| Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2013: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2011: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
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| Research Abstract |
We investigated the function and physiological role of the sweet taste receptor in pancreatic beta-cells, adipocytes and enteroendocrine cells. In pancreatic beta-cells, the sweet taste receptor subunit T1R3 forms a homodimer and function as a sweet taste-sensing receptor. This receptor is activated by glucose, the most important regulator of insulin secretion. Glucose activates the receptor and promotes its own metabolism in beta-cells. Hence, the sweet taste-sensing receptor plays a vital role in the regulation of insulin secretion. In adipocytes, the sweet taste-sensing receptor, a homodimer of T1R3, negatively regulates differentiation of preadipocytes to mature adipocytes. In enteroendocrine L-cells, the sweet taste-sensing receptor, a homodimer of T1R3, is activated by glucose and other sweet substances and promotes secretion of glucagon-like peptide-1 (GLP-1).
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