Molecular analysis of cell stress regulation by molecular chaperon and application for diabetes treatment
Project/Area Number |
23390243
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Metabolomics
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Research Institution | Kumamoto University |
Principal Investigator |
ARAKI Eiichi 熊本大学, 生命科学研究部, 教授 (10253733)
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Co-Investigator(Kenkyū-buntansha) |
KONDO Tatsuya 熊本大学, 大学院・生命科学研究部, 助教 (70398204)
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Project Period (FY) |
2011-11-18 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2013: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
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Keywords | 糖尿病 / 小胞体ストレス / 分子シャペロン / BiP / HSP72 |
Research Abstract |
Induction of molecular chaperone, such as BiP or HSP72 on insulin sensitive tissues improved glucose homeostasis, insulin signaling and ER stress resistance both in vitro and in vivo. On the other hand, attenuation of BiP or HSP72 resulted in impairment of glucose handling and less ER stress resistance. On analyses of gene expressions when HSP72 was over expressed, AMPK, PGC-1a and Sirt1 mRNA were un-regulated. These molecules may exert anti-diabetic effects upon HSP72 induction.
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Report
(4 results)
Research Products
(92 results)
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[Journal Article] The serine protease prostasin regulates hepatic insulin sensitivity by modulating TLR4 signalling.2014
Author(s)
Uchimura K, Hayata M, Mizumoto T, Miyasato Y, Kakizoe Y, Morinaga J, Onoue T, Yamazoe R, Ueda M, Adachi M, Miyoshi T, Shiraishi N, Ogawa W, Fukuda K, Kondo T, Matsumura T, Araki E, Tomita K, Kitamura K.
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Journal Title
Nat Commun.
Volume: 11
Issue: 1
Pages: 3428-3428
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] for the Tofogliflozin 004 and 005 Study group. Long-term safety and efficacy of tofogliflozin, a selective inhibitor of sodium-glucose cotransporter 2, as monotherapy or in combination with other oral antidiabetic agents in Japanese patients with type 2 diabetes mellitus: multicenter, open-label, randomized controlled trials2014
Author(s)
Tanizawa Y, Kaku K, Araki E, Tobe K, Terauchi Y, Utsunomiya K, Iwamoto Y, Watada H, Ohtsuka W, Watanabe D, Suganami H
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Journal Title
Expert Opin Pharmacother
Volume: 15(6)
Issue: 6
Pages: 749-766
DOI
Related Report
Peer Reviewed
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[Journal Article] Association between circulating leukocyte subtype counts and carotid intima-media thickness in Japanese subjects with type 2 diabetes.2013
Author(s)
Matsumura T, Taketa K, Motoshima H, Senokuchi T, Ishii N, Kinoshita H, Fukuda K, Yamada S, Kukidome D, Kondo T, Hisada A, Katoh T, Shimoda S, Nishikawa T, Araki E.
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Journal Title
Cardiovascular Diabetology
Volume: 12(1)
Issue: 1
Pages: 177-177
DOI
Related Report
Peer Reviewed
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[Journal Article] Effects of combination therapy with vildagliptin and valsartan in a mouse model of type 2 diabetes.2013
Author(s)
Miyagawa K, Kondo T, Goto R, Matsuyama R, Ono K, Kitano S, Kawasaki S, Igata M, Kawashima J, Matsumura T, Motoshima H, Araki E.
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Journal Title
Cardiovascular Diabetology
Volume: 12(1)
Issue: 1
Pages: 160-160
DOI
Related Report
Peer Reviewed
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[Journal Article] Efficacy and safety of sitagliptin as add-on therapy on glycemic control and blood glucose fluctuation in Japanese type 2 diabetes subjects ongoing with multiple daily insulin injections therapy2013
Author(s)
Shimoda S, Iwashita S, Ichimori S, Matsuo Y, Goto R, Maeda T, Matsuo T, Sekigami T, Kawashima J, Kondo T, Matsumura T, Motoshima H, Furukawa N, Nishida K, Araki E.
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Journal Title
Endocrine Journal
Volume: 60
Issue: 10
Pages: 1207-1214
DOI
NAID
ISSN
0918-8959, 1348-4540
Related Report
Peer Reviewed
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[Journal Article] Relationship between lifestyle and lifestyle-related factors in a rural-urban population of Japan.2013
Author(s)
Zhang SC, Wei CN, Harada K, Ueda K, Fukumoto K, Matsuo H, Minamoto K, Nishikawa T, Araki E, Ueda A, Fang J
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Journal Title
Environ Health Prev Med
Volume: 18
Issue: 4
Pages: 267-274
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Long-term safety of linagliptin monotherapy in Japanese patients with type 2 diabetes.2013
Author(s)
Araki E, Kawamori R, Inagaki N, Watada H, Hayashi N, Horie Y, Sarashina A, Thiemann S, von Eynatten M, Dugi K, Woerle HJ
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Journal Title
Diabetes Obes Metab
Volume: 15
Issue: 4
Pages: 364-371
DOI
Related Report
Peer Reviewed
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[Journal Article] The phosphatase Dullard negatively regulates BMP signalling and is essential for nephron maintenance after birth.2013
Author(s)
Sakaguchi M, Sharmin S, Taguchi A, Ohmori T, Fujimura S, Abe T, Kiyonari H, Komatsu Y, Mishina Y, Asashima M, Araki E, Nishinakamura R
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Journal Title
Nature Communications
Volume: 4
Issue: 1
Pages: 1398-1398
DOI
Related Report
Peer Reviewed
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[Journal Article] Hyperthermia With Mild Electrical Stimulation Protects Pancreatic β-Cells From Cell Stresses and Apoptosis2012
Author(s)
Kondo T, Sasaki K, Matsuyama R, Morino-Koga S, Adachi H, Suico MA, Kawashima J, Motoshima H, Furukawa N, Kai H, Araki E
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Journal Title
Diabetes
Volume: 61(4)
Issue: 4
Pages: 838-847
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] The impact of Ca²⁺/calmodulin-dependent protein kinase II on insulin gene expression in MIN6 cells.2012
Author(s)
Suefuji M, Furukawa N, Matsumoto K, Oiso H, Shimoda S, Yoshinaga T, Matsuyama R, Miyagawa K,Kondo T, Kawashima J, Tsuruzoe K, Araki E.
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Journal Title
Biochem Biophys Res Commun.
Volume: 421 (4)
Issue: 4
Pages: 801-807
DOI
Related Report
Peer Reviewed
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[Journal Article] Glucose Uptake in Rat Skeletal Muscle L6 Cells Is Increased by Low-Intensity Electrical Current Through the Activation of the Phosphatidylinositol-3-OH Kinase (PI-3K) / Akt Pathway2011
Author(s)
Yano S, Morino-Koga S, Kondo T, Suico MA, Koga T, Shimauchi Y, Matsuyama S, Shuto T, Sato T, Araki E, Kai H
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Journal Title
Journal of Pharmacological Sciences
Volume: 115
Issue: 1
Pages: 94-98
DOI
NAID
ISSN
1347-8613, 1347-8648
Related Report
Peer Reviewed
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[Presentation] Heat Treatment with Mild Electrical Stimulation Attenuates Systemic Inflammation and Reduces Cytokine Expression in Monocytes from subjects with Metabolic Syndrome2014
Author(s)
Tatsuya Kondo, Rina Matsuyama, Rieko Goto, Kaoru Ono, Sayaka Kitano, Junji Kawashima, Hiroyuki Motoshima, Takeshi Matsumura, Hirofumi Kai, Eiichi Araki
Organizer
The 74th Annual Meeting of American Diabetes Association
Place of Presentation
San Francisco, USA
Related Report
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[Presentation] Activation of Heat Shock Response Improves Metabolic Profiles in Type 2 Diabetes.2013
Author(s)
Tatsuya Kondo, Katsutoshi Miyagawa, Rina Matsuyama, Rieko Goto, Kaoru Ono, Sayaka Kitano, Hiroyuki Motoshima, Junji Kawashima, Takeshi Matsumura, Hirofumi Kai, Eiichi Araki.
Organizer
2013 International Conference of Diabetes and Metabolism and 5th AASD
Place of Presentation
Seoul, Korea
Related Report
Invited
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[Presentation] The Role of Aldosterone in the Pathogenesis of Diabetes in Human and Rats.2013
Author(s)
Goto R, Kondo T, Ono K, Matsuyama R, Miyagawa K, Igata M, Kawashima J, Matsumura T, Motoshima H, Shimoda S, Araki E
Organizer
The 73th Annual Meeting of American Diabetes Association
Place of Presentation
Chicago, USA
Related Report
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[Presentation] The Critical Role of Heat Shock Protein 72 in Diabetic Pathophysiology.2013
Author(s)
Matsuyama R, Kondo T, Miyagawa K, Goto R, Ono K, Igata M, Kawashima J, Matsumura T, Motoshima H, Araki E
Organizer
The 73th Annual Meeting of American Diabetes Association
Place of Presentation
Chicago, USA
Related Report
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[Presentation] Heat Shock Response Activation using Heat Treatment with Mild Electrical Stimulation Reduces Visceral Adiposity and Improves Insulin Resistance and Inflammation in Male Subjects with Type 2 Diabetes2013
Author(s)
Tatsuya Kondo, Rina Matsuyama, Rieko Goto, Kaoru Ono, Sayaka Kitano, Junji Kawashima, Hiroyuki Motoshima, Takeshi Matsumura, Hirofumi Kai, Eiichi Araki
Organizer
CSSI scientific meeting.
Place of Presentation
Sheffield, United Kingdom
Related Report
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[Presentation] Activation of Heat Shock Response Reduces Visceral Adiposity, Improves Insulin Resistance and Inflammatory Markers in Male Subjects with Metabolic Syndrome and Type 2 Diabetes2011
Author(s)
Tatsuya Kondo, Rina Matsuyama, Saori Koga, Katsutoshi Miyagawa, Rieko Goto, Mary Ann Suico, Junji Kawashima, Hiroyuki Motoshima, Noboru Furukawa, Kaku Tsuruzoe, Hirofumi Kai, Eiichi Araki
Organizer
ENDO 2011 (American Endocrine Society Meeting)
Place of Presentation
Boston, USA
Year and Date
2011-06-04
Related Report
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