| Project/Area Number |
23390229
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
YAMADA Hideomi 東京大学, 医学部附属病院, 助教 (60396752)
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| Co-Investigator(Kenkyū-buntansha) |
GOTO Jun 東京大学, 医学部, 講師 (10211252)
HORITA Shoko 東京大学, 医学部, 助教 (20534895)
SEKI George 東京大学, 医学部, 講師 (30206619)
高橋 祐二 東京大学, 医学部附属病院, 助教 (00372392)
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| Co-Investigator(Renkei-kenkyūsha) |
TOKUNAGA Katsushi 東京大学, 医学部, 教授 (40163977)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
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| Keywords | NBCe1 / IRBIT / 片頭痛 / NBC1 / 尿細管性アシドーシス / NBCe1変異 |
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| Research Abstract |
For pathogenic mechanism of migraine, NBCe1 presents nerve synaptic cleft side in the membrane of the glia-cells. Genetic abnormalities of the NBCe1 cause proximal renal tubular acidosis in an autosomal recessive. We presented the possibility of onset migraine that this NBCe1 adjusts pH the synaptic cleft.
Mutations K558R, reported a SNP in the database, is shown less than half functions as WT. Other Bicarbonate transporters have known dimmer-form and Dominant Negative(DN) effect. We think that NBCe1 is also dimmer-form, must have DN effect. We show that co-expressed WT and L522P mutations (No expression the membrane) clearly decreases the function of NBCe1. We lead the conclusion that the migraine possibility of NBCe1 dysfunction may be more frequent as expected.
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