Identification of small molecules that down-regulate alpha-synuclein transcription

• Project/Area Number: 23390232
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurology
• Research Institution: Kyoto University
• Principal Investigator: TAKAHASHI RYOSUKE 京都大学, 医学(系)研究科(研究院), 教授 (90216771)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000); Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000); Fiscal Year 2011: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
• Keywords: α-シヌクレイン / HTS / パーキンソン病 / 疾患モデルマウス / 遺伝子 / ゲノム / 神経科学 / 脳神経疾患 / 発現制御

Research Abstract

To identify the small molecules that down-regulate alpha-synuclein (alpha-syn), we employed BAC clone that contains the alpha-syn genes and its expression regulatory regions, and inserted the secretory luciferase into this BAC clone. Next, we generated the stable SH-SY5Y cells that express the construct. By using these cell lines, we screened the FDA-approved small molecules and found the several hit molesules that down-regulate alpha-syn. We also revealed one of the molecular mechanism of alpha-syn down-regulation by these molecules. Finally, we tried to generate symptomatic PD mice models to verify the in vivo efficacy of these molecules. We created alpha-syn transgenic mice crossed with transgenic mice that increase oxidative stress in neurons. These mice showed protease K-resistant alpha-syn aggregation that recapitulate some of PD features. Now we tried to administrate and confirm the efficacy of these drugs in newly created PD mice model.

Research Products

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• [Journal Article] Nardilysin prevents amyloid plaque formation by enhancing a-secretase activity in an Alzheimer's disease mouse model (2014)
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  • Journal Title: J Alzheimers Dis Volume: 38（3） Issue: 3 Pages: 601-609
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• [Journal Article] Design, evaluation, and screening methods for efficient targeted mutage nesis with TALENs' in medaka. (2014)
  • Author(s): S. Ansai, K. Inohaya, Y. Yoshiu ra, M. Schartl, N. Uemura, R. Takahashi, M. Kinoshita
  • Journal Title: Development, Growth & Differentiation Volume: 56 Issue: 1 Pages: 98-107
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• [Journal Article] XIAP immunoreactivity in glial and neuronal cytoplasmic inclusions in multiple system atrophy. (2014)
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• [Journal Article] Involvement of Wnt/β-catenin signaling in the development of neuropathic pain. (2014)
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• [Journal Article] Transglutaminase 2 accelerates neuroinflammation in amyotrophic lateral sclerosis through interaction with misfolded superoxide dismutase 1. (2014)
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• [Journal Article] Exploring the Pathogenetic Mechanisms underlying Parkinson' s Disease in Medaka Fish (2013)
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• [Journal Article] S-nitrosylation regulates mitochondrial quality control via activation of parkin (2013)
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• [Journal Article] A progressive dopaminergic phenotype associated with neurotoxic conversion of α -synuclein in BAC-transgenic rats (2013)
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• [Journal Article] Efficient targeted mutagenesis in medaka using custom-designed transcription activator-like effector nucleases (2013)
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• [Journal Article] PINK1 and Parkin complementarily protect dopaminergic neurons in vertebrates (2013)
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• [Journal Article] Modeling Alzheimer' s disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness (2013)
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• [Journal Article] ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neurons (2013)
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• [Journal Article] Tricornered/NDR kinase signaling mediates PINK1-directed mitochondrial quality control and tissue maintenance (2013)
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• [Journal Article] A drug screening platform for Alzheimer's disease with intracellular Aβ oligomers using patient-specific iPSCs (2013)
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  • Journal Title: Cell Stem Cell Volume: 12 Issue: 4 Pages: 487-496
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• [Journal Article] ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neurons. (2013)
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• [Journal Article] Aberrant assembly of RNA-recognition motif 1 links to pathogenic conversion of TAR DNA-binding protein-43 (TDP-43) (2013)
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• [Journal Article] Synthesis and biological evaluation of novel styryl benzimidazole derivatives as probes for imaging of neurofibrillary tangles in Alzheimer's disease. (2013)
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• [Journal Article] Response to comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells". (2013)
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• [Journal Article] PINK1 and Parkin complementarily protect dopaminergic neurons in vertebrates. (2013)
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• [Journal Article] Chronic overload of SEPT4, a parkin substrate that aggregates in Parkinson's disease, causes behavioral alterations but not neurodegeneration in mice (2013)
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• [Journal Article] Optineurin suppression causes neuronal cell death via NF-κB pathway. (2013)
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• [Journal Article] Continuation of exercise is necessary to inhibit high fat diet-inducde β-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice. (2013)
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• [Journal Article] The function of parkin: revisited. (2013)
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• [Journal Article] Genetic correction will be a standard method for the patient-derived ips cell research? (2013)
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• [Journal Article] Development of Novel (123)I-Labeled Pyridyl Benzofuran Derivatives for SPECT Imaging of β-Amyloid Plaques in Alzheimer's Disease. (2013)
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• [Journal Article] Chicken DT40 cell line lacking DJ-1, the gene responsible for familial Parkinson's disease, displays mitochondrial dysfunction. (2013)
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• [Journal Article] Exploring the Pathogenetic Mechanisms underlying Parkinson's Disease in Medaka Fish. (2013)
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• [Journal Article] Tricornered/NDR kinase signaling mediates PINK1-directed mitochondrial quality control and tissue maintenance (2013)
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  • Journal Title: Genes Dev. Volume: 27 Issue: 2 Pages: 157-62
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• [Journal Article] Visualization of Lenticulostriate Arteries by Flow-Sensitive Black-Blood MR Angiography on a 1.5T MRI System: A Comparative Study between Subjects with and without Stroke. AJNR Am J Neuroradiol. (2013)
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• [Journal Article] PINK1 and Parkin complementarily protect dopaminergic neurons in vertebrates. (2013)
  • Author(s): Matsui H
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• [Journal Article] α -synuclein BAC transgenic mice as a model for Parkinson' s disease manifested decreased anxiety-like behavior and hyperlocomotion (2012)
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• [Journal Article] Parkin pathway activation mitigates glioma cell proliferation and predicts patient survival (2012)
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• [Journal Article] Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells (2012)
  • Author(s): Egawa N, Kitaoka S, Tsukita K, Naitoh M, Takahashi K, Yamamoto T, Adachi F, Kondo T, Okita K, Asaka I, Aoi T, Watanabe A, Yamada Y, Morizane A, Takahashi J, Ayaki T, Ito H, Yoshikawa K, Yamawaki S, Suzuki S, Watanabe D, Hioki H, Kaneko T, Makioka K, Okamoto K, Takuma H, Tamaoka A, Hasegawa K, Nonaka T, Hasegawa M, Kawata A, Yoshida M, Nakahata T, Takahashi R, Marchetto MC, Gage FH, Yamanaka S, Inoue H
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• [Journal Article] Parkinson' s Disease-Associated Kinase PINK1 Regulates Miro Protein Level and Axonal Transport of Mitochondria (2012)
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• [Journal Article] The Nitric Oxide-Cyclic GMP Pathway Regulates FoxO and Alters Dopaminergic Neuron Survival in Drosophila (2012)
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• [Journal Article] Parkin interacts with Klokin1 for mitochondrial import and maintenance of membrane potential (2012)
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• [Journal Article] Parkin interacts with Klokin1 for mitochondrial import and maintenance of membrane potential. (2012)
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• [Journal Article] α-Synuclein BAC transgenic mice as a model for Parkinson's disease manifested decreased anxiety-like behavior and hyperlocomotion. (2012)
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• [Journal Article] Parkin pathway activation mitigates glioma cell proliferation and predicts patient survival. (2012)
  • Author(s): Yeo CW
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• [Journal Article] Drug screening for ALS using patient-specific induced pluripotent stem cells (2012)
  • Author(s): Egawa, N., Kitaoka, S., Tsukita, K., Naitoh, M., Takahashi, K., Yamamoto, T., Adachi, F., Kondo, T., Okita, K., Asaka, I., Aoi, T., Watanabe, A., Yamada, Y., Morizane, A., Takahashi, J., Ayaki, T., Ito, H., Yoshikawa, K., Yamawaki, S., Suzuki, S., Watanabe, D., Hioki, H., Kaneko, T., Makioka, K., Okamoto, K., Takuma, H., Tamaoka, A., Hasegawa, K., Nonaka, T., Hasegawa, M., Kawata, A., Yoshida, M., Nakahata, T., Takahashi, R., Marchetto, M. C. N., Gage, F. H., Yamanaka, S., and Inoue, H
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• [Journal Article] Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis (2012)
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• [Journal Article] Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria (2012)
  • Author(s): Liu Song
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• [Journal Article] The endoplasmic reticulum stress sensor, ATF6, protects against neurotoxin-induced dopaminergic neuronal death (2011)
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• [Journal Article] Chemical library screening identifies a small molecule that downregulates SOD1 transcription for drugs to treat amyotrophic lateral sclerosis (2011)
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  • NAID: 120004225661
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• [Journal Article] Clinicopathologic study on an ALS family with a heterozygous E478G optineurin mutation (2011)
  • Author(s): Ito H, Nakamura M, Komure O, Ayaki T, Wate R, Maruyama H, Nakamura Y, FujitaK, Kaneko S, Okamoto Y, Ihara M, Konishi T, Ogasawara K, Hirano A, Kusaka H, KajiR, Takahashi R, Kawakami H
  • Journal Title: Acta Neuropathologica Volume: 122 Issue: 2 Pages: 223-229
  • DOI: 10.1007/s00401-011-0842-y
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• [Presentation] Optineurin suppression causes neuronal cell death via NF-κ B pathway (2014)
  • Author(s): Akizuki M, Yamashita H, Uemura K, Maruyama H, Kawakami H, Ito H, Takahashi R
  • Organizer: 14th Asian & Oceanian congress of Neurology
  • Place of Presentation: マカオ
• [Presentation] PINK1とParkinは脊椎動物において相補的にミトコンドリアを保護する (2013)
  • Author(s): 浅野剛史, 松井秀彰, Robert Gavinio, 上村紀人, 伊東秀文, 谷口 善仁, Jie Shen, 武田俊一, 植村健吾, 山門穂高, 高橋良輔
  • Organizer: 第36回日本分子生物学会
  • Place of Presentation: 神戸
  • Year and Date: 2013-12-14
• [Presentation] Neurodegeneration, molecular mechanism, Parkinson' s diease, animal model, medaka, mouse (2013)
  • Author(s): Takahashi R
  • Organizer: Swiss-Kyoto Symposium
  • Place of Presentation: Kyoto
  • Year and Date: 2013-11-22
  • Invited
• [Presentation] Viable Gaucher' s disease model of medaka fish completely deficienct in glucocerebrosidase activity developed alpha-synuclein aggregation in the brain (2013)
  • Author(s): Uemura N, Fujiwara-Ishikawa T, Kinoshita M, Koike M, Matsui H, Yamakado H, Uemura K, Uchiyama Y, Todo T, Takeda S, Takahashi R
  • Organizer: Neuroscience 2013
  • Place of Presentation: SanDiego
  • Year and Date: 2013-11-10
• [Presentation] Exploring the molecular mechanism underlying Parkinson' s diease with genetic medaka models (2013)
  • Author(s): Takahashi R
  • Organizer: International Symposium on Mitochondria 2013
  • Place of Presentation: Tokyo
  • Year and Date: 2013-11-06
  • Invited
• [Presentation] マウスを用いたゾニサミドの作用機序の解析 (2013)
  • Author(s): 浅野剛史, 山門穂高, 高橋良輔
  • Organizer: 第7回パーキンソン病・運動障害疾患コングレス
  • Place of Presentation: 東京
  • Year and Date: 2013-10-11
• [Presentation] PINK1とParkinは脊椎動物において相補的にミトコンドリアを保護する (2013)
  • Author(s): 浅野剛史, 松井秀彰, Robert Gavinio, 上村紀人, 伊東秀文, 谷口 善仁, Jie Shen, 武田俊一, 植村健吾, 山門穂高, 高橋良輔
  • Organizer: 第22回日本CellDeath学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2013-07-19
• [Presentation] NF-κB経路を介したOptineurinのノックダウンによる神経細胞死 (2013)
  • Author(s): 秋月 真由 美, 山下博文, 植村健吾, 丸山博文, 川上秀史, 伊東秀文, 高橋良輔
  • Organizer: 第22回日本Cell Death学会
  • Place of Presentation: 京都
  • Year and Date: 2013-07-19
• [Presentation] GBAノックアウトメダカは脳にアルファシヌクレイン凝集体を形成する (2013)
  • Author(s): 上村紀仁, 石川智子, 木下政人, 小池正人, 松井秀彰, 山門穂高, 植村健吾, 内山安男, 藤堂剛, 武田俊一, 高橋良輔
  • Organizer: 第22回日本Cell death学会
  • Place of Presentation: 京都
  • Year and Date: 2013-07-19
• [Presentation] Viable Gaucher' s disease model of medaka fish completely deficienct in glucocerebrosidase activity developed alpha-synuclein aggregation in the brain (2013)
  • Author(s): Uemura N, Fujiwara-Ishikawa T, Kinoshita M, Koike M, Matsui H, Yamakado H, Uemura K, Uchiyama Y, Todo T, Takeda S, Takahashi R
  • Organizer: 日本神経科学学会
  • Place of Presentation: 京都
  • Year and Date: 2013-06-22
• [Presentation] Viable Gaucher' s disease model of medaka fish completely deficienct in glucocerebrosidase activity developed alpha-synuclein aggregation in the brain (2013)
  • Author(s): Uemura N, Fujiwara-Ishikawa T, Kinoshita M, Koike M, Matsui H, Yamakado H, Uemura K, Uchiyama Y, Todo T, Takeda S, Takahashi R
  • Organizer: 17th international congress of Parkinson' s disease and movement disorders
  • Place of Presentation: Sydney
  • Year and Date: 2013-06-20
• [Presentation] NF-κB経路を介したOptineurinのノックダウンによる神経細胞死 (2013)
  • Author(s): 秋月真由美, 山下博文, 植村健吾, 丸山博文, 川上秀史, 伊東秀文, 高橋良輔
  • Organizer: Neuro2013
  • Place of Presentation: 京都
  • Year and Date: 2013-06-20
• [Presentation] α-Synucleinの発現量の調節を標的とするパーキンソン病治療薬剤のスクリーニング (2013)
  • Author(s): 浅野剛史, 山門穂高, 高橋良輔
  • Organizer: Neuro2013
  • Place of Presentation: 京都
  • Year and Date: 2013-06-20
• [Presentation] Therapeutic approach to Parkinson' s disease by modifying α -synuclein expression (2013)
  • Author(s): Yamakado H, Asano T, Takahashi R
  • Organizer: The MDS 17th International Congress of Parkinson' s Disease and Movement Disorders
  • Place of Presentation: Sydney
  • Year and Date: 2013-06-17
• [Presentation] メダカを用いたGBA変異とパーキンソン病の関連性の解析 (2013)
  • Author(s): 上村紀仁, 石川智子, 木下政人, 小池正人, 松井秀彰, 山門穂高, 植村健吾, 内山安男, 藤堂剛, 武田俊一, 高橋良輔
  • Organizer: 日本神経学会
  • Place of Presentation: 京都
  • Year and Date: 2013-05-31
• [Presentation] 疾患特異的iPS細胞モデルによるLRRK2変異パーキンソン病の研究 (2013)
  • Author(s): 小芝泰, 森実飛鳥, 山門穂高, 陣上直人, 菊地哲広, 土井大輔, 皆川栄子, 江川斉宏, 井上治久, 高橋淳, 高橋良輔
  • Organizer: 第7回パーキンソン病・運動障害疾患コングレス
  • Place of Presentation: 東京
• [Presentation] 疾患特異的iPS細胞モデルによる遺伝性パーキンソン病の研究 (2013)
  • Author(s): 小芝泰, 森実飛鳥, 山門穂高, 菊地哲広, 皆川栄子, 土井大輔, 西村周泰江川斉宏, 井上治久, 高橋淳, 高橋良輔
  • Organizer: 第54回日本神経学会学術総会
  • Place of Presentation: 東京
• [Presentation] 疾患特異的iPS細胞モデルによる遺伝性パーキンソン病の研究 (2013)
  • Author(s): 小芝泰, 森実飛鳥, 山門穂高, 菊地哲広, 土井大輔, 西村周泰, 皆川栄子, 江川斉宏, 近藤孝之, 井上治久, 高橋淳, 高橋良輔
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 京都
• [Presentation] Exploring the molecular mechanism underlying Parkinson's diease with genetic medaka models. (2013)
  • Author(s): Ryosuke Takahashi
  • Organizer: International Symposium on Mitochondria 2013
  • Place of Presentation: Tokyo
  • Invited
• [Presentation] Fish model of Parkinson's disease (2013)
  • Author(s): Ryosuke Takahashi
  • Organizer: Swiss-Kyoto Symposium
  • Place of Presentation: Kyoto
  • Invited
• [Presentation] Parkinson's disease by modifying α-synuclein expression. (2013)
  • Author(s): Hodaka Yamakado, Takeshi Asano, Ryosuke Takahashi
  • Organizer: The MDS 17th International Congress of Parkinson's Disease and Movement Disorders
  • Place of Presentation: Sydney
• [Presentation] Viable Gaucher's disease model of medaka fish completely deficienct in glucocerebrosidase activity developed alpha-synuclein aggregation in the brain. (2013)
  • Author(s): Norihito Uemura, Tomoko Fujiwara-Ishikawa, Masato Kinoshita, Masato Koike, Hideaki Matsui, Hodaka Yamakado, Kengo Uemura, Yasuo Uchiyama, Takeshi Todo, Shun-ichi Takeda, Ryosuke Takahashi.
  • Organizer: Neuroscience 2013
  • Place of Presentation: SanDiego
• [Presentation] α-Synucleinの発現量の調節を標的とするパーキンソン病治療薬剤のスクリーニング (2013)
  • Author(s): 浅野剛史、山門穂高、高橋良輔
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 京都
• [Presentation] パーキンソン病の分子病態 (2012)
  • Author(s): 高橋良輔
  • Organizer: 第50回日本神経眼科学会総会
  • Place of Presentation: 京都
  • Year and Date: 2012-11-16
  • Invited
• [Presentation] Regulation of the PINK1 signaling by mitochondrial protein PGAM5 (2012)
  • Author(s): 澤田知世, 高橋良輔
  • Organizer: Neuroscience 2012
  • Place of Presentation: ニューオーリンズ
  • Year and Date: 2012-10-15
• [Presentation] BACテクノロジーを用いたパーキンソン病の治療薬候補の探索 (2012)
  • Author(s): 浅野剛史, 山門穂高, 高橋良輔
  • Organizer: 第6回パーキンソン病・運動障害疾患コングレス
  • Place of Presentation: 京都
  • Year and Date: 2012-10-13
• [Presentation] CONGNITIVE AND PHYCHIATRIC FEATURES IN ANIMAL PD MODELS (2012)
  • Author(s): Takahashi R, H. Yamakado H, Gavinio R
  • Organizer: 8th International Congress On Mental Dysfunction & Other Non-Motor Features In Parkinson' s Diease and Related Disorders
  • Place of Presentation: Inter Continental Berlin, Germany
  • Year and Date: 2012-05-04
  • Invited
• [Presentation] パーキンソン病の分子病態 (2012)
  • Author(s): 高橋良輔
  • Organizer: 第8回Clinician-Scientist育成セミナー
  • Place of Presentation: 山口
  • Year and Date: 2012-03-07
  • Invited
• [Presentation] パーキンソン病のメダカモデル神経疾患の克服に向けて (2012)
  • Author(s): 高橋良輔
  • Organizer: 大阪大学蛋白質研究所セミナー
  • Place of Presentation: 大阪大学
  • Invited
• [Presentation] CONGNITIVE AND PHYCHIATRIC FEATURES IN ANIMAL PD MODELS. (2012)
  • Author(s): Takahashi R
  • Organizer: 8th International Congress On Mental Dysfunction & Other Non-Motor Features In Parkinson’s Diease and Related Disorders
  • Place of Presentation: Berlin, Germany
  • Invited
• [Presentation] α-synuclein BAC transgenic mice as a model for Parkinson’s disease manifested decreased anxiety-like behavior. (2012)
  • Author(s): Yamakado H
  • Organizer: The MDS 17th International Congress of Parkinson's Disease and Movement Disorders
  • Place of Presentation: Dablin, Ireland
• [Presentation] Regulation of the PINK1 signaling by a mitochondrial protein PGAM5. (2012)
  • Author(s): Sawada T
  • Organizer: Neuroscience 2012
  • Place of Presentation: New Orleans, U.S.A.
• [Presentation] BACテクノロジーを用いたパーキンソン病の治療薬候補の探索。第6回パーキンソン病・運動障害疾患コングレス (2012)
  • Author(s): 浅野 剛史
  • Organizer: 第6回パーキンソン病・運動障害疾患コングレス
  • Place of Presentation: 京都ホテルオークラ
• [Presentation] PINK1 and Parkin regulate the mitochondrial transport machinery (2011)
  • Author(s): Sawada T, Liu S, Kanao T, Lu B, Hattori N, Takahashi R. Imai Y
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-14
• [Presentation] PINK1 and Parkin regulate the mitochondrial transport machinery (2011)
  • Author(s): 澤田知世
  • Organizer: 第34回日本分子生物学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-12-14
• [Presentation] パーキンソン病の治療と研究の最近の進歩 (2011)
  • Author(s): 高橋良輔
  • Organizer: 第122回山口県医師会生涯研修セミナー平成23年度第3回日本医師会生涯教育講座山口県特定疾患専門医師研修会
  • Place of Presentation: 山口
  • Year and Date: 2011-11-27
  • Invited
• [Presentation] GBA変異とパーキンソン病の関係 (2011)
  • Author(s): 上村紀仁, 石川智子, 藤堂剛, 高橋良輔
  • Organizer: 第5回パーキンソン病・運動障害疾患コングレス
  • Place of Presentation: 東京
  • Year and Date: 2011-10-07
• [Presentation] 遺伝性パーキンソン病 (2011)
  • Author(s): 高橋良輔
  • Organizer: 第5回パーキンソン病・運動障害疾患コングレス
  • Place of Presentation: 東京
  • Year and Date: 2011-10-06
  • Invited
• [Presentation] The HECT-Type ubiquitin ligase Huwe1/Mule mediates the stability of PINK1 (2011)
  • Author(s): Sawada T, Kanao T, Kobayashi Y, Takahashi R, Imai Y
  • Organizer: The 34th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Yokohama
  • Year and Date: 2011-09-17
• [Presentation] HECT型ユビキチンリガーゼHuwel/MuleはPINKl安定性を制御する (2011)
  • Author(s): 澤田知世
  • Organizer: Neuroscience2011
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-09-17
• [Presentation] Decreased anxiety-like behavior in alpha-synuclein BAC transgenic mice recapitulates early non-motor symptoms in Parkinson disease (2011)
  • Author(s): Yamakado H, Moriwaki Y, Ymazaki N, Kurisu J, Miyagawa T, Uemura K, Inoue H, Takahashi R
  • Organizer: The 34th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Yokohama
  • Year and Date: 2011-09-15
• [Presentation] アルファ・シヌクレインBACトランスジェニックマウスにおける不安の低下とパーキンソン病非運動症状について (2011)
  • Author(s): 山門穂高
  • Organizer: Neuroscience2011
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-09-15
• [Presentation] パーキンソン病遺伝子治療の是非 (2011)
  • Author(s): 高橋良輔
  • Organizer: 第26回日本大脳基底核研究会
  • Place of Presentation: 第 26 回日 本大脳基底核研究会
  • Year and Date: 2011-07-02
  • Invited
• [Presentation] Molecular mechanisms underlying Parkin / PINK1-related Parkinson ' s disease (2011)
  • Author(s): Takahashi R
  • Organizer: International Symposium Parkinson Disease and Mitophagy
  • Place of Presentation: Tokyo
  • Year and Date: 2011-06-11
  • Invited
• [Presentation] Molecular mechanisms underlying Parkin/PINK1-related Parkinson's disease (2011)
  • Author(s): Ryosuke Takahashi
  • Organizer: International Symposium "Parkinson Disease and Mitophagy"
  • Place of Presentation: 東京医科歯科大学講堂(招待講演)
  • Year and Date: 2011-06-11
• [Presentation] 中枢神経疾患に対する細胞治療御展望と課題(オーバービュー)シンポジウム23 : 神経疾患に対する細胞治療の開発-現状と展望 (2011)
  • Author(s): 高橋良輔
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-05-20
  • Invited
• [Presentation] 神経疾患に対する細胞治療の開発-現状と展望 (2011)
  • Author(s): 高橋良輔
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋国際会議場(招待講演)
  • Year and Date: 2011-05-20
• [Presentation] HECT型ユビキチンリガーゼMule/HuwelによるPINK1安定性の調節 (2011)
  • Author(s): 澤田知世
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2011-05-20
• [Presentation] HECT型ユビキチンリガーゼMule/Huwe1によるPINK1安定性の調節 (2011)
  • Author(s): 澤田知世, 金尾智子, 小林芳人, 高橋良輔, 今井譲
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-05-18
• [Book] ミスフォールド蛋白質による神経細胞死と治療戦略.MOOK別冊「細胞死研究の今-疾患との関わり 創薬に向けてのアプローチ」 (2013)
  • Author(s): 守村敏史, 高橋良輔, 漆谷真
  • Total Pages: 44
  • Publisher: メディカルドゥ
• [Book] 細胞死研究の今-疾患との関わり、創薬に,創薬に向けてのアプローチ- (2013)
  • Author(s): 守村敏史，高橋良輔，漆谷 真
  • Total Pages: 8
  • Publisher: メディカルドゥ
• [Remarks] ホームページ等に業績等を記載
  • URL: http://www.kuhp.kyoto-u.ac.jp/~neurology/
• [Remarks] 京都大学医学研究科臨床神経学
  • URL: http://www.kuhp.kyoto-u.ac.jp/~neurology/
• [Remarks]
  • URL: http://www.kuhp.kyoto-u.ac.jp/neurology/