • Author(s): 木戸慎介
  • Organizer: 第29回日本骨代謝学会学術集会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2011-07-28
• [Presentation] リン代謝調節機構up to date (2011)
  • Author(s): 瀬川博子
  • Organizer: 第56回日本透析医学会学術集会・総会
  • Place of Presentation: パシフィコ横浜(神奈川県)(招待講演)
  • Year and Date: 2011-06-17
• [Presentation] 高カルシウム尿を伴つ遺伝性低リン血症性クル病の原因遺伝子リン酸トランスポーターNPT2cの変異体解析 (2011)
  • Author(s): 塩崎雄治
  • Organizer: 第54回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-06-16
• [Presentation] レチノイン酸受容体RAR/RXRを介したナトリウム依存性リン酸輸送担体遺伝子の発現調節機構 (2011)
  • Author(s): 山本浩範
  • Organizer: 第65回日本栄養・食糧学会大会
  • Place of Presentation: お茶の水女子大学(東京都)
  • Year and Date: 2011-05-15
• [Presentation] リン代謝におけるカルシウム受容体の役割 (2011)
  • Author(s): 辰巳佐和子
  • Organizer: 第65回日本栄養・食糧学会大会
  • Place of Presentation: お茶の水女子大学(東京都)
  • Year and Date: 2011-05-15
• [Presentation] イタイイタイ病に見られる骨障害の発症・進展におけるFGF23の関与 (2011)
  • Author(s): 木戸慎介
  • Organizer: 第65回日本栄養・食糧学会大会
  • Place of Presentation: お茶の水女子大学(東京都)
  • Year and Date: 2011-05-15
• [Presentation] リン制限食によるFibroblast growth factor15遺伝子の発現制御機構 (2011)
  • Author(s): 中橋乙起
  • Organizer: 第65回日本栄養・食糧学会大会
  • Place of Presentation: お茶の水女子大学(東京都)
  • Year and Date: 2011-05-15
• [Presentation] 慢性腎臓病における食事リンによる腸管ペプチドトランスポーター調節 (2011)
  • Author(s): 瀬川博子
  • Organizer: 第65回日本栄養・食糧学会大会
  • Place of Presentation: お茶の水女子大学(東京都)
  • Year and Date: 2011-05-15
• [Book] 別冊・医学のあゆみ トランスポーターと疾患研究の最前線. (2014)
  • Author(s): 野村憲吾,宮本賢一.
  • Total Pages: 160
  • Publisher: 医歯薬出版株式会社.
• [Book] Medical Practice (2014)
  • Author(s): 大西律子,佐々木祥平,宮本賢一.
  • Total Pages: 166
  • Publisher: 文光堂
• [Book] 医学のあゆみ (2013)
  • Author(s): 野村憲吾,宮本賢一.
  • Total Pages: 147
  • Publisher: 医歯薬出版株式会社
• [Book] CKD-MBDハンドブック2nd Edition (2013)
  • Author(s): 辰巳佐和子,野村憲吾,宮本賢一.
  • Total Pages: 325
  • Publisher: 日本メディカルセンター
• [Book] CKD-MBDハンドブック2nd Edition (2013)
  • Author(s): 塩崎雄治，野村憲吾，宮本賢一.
  • Publisher: 日本メディカルセンター
• [Book] CKD-MBDハンドブック2nd Edition (2013)
  • Author(s): 瀬川博子，宮本賢一.
  • Total Pages: 325
  • Publisher: 日本メディカルセンター
• [Book] 腎と骨代謝 (2013)
  • Author(s): 宮本賢一.
  • Total Pages: 333
  • Publisher: 日本メディカルセンター
• [Book] 腎と骨代謝 (2013)
  • Author(s): 瀬川博子,大西沙織,塩崎雄治,佐々木祥平,宮本賢一.
  • Total Pages: 333
  • Publisher: 日本メディカルセンター
• [Book] 腎不全を生きる (2013)
  • Author(s): 宮本賢一.
  • Total Pages: 64
  • Publisher: 日本腎臓財団
• [Book] 臨床栄養 (2013)
  • Author(s): 大西律子,木戸慎介,宮本賢一.
  • Total Pages: 390
  • Publisher: 医歯薬出版株式会社
• [Book] NephrologyFrontier (2013)
  • Author(s): 辰巳佐和子,藤田みゆき,野村憲吾,藤井理,宮本賢一.
  • Total Pages: 104
  • Publisher: メディカルレビュー社
• [Book] Anual Review腎臓 (2013)
  • Author(s): 野村憲吾
  • Publisher: 中外医薬社
• [Book] 医学のあゆみ (2013)
  • Author(s): 野村憲吾
  • Publisher: 医歯薬出版株式会社
• [Book] 栄養生化学 人体の構造と機能 (2012)
  • Author(s): 加藤秀夫
  • Total Pages: 192
  • Publisher: 講談社サイエンティフィク
• [Book] 透析療法ネクストVIII～新時代の高リン血症治療～ (2012)
  • Author(s): 辰巳佐和子
  • Publisher: 医学図書出版株式会社
• [Book] 腎と骨代謝2012Vol25,No1 (2012)
  • Author(s): 木戸慎介
  • Publisher: 日本メディカルセンター
• [Book] CLINICAL CALCIUM 2012 Vol.22 No.10 (2012)
  • Author(s): 瀬川博子
  • Publisher: 医薬ジャーナル社
• [Book] CLINICAL CALCIUM 2012 Vol.22 No.10 (2012)
  • Author(s): 辰巳佐和子
  • Publisher: 医薬ジャーナル社
• [Book] 腎と透析 (2012)
  • Author(s): 桑原頌治, 他
  • Publisher: 東京医学社
• [Book] 栄養生化学実験 (2012)
  • Author(s): 宮本賢一, 他
  • Publisher: 共立出版株式会社
• [Book] 改訂第2版カラー図解人体の正常構造と機能X運動器 (2012)
  • Author(s): 坂井建雄, 他
  • Total Pages: 101
  • Publisher: 日本医事新報社
• [Book] 循環器医のための知っておくべき電解質異常 (2011)
  • Author(s): 大井彰子, 他
  • Publisher: メディカルレビュー社
• [Book] 循環器医のための知っておくべき電解質異常 (2011)
  • Author(s): 宮本賢一, 他
  • Publisher: メディカルレビュー社
• [Book] 栄養・食品機能とトランスポーター (2011)
  • Author(s): 宮本賢一, 他
  • Publisher: けんぱく社
• [Book] 腎不全医療における栄養管理の基礎知識 (2011)
  • Author(s): 伊藤美紀子, 他
  • Publisher: 日本メディカルセンター
• [Book] Bio Clinica腎臓トランスポーター異常による疾患 (2011)
  • Author(s): 瀬川博子, 他
  • Publisher: 北隆館