| Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2013: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2012: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2011: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Research Abstract |
The adult kidney never regenerates, but the embryonic kidney contains nephron progenitors. The purpose of this project was to reveal molecular mechanisms underlying the maintenance of the embryonic nephron progenitors. We generated progenitor-specific and drug-inducible Sall1 mutant mice, and found that nephron progenitors were rapidly depleted upon Sall1 deletion. We identified the direct downstream targets of Sall1 and found that Sall1 functions as a positive regulator in the progenitors, while repressing aberrant gene expression in differentiating nascent nephrons. We are currently trying to establish a method to self-renew the progenitors, by utilizing the obtained information. If successful, it would serve as a basis toward kidney regeneration, because the nephron progenitors disappear shortly after birth in a normal condition.
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