Regenerative therapy for Alzheimer's disease and cerebral amyloid angiopathy

• Project/Area Number: 23390233
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurology
• Research Institution: National Cardiovascular Center Research Institute (2013); Foundation for Biomedical Research and Innovation (2012); Kyoto University (2011)
• Principal Investigator: IHARA Masafumi 独立行政法人国立循環器病研究センター, 病院, 医長 (00372590)
• Co-Investigator(Renkei-kenkyūsha): TOMIMOTO Hidekazu 三重大学, 大学院・医学系研究科・ 神経感覚医学講座神経病態内科学, 教授 (80324648)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000); Fiscal Year 2013: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2012: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
• Keywords: アルツハイマー病 / アミロイド血管症 / βアミロイド / シロスタゾール / 臨床試験 / 医師主導治験 / 微小梗塞 / モデルマウス / Tg-SwDIマウス

Research Abstract

Dementia will become one of the most important health problems worldwide. The discouraging results of the immunotherapy clinical trials for Alzheimer's disease have shifted scientific attention from the mechanism underlying beta amyloid (Abeta) synthesis toward clearance. Arterial pulsations may be the motive force for the drainage of interstitial fluid and solutes. As arteries stiffen with age or with other co-morbid factors, the amplitude of pulsations is reduced, perivascular drainage of Abeta becomes less efficient, and insoluble Abeta is deposited in the drainage pathways. Therefore, therapeutic strategies that enhance the patency of this perivascular drainage pathway with vasoactive drugs may facilitate Abeta removal and help prevent cognitive decline in the elderly. Based on this emerging paradigm, we will start a clinical trial to determine whether such a hemodynamic strategy is effective to halt cognitive decline as a preemptive medicine.

Research Products

• [Journal Article] Cilostazol add-on therapy in patients with mild dementia receiving donepezil : a retrospective study (2014)
  • Author(s): Ihara M, Nishino M, Taguchi A, Yamamoto Y, Hattori Y, Saito S, Takahashi Y, Tsuji M, Kasahara Y, Takata Y, Okada M
  • Journal Title: PloS ONE Volume: 9(2) Issue: 2 Pages: e89516-e89516
  • DOI: 10.1371/journal.pone.0089516
  • Peer Reviewed
• [Journal Article] A mouse model of chronic cerebral hypoperfusion characterizing features of cognitive impairment (2014)
  • Author(s): Ihara M, Taguchi A, Maki T, Washida K, Tomimoto H
  • Journal Title: Methods Mol Biol Volume: 1135 Pages: 95-102
  • DOI: 10.1007/978-1-4939-0320-7_8
  • ISBN: 9781493903191, 9781493903207
  • Peer Reviewed
• [Journal Article] 注目される脳小血管病による認知症 (2014)
  • Author(s): 猪原匡史
  • Journal Title: Dementia Japan Volume: 28(1) Pages: 57-67
  • Peer Reviewed
• [Journal Article] Effects of intravenous administration of umbilical cord blood CD34+ cells in a mouse model of neonatal stroke. (2014)
  • Author(s): Tsuji M, Taguchi A, Ohshima M, Kasahara Y, Sato Y, Tsuda H, Otani K, Yamahara K, Ihara M, Harada-Shiba M, Ikeda T, Matsuyama T.
  • Journal Title: Neuroscience Volume: 263 Pages: 148-158
  • DOI: 10.1016/j.neuroscience.2014.01.018
  • Peer Reviewed
• [Journal Article] 高血糖とアルツハイマー病． (2014)
  • Author(s): 猪原匡史
  • Journal Title: 医学のあゆみ Volume: 249 Pages: 545-550
  • Peer Reviewed
• [Journal Article] 注目される脳小血管病による認知症． (2014)
  • Author(s): 猪原匡史
  • Journal Title: Dementia Japan Volume: 28 Pages: 57-67
  • Peer Reviewed
• [Journal Article] White matter pathology and disconnection in the frontal lobe in CADASIL (2013)
  • Author(s): Craggs LJL, Yamamoto Y, et al.
  • Journal Title: Neuropathol Appl Neurobiol Volume: (Epub ahead of orint) Issue: 5 Pages: 591-602
  • DOI: 10.1111/nan.12073
  • Peer Reviewed
• [Journal Article] Vascular and neurodegenerative pathways-will they meet? (2013)
  • Author(s): Kalaria RN, Ihara M
  • Journal Title: Nat Rev Neurol Volume: 9(9) Issue: 9 Pages: 487-488
  • DOI: 10.1038/nrneurol.2013.164
  • Peer Reviewed
• [Journal Article] Cilostazol improves cognitive function in patients with mild cognitive impairment : A retrospective analysis (2013)
  • Author(s): Taguchi A, Takata Y, Ihara M, Kasahara Y, Tsuji M, Nishino M, Stern D, Okada M
  • Journal Title: Psychogeriatrics Volume: 13(3) Issue: 3 Pages: 164-169
  • DOI: 10.1111/psyg.12021
  • Peer Reviewed
• [Journal Article] Association of Physical Activity with the Visuospatial/Executive Functions of the Montreal Cognitive Assessment in Patients with Vascular Cognitive Impairment (2013)
  • Author(s): Ihara M, Okamoto Y, Hase Y, Takahashi R
  • Journal Title: J Stroke Cerebrovasc Dis Volume: 22(7) Issue: 7 Pages: 339-4
  • DOI: 10.1016/j.jstrokecerebrovasdis.2012.10.007
  • Peer Reviewed
• [Journal Article] Vascular Risk Factors and Neurodegeneration in Ageing related Dementias : Alzheimer' s Disease and Vascular Dementia (2013)
  • Author(s): Akinyemi R, Mukaetova-Ladinska E, Attems J, Ihara M, Kalaria RN
  • Journal Title: Curr Alzheimer Res Volume: 10(6) Issue: 6 Pages: 642-53
  • DOI: 10.2174/15672050113109990037
  • Peer Reviewed
• [Journal Article] Greater suitability of the Montreal Cognitive Assessment against the Mini-Mental State Examination in the detection of vascular cognitive impairment (2013)
  • Author(s): Ihara M, Okamoto Y, Takahashi R
  • Journal Title: J Stroke Cerebrovasc Dis Volume: 22(6) Issue: 6 Pages: 737-41
  • DOI: 10.1016/j.jstrokecerebrovasdis.2012.01.001
  • Peer Reviewed
• [Journal Article] 認知症における血管病の重要性 (2013)
  • Author(s): 猪原匡史
  • Journal Title: 脳循環代謝 Volume: 24(2) Pages: 83-88
  • Peer Reviewed
• [Journal Article] 認知症の診断と治療を目指した小血管病の管理 (2013)
  • Author(s): 猪原匡史
  • Journal Title: Brain and Nerve Volume: 65(7) Pages: 801-809
  • Peer Reviewed
• [Journal Article] Development of Novel (123)I-Labeled Pyridyl Benzofuran Derivatives for SPECT Imaging of β-Amyloid Plaques in Alzheimer's Disease. (2013)
  • Author(s): Ono M, Cheng Y, Kimura H, Watanabe H, Matsumura K, Yoshimura M, Iikuni S, Okamoto Y, Ihara M, Takahashi R, Saji H.
  • Journal Title: PLoS One Volume: 8 Issue: 9 Pages: e74104-e74104
  • DOI: 10.1371/journal.pone.0074104
  • Peer Reviewed
• [Journal Article] Structure-activity Relationships and in vivo Evaluation of Quinoxaline Derivatives for PET Imaging of β-Amyloid Plaques. (2013)
  • Author(s): Yoshimura M, Ono M, Matsumura K, Watanabe H, Kimura H, Cui M, Nakamoto Y, Togashi K, Okamoto Y, Ihara M, Takahashi R, Saji H.
  • Journal Title: ACS Med Chem Lett Volume: 4 Issue: 7 Pages: 596-600
  • DOI: 10.1021/ml4000707
  • Peer Reviewed
• [Journal Article] Experimental and clinical challenge for neuroregeneration following stroke. (2013)
  • Author(s): Kasahara Y, Ihara M, Taguchi A.
  • Journal Title: Front Neurol Neurosci Volume: 32 Pages: 69-75
  • DOI: 10.1159/000346416
  • ISBN: 9783318023084, 9783318023091
  • Peer Reviewed
• [Journal Article] An highly reproducible model of cerebralischemia/reperfusion with extended survival in CB-17 mice (2013)
  • Author(s): Kasahara Y, Ihara M, Nakagomi T, Momota Y, Sterm D, Matsuyama T, Taguchi A
  • Journal Title: Neurosci Res Volume: 76 Issue: 3 Pages: 163-168
  • DOI: 10.1016/j.neures.2013.04.001
  • Peer Reviewed
• [Journal Article] Synthesis and biological evaluation of novel styryl benzimidazole derivatives as probes for imaging of neurofibrillary tangles in Alzheimer's disease. (2013)
  • Author(s): Matsumura K, Ono M, Yoshimura M, Kimura H, Watanabe H, Okamoto Y, Ihara M, Takahashi R, Saji H.
  • Journal Title: Bioorg Med Chem Volume: 21 Issue: 11 Pages: 3356-3362
  • DOI: 10.1016/j.bmc.2013.02.054
  • Peer Reviewed
• [Journal Article] Visualization of Lenticulostriate Arteries by Flow-Sensitive Black-Blood MR Angiography on a 1.5T MRI System: A Comparative Study between Subjects with and without Stroke. AJNR Am J Neuroradiol. (2013)
  • Author(s): Okuchi S
  • Journal Title: AJNR Am J Neuroradiol Volume: 34 Issue: 4 Pages: 780-784
  • DOI: 10.3174/ajnr.a3310
  • Peer Reviewed
• [Journal Article] 認知症における血管病の重要性． (2013)
  • Author(s): 猪原匡史
  • Journal Title: 脳循環代謝 Volume: 24 Pages: 83-88
  • Peer Reviewed
• [Journal Article] Selective white matter abnormalities in a novel rat model of vascular dementia (2012)
  • Author(s): Kitamura A, Fujita Y, Oishi N, KalariaR N, Washida K, Maki T, Okamoto Y, HaseY, Yamada M, Takahashi J, Ito H, Tomimoto H, Fukuyama H, Takahashi R, Ihara M
  • Journal Title: Neurobiology of Aging Volume: 33 Issue: 5 Pages: 25-35
  • DOI: 10.1016/j.neurobiolaging.2011.10.033
  • NAID: 120003988349
  • Peer Reviewed
• [Journal Article] Cerebral hypoperfusion induces microinfarcts in cerebral amyloid angiopathy (2012)
  • Author(s): Okamoto Y, Yamamoto T, Kalaria RN, Senzaki H, Maki T, Hase Y, Kitamura A, Washida K, Yamada M, Ito H, Tomimoto H, Takahashi R, Ihara M
  • Journal Title: Acta Neuropathol Volume: 123(3) Issue: 3 Pages: 381-394
  • DOI: 10.1007/s00401-011-0925-9
  • Peer Reviewed
• [Journal Article] In vivo imaging of brain ischemia using an oxygen-dependent degradative fusion prote in probe (2012)
  • Author(s): Fujita Y, Kuchimaru T、Kadonosono T, Tanaka S, Hase Y, Tomimoto H, Hiraoka M, Kizaka-Kondoh S, Ihara M, Takahashi R
  • Journal Title: PLoS ONE Volume: 7 Issue: 10 Pages: e48051-e48051
  • DOI: 10.1371/journal.pone.0048051
  • Peer Reviewed
• [Journal Article] Synthesis and biological evaluation of novel oxindole (2012)
  • Author(s): Kalaria RN
  • Journal Title: J Neurol Sci Volume: 322 Issue: 1-2 Pages: 141-7
  • DOI: 10.1016/j.jns.2012.07.032
  • Peer Reviewed
• [Journal Article] Synthesis and biological evaluation of novel oxindole derivatives for imaging neurofibrillary tangles in Alzheimer's disease. (2012)
  • Author(s): Hiroyuki Watanabe, Masahiro Ono, Hiroyuki Kimura, Kenji Matsumura, Masashi Yoshimura, Yok Okamoto, Masafumi Ihara, Ryosuke Takahashi, Hiden Saji
  • Journal Title: Bioorganic & Medicinal Chemistry Letter Volume: 22 Issue: 17 Pages: 5700-5703
  • DOI: 10.1016/j.bmcl.2012.06.086
  • Peer Reviewed
• [Journal Article] Novel ¹⁸F-labeled benzoxazole derivatives as potential positron emission tomography probes for imaging of cerebral β-amyloid plaques in Alzheimer's disease (2012)
  • Author(s): Cui M
  • Journal Title: J Med Chem Volume: 55 Issue: 21 Pages: 9136-45
  • DOI: 10.1021/jm300251n
  • Peer Reviewed
• [Journal Article] A Case of Follicular Lymphoma Associated with Paraneoplastic Cerebellar Degeneration (2012)
  • Author(s): Shimazu Y
  • Journal Title: Internal Medicine Volume: 51 Issue: 11 Pages: 1387-1392
  • DOI: 10.2169/internalmedicine.51.7019
  • NAID: 130002062123
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] Environmental enrichment ameliorated high fat diet-induced Aβdeposition and memory deficit in APP transgenic mice (2012)
  • Author(s): Maesako M, Uemura K, Kubota M, Kuzuya A, Sasaki K, Asada M, Watanabe K, Hayashida N, Ihara M, Ito H, ShimohamaS, Kihara T, Kinoshita A
  • Journal Title: Neurobiology of Aging Volume: 33 Issue: 5 Pages: 11-23
  • DOI: 10.1016/j.neurobiolaging.2011.10.028
  • NAID: 120003988394
  • Peer Reviewed
• [Journal Article] 水頭症を呈したトランスサイレチンVal30Met変異型familial amyloid polyneuropathyの兄弟例 (2012)
  • Author(s): 武山博文
  • Journal Title: 臨床神経学 Volume: 52 Pages: 257-260
  • Peer Reviewed
• [Journal Article] Cilostazol, a phosphodiesterase inhibitor, prevents no-reflow and hemorrhage in mice with focal cerebral ischemia (2012)
  • Author(s): Hase Y, Okamoto Y, Fujita Y, KitamuraA, Ito H, Maki T, Washida K, TakahashiR, Ihara M
  • Journal Title: Experimental Neurology Volume: 233 Issue: 1 Pages: 523-533
  • DOI: 10.1016/j.expneurol.2011.11.038
  • Peer Reviewed
• [Journal Article] 18F-labeled Phenyldiazenyl Benzothiazole for in vivo Imaging of Neurofibrillary Tangles in Alzheimer's Disease Brains (2012)
  • Author(s): Matsumura K, Ono M, et al
  • Journal Title: ACS Med Chem Lett Volume: 3 Pages: 58-62
  • Peer Reviewed
• [Journal Article] Lessons from a mouse model characterizing features of vascular cognitive impairment with white matter changes (2011)
  • Author(s): Ihara M, Tomimoto H
  • Journal Title: J Aging Res Volume: 2011 Pages: 978761-978761
  • DOI: 10.4061/2011/978761
  • Peer Reviewed
• [Journal Article] Watershed Infarcts in a multiple microembolic model of monkey (2011)
  • Author(s): Maki T, Wakita H, Mase M, Itagaki I, Saito N, Ono F, Adachi K, Ito H, Takahashi R, Ihara M, Tomimoto H
  • Journal Title: Neuroscience Letters Volume: 499 Issue: 2 Pages: 80-83
  • DOI: 10.1016/j.neulet.2011.05.036
  • NAID: 120003238944
  • Peer Reviewed
• [Journal Article] Angiogenic roles of adreno medullin through VEGF induction (2011)
  • Author(s): Maki T, Ihara M, Fujita Y, Nambu T, Harada H, Ito H, Nakao K, Tomimoto H, Takahashi R
  • Journal Title: Neuroreport Volume: 22 Issue: 9 Pages: 442-447
  • DOI: 10.1097/wnr.0b013e32834757e4
  • Peer Reviewed
• [Journal Article] The influence of chronic cerebral hypoperfusion on cognitive function and amyloid b metabolism in APP overexpressing mice (2011)
  • Author(s): Yamada M, Ihara M, Okamoto Y, Maki T, Washida K, Kitamura A, Hase Y, Ito H, Takao K, Miyakawa T, Kalaria RN, Tomimoto H, Takahashi R
  • Journal Title: PLoS One Volume: 6 Issue: 1 Pages: e16567-e16567
  • DOI: 10.1371/journal.pone.0016567
  • Peer Reviewed
• [Journal Article] An autopsy case of SOD1-related ALS with TDP-43 positive inclusions (2011)
  • Author(s): Okamoto Y, Ihara M, Urushitani M, Yamashita H, Kondo T, Tanigaki A, Oono M, Kawamata J, Ikemoto A, Kawamoto Y, Takahashi R, Ito H
  • Journal Title: Neurology Volume: 77:1993-1995 Issue: 22 Pages: 1993-1995
  • DOI: 10.1212/wnl.0b013e31823a0cfc
  • Peer Reviewed
• [Journal Article] Clinicopathologic study on an ALS family with a heterozygous E478G optineurin mutation (2011)
  • Author(s): Ito H, Nakamura M, Komure O, Ayaki T, Wate R, Maruyama H, Nakamura Y, FujitaK, Kaneko S, Okamoto Y, Ihara M, Konishi T, Ogasawara K, Hirano A, Kusaka H, KajiR, Takahashi R, Kawakami H
  • Journal Title: Acta Neuropathologica Volume: 122 Issue: 2 Pages: 223-229
  • DOI: 10.1007/s00401-011-0842-y
  • Peer Reviewed
• [Journal Article] Co localization of 14-3-3 proteins with SOD1 in Lewy Body-like hyaline inclusions in familial amyotrophic lateral sclerosis cases and the animal model (2011)
  • Author(s): Okamoto Y, Shirakashi Y, Ihara M, Urushitani M, Oono M, Kawamoto Y, Yamashita H, Shimohama S, Kato S, Hirano A, Tomimoto H, Ito H, Takahashi R
  • Journal Title: PLoS One Volume: 6 Issue: 5 Pages: e20427-e20427
  • DOI: 10.1371/journal.pone.0020427
  • Peer Reviewed
• [Journal Article] Phenyldiazenyl benzothiazole derivatives as probes for in vivo imaging of neurofibrillary tangles in Alzheimer's disease brains (2011)
  • Author(s): Matsumura K, Ono M, et al
  • Journal Title: Med Chem Comm Volume: 2 Issue: 7 Pages: 596-600
  • DOI: 10.1039/c1md00034a
  • Peer Reviewed
• [Journal Article] Rhodanine and thiohydantoin derivatives for detecting tau pathology in Alzheimer's brains (2011)
  • Author(s): Ono M, Hayashi S, et al
  • Journal Title: ACS Chem Neurosci Volume: 2 Issue: 5 Pages: 269-275
  • DOI: 10.1021/cn200002t
  • Peer Reviewed
• [Journal Article] Selective white matter pathology induces a specific impainnent in spatial working memory (2011)
  • Author(s): Coltman R, Spain A, et al
  • Journal Title: Neurobiol Aging Volume: 32 Issue: 12 Pages: 2324.e7-2324.e12
  • DOI: 10.1016/j.neurobiolaging.2010.09.005
  • Peer Reviewed
• [Journal Article] Angiogenic and vasoprotective effects of adrenomedullin on prevention of cognitive decline after chronic cerebral hypoperfusion in mice (2011)
  • Author(s): Tomimoto H
  • Journal Title: Stroke Volume: 42(4) Issue: 4 Pages: 1122-8
  • DOI: 10.1161/strokeaha.110.603399
  • Peer Reviewed
• [Journal Article] Phosphodiesterase III inhibitor promotes drainage of cerebrovascular β -amyloid
  • Author(s): Maki T, Okamoto Y, Carare R, Hase Y, Hattori Y, Hawkes C, Saito S, Yamamoto Y, Terasaki Y, Ishibashi-Ueda, H, Taguchi A, Takahashi R, Miyakawa T, Kalaria R, Lo E, Arai K, Ihara M
  • Journal Title: Ann Clin Transl Neurol Volume: (in press)
  • Peer Reviewed
• [Journal Article] 高血糖とアルツハイマー病
  • Author(s): 猪原匡史
  • Journal Title: 医学のあゆみ Volume: (印刷中)
  • Peer Reviewed
• [Presentation] Bench to bedside : using mouse models to identify new treatment approaches for Alzheimer' s disease (2013)
  • Author(s): Ihara M
  • Organizer: Invited lecture : 19th Southampton Neuroscience Group (SoNG) Meeting
  • Place of Presentation: Southampton, UK
  • Year and Date: 2013-09-19
• [Presentation] Generating rodent models of chronic cerebral hypoperfusion and investigating the pathogenesis of vascular cognitive impairment (2013)
  • Author(s): Ihara M
  • Organizer: Plenary session (Special session on animal models of VCI) . Vas-Cog2013
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2013-06-26
• [Presentation] Lessons from rodent models characterizing features of vascular cognitive impairment (2013)
  • Author(s): Ihara M
  • Organizer: Minisymposium (Animal models of VCI) . Vas-Cog2013
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2013-06-26
• [Presentation] S2-5-2中枢神経疾患治療に対するトランスレーショナルリサーチの現状とその課題 (2013)
  • Author(s): Ihara M
  • Organizer: Novel mechanism and therapy to treat patient with dementia. Neuro2013
  • Place of Presentation: 京都
  • Year and Date: 2013-06-21
• [Presentation] Symposium S(4) -1. Vascular Dementia and Its Associated Conditions-Vascular Cognitive Impairment (VCI) . Cerebral amyloid angiopathy and cognitive impairment (2013)
  • Author(s): Ihara M
  • Organizer: 第54回日本神経学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2013-06-01
• [Presentation] βアミロイドの血管依存性クリアランス (2011)
  • Author(s): 猪原匡史
  • Organizer: 日本認知症学会学術集会
  • Place of Presentation: タワーホール船堀(東京都)
  • Year and Date: 2011-11-12
• [Presentation] 脳低灌流によりβアミロイドの血管依存性クリアランスが障害される (2011)
  • Author(s): 猪原匡史, 他
  • Organizer: 日本認知症学会学術集会
  • Place of Presentation: タワーホール船堀(東京都)
  • Year and Date: 2011-11-11
• [Presentation] Animal models for vascular cognitive impairment due to large vessel disease. Stroke Symposium in National University of Singapore (2011)
  • Author(s): Masafumi Ihara
  • Organizer: Stroke Symposium in National University of Singapore
  • Place of Presentation: Singapore(招待講演)
  • Year and Date: 2011-10-31
• [Presentation] Angiogenic and vasoprotectivc effects of adrenomedullin on prevention of cognitive decline after chronic cerebral hypoperfusion in mice (2011)
  • Author(s): Masafumi Ihara
  • Organizer: Vas-Cog2011
  • Place of Presentation: France
  • Year and Date: 2011-09-14
• [Presentation] モントリオール認知評価法MoCAはMMSEよりも皮質下血管性認知障害の検出感度が高い (2011)
  • Author(s): 猪原匡史
  • Organizer: 日本神経学会総会
  • Place of Presentation: 名古屋国際会議場(名古屋市)
  • Year and Date: 2011-05-18
• [Presentation] Bench to bedside: using mouse models to identify new treatment approaches for Alzheimer’s disease.
  • Author(s): Masafumi Ihara.
  • Organizer: Invited lecture: 19th Southampton Neuroscience Group (SoNG) Meeting
  • Place of Presentation: Southampton
  • Invited
• [Presentation] Generating rodent models of chronic cerebral hypoperfusion and investigating the pathogenesis of vascular cognitive impairment.
  • Author(s): Masafumi Ihara.
  • Organizer: Plenary session (Special session on animal models of VCI). Vas-Cog2013
  • Place of Presentation: Toronto
  • Invited
• [Presentation] Lessons from rodent models characterizing features of vascular cognitive impairment.
  • Author(s): Masafumi Ihara.
  • Organizer: Minisymposium (Animal models of VCI). Vas-Cog2013
  • Place of Presentation: Toronto
  • Invited
• [Presentation] シンポジウム5「血管性認知障害」血管性認知障害の病態－モデル動物を用いて明らかとなった知見－
  • Author(s): 猪原匡史
  • Organizer: 第39回日本脳卒中学会総会
  • Place of Presentation: 大阪
  • Invited
• [Presentation] 「認知症の発症にかかわる脳血管の機能」．
  • Author(s): 猪原匡史
  • Organizer: 脳心血管抗加齢研究会2013
  • Place of Presentation: 大阪
  • Invited
• [Presentation] シロスタゾールによる血管依存性βアミロイドクリアランスの促進．
  • Author(s): 猪原匡史
  • Organizer: 脳循環代謝学会
  • Place of Presentation: 札幌
  • Invited
• [Presentation] 「血管病としての認知症」
  • Author(s): 猪原匡史
  • Organizer: Vas-Cog Japan
  • Place of Presentation: 東京
• [Presentation] S2-5-2中枢神経疾患治療に対するトランスレーショナルリサーチの現状とその課題．
  • Author(s): Masafumi Ihara.
  • Organizer: Novel mechanism and therapy to treat patient with dementia. Neuro2013
  • Place of Presentation: 京都
• [Presentation] Symposium S（4）-1.Vascular Dementia and Its Associated Conditions-Vascular Cognitive Impairment （VCI）．Cerebral amyloid angiopathy and cognitive impairment．
  • Author(s): Masafumi Ihara.
  • Organizer: 第54回日本神経学会学術大会
  • Place of Presentation: 東京
• [Presentation] Animal models of brain hypoperfusion and cognitive impairment
  • Author(s): Masafumi Ihara
  • Organizer: BRAIN AGEING AND DEMENTIA IN DEVELOPING COUNTRIES 2012
  • Place of Presentation: Nairobi
  • Invited
• [Presentation] Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical
  • Author(s): Masafumi Ihara
  • Organizer: 3rd CAA meeting (Plenary lecture)
  • Place of Presentation: Leiden
  • Invited
• [Presentation] Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical
  • Author(s): Masafumi Ihara
  • Organizer: World Stroke Congress
  • Place of Presentation: Brazilia
• [Presentation] シンポジウム１．血管性認知症の最先端「血管性認知症とAlzheimer病理」
  • Author(s): 猪原匡史
  • Organizer: 第31回日本認知症学会学術集会
  • Place of Presentation: つくば
  • Invited
• [Presentation] 血管病としての認知症～その制圧へ向けた試み～
  • Author(s): 猪原匡史
  • Organizer: 第3回VAS-COG Japan 2012
  • Place of Presentation: 東京
  • Invited
• [Presentation] 認知症における脳血管病変
  • Author(s): 猪原匡史
  • Organizer: 第3回VAS-COG Japan 2012
  • Place of Presentation: 東京
  • Invited
• [Presentation] 小血管病における虚血性線条体障害：11C-フルマゼニルPETによる解析
  • Author(s): 猪原匡史
  • Organizer: 第5回J-CAN (Japanese Consortium for Age-related Neurodegenerative disorders) 2012
  • Place of Presentation: 東京
  • Invited
• [Presentation] 皮質下血管性認知症患者におけるモントリオール認知評価スコアと身体活動度との相関
  • Author(s): 猪原匡史
  • Organizer: 第53回日本神経学会総会
  • Place of Presentation: 東京
• [Presentation] 認知症患者における抗血栓療法の有効性と安全性に関する分子病理学的検討
  • Author(s): 猪原匡史
  • Organizer: 第37回日本脳卒中学会
  • Place of Presentation: 東京
• [Book] 慢性脳低灌流モデル.北徹, 堀内久徳, 柳田素子, 猪原匡史, 冨本秀和, 並河徹編「モデル動物利用マニュアル. 疾患モデルの作製と利用-循環器疾患」(株)
  • Author(s): 猪原匡史, 冨本秀和
  • Total Pages: 486
  • Publisher: エル・アイ・シー
• [Patent(Industrial Property Rights)] 間質流改善薬 (2012)
  • Inventor(s): 猪原匡史, 眞木崇州, 田口明彦
  • Industrial Property Rights Holder: 公益財団法人・先端医療振興財団
  • Industrial Property Number: 2012-135906
  • Filing Date: 2012-06-15
• [Patent(Industrial Property Rights)] 間質流改善薬 (2012)
  • Inventor(s): 猪原匡史、眞木崇州、田口明彦
  • Industrial Property Rights Holder: 猪原匡史、眞木崇州、田口明彦
  • Industrial Property Rights Type: 特許
  • Filing Date: 2012-06-15